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ONTOLOGY REPORT - ANNOTATIONS

Term:peptidyl-diphthamide biosynthetic process from peptidyl-histidine
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Accession:GO:0017183 term browser browse the term
Definition:The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria.
Synonyms:exact_synonym: peptidyl-diphthamide anabolism from peptidyl-histidine;   peptidyl-diphthamide formation from peptidyl-histidine;   peptidyl-diphthamide synthesis from peptidyl-histidine
 xref: RESID:AA0040


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peptidyl-diphthamide biosynthetic process from peptidyl-histidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dph1 diphthamide biosynthesis 1 involved_in ISO
IEA
IBA		 (MGI:5603957|PMID:24895408)
GO_REF:0000041
PMID:21873635		 RGD
UniProt		 PMID:24895408 PMID:21873635 GO_REF:0000041 MGI:5603957, RGD:13792537 NCBI chr10:60,028,081...60,039,764
Ensembl chr10:60,026,048...60,039,850 		JBrowse link
G Dph2 diphthamide biosynthesis 2 involved_in IEA
ISS
ISO
IBA		 GO_REF:0000041
GO_REF:0000024
(PMID:32576952)
PMID:21873635		 UniProt
RGD		 PMID:32576952 PMID:21873635 GO_REF:0000024 GO_REF:0000041, RGD:13792537 NCBI chr 5:131,428,434...131,431,394
Ensembl chr 5:131,428,268...131,431,395 		JBrowse link
G Dph3 diphthamide biosynthesis 3 involved_in ISO (MGI:3625663|PMID:16648478) RGD PMID:16648478 MGI:3625663 NCBI chr16:7,288,295...7,293,734
Ensembl chr16:7,282,705...7,291,265 		JBrowse link
G Dph5 diphthamide biosynthesis 5 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 2:203,804,620...203,858,196
Ensembl chr 2:203,804,936...203,840,433 		JBrowse link
G Dph6 diphthamine biosynthesis 6 involved_in IEA
IBA		 GO_REF:0000041
PMID:21873635		 UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 3:101,307,229...101,437,463
Ensembl chr 3:101,307,231...101,534,603 		JBrowse link
G Dph7 diphthamide biosynthesis 7 involved_in ISO
ISS
IBA		 (PMID:19965467)
GO_REF:0000024
PMID:21873635		 RGD
UniProt		 PMID:19965467 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 3:7,770,385...7,778,994
Ensembl chr 3:7,770,379...7,778,982 		JBrowse link
G Ovca2 OVCA2 serine hydrolase domain containing involved_in IEA
IBA		 GO_REF:0000041
PMID:21873635		 UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr10:60,026,048...60,029,211
Ensembl chr10:60,026,048...60,039,850 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19818
    metabolic process 12096
      biosynthetic process 6307
        cellular biosynthetic process 2928
          peptidyl-diphthamide biosynthetic process from peptidyl-histidine 7
Path 2
Term Annotations click to browse term
  biological_process 19818
    metabolic process 12096
      nitrogen compound metabolic process 8258
        cellular nitrogen compound metabolic process 4012
          cellular nitrogen compound biosynthetic process 2214
            amide biosynthetic process 1368
              peptide biosynthetic process 1238
                translation 1214
                  cytoplasmic translation 197
                    cytoplasmic translational elongation 16
                      regulation of cytoplasmic translational elongation 10
                        peptidyl-diphthamide biosynthetic process from peptidyl-histidine 7
paths to the root