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ONTOLOGY REPORT - ANNOTATIONS

Term:NMDA selective glutamate receptor complex
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Accession:GO:0017146 term browser browse the term
Definition:An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. NMDA receptors are composed of assemblies of NR1 subunits (Figure 3) and NR2 subunits, which can be one of four separate gene products (NR2A-D). Expression of both subunits are required to form functional channels. The glutamate binding domain is formed at the junction of NR1 and NR2 subunits. NMDA receptors are permeable to calcium ions as well as being permeable to other ions. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells, a signal thought to be crucial for the induction of NMDA-receptor dependent LTP and LTD.
Synonyms:exact_synonym: N-methyl-D-aspartate selective glutamate receptor complex;   NMDA-selective glutamate receptor


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NMDA selective glutamate receptor complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eps8 epidermal growth factor receptor pathway substrate 8 part_of IDA (PMID:17018287) MGI PMID:17018287 NCBI chr 6:137,454,242...137,626,262
Ensembl chr 6:137,454,243...137,631,874 		JBrowse link
G Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) part_of
located_in		 ISO
IBA
IPI		 PMID:24876489
PMID:24462099
(PMID:9003035)		 RGD
MGI
ComplexPortal
GO_Central		 PMID:9003035 PMID:16477151 PMID:17050728 PMID:22493736 PMID:24462099 More... GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:13432263 RGD:150521652 RGD:1642190 RGD:1642380 RGD:7241301 NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199 		JBrowse link
G Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) part_of
located_in		 ISO
IPI
IBA		 PMID:24462099
(PMID:7929101)
(PMID:9003035)		 RGD
MGI
ComplexPortal
GO_Central		 PMID:7929101 PMID:9003035 PMID:16477151 PMID:22493736 PMID:24462099 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:150521652 RGD:1642190 RGD:7241301 NCBI chr16:9,385,765...9,813,744
Ensembl chr16:9,385,762...9,813,424 		JBrowse link
G Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) part_of
located_in		 ISO
IPI
IBA		 PMID:24876489
(PMID:9003035)		 RGD
MGI
ComplexPortal
GO_Central		 PMID:1350383 PMID:9003035 PMID:16477151 PMID:24876489 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:13432263 RGD:1642190 RGD:727540 NCBI chr 6:135,690,219...136,150,658
Ensembl chr 6:135,690,231...136,150,509 		JBrowse link
G Grin2c glutamate receptor, ionotropic, NMDA2C (epsilon 3) part_of ISO
IPI
IBA		 (PMID:7929101) MGI
GO_Central		 PMID:7929101 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr11:115,139,995...115,158,123
Ensembl chr11:115,139,995...115,158,069 		JBrowse link
G Grin2d glutamate receptor, ionotropic, NMDA2D (epsilon 4) part_of ISO
IBA		 RGD
MGI
GO_Central		 PMID:17050728 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:1642380 NCBI chr 7:45,481,307...45,520,708
Ensembl chr 7:45,481,307...45,527,802 		JBrowse link
G Grin3a glutamate receptor ionotropic, NMDA3A part_of ISO RGD
MGI		 PMID:16477151 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:1642190 NCBI chr 4:49,661,611...49,846,023
Ensembl chr 4:49,661,611...49,845,744 		JBrowse link
G Grin3b glutamate receptor, ionotropic, NMDA3B part_of IMP
ISO		 (MGI:3688366|PMID:14602821) UniProt
RGD
MGI		 PMID:11823786 PMID:14602821 GO_REF:0000096 MGI:3688366 MGI:4417868 RGD:632842 NCBI chr10:79,806,227...79,813,024
Ensembl chr10:79,806,549...79,813,024 		JBrowse link
G Ptk2b PTK2 protein tyrosine kinase 2 beta part_of
is_active_in		 ISO PMID:15814199 MGI
Alzheimers_University_of_Toronto		 PMID:15814199 GO_REF:0000096 MGI:4417868 RGD:8655534 NCBI chr14:66,390,706...66,518,549
Ensembl chr14:66,390,706...66,518,501 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 28583
    protein-containing complex 6171
      receptor complex 420
        plasma membrane signaling receptor complex 200
          neurotransmitter receptor complex 47
            ionotropic glutamate receptor complex 45
              NMDA selective glutamate receptor complex 9
Path 2
Term Annotations click to browse term
  cellular_component 28583
    cellular anatomical entity 19615
      membrane 9792
        membrane protein complex 1286
          plasma membrane protein complex 614
            plasma membrane signaling receptor complex 200
              neurotransmitter receptor complex 47
                ionotropic glutamate receptor complex 45
                  NMDA selective glutamate receptor complex 9
paths to the root