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ONTOLOGY REPORT - ANNOTATIONS


Term:oxidative phosphorylation uncoupler activity
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Accession:GO:0017077 term browser browse the term
Definition:Enables the transfer of protons from mitochondrial intermembrane space into mitochondrial matrix, dissipating the proton gradient across the mitochondrial inner membrane established by the electron transport chain during the oxidative phosphorylation (proton leak). Proton leak uncouples the processes of electron transport/proton generation and ATP synthesis.
Synonyms:narrow_synonym: mitochondrial uncoupling protein activity;   uncoupling protein activity
 alt_id: GO:0015302



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oxidative phosphorylation uncoupler activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc25a4 solute carrier family 25 member 4 enables ISS
ISO
IEA
GO_REF:0000024
(PMID:31341297)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:31341297 GO_REF:0000024 GO_REF:0000107 NCBI chr16:52,805,521...52,809,316
Ensembl chr16:46,072,939...46,076,733
JBrowse link
G Slc25a5 solute carrier family 25 member 5 enables ISS
ISO
GO_REF:0000024
(PMID:31341297)
UniProt
RGD
PMID:31341297 GO_REF:0000024 NCBI chr  X:120,897,616...120,900,683
Ensembl chr  X:116,031,803...116,034,967
JBrowse link
G Ucp1 uncoupling protein 1 enables IDA
ISO
IBA
(PMID:12910269), (PMID:20416274), (PMID:23063128)
GO_REF:0000033
PMID:22952235
RGD
GO_Central
PMID:12910269 PMID:20416274 PMID:23063128 PMID:16451125 PMID:22952235 GO_REF:0000033, RGD:1624981, RGD:11541104 NCBI chr19:41,713,350...41,721,421
Ensembl chr19:24,808,783...24,816,852
JBrowse link
G Ucp2 uncoupling protein 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:154,839,209...154,845,611
JBrowse link
G Ucp3 uncoupling protein 3 NOT|enables ISO
IBA
(PMID:11707458)
(PMID:11707458), (PMID:20363757)
MGI:2183166|MGI:2183202 (PMID:10748195), (PMID:10748196)
GO_REF:0000033
(PMID:21775425), (PMID:36114012), (PMID:9305858)
RGD
GO_Central
PMID:9305858 PMID:10748195 PMID:10748196 PMID:11707458 PMID:20363757 More... GO_REF:0000033 NCBI chr 1:164,227,910...164,240,893
Ensembl chr 1:154,815,777...154,828,762
JBrowse link

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  molecular_function 21088
    transporter activity 1269
      transmembrane transporter activity 1162
        oxidative phosphorylation uncoupler activity 5
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