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ONTOLOGY REPORT - ANNOTATIONS

Term:endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
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Accession:GO:0016893 term browser browse the term
Definition:Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters.
Comment:Note that this activity can catalyze cleavage of DNA or RNA.
Synonyms:exact_synonym: 5'-endonuclease activity
 related_synonym: endoribonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
 xref: EC:3.1.30


show annotations for term's descendants           Sort by:
3'-tRNA processing endoribonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Elac1 elaC ribonuclease Z 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr18:67,321,231...67,341,358
Ensembl chr18:67,323,583...67,340,936 		JBrowse link
G Elac2 elaC ribonuclease Z 2 enables IEA
IBA		 GO_REF:0000003
GO_REF:0000033
GO_REF:0000002		 UniProt
GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 NCBI chr10:49,632,308...49,655,614
Ensembl chr10:49,632,378...49,655,614 		JBrowse link
5'-flap endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dna2 DNA replication helicase/nuclease 2 enables ISS
IBA
IEA		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000104		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000104 NCBI chr20:25,661,652...25,690,598
Ensembl chr20:25,662,055...25,716,319 		JBrowse link
G Exo1 exonuclease 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654 		JBrowse link
G Fan1 FANCD2 and FANCI associated nuclease 1 enables ISO
IBA		 (PMID:20603015), (PMID:20603016), (PMID:20603073), (PMID:24981866)
GO_REF:0000033		 RGD
GO_Central		 PMID:20603015 PMID:20603016 PMID:20603073 PMID:24981866 GO_REF:0000033 NCBI chr 1:117,915,323...117,945,044
Ensembl chr 1:117,917,099...117,944,977 		JBrowse link
G Fen1 flap structure-specific endonuclease 1 enables ISO
IBA		 (PMID:11986308), (PMID:18995831), (PMID:8621570)
GO_REF:0000033		 RGD
GO_Central		 PMID:8621570 PMID:11986308 PMID:18995831 GO_REF:0000033 NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003 		JBrowse link
G Gen1 GEN1 Holliday junction 5' flap endonuclease enables ISO
IBA		 (PMID:26578604)
GO_REF:0000033		 RGD
GO_Central		 PMID:26578604 GO_REF:0000033 NCBI chr 6:33,947,599...33,978,461
Ensembl chr 6:33,948,206...33,978,401 		JBrowse link
G Slc25a16 solute carrier family 25 member 16 enables IEA
IBA
ISS		 GO_REF:0000104
GO_REF:0000033
GO_REF:0000024		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000104 NCBI chr20:25,691,474...25,717,558
Ensembl chr20:25,662,055...25,716,319 		JBrowse link
G Slx1b SLX1 homolog B, structure-specific endonuclease subunit enables ISO
IBA
IEA		 (PMID:19596235), (PMID:19596236)
GO_REF:0000033
GO_REF:0000104		 RGD
GO_Central
UniProt		 PMID:19596235 PMID:19596236 GO_REF:0000033 GO_REF:0000104 NCBI chr 1:181,286,190...181,291,739
Ensembl chr 1:181,283,921...181,291,775 		JBrowse link
class II DNA-(apurinic or apyrimidinic site) endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 enables ISO
ISS
IEA		 (PMID:11160897), (PMID:11286553), (PMID:1627644), (PMID:9804798)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:1627644 PMID:9804798 PMID:11160897 PMID:11286553 GO_REF:0000024 GO_REF:0000107 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785 		JBrowse link
deoxyribonuclease I activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dicer1 dicer 1 ribonuclease III enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965 		JBrowse link
G Dnase1 deoxyribonuclease 1 enables IDA
ISO
IBA		 (PMID:15015938)
GO_REF:0000033
(MGI:3687616|PMID:15015938)		 RGD
GO_Central		 PMID:15015938 PMID:12005024 GO_REF:0000033 MGI:3687616, RGD:1298888 NCBI chr10:11,498,930...11,505,151
Ensembl chr10:11,498,931...11,501,869 		JBrowse link
G Dnase1l1 deoxyribonuclease 1-like 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:152,056,942...152,065,518
Ensembl chr  X:152,056,942...152,065,518 		JBrowse link
G Dnase1l2 deoxyribonuclease 1 like 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:13,471,850...13,473,447
Ensembl chr10:13,471,479...13,473,763 		JBrowse link
G Dnase1l3 deoxyribonuclease 1L3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:16,922,335...16,948,322
Ensembl chr15:16,922,335...16,948,317 		JBrowse link
