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ONTOLOGY REPORT - ANNOTATIONS


Term:phospholipid scramblase activity
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Accession:GO:0017128 term browser browse the term
Definition:Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism.
Comment:Nomenclature note. Scramblases are ATP-independent, non-selective, inducing non-specific transbilayer movements across the membrane. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). Some authors however use the name floppase to denote any enzyme catalyzing transbilayer lipid motion, in some cases even in the absence of ATP requirements (PMID 20043909).


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phospholipid scramblase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ano1 anoctamin 1 JBrowse link 1 217,754,349 217,902,540 RGD:1624291
G Ano10 anoctamin 10 JBrowse link 8 130,812,941 130,931,021 RGD:1624291
G Ano2 anoctamin 2 JBrowse link 4 158,222,650 158,577,595 RGD:1624291
G Ano3 anoctamin 3 JBrowse link 3 101,843,516 102,203,368 RGD:1624291
RGD:13792537
G Ano4 anoctamin 4 JBrowse link 7 29,492,017 30,025,587 RGD:1624291
RGD:13792537
G Ano5 anoctamin 5 JBrowse link 1 106,873,580 106,971,769 RGD:1624291
G Ano6 anoctamin 6 JBrowse link 7 137,142,063 137,335,208 RGD:1624291
G Ano7 anoctamin 7 JBrowse link 9 100,511,610 100,551,798 RGD:1624291
G Ano8 anoctamin 8 JBrowse link 16 19,884,661 19,894,608 RGD:1624291
G Ano9 anoctamin 9 JBrowse link 1 213,908,389 213,929,291 RGD:1624291
RGD:13792537
G LOC102551265 phospholipid scramblase 1-like JBrowse link 8 99,740,031 99,783,260 RGD:13792537
G Plscr1 phospholipid scramblase 1 JBrowse link 8 99,625,523 99,645,882 RGD:1600115
RGD:13792537
RGD:1624291
G Plscr2 phospholipid scramblase 2 JBrowse link 8 99,650,351 99,725,514 RGD:1600115
G Plscr3 phospholipid scramblase 3 JBrowse link 10 56,452,632 56,458,390 RGD:13792537
G Plscr4 phospholipid scramblase 4 JBrowse link 8 99,880,073 99,917,733 RGD:13792537
G Plscr5 phospholipid scramblase family, member 5 JBrowse link 8 99,558,279 99,579,791 RGD:13792537

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  molecular_function 19678
    transporter activity 1243
      lipid transporter activity 155
        intramembrane lipid transporter activity 43
          phospholipid scramblase activity 16
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.