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ONTOLOGY REPORT - ANNOTATIONS

Term:endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters
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Accession:GO:0016894 term browser browse the term
Definition:Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters.
Comment:Note that this activity can catalyze cleavage of DNA or RNA.
Synonyms:exact_synonym: 3'-endonuclease activity
 related_synonym: endoribonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters
 xref: EC:3.1.31.1


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endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Snd1 staphylococcal nuclease and tudor domain containing 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 4:57,095,205...57,494,501
Ensembl chr 4:57,095,208...57,530,843 		JBrowse link
3'-flap endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mus81 MUS81 structure-specific endonuclease subunit enables ISO
IEA
IBA		 (PMID:19595721)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:19595721 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:202,790,295...202,796,008
Ensembl chr 1:202,790,466...202,795,843 		JBrowse link
crossover junction DNA endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eme1 essential meiotic structure-specific endonuclease 1 contributes_to IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:79,586,718...79,595,515
Ensembl chr10:79,586,729...79,595,435 		JBrowse link
G Eme2 essential meiotic structure-specific endonuclease subunit 2 contributes_to IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:13,913,216...13,915,991
Ensembl chr10:13,913,221...13,915,968 		JBrowse link
G Gen1 GEN1 Holliday junction 5' flap endonuclease enables ISO (PMID:23108668), (PMID:26578604), (PMID:26682650), (PMID:28049850) RGD PMID:23108668 PMID:26578604 PMID:26682650 PMID:28049850 NCBI chr 6:33,947,599...33,978,461
Ensembl chr 6:33,948,206...33,978,401 		JBrowse link
G Mus81 MUS81 structure-specific endonuclease subunit enables
contributes_to		 IEA
IBA		 GO_REF:0000104
GO_REF:0000033		 UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000104 NCBI chr 1:202,790,295...202,796,008
Ensembl chr 1:202,790,466...202,795,843 		JBrowse link
G Rad51c RAD51 paralog C contributes_to
enables		 ISO
IBA		 (PMID:14716019)
MGI:3707422|MGI:3707425 (PMID:17312021)
GO_REF:0000033		 RGD
GO_Central		 PMID:14716019 PMID:17312021 GO_REF:0000033 NCBI chr10:72,205,032...72,231,643
Ensembl chr10:72,205,032...72,231,248 		JBrowse link
G Slx1b SLX1 homolog B, structure-specific endonuclease subunit enables ISO
IBA
IEA		 (PMID:19595721), (PMID:19596235), (PMID:19596236)
GO_REF:0000033
GO_REF:0000104		 RGD
GO_Central
UniProt		 PMID:19595721 PMID:19596235 PMID:19596236 GO_REF:0000033 GO_REF:0000104 NCBI chr 1:181,286,190...181,291,739
Ensembl chr 1:181,283,921...181,291,775 		JBrowse link
G Tefm transcription elongation factor, mitochondrial NOT|enables ISO (PMID:21278163) RGD PMID:21278163 NCBI chr10:65,119,657...65,124,233
Ensembl chr10:65,119,659...65,124,486 		JBrowse link
G Xrcc3 X-ray repair cross complementing 3 contributes_to ISO (PMID:14716019), (PMID:23108668) RGD PMID:14716019 PMID:23108668 NCBI chr 6:130,863,405...130,873,765
Ensembl chr 6:130,863,959...130,872,444 		JBrowse link
deoxyribonuclease II activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnase2 deoxyribonuclease 2, lysosomal enables IBA
ISO
IEA		 GO_REF:0000033
(PMID:11375492)
GO_REF:0000104		 GO_Central
RGD
UniProt		 PMID:11375492 GO_REF:0000033 GO_REF:0000104 NCBI chr19:23,244,656...23,247,376
Ensembl chr19:23,244,664...23,247,376 		JBrowse link
G Dnase2b deoxyribonuclease 2 beta enables IDA
IEA
IBA		 GO_REF:0000003
GO_REF:0000033
GO_REF:0000104		 UniProt
GO_Central
RGD		 PMID:10558878 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104, RGD:70721 NCBI chr 2:235,470,915...235,515,211
Ensembl chr 2:235,470,919...235,486,295 		JBrowse link
ribonuclease A activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rnase1 ribonuclease A family member 1, pancreatic enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr15:24,361,924...24,363,633
Ensembl chr15:24,361,927...24,363,624 		JBrowse link
G Rnase1l1 ribonuclease, RNase A family, 1-like 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr15:24,338,216...24,339,934
Ensembl chr15:24,338,479...24,338,931 		JBrowse link
G Rnase1l2 ribonuclease, RNase A family, 1-like 2 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr15:24,421,825...24,423,513
Ensembl chr15:24,421,859...24,423,611 		JBrowse link
RNA endonuclease activity, producing 3'-phosphomonoesters term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rida reactive intermediate imine deaminase A homolog IDA RGD PMID:10400702 RGD:9685547 NCBI chr 7:65,691,429...65,705,257
Ensembl chr 7:65,691,435...65,705,716 		JBrowse link
tRNA-intron endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tsen2 tRNA splicing endonuclease subunit 2 enables IEA
IBA		 GO_REF:0000002
GO_REF:0000033		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 4:148,602,805...148,638,219
Ensembl chr 4:148,602,863...148,638,215 		JBrowse link
G Tsen34 tRNA splicing endonuclease subunit 34 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:65,517,324...65,525,194
Ensembl chr 1:65,517,330...65,524,412 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20736
    catalytic activity 6109
      hydrolase activity 2583
        hydrolase activity, acting on ester bonds 813
          nuclease activity 229
            endonuclease activity 134
              endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 17
                DNA endonuclease activity, producing 3'-phosphomonoesters + 10
                RNA endonuclease activity, producing 3'-phosphomonoesters + 6
paths to the root