Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:aminoacyl-tRNA synthetase multienzyme complex
go back to main search page
Accession:GO:0017101 term browser browse the term
Definition:A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates.
Synonyms:exact_synonym: aminoacyl-tRNA synthetase complex;   multisynthetase complex


show annotations for term's descendants           Sort by:
 
aminoacyl-tRNA synthetase multienzyme complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aimp1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 ISO (MGI:MGI:3055639|PMID:12060739)
(PMID:10791971), (PMID:14500886), (PMID:19131329)
RGD PMID:10791971, PMID:12060739, PMID:14500886, PMID:19131329 MGI:MGI:3055639 NCBI chr 2:237,727,782...237,751,327
Ensembl chr 2:237,727,764...237,751,378
JBrowse link
G Aimp2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 IDA
IBA
IEA
ISO
PMID:19524539
PMID:21873635
GO_REF:0000002
(MGI:MGI:3055639|PMID:12060739)
(PMID:19131329)
InterPro
RGD
PMID:12060739, PMID:19131329, PMID:19524539, PMID:21873635 GO_REF:0000002, MGI:MGI:3055639, RGD:12793003, RGD:13792537 NCBI chr12:12,738,784...12,748,345
Ensembl chr12:12,738,812...12,748,345
JBrowse link
G Dars1 aspartyl-tRNA synthetase 1 TAS
IBA
ISS
ISO
PMID:21873635
GO_REF:0000024
(PMID:19131329)
(MGI:MGI:3055639|PMID:12060739)
UniProt
RGD
PMID:12060739, PMID:19131329, PMID:2642907, PMID:21873635 GO_REF:0000024, MGI:MGI:3055639, RGD:631931, RGD:13792537 NCBI chr13:45,074,067...45,127,815
Ensembl chr13:45,074,072...45,127,815
JBrowse link
G Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 ISO (MGI:MGI:3055639|PMID:12060739)
(PMID:19131329)
RGD PMID:12060739, PMID:19131329 MGI:MGI:3055639 NCBI chr17:26,785,017...26,795,723
Ensembl chr17:26,785,029...26,797,161
JBrowse link
G Eprs glutamyl-prolyl-tRNA synthetase ISO
IBA
(PMID:10791971), (PMID:19131329)
PMID:21873635
(MGI:MGI:3055639|PMID:12060739), (MGI:MGI:5466658|PMID:23071094), (MGI:MGI:5913528|PMID:28178239)
RGD PMID:10791971, PMID:12060739, PMID:19131329, PMID:23071094, PMID:28178239, PMID:21873635 MGI:MGI:3055639, MGI:MGI:5466658, MGI:MGI:5913528, RGD:13792537 NCBI chr13:103,300,911...103,371,651
Ensembl chr13:103,300,932...103,371,577
JBrowse link
G Iars1 isoleucyl-tRNA synthetase 1 ISO (MGI:MGI:3055639|PMID:12060739)
(PMID:19131329)
RGD PMID:12060739, PMID:19131329 MGI:MGI:3055639 NCBI chr17:15,356,016...15,402,680
Ensembl chr17:15,355,529...15,402,649
JBrowse link
G Kars lysyl-tRNA synthetase IDA
IBA
ISO
PMID:21873635
(PMID:19131329)
(MGI:MGI:3055639|PMID:12060739)
PMID:19524539
RGD PMID:12060739, PMID:19131329, PMID:7372681, PMID:21873635, PMID:19524539, PMID:7082655, PMID:3988754 MGI:MGI:3055639, RGD:2303393, RGD:13792537, RGD:12793003, RGD:2303394, RGD:2303396 NCBI chr19:44,212,205...44,231,209
Ensembl chr19:44,212,206...44,231,157
JBrowse link
G Lars1 leucyl-tRNA synthetase 1 ISO (MGI:MGI:3055639|PMID:12060739)
(PMID:19131329)
RGD PMID:12060739, PMID:19131329 MGI:MGI:3055639 NCBI chr18:36,524,013...36,579,471
Ensembl chr18:36,524,007...36,579,403
JBrowse link
G LOC100911132 glutamine--tRNA ligase-like IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Mars1 methionyl-tRNA synthetase 1 IDA
ISO
PMID:19524539
(PMID:10791971), (PMID:19131329)
(MGI:MGI:3055639|PMID:12060739)
RGD PMID:10791971, PMID:12060739, PMID:19131329, PMID:19524539 MGI:MGI:3055639, RGD:12793003 NCBI chr 7:70,585,011...70,602,425
Ensembl chr 7:70,585,013...70,602,310
JBrowse link
G Qars1 glutaminyl-tRNA synthetase 1 ISO
IBA
ISS
(MGI:MGI:3055639|PMID:12060739)
PMID:21873635
GO_REF:0000024
(PMID:19131329)
RGD
UniProt
PMID:12060739, PMID:19131329, PMID:21873635 GO_REF:0000024, MGI:MGI:3055639, RGD:13792537 NCBI chr 8:117,297,670...117,305,708
Ensembl chr 8:117,297,670...117,305,702
JBrowse link
G Rars1 arginyl-tRNA synthetase 1 IDA
ISO
(PMID:19131329)
(MGI:MGI:3055639|PMID:12060739)
PMID:19524539
RGD PMID:12060739, PMID:19131329, PMID:7082655, PMID:19524539 MGI:MGI:3055639, RGD:2303394, RGD:12793003 NCBI chr10:20,633,630...20,658,074
Ensembl chr10:20,633,632...20,658,100
JBrowse link
G Rpl5 ribosomal protein L5 IDA RGD PMID:8982850 RGD:2316859 NCBI chr14:2,860,963...2,867,397
Ensembl chr14:2,860,965...2,867,397
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20609
    protein-containing complex 6092
      aminoacyl-tRNA synthetase multienzyme complex 13
Path 2
Term Annotations click to browse term
  cellular_component 20609
    cellular anatomical entity 20358
      intracellular anatomical structure 14706
        aminoacyl-tRNA synthetase multienzyme complex 13
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.