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ONTOLOGY REPORT - ANNOTATIONS

Term:plasma membrane phospholipid scrambling
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Accession:GO:0017121 term browser browse the term
Definition:The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet, resulting in loss of lipid asymmetry and surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE).
Comment:Note that this term describes the trans-bilayer motion of a population of phospholipid molecules, and should not be confused with 'phospholipid translocation ; GO:0045332'.
Synonyms:exact_synonym: PL scrambling
 related_synonym: phospholipid scrambling


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plasma membrane phospholipid scrambling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ano3 anoctamin 3 acts_upstream_of_or_within ISO (MGI:5496475|PMID:23532839) RGD PMID:23532839 MGI:5496475 NCBI chr 3:97,235,671...97,550,090
Ensembl chr 3:97,238,354...97,550,154 		JBrowse link
G Ano6 anoctamin 6 involved_in
acts_upstream_of_or_within		 ISO (PMID:25651887), (PMID:30700552)
(MGI:5496475|PMID:23532839)
(MGI:5440105|PMID:23021219)		 RGD PMID:23021219 PMID:23532839 PMID:25651887 PMID:30700552 MGI:5440105 MGI:5496475 NCBI chr 7:126,933,629...127,113,589
Ensembl chr 7:126,933,936...127,113,589 		JBrowse link
G Ano7 anoctamin 7 acts_upstream_of_or_within ISO (MGI:5496475|PMID:23532839) RGD PMID:23532839 MGI:5496475 NCBI chr 9:93,917,524...93,945,323
Ensembl chr 9:93,917,524...93,945,323 		JBrowse link
G Ano9 anoctamin 9 acts_upstream_of_or_within ISO (MGI:5496475|PMID:23532839) RGD PMID:23532839 MGI:5496475 NCBI chr 1:196,208,863...196,230,381
Ensembl chr 1:196,197,341...196,229,900 		JBrowse link
G Atg9a autophagy related 9A involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 9:76,677,403...76,688,035
Ensembl chr 9:76,677,404...76,687,986 		JBrowse link
G Clptm1l CLPTM1-like involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:29,667,545...29,683,530
Ensembl chr 1:29,667,545...29,683,530 		JBrowse link
G LOC102551265 phospholipid scramblase 1-like involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:92,860,465...92,903,695
Ensembl chr 8:92,860,469...92,903,755 		JBrowse link
G P2rx7 purinergic receptor P2X 7 involved_in ISO (PMID:25651887) RGD PMID:25651887 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619 		JBrowse link
G Plscr1 phospholipid scramblase 1 involved_in IMP
IBA
ISO
IEA		 PMID:17712045
PMID:21873635
(MGI:5284813|PMID:12509439)
(PMID:10770950), (PMID:18629440), (PMID:9218461)
GO_REF:0000002		 RGD
InterPro		 PMID:9218461 PMID:10770950 PMID:12509439 PMID:18629440 PMID:17712045 More... GO_REF:0000002 MGI:5284813, RGD:8553758, RGD:13792537 NCBI chr 8:92,784,279...92,804,698
Ensembl chr 8:92,784,356...92,804,692 		JBrowse link
G Plscr2 phospholipid scramblase 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 8:92,809,422...92,845,947
Ensembl chr 8:92,808,398...92,845,932 		JBrowse link
G Plscr3 phospholipid scramblase 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:54,566,556...54,573,240
Ensembl chr10:54,566,873...54,578,709 		JBrowse link
G Plscr4 phospholipid scramblase 4 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:92,987,290...93,026,056
Ensembl chr 8:92,987,381...93,026,049 		JBrowse link
G Plscr5 phospholipid scramblase family, member 5 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:92,717,479...92,741,436
Ensembl chr 8:92,722,600...92,738,299 		JBrowse link
G Slc4a1 solute carrier family 4 member 1 (Diego blood group) acts_upstream_of_or_within ISO MGI:1857140 (MGI:3619187|PMID:9716609) RGD PMID:9716609 MGI:3619187 NCBI chr10:87,306,865...87,323,132
Ensembl chr10:87,306,872...87,323,117 		JBrowse link
G Tmem41b transmembrane protein 41B involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:164,012,585...164,026,967
Ensembl chr 1:164,012,592...164,026,933 		JBrowse link
G Vmp1 vacuole membrane protein 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr10:71,405,058...71,505,045
