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Term:keratan sulfate biosynthetic process
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Accession:GO:0018146 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues.
Synonyms:exact_synonym: keratan sulfate anabolism;   keratan sulfate biosynthesis;   keratan sulfate formation;   keratan sulfate synthesis;   keratan sulphate biosynthesis;   keratan sulphate biosynthetic process
 xref: RESID:AA0247

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keratan sulfate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B3gnt7 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 involved_in ISO
(MGI:6151274|PMID:29625490) MGI
PMID:29625490 GO_REF:0000096 MGI:4834177 MGI:6151274 NCBI chr 1:86,303,221...86,307,305
Ensembl chr 1:86,302,832...86,307,305
JBrowse link
G B4galt4 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 4 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr16:38,742,220...38,769,054
Ensembl chr16:38,742,264...38,769,049
JBrowse link
G Chst1 carbohydrate sulfotransferase 1 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 2:92,599,632...92,615,252
Ensembl chr 2:92,599,707...92,615,250
JBrowse link
G Chst5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 involved_in IBA
PMID:11278593 PMID:21873635 MGI:1934540 MGI:6201960 NCBI chr 8:111,889,135...111,910,199
Ensembl chr 8:111,889,136...111,910,447
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  biological_process 28615
    metabolic process 11339
      cellular metabolic process 10169
        sulfur compound metabolic process 331
          sulfur compound biosynthetic process 94
            keratan sulfate biosynthetic process 4
Path 2
Term Annotations click to browse term
  biological_process 28615
    metabolic process 11339
      organic substance metabolic process 10921
        macromolecule metabolic process 9377
          aminoglycan metabolic process 111
            glycosaminoglycan metabolic process 94
              mucopolysaccharide metabolic process 74
                keratan sulfate metabolic process 5
                  keratan sulfate biosynthetic process 4
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