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ONTOLOGY REPORT - ANNOTATIONS


Term:aminoacyl-tRNA synthetase multienzyme complex
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Accession:GO:0017101 term browser browse the term
Definition:A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates.
Synonyms:exact_synonym: aminoacyl-tRNA synthetase complex;   multisynthetase complex



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aminoacyl-tRNA synthetase multienzyme complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aimp1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 part_of ISO (PMID:10791971), (PMID:14500886), (PMID:19131329)
(MGI:3055639|PMID:12060739)
RGD PMID:10791971 PMID:12060739 PMID:14500886 PMID:19131329 MGI:3055639 NCBI chr 2:221,151,907...221,175,458
Ensembl chr 2:221,151,904...221,175,728
JBrowse link
G Aimp2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 part_of IEA
ISO
IDA
IBA
GO_REF:0000002
(MGI:3055639|PMID:12060739)
PMID:19524539
(PMID:19131329)
PMID:21873635
InterPro
RGD
PMID:12060739 PMID:19131329 PMID:19524539 PMID:21873635 GO_REF:0000002 MGI:3055639, RGD:12793003, RGD:13792537 NCBI chr12:10,701,194...10,710,772
Ensembl chr12:10,701,194...10,710,769
JBrowse link
G Dars1 aspartyl-tRNA synthetase 1 part_of TAS
ISO
ISS
IBA
(MGI:3055639|PMID:12060739)
(PMID:19131329)
GO_REF:0000024
PMID:21873635
RGD
UniProt
PMID:12060739 PMID:19131329 PMID:2642907 PMID:21873635 GO_REF:0000024 MGI:3055639, RGD:631931, RGD:13792537 NCBI chr13:39,857,936...39,913,055
Ensembl chr13:39,857,936...39,913,116
JBrowse link
G Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 part_of ISO (PMID:19131329)
(MGI:3055639|PMID:12060739)
RGD PMID:12060739 PMID:19131329 MGI:3055639 NCBI chr17:26,148,652...26,159,358
Ensembl chr17:26,148,633...26,215,720
JBrowse link
G Eprs glutamyl-prolyl-tRNA synthetase part_of IBA
ISO
PMID:21873635
(MGI:3055639|PMID:12060739), (MGI:5913528|PMID:28178239)
(MGI:5466658|PMID:23071094)
(PMID:10791971), (PMID:19131329)
RGD PMID:10791971 PMID:12060739 PMID:19131329 PMID:23071094 PMID:28178239 More... MGI:3055639 MGI:5466658 MGI:5913528, RGD:13792537 NCBI chr13:96,901,548...96,971,966
Ensembl chr13:96,901,575...96,971,966
JBrowse link
G Iars1 isoleucyl-tRNA synthetase 1 part_of ISO (PMID:19131329)
(MGI:3055639|PMID:12060739)
RGD PMID:12060739 PMID:19131329 MGI:3055639 NCBI chr17:14,940,919...14,987,277
Ensembl chr17:14,940,924...14,987,237
JBrowse link
G Kars1 lysyl-tRNA synthetase 1 part_of IDA
ISO
IBA
(MGI:3055639|PMID:12060739)
PMID:21873635
(PMID:19131329)
PMID:19524539
RGD PMID:12060739 PMID:19131329 PMID:7372681 PMID:21873635 PMID:19524539 More... MGI:3055639, RGD:2303393, RGD:13792537, RGD:12793003, RGD:2303394, RGD:2303396 NCBI chr19:39,957,846...39,976,886
Ensembl chr19:39,957,846...39,977,632
JBrowse link
G Lars1 leucyl-tRNA synthetase 1 part_of ISO (PMID:19131329)
(MGI:3055639|PMID:12060739)
RGD PMID:12060739 PMID:19131329 MGI:3055639 NCBI chr18:34,201,555...34,256,003
Ensembl chr18:34,201,549...34,255,931
JBrowse link
G LOC100911132 glutamine--tRNA ligase-like part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Mars1 methionyl-tRNA synthetase 1 part_of ISO
IDA
(PMID:10791971), (PMID:19131329)
(MGI:3055639|PMID:12060739)
PMID:19524539
RGD PMID:10791971 PMID:12060739 PMID:19131329 PMID:19524539 MGI:3055639, RGD:12793003 NCBI chr 7:63,121,142...63,138,550
Ensembl chr 7:63,121,142...63,138,495
JBrowse link
G Qars1 glutaminyl-tRNA synthetase 1 part_of ISO
ISS
IBA
(PMID:19131329)
(MGI:3055639|PMID:12060739)
GO_REF:0000024
PMID:21873635
RGD
UniProt
PMID:12060739 PMID:19131329 PMID:21873635 GO_REF:0000024 MGI:3055639, RGD:13792537 NCBI chr 8:109,207,705...109,215,738
Ensembl chr 8:109,207,705...109,215,739
JBrowse link
G Rars1 arginyl-tRNA synthetase 1 part_of IDA
ISO
(MGI:3055639|PMID:12060739)
PMID:19524539
(PMID:19131329)
RGD PMID:12060739 PMID:19131329 PMID:7082655 PMID:19524539 MGI:3055639, RGD:2303394, RGD:12793003 NCBI chr10:20,270,744...20,295,192
Ensembl chr10:20,270,483...20,295,196
JBrowse link
G Rpl5 ribosomal protein L5 IDA RGD PMID:8982850 RGD:2316859 NCBI chr14:1,843,856...1,850,301
Ensembl chr14:1,843,770...1,850,290
JBrowse link

Term paths to the root
Path 1
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  cellular_component 20009
    protein-containing complex 6180
      aminoacyl-tRNA synthetase multienzyme complex 13
Path 2
Term Annotations click to browse term
  cellular_component 20009
    cellular anatomical entity 19717
      intracellular anatomical structure 14398
        aminoacyl-tRNA synthetase multienzyme complex 13
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