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ONTOLOGY REPORT - ANNOTATIONS


Term:endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
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Accession:GO:0016893 term browser browse the term
Definition:Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters.
Comment:Note that this activity can catalyze cleavage of DNA or RNA.
Synonyms:exact_synonym: 5'-endonuclease activity
 related_synonym: endoribonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
 xref: EC:3.1.30


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3'-tRNA processing endoribonuclease activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Elac1 elaC ribonuclease Z 1 JBrowse link 18 69,706,522 69,723,869 RGD:13792537
5'-flap endonuclease activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dna2 DNA replication helicase/nuclease 2 RGD:1600115
RGD:13792537
G Exo1 exonuclease 1 JBrowse link 13 93,936,989 93,962,749 RGD:13792537
G Fan1 FANCD2 and FANCI associated nuclease 1 JBrowse link 1 125,182,117 125,209,772 RGD:1624291
RGD:13792537
G Fen1 flap structure-specific endonuclease 1 JBrowse link 1 226,251,516 226,256,160 RGD:1624291
RGD:13792537
G Gen1 GEN1 Holliday junction 5' flap endonuclease JBrowse link 6 36,910,064 36,940,868 RGD:1624291
RGD:13792537
G Slc25a16 solute carrier family 25 member 16 JBrowse link 20 27,283,383 27,308,069 RGD:1600115
G Slx1b SLX1 homolog B, structure-specific endonuclease subunit JBrowse link 1 198,114,514 198,120,061 RGD:1624291
RGD:13792537
G Slx4 SLX4 structure-specific endonuclease subunit JBrowse link 10 11,787,756 11,808,326 RGD:1624291
RGD:13792537
deoxyribonuclease I activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dicer1 dicer 1 ribonuclease III JBrowse link 6 128,388,084 128,453,234 RGD:13792537
G Dnase1 deoxyribonuclease 1 JBrowse link 10 11,757,681 11,760,672 RGD:1298888
RGD:13792537
RGD:1624291
G Dnase1l1 deoxyribonuclease 1-like 1 JBrowse link X 156,429,521 156,438,066 RGD:13792537
G Dnase1l2 deoxyribonuclease 1 like 2 JBrowse link 10 13,812,335 13,814,514 RGD:13792537
G Dnase1l3 deoxyribonuclease 1-like 3 JBrowse link 15 18,710,492 18,736,476 RGD:13792537
endodeoxyribonuclease activity, producing 5'-phosphomonoesters term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Endov endonuclease V JBrowse link 10 108,630,723 108,646,679 RGD:1624291
G LOC103690794 nascent polypeptide-associated complex subunit alpha, muscle-specific form-like JBrowse link X 5,881,524 5,887,879 RGD:1600115
G Tatdn1 TatD DNase domain containing 1 JBrowse link 7 98,782,164 98,813,001 RGD:1600115
G Tatdn2 TatD DNase domain containing 2 JBrowse link 4 145,653,299 145,669,343 RGD:1600115
endoribonuclease activity, cleaving miRNA-paired mRNA term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ago2 argonaute RISC catalytic component 2 JBrowse link 7 114,339,607 114,377,277 RGD:1600115
RGD:1624291
G Ago3 argonaute RISC catalytic component 3 JBrowse link 5 144,355,792 144,436,509 RGD:1624291
endoribonuclease activity, cleaving siRNA-paired mRNA term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ago2 argonaute RISC catalytic component 2 JBrowse link 7 114,339,607 114,377,277 RGD:1600115
RGD:1624291
endoribonuclease activity, producing 5'-phosphomonoesters term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Endov endonuclease V JBrowse link 10 108,630,723 108,646,679 RGD:1624291
RGD:13792537
