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ONTOLOGY REPORT - ANNOTATIONS

Term:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
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Accession:GO:0016814 term browser browse the term
Definition:Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2.
Synonyms:xref: EC:3.5.4

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hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AICDA activation induced cytidine deaminase enables IEA InterPro GO_REF:0000002 NCBI chr11:8,426,920...8,438,331
Ensembl chr11:8,428,922...8,431,641 		JBrowse link
2'-deoxyadenosine deaminase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase enables ISO (PMID:10720488)
(PMID:9361033) 		MGI
UniProt		 PMID:9361033 PMID:10720488 NCBI chr 2:19,167,209...19,200,233 JBrowse link
adenosine deaminase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase enables ISO
IEA 		RGD
TreeGrafter
UniProt		 PMID:3746429 PMID:4462574 PMID:6815190 PMID:11038259 PMID:12675911 GO_REF:0000117 GO_REF:0000118 RGD:2291853 RGD:2291855 RGD:2291857 RGD:2291861 RGD:631747 NCBI chr 2:19,167,209...19,200,233 JBrowse link
G ADA2 adenosine deaminase 2 enables IEA TreeGrafter
InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
G ADAD1 adenosine deaminase domain containing 1 enables IEA InterPro GO_REF:0000002 NCBI chr 7:69,657,076...69,708,627
Ensembl chr 7:69,658,260...69,708,633 		JBrowse link
G ADAD2 adenosine deaminase domain containing 2 enables IEA InterPro GO_REF:0000002 NCBI chr 5:69,599,376...69,605,956
Ensembl chr 5:69,600,012...69,605,762 		JBrowse link
G ADAR adenosine deaminase RNA specific enables IEA InterPro GO_REF:0000002 NCBI chr20:9,194,611...9,241,102
Ensembl chr20:9,219,937...9,241,329 		JBrowse link
G ADARB1 adenosine deaminase RNA specific B1 enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr 2:88,780,954...88,915,672
Ensembl chr 2:88,833,707...88,918,066 		JBrowse link
G ADARB2 adenosine deaminase RNA specific B2 (inactive) enables IEA InterPro GO_REF:0000002 NCBI chr 9:1,136,461...1,644,196
Ensembl chr 9:1,137,037...1,301,657 		JBrowse link
G ADAT1 adenosine deaminase tRNA specific 1 enables IEA InterPro GO_REF:0000002 NCBI chr 5:61,083,029...61,108,751
Ensembl chr 5:61,082,819...61,108,330 		JBrowse link
G LACC1 laccase domain containing 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 3:21,995,405...22,008,310
Ensembl chr 3:21,997,133...22,006,418 		JBrowse link
G MAPDA N6-Methyl-AMP deaminase enables IEA TreeGrafter GO_REF:0000118 NCBI chr26:39,648,164...39,669,734 JBrowse link
AMP deaminase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMPD1 adenosine monophosphate deaminase 1 enables IEA UniProt
Ensembl
TreeGrafter
InterPro
RHEA		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000116 GO_REF:0000118 NCBI chr20:18,973,547...18,996,082
Ensembl chr20:18,974,204...18,996,293 		JBrowse link
G AMPD2 adenosine monophosphate deaminase 2 enables IEA RHEA
Ensembl
TreeGrafter
InterPro
UniProt		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000116 GO_REF:0000118 NCBI chr20:23,914,652...23,926,848
Ensembl chr20:23,913,254...23,926,904 		JBrowse link
G AMPD3 adenosine monophosphate deaminase 3 enables ISO
IEA 		RGD
TreeGrafter
InterPro
RHEA
UniProt		 PMID:9291127 GO_REF:0000002 GO_REF:0000003 GO_REF:0000116 GO_REF:0000118 RGD:632203 NCBI chr 1:54,318,746...54,374,361
Ensembl chr 1:54,316,334...54,373,619 		JBrowse link
cytidine deaminase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AICDA activation induced cytidine deaminase enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr11:8,426,920...8,438,331
Ensembl chr11:8,428,922...8,431,641 		JBrowse link
G APOBEC1 apolipoprotein B mRNA editing enzyme catalytic subunit 1 enables ISO
IEA 		RGD
TreeGrafter		 PMID:8511591 GO_REF:0000118 RGD:634661 NCBI chr11:7,696,571...7,700,424
Ensembl chr11:7,696,259...7,700,643 		JBrowse link