endodeoxyribonuclease activity, producing 5'-phosphomonoesters term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Endov endonuclease V NOT|enables ISO (PMID:23139746), (PMID:23912683)
(PMID:12853604)
(MGI:5009179|PMID:12853604)		 RGD PMID:12853604 PMID:23139746 PMID:23912683 MGI:5009179 NCBI chr10:104,760,059...104,777,732
Ensembl chr10:104,760,137...104,775,969 		JBrowse link
endoribonuclease activity, cleaving miRNA-paired mRNA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ago2 argonaute RISC catalytic component 2 enables IEA
ISO		 GO_REF:0000107
(PMID:15260970), (PMID:22795694)		 Ensembl
RGD		 PMID:15260970 PMID:22795694 GO_REF:0000107 NCBI chr 7:105,018,202...105,105,118
Ensembl chr 7:105,029,120...105,104,974 		JBrowse link
G Ago3 argonaute RISC catalytic component 3 enables ISO (PMID:29040713) RGD PMID:29040713 NCBI chr 5:138,632,367...138,714,230
Ensembl chr 5:138,639,569...138,714,230 		JBrowse link
endoribonuclease activity, cleaving siRNA-paired mRNA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ago2 argonaute RISC catalytic component 2 enables IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000002
GO_REF:0000024
(PMID:15260970), (PMID:17524464)		 Ensembl
InterPro
UniProt
RGD		 PMID:15260970 PMID:17524464 GO_REF:0000002 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:105,018,202...105,105,118
Ensembl chr 7:105,029,120...105,104,974 		JBrowse link
phosphodiesterase decapping endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nudt12 nudix hydrolase 12 enables ISO (PMID:31875550) RGD PMID:31875550 NCBI chr 9:98,741,627...98,755,039
Ensembl chr 9:98,742,360...98,755,039 		JBrowse link
G Nudt16 nudix hydrolase 16 enables ISO
IBA		 (PMID:29483298)
GO_REF:0000033		 RGD
GO_Central		 PMID:29483298 GO_REF:0000033 NCBI chr 8:105,739,927...105,741,982
Ensembl chr 8:105,739,623...105,741,998 		JBrowse link
G Nudt16l1 nudix hydrolase 16 like 1 NOT|enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:10,636,174...10,638,090
Ensembl chr10:10,636,174...10,688,370 		JBrowse link
G Nudt16l2 nudix hydrolase 16 like 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:105,754,821...105,756,548
Ensembl chr 8:105,754,844...105,756,518 		JBrowse link
ribonuclease III activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dicer1 dicer 1 ribonuclease III enables ISO
IBA		 (PMID:12411504), (PMID:12411505), (PMID:21753850)
GO_REF:0000033		 RGD
GO_Central		 PMID:12411504 PMID:12411505 PMID:21753850 GO_REF:0000033 NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965 		JBrowse link
G Drosha drosha ribonuclease III enables ISO
IBA		 (PMID:14508493), (PMID:15574589)
GO_REF:0000033		 RGD
GO_Central		 PMID:14508493 PMID:15574589 GO_REF:0000033 NCBI chr 2:61,864,886...61,976,688
Ensembl chr 2:61,864,970...61,976,688 		JBrowse link
G Mrpl44 mitochondrial ribosomal protein L44 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 9:81,106,658...81,111,709
Ensembl chr 9:81,106,655...81,112,812 		JBrowse link
ribonuclease P activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pop1 POP1 homolog, ribonuclease P/MRP subunit contributes_to ISO (PMID:30454648), (PMID:8918471) RGD PMID:8918471 PMID:30454648 NCBI chr 7:65,705,348...65,733,143
Ensembl chr 7:65,705,368...65,733,141 		JBrowse link
G Pop4 POP4 homolog, ribonuclease P/MRP subunit contributes_to ISS
ISO		 GO_REF:0000024
(PMID:30454648)		 UniProt
RGD		 PMID:30454648 GO_REF:0000024 NCBI chr 1:90,960,026...90,968,360
Ensembl chr 1:90,960,022...90,968,443 		JBrowse link
G Pop5 POP5 homolog, ribonuclease P/MRP subunit contributes_to
enables		 ISO (PMID:30454648)
(PMID:11413139)		 RGD PMID:11413139 PMID:30454648 NCBI chr12:41,376,755...41,384,882
Ensembl chr12:41,376,755...41,381,336 		JBrowse link
G Pop7 POP7 homolog, ribonuclease P/MRP subunit contributes_to ISO (PMID:30454648) RGD PMID:30454648 NCBI chr12:19,189,384...19,190,425
Ensembl chr12:19,189,138...19,190,674 		JBrowse link
G Prorp protein only RNase P catalytic subunit enables ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(PMID:25953853)		 UniProt
GO_Central
RGD		 PMID:25953853 GO_REF:0000024 GO_REF:0000033 NCBI chr 6:72,669,659...72,762,419
Ensembl chr 6:72,670,847...72,762,416 		JBrowse link
G Rpp14 ribonuclease P/MRP subunit p14 contributes_to ISO (PMID:30454648) RGD PMID:30454648 NCBI chr15:16,837,796...16,847,970
Ensembl chr15:16,836,859...16,852,101
Ensembl chr15:16,836,859...16,852,101 		JBrowse link
G Rpp21 ribonuclease P/MRP subunit p21 contributes_to ISO (PMID:30454648) RGD PMID:30454648 NCBI chr20:2,018,170...2,020,100
Ensembl chr20:2,018,147...2,020,106 		JBrowse link
G Rpp25 ribonuclease P and MRP subunit p25 contributes_to ISS
ISO		 GO_REF:0000024
(PMID:30454648)		 UniProt
RGD		 PMID:30454648 GO_REF:0000024 NCBI chr 8:57,907,352...57,908,732
Ensembl chr 8:57,907,352...57,908,732 		JBrowse link
G Rpp30 ribonuclease P/MRP subunit p30 contributes_to ISO (PMID:30454648) RGD PMID:30454648 NCBI chr 1:233,786,048...233,808,958
Ensembl chr 1:233,786,099...233,808,952 		JBrowse link
G Rpp38 ribonuclease P/MRP subunit p38 contributes_to ISO
IBA		 (PMID:30454648)
GO_REF:0000033		 RGD
GO_Central		 PMID:30454648 GO_REF:0000033 NCBI chr17:74,914,066...74,917,742
Ensembl chr17:74,908,932...74,927,431 		JBrowse link
G Rpp40 ribonuclease P/MRP subunit p40 contributes_to
enables		 ISO
IBA
IEA		 (PMID:30454648)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:30454648 GO_REF:0000033 GO_REF:0000107 NCBI chr17:28,947,752...28,956,788
Ensembl chr17:28,947,734...28,956,788 		JBrowse link
RNA endonuclease activity, producing 5'-phosphomonoesters term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Endov endonuclease V enables ISO
IBA		 (PMID:23912683), (PMID:23912718), (PMID:27573237)
GO_REF:0000033
(PMID:3170309)		 RGD
GO_Central		 PMID:3170309 PMID:23912683 PMID:23912718 PMID:27573237 GO_REF:0000033 NCBI chr10:104,760,059...104,777,732
Ensembl chr10:104,760,137...104,775,969 		JBrowse link
G Pld6 phospholipase D family, member 6 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:44,578,536...44,581,187
Ensembl chr10:44,577,675...44,581,077 		JBrowse link
RNA lariat debranching enzyme activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dbr1 debranching RNA lariats 1 enables ISO
IBA		 (PMID:10982890), (PMID:29474921)
GO_REF:0000033		 RGD
GO_Central		 PMID:10982890 PMID:29474921 GO_REF:0000033 NCBI chr 8:100,139,039...100,150,768
Ensembl chr 8:100,139,034...100,151,030 		JBrowse link
RNA-DNA hybrid ribonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENSRNOG00000067229 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 Ensembl chr 4:83,921,470...83,930,590 JBrowse link
G ENSRNOG00000067248 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 Ensembl chr 9:77,055,483...77,060,879 JBrowse link
G ENSRNOG00000069624 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 Ensembl chr 4:147,700,824...147,706,682 JBrowse link
G Fen1 flap structure-specific endonuclease 1 enables ISO
IBA		 (PMID:7961795)
GO_REF:0000033		 RGD
GO_Central		 PMID:7961795 GO_REF:0000033 NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003 		JBrowse link
G Nynrin NYN domain and retroviral integrase containing enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr15:29,332,873...29,355,215
Ensembl chr15:29,332,869...29,355,215 		JBrowse link
G Ormdl1 ORMDL sphingolipid biosynthesis regulator 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 9:48,243,365...48,253,316
Ensembl chr 9:48,237,572...48,253,211 		JBrowse link
G Rnaseh1 ribonuclease H1 enables ISO
IBA
ISS		 (PMID:21700224)
(PMID:15831789)
GO_REF:0000033
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:15831789 PMID:21700224 GO_REF:0000024 GO_REF:0000033 NCBI chr 6:45,282,849...45,292,258
Ensembl chr 6:45,282,854...45,292,236 		JBrowse link
G Rnaseh2a ribonuclease H2, subunit A enables ISO
IBA
ISS		 (PMID:21177858)
GO_REF:0000033
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:21177858 GO_REF:0000024 GO_REF:0000033 NCBI chr19:23,186,325...23,196,045
Ensembl chr19:23,186,383...23,196,041 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20732
    catalytic activity 6109
      hydrolase activity 2595
        hydrolase activity, acting on ester bonds 811
          nuclease activity 229
            endonuclease activity 134
              endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 44
                RNA endonuclease activity, producing 5'-phosphomonoesters + 33
                endodeoxyribonuclease activity, producing 5'-phosphomonoesters + 14
paths to the root