ONTOLOGY REPORT - ANNOTATIONS
Term: oxidative phosphorylation uncoupler activity
Accession: GO:0017077
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Definition: Enables the transfer of protons from mitochondrial intermembrane space into mitochondrial matrix, dissipating the proton gradient across the mitochondrial inner membrane established by the electron transport chain during the oxidative phosphorylation (proton leak). Proton leak uncouples the processes of electron transport/proton generation and ATP synthesis.
Synonyms: narrow_synonym: mitochondrial uncoupling protein activity; uncoupling protein activity
alt_id: GO:0015302
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Slc25a4
solute carrier family 25 member 4
enables
ISS ISO IEA
GO_REF:0000024 (PMID:31341297) GO_REF:0000107
UniProt RGD Ensembl
PMID:31341297
GO_REF:0000024 GO_REF:0000107
NCBI chr16:52,805,521...52,809,316
Ensembl chr16:46,072,939...46,076,733
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Slc25a5
solute carrier family 25 member 5
enables
ISS ISO
GO_REF:0000024 (PMID:31341297)
UniProt RGD
PMID:31341297
GO_REF:0000024
NCBI chr X:120,897,616...120,900,683
Ensembl chr X:116,031,803...116,034,967
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Ucp1
uncoupling protein 1
enables
IDA ISO IBA
(PMID:12910269), (PMID:20416274), (PMID:23063128) GO_REF:0000033 PMID:22952235
RGD GO_Central
PMID:12910269 PMID:20416274 PMID:23063128 PMID:16451125 PMID:22952235
GO_REF:0000033, RGD:1624981 , RGD:11541104
NCBI chr19:41,713,350...41,721,421
Ensembl chr19:24,808,783...24,816,852
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Ucp2
uncoupling protein 2
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:154,839,209...154,845,611
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Ucp3
uncoupling protein 3
NOT|enables
ISO IBA
(PMID:11707458) (PMID:11707458), (PMID:20363757) MGI:2183166|MGI:2183202 (PMID:10748195), (PMID:10748196) GO_REF:0000033 (PMID:21775425), (PMID:36114012), (PMID:9305858)
RGD GO_Central
PMID:9305858 PMID:10748195 PMID:10748196 PMID:11707458 PMID:20363757 PMID:21775425 PMID:36114012 More...
GO_REF:0000033
NCBI chr 1:164,227,910...164,240,893
Ensembl chr 1:154,815,777...154,828,762
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