Ensembl chr10:71,405,452...71,505,007 		JBrowse link
calcium activated galactosylceramide scrambling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ano3 anoctamin 3 acts_upstream_of_or_within ISO (MGI:5496475|PMID:23532839) RGD PMID:23532839 MGI:5496475 NCBI chr 3:97,235,671...97,550,090
Ensembl chr 3:97,238,354...97,550,154 		JBrowse link
G Ano4 anoctamin 4 acts_upstream_of_or_within ISO (MGI:5496475|PMID:23532839) RGD PMID:23532839 MGI:5496475 NCBI chr 7:23,329,015...23,738,423
Ensembl chr 7:23,329,070...23,738,434 		JBrowse link
G Ano6 anoctamin 6 acts_upstream_of_or_within ISO (MGI:5496475|PMID:23532839) RGD PMID:23532839 MGI:5496475 NCBI chr 7:126,933,629...127,113,589
Ensembl chr 7:126,933,936...127,113,589 		JBrowse link
G Ano7 anoctamin 7 acts_upstream_of_or_within ISO (MGI:5496475|PMID:23532839) RGD PMID:23532839 MGI:5496475 NCBI chr 9:93,917,524...93,945,323
Ensembl chr 9:93,917,524...93,945,323 		JBrowse link
G Ano9 anoctamin 9 acts_upstream_of_or_within ISO (MGI:5496475|PMID:23532839) RGD PMID:23532839 MGI:5496475 NCBI chr 1:196,208,863...196,230,381
Ensembl chr 1:196,197,341...196,229,900 		JBrowse link
calcium activated phosphatidylcholine scrambling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ano3 anoctamin 3 acts_upstream_of_or_within ISO (MGI:5496475|PMID:23532839) RGD PMID:23532839 MGI:5496475 NCBI chr 3:97,235,671...97,550,090
Ensembl chr 3:97,238,354...97,550,154 		JBrowse link
G Ano4 anoctamin 4 acts_upstream_of_or_within ISO (MGI:5496475|PMID:23532839) RGD PMID:23532839 MGI:5496475 NCBI chr 7:23,329,015...23,738,423
Ensembl chr 7:23,329,070...23,738,434 		JBrowse link
G Ano6 anoctamin 6 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(MGI:5496475|PMID:23532839)		 RGD PMID:23532839 PMID:21873635 MGI:5496475, RGD:13792537 NCBI chr 7:126,933,629...127,113,589
Ensembl chr 7:126,933,936...127,113,589 		JBrowse link
G Ano7 anoctamin 7 acts_upstream_of_or_within ISO (MGI:5496475|PMID:23532839) RGD PMID:23532839 MGI:5496475 NCBI chr 9:93,917,524...93,945,323
Ensembl chr 9:93,917,524...93,945,323 		JBrowse link
G Ano9 anoctamin 9 acts_upstream_of_or_within ISO (MGI:5496475|PMID:23532839) RGD PMID:23532839 MGI:5496475 NCBI chr 1:196,208,863...196,230,381
Ensembl chr 1:196,197,341...196,229,900 		JBrowse link
calcium activated phosphatidylserine scrambling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ano4 anoctamin 4 acts_upstream_of_or_within ISO (MGI:5496475|PMID:23532839) RGD PMID:23532839 MGI:5496475 NCBI chr 7:23,329,015...23,738,423
Ensembl chr 7:23,329,070...23,738,434 		JBrowse link
G Ano6 anoctamin 6 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(MGI:5496475|PMID:23532839)		 RGD PMID:23532839 PMID:21873635 MGI:5496475, RGD:13792537 NCBI chr 7:126,933,629...127,113,589
Ensembl chr 7:126,933,936...127,113,589 		JBrowse link
G Ano7 anoctamin 7 acts_upstream_of_or_within ISO (MGI:5496475|PMID:23532839) RGD PMID:23532839 MGI:5496475 NCBI chr 9:93,917,524...93,945,323
Ensembl chr 9:93,917,524...93,945,323 		JBrowse link
G Ano9 anoctamin 9 acts_upstream_of_or_within ISO (MGI:5496475|PMID:23532839) RGD PMID:23532839 MGI:5496475 NCBI chr 1:196,208,863...196,230,381
Ensembl chr 1:196,197,341...196,229,900 		JBrowse link
calcium activated phospholipid scrambling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ano6 anoctamin 6 acts_upstream_of_or_within ISO MGI:4127698 (MGI:5486117|PMID:22936354), (MGI:5496475|PMID:23532839) RGD PMID:22936354 PMID:23532839 MGI:5486117 MGI:5496475 NCBI chr 7:126,933,629...127,113,589
Ensembl chr 7:126,933,936...127,113,589 		JBrowse link
G Ano7 anoctamin 7 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:93,917,524...93,945,323
Ensembl chr 9:93,917,524...93,945,323 		JBrowse link
phosphatidylserine exposure on apoptotic cell surface term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ano6 anoctamin 6 NOT|acts_upstream_of_or_within ISO MGI:4127698 (MGI:5486117|PMID:22936354), (MGI:5496475|PMID:23532839) RGD PMID:22936354 PMID:23532839 MGI:5486117 MGI:5496475 NCBI chr 7:126,933,629...127,113,589