G APOBEC2 apolipoprotein B mRNA editing enzyme catalytic subunit 2 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr17:31,091,668...31,104,534
Ensembl chr17:31,095,184...31,103,526 		JBrowse link
G APOBEC3A apolipoprotein B mRNA editing enzyme catalytic subunit 3A enables ISO (PMID:16527742), (PMID:21123384)
(PMID:20062055), (PMID:22457529) 		UniProt PMID:16527742 PMID:20062055 PMID:21123384 PMID:22457529
G APOBEC3B apolipoprotein B mRNA editing enzyme catalytic subunit 3B enables ISO (PMID:22457529) UniProt PMID:22457529
G APOBEC3B apolipoprotein B mRNA editing enzyme catalytic subunit 3B enables IEA TreeGrafter GO_REF:0000118 Ensembl chr19:21,625,056...21,635,889 JBrowse link
G APOBEC3C apolipoprotein B mRNA editing enzyme catalytic subunit 3C enables IEA TreeGrafter GO_REF:0000118 NCBI chr19:21,657,588...21,662,061
Ensembl chr19:21,657,702...21,661,643 		JBrowse link
G APOBEC3D apolipoprotein B mRNA editing enzyme catalytic subunit 3D enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr19:21,606,278...21,695,429
Ensembl chr19:21,665,117...21,698,449 		JBrowse link
G APOBEC3F apolipoprotein B mRNA editing enzyme catalytic subunit 3F enables ISO (PMID:17121840) HGNC-UCL PMID:17121840 NCBI chr19:21,680,110...21,684,537 JBrowse link
G APOBEC3G apolipoprotein B mRNA editing enzyme catalytic subunit 3G enables IEA UniProt
TreeGrafter
Ensembl		 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr19:21,717,867...21,732,276
Ensembl chr19:21,717,889...21,732,839 		JBrowse link
G APOBEC3H apolipoprotein B mRNA editing enzyme catalytic subunit 3H enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr19:21,734,362...21,749,148
Ensembl chr19:21,742,084...21,749,288 		JBrowse link
G CDA cytidine deaminase enables IEA UniProt
Ensembl
RHEA
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000104 GO_REF:0000107 GO_REF:0000116 GO_REF:0000117 GO_REF:0000118 NCBI chr20:111,931,365...111,960,172
Ensembl chr20:111,931,364...111,960,036 		JBrowse link
G CDADC1 cytidine and dCMP deaminase domain containing 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 3:27,165,870...27,212,179
Ensembl chr 3:27,177,026...27,212,171 		JBrowse link
cytosine deaminase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOBEC1 apolipoprotein B mRNA editing enzyme catalytic subunit 1 ISO RGD PMID:12697753 RGD:1358271 NCBI chr11:7,696,571...7,700,424
Ensembl chr11:7,696,259...7,700,643 		JBrowse link
dCMP deaminase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDADC1 cytidine and dCMP deaminase domain containing 1 enables IEA TreeGrafter GO_REF:0000118 NCBI chr 3:27,165,870...27,212,179
Ensembl chr 3:27,177,026...27,212,171 		JBrowse link
G DCTD dCMP deaminase enables IEA TreeGrafter GO_REF:0000118 NCBI chr 7:128,874,164...128,902,036
Ensembl chr 7:128,874,117...128,901,910 		JBrowse link
GTP cyclohydrolase I activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GCH1 GTP cyclohydrolase 1 NOT|enables ISO
IEA 		(PMID:11284739), (PMID:8068008) UniProt
TreeGrafter
UniProt
RGD
Ensembl
InterPro		 PMID:2557335 PMID:8068008 PMID:8486153 PMID:8702680 PMID:9636709 More... GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 RGD:1601284 RGD:2298653 RGD:2298654 RGD:2298655 RGD:728623 NCBI chr24:32,029,997...32,079,656
Ensembl chr24:32,027,648...32,079,490 		JBrowse link
guanine deaminase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GDA guanine deaminase enables ISO
IEA 		RGD
TreeGrafter
Ensembl
RHEA
UniProt
InterPro		 PMID:11784697 GO_REF:0000002 GO_REF:0000003 GO_REF:0000104 GO_REF:0000107 GO_REF:0000116 GO_REF:0000118 RGD:708341 NCBI chr12:83,195,746...83,305,181
Ensembl chr12:83,195,994...83,306,792 		JBrowse link
IMP cyclohydrolase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase enables ISO (PMID:6480832)
(PMID:26588576) 		RGD
MGI		 PMID:6480832 PMID:9332377 PMID:26588576 RGD:70804 NCBI chr10:101,128,583...101,166,668 JBrowse link
methenyltetrahydrofolate cyclohydrolase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 enables IEA UniProt
Ensembl
TreeGrafter		 GO_REF:0000003 GO_REF:0000107 GO_REF:0000118 NCBI chr24:41,590,655...41,663,551
Ensembl chr24:41,590,590...41,666,952 		JBrowse link
G MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase enables IEA Ensembl
TreeGrafter
UniProt		 GO_REF:0000003 GO_REF:0000107 GO_REF:0000118 NCBI chr14:33,063,485...33,080,703
Ensembl chr14:33,064,542...33,080,366 		JBrowse link
G MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase enables IEA Ensembl
UniProt
TreeGrafter		 GO_REF:0000003 GO_REF:0000107 GO_REF:0000118 Ensembl chr14:33,064,542...33,080,366 JBrowse link
G MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like enables IEA UniProt
TreeGrafter		 GO_REF:0000003 GO_REF:0000118 NCBI chr 7:22,696,362...22,838,955
Ensembl chr 7:22,696,309...22,838,967 		JBrowse link
tRNA-specific adenosine deaminase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAD1 adenosine deaminase domain containing 1 enables IEA TreeGrafter GO_REF:0000118 NCBI chr 7:69,657,076...69,708,627
Ensembl chr 7:69,658,260...69,708,633 		JBrowse link
G ADAD2 adenosine deaminase domain containing 2 enables IEA TreeGrafter GO_REF:0000118 NCBI chr 5:69,599,376...69,605,956
Ensembl chr 5:69,600,012...69,605,762 		JBrowse link
G ADAR adenosine deaminase RNA specific enables IEA TreeGrafter GO_REF:0000118 NCBI chr20:9,194,611...9,241,102
Ensembl chr20:9,219,937...9,241,329 		JBrowse link
G ADARB1 adenosine deaminase RNA specific B1 enables IEA TreeGrafter GO_REF:0000118 NCBI chr 2:88,780,954...88,915,672
Ensembl chr 2:88,833,707...88,918,066 		JBrowse link
G ADARB2 adenosine deaminase RNA specific B2 (inactive) enables IEA TreeGrafter GO_REF:0000118 NCBI chr 9:1,136,461...1,644,196
Ensembl chr 9:1,137,037...1,301,657 		JBrowse link
G ADAT1 adenosine deaminase tRNA specific 1 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:61,083,029...61,108,751
Ensembl chr 5:61,082,819...61,108,330 		JBrowse link
G ADAT2 adenosine deaminase tRNA specific 2 enables IEA InterPro GO_REF:0000002 NCBI chr13:29,792,337...29,815,537 JBrowse link
tRNA-specific adenosine-34 deaminase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAT2 adenosine deaminase tRNA specific 2 enables IEA TreeGrafter GO_REF:0000118 NCBI chr13:29,792,337...29,815,537 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19734
    catalytic activity 5499
      hydrolase activity 2258
        hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 130
          hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 35
            1-pyrroline-4-hydroxy-2-carboxylate deaminase activity 0
            2'-deoxyadenosine deaminase activity 1
            5'-deoxyadenosine deaminase activity 0
            5'-methylthioadenosine deaminase activity 0
            8-oxoguanine deaminase activity 0
            N-cyclopropylammelide alkylamino hydrolase activity 0
            N-cyclopropylammeline deaminase activity 0
            N-cyclopropylmelamine deaminase activity 0
            S-adenosylhomocysteine deaminase activity 0
            adenine deaminase activity 0
            adenosine deaminase activity + 11
            adenosine-phosphate deaminase activity + 3
            aminoimidazolase activity 0
            blasticidin-S deaminase activity 0
            cAMP deaminase activity 0
            creatinine deaminase activity 0
            cyclohydrolase activity + 6
            cytidine deaminase activity 13
            cytosine deaminase activity 1
            dCMP deaminase activity 2
            dCTP deaminase (dUMP-forming) activity 0
            dCTP deaminase activity 0
            diaminohydroxyphosphoribosylaminopyrimidine deaminase activity 0
            dihydropterin deaminase activity 0
            guanine deaminase activity 1
            guanosine deaminase activity 0
            isoguanine deaminase activity 0
            pterin deaminase activity 0
            pyrithiamine deaminase activity 0
            sepiapterin deaminase activity 0
paths to the root