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Term:keratan sulfate biosynthetic process
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Accession:GO:0018146 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues.
Synonyms:exact_synonym: keratan sulfate anabolism;   keratan sulfate biosynthesis;   keratan sulfate formation;   keratan sulfate synthesis;   keratan sulphate biosynthesis;   keratan sulphate biosynthetic process
 xref: RESID:AA0247

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keratan sulfate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B3GNT7 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 involved_in ISO (PMID:17690104)
UniProt PMID:17690104 PMID:29625490 MGI:6151274 NCBI chr25:43,287,937...43,293,416 JBrowse link
G B4GALT4 beta-1,4-galactosyltransferase 4 involved_in IEA Ensembl
GO_REF:0000107 NCBI chr33:22,903,842...22,920,955
Ensembl chr33:22,904,149...22,920,956
JBrowse link
G CHST1 carbohydrate sulfotransferase 1 involved_in ISO (PMID:17690104) UniProt PMID:17690104 NCBI chr18:43,734,469...43,739,640 JBrowse link
G LOC489707 carbohydrate sulfotransferase 6 involved_in IBA (PMID:21873635) GO_Central
PMID:21873635 NCBI chr 5:75,266,932...75,280,790 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16237
    metabolic process 10499
      cellular metabolic process 9515
        sulfur compound metabolic process 296
          sulfur compound biosynthetic process 104
            keratan sulfate biosynthetic process 4
Path 2
Term Annotations click to browse term
  biological_process 16237
    metabolic process 10499
      organic substance metabolic process 10087
        macromolecule metabolic process 8743
          aminoglycan metabolic process 102
            glycosaminoglycan metabolic process 90
              mucopolysaccharide metabolic process 74
                keratan sulfate metabolic process 5
                  keratan sulfate biosynthetic process 4
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