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ONTOLOGY REPORT - ANNOTATIONS

Term:3'-tyrosyl-DNA phosphodiesterase activity
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Accession:GO:0017005 term browser browse the term
Definition:Catalysis of the hydrolysis of 3'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase I and DNA.
Comment:See also the molecular function term 'DNA topoisomerase type I activity ; GO:0003917'.


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3'-tyrosyl-DNA phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tdp1 tyrosyl-DNA phosphodiesterase 1 enables ISS
ISO
IEA
IBA		 GO_REF:0000024
(PMID:17118488), (PMID:17576665), (PMID:17948061), (PMID:22822062)
GO_REF:0000107
GO_REF:0000033
GO_REF:0000118		 UniProt
RGD
Ensembl
GO_Central
TreeGrafter		 PMID:17118488 PMID:17576665 PMID:17948061 PMID:22822062 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:119,163,192...119,231,029
Ensembl chr 6:119,163,166...119,231,021 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21010
    catalytic activity 6145
      catalytic activity, acting on a nucleic acid 642
        catalytic activity, acting on DNA 260
          tyrosyl-DNA phosphodiesterase activity 2
            3'-tyrosyl-DNA phosphodiesterase activity 1
Path 2
Term Annotations click to browse term
  molecular_function 21010
    catalytic activity 6145
      hydrolase activity 2639
        hydrolase activity, acting on ester bonds 837
          phosphoric ester hydrolase activity 387
            phosphoric diester hydrolase activity 91
              tyrosyl-DNA phosphodiesterase activity 2
                3'-tyrosyl-DNA phosphodiesterase activity 1
paths to the root