Ensembl chr 7:126,933,936...127,113,589 		JBrowse link
G Plscr1 phospholipid scramblase 1 involved_in
acts_upstream_of_or_within		 ISS
ISO
IBA		 GO_REF:0000024
(MGI:5284813|PMID:12509439)
(MGI:6450314|PMID:32110987)
PMID:21873635
(PMID:32110987)		 UniProt
RGD		 PMID:12509439 PMID:32110987 PMID:21873635 GO_REF:0000024 MGI:5284813 MGI:6450314, RGD:13792537 NCBI chr 8:92,784,279...92,804,698
Ensembl chr 8:92,784,356...92,804,692 		JBrowse link
G Trpc5 transient receptor potential cation channel, subfamily C, member 5 involved_in ISO (MGI:6450314|PMID:32110987) RGD PMID:32110987 MGI:6450314 NCBI chr  X:107,946,163...108,230,978
Ensembl chr  X:107,939,131...108,230,991 		JBrowse link
G Xkr4 XK related 4 involved_in ISO
IBA
ISS		 (PMID:33725486)
PMID:21873635
(MGI:6706096|PMID:33725486), (MGI:6716960|PMID:25231987)
GO_REF:0000024		 RGD
UniProt		 PMID:25231987 PMID:33725486 PMID:21873635 GO_REF:0000024 MGI:6706096 MGI:6716960, RGD:13792537 NCBI chr 5:15,896,188...16,297,733
Ensembl chr 5:15,895,863...16,282,962 		JBrowse link
G Xkr6 XK related 6 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:37,857,096...38,059,699
Ensembl chr15:37,857,096...38,059,682 		JBrowse link
G Xkr7 XK related 7 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:141,500,908...141,525,062
Ensembl chr 3:141,501,284...141,525,062 		JBrowse link
G Xkr8 XK related 8 involved_in
acts_upstream_of_or_within		 ISO
IBA		 (PMID:23845944)
PMID:21873635
(MGI:5502792|PMID:23845944), (MGI:6435898|PMID:31712393), (MGI:6716960|PMID:25231987), (MGI:6716970|PMID:30718401)
MGI:5528895 (MGI:6120635|PMID:29440417)		 RGD PMID:23845944 PMID:25231987 PMID:29440417 PMID:30718401 PMID:31712393 More... MGI:5502792 MGI:6120635 MGI:6435898 MGI:6716960 MGI:6716970, RGD:13792537 NCBI chr 5:144,938,061...144,945,195
Ensembl chr 5:144,938,064...144,945,195 		JBrowse link
G Xkr9 XK related 9 involved_in ISO
IBA		 (MGI:6716960|PMID:25231987)
PMID:21873635		 RGD PMID:25231987 PMID:21873635 MGI:6716960, RGD:13792537 NCBI chr 5:5,530,384...5,562,168
Ensembl chr 5:5,533,416...5,562,168 		JBrowse link
phosphatidylserine exposure on blood platelet term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ano6 anoctamin 6 involved_in ISO (PMID:21107324) RGD PMID:21107324 NCBI chr 7:126,933,629...127,113,589
Ensembl chr 7:126,933,936...127,113,589 		JBrowse link
positive regulation of phosphatidylserine exposure on apoptotic cell surface term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Faslg Fas ligand involved_in ISO (PMID:24904167) RGD PMID:24904167 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Xrcc4 X-ray repair cross complementing 4 involved_in ISO (PMID:33725486) RGD PMID:33725486 NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18737
    cellular process 17432
      cellular component organization or biogenesis 6534
        cellular component organization 6309
          membrane organization 812
            plasma membrane organization 164
              plasma membrane phospholipid scrambling 25
                calcium activated phospholipid scrambling + 5
                phosphatidylserine exposure on apoptotic cell surface + 10
                phosphatidylserine exposure on blood platelet 1
                phosphatidylserine exposure on osteoblast involved in bone mineralization 0
Path 2
Term Annotations click to browse term
  biological_process 18737
    localization 5475
      establishment of localization 4825
        transport 4663
          organic substance transport 2480
            organophosphate ester transport 148
              phospholipid transport 101
                phospholipid translocation 56
                  plasma membrane phospholipid scrambling 25
                    calcium activated phospholipid scrambling + 5
                    phosphatidylserine exposure on apoptotic cell surface + 10
                    phosphatidylserine exposure on blood platelet 1
                    phosphatidylserine exposure on osteoblast involved in bone mineralization 0
paths to the root