phosphodiesterase decapping endonuclease activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Edc3 enhancer of mRNA decapping 3 JBrowse link 8 62,482,126 62,527,665 RGD:1624291
G LOC688828 similar to Nucleoside diphosphate-linked moiety X motif 16 (Nudix motif 16) JBrowse link 8 113,687,983 113,689,657 RGD:13792537
G Nudt16 nudix hydrolase 16 JBrowse link 8 113,673,069 113,675,124 RGD:1624291
RGD:13792537
G Nudt16l1 nudix hydrolase 16 like 1 JBrowse link 10 10,829,866 10,831,782 RGD:13792537
ribonuclease III activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dgcr8 DGCR8 microprocessor complex subunit JBrowse link 11 86,852,682 86,885,233 RGD:1624291
RGD:13792537
G Dicer1 dicer 1 ribonuclease III JBrowse link 6 128,388,084 128,453,234 RGD:1624291
RGD:13792537
G Drosha drosha ribonuclease III JBrowse link 2 62,887,267 63,000,307 RGD:1624291
RGD:13792537
G Mrpl44 mitochondrial ribosomal protein L44 JBrowse link 9 85,542,763 85,547,814 RGD:13792537
ribonuclease P activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pop1 POP1 homolog, ribonuclease P/MRP subunit JBrowse link 7 73,270,403 73,298,209 RGD:1624291
RGD:13792537
G Pop4 POP4 homolog, ribonuclease P/MRP subunit JBrowse link 1 94,661,127 94,669,461 RGD:13792537
RGD:1600115
RGD:1624291
G Pop5 POP5 homolog, ribonuclease P/MRP subunit JBrowse link 12 47,138,346 47,143,152 RGD:1624291
RGD:13792537
G Pop7 POP7 homolog, ribonuclease P/MRP subunit JBrowse link 12 22,259,713 22,260,754 RGD:13792537
RGD:1624291
G Prorp protein only RNase P catalytic subunit JBrowse link 6 76,079,880 76,171,298 RGD:1600115
RGD:13792537
RGD:1624291
G Rpp14 ribonuclease P/MRP subunit p14 JBrowse link 15 18,625,963 18,636,157 RGD:1624291
G Rpp21 ribonuclease P/MRP subunit p21 JBrowse link 20 2,515,541 2,517,471 RGD:13792537
RGD:1624291
G Rpp25 ribonuclease P and MRP subunit p25 JBrowse link 8 62,283,336 62,284,716 RGD:1624291
RGD:1600115
G Rpp30 ribonuclease P/MRP subunit p30 JBrowse link 1 254,697,247 254,720,093 RGD:1624291
RGD:13792537
G Rpp38 ribonuclease P/MRP subunit p38 JBrowse link 17 78,915,450 78,919,144 RGD:1624291
G Rpp40 ribonuclease P/MRP subunit p40 JBrowse link 17 29,638,647 29,647,709 RGD:1624291
RNA lariat debranching enzyme activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dbr1 debranching RNA lariats 1 JBrowse link 8 107,826,690 107,838,186 RGD:1624291
RGD:13792537
RNA-DNA hybrid ribonuclease activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fen1 flap structure-specific endonuclease 1 JBrowse link 1 226,251,516 226,256,160 RGD:1624291
RGD:13792537
G Rnaseh1 ribonuclease H1 JBrowse link 6 47,916,188 47,925,582 RGD:1624291
RGD:13792537
RGD:1600115
G Rnaseh2a ribonuclease H2, subunit A JBrowse link 19 26,074,980 26,084,780 RGD:1624291
RGD:13792537
RGD:1600115
G Rnaseh2b ribonuclease H2, subunit B JBrowse link 15 45,422,010 45,472,792 RGD:1624291
RGD:13792537

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Term Annotations click to browse term
  molecular_function 19527
    catalytic activity 6039
      hydrolase activity 2608
        hydrolase activity, acting on ester bonds 781
          nuclease activity 213
            endonuclease activity 124
              endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 42
                endodeoxyribonuclease activity, producing 5'-phosphomonoesters + 17
                endoribonuclease activity, producing 5'-phosphomonoesters + 28
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.