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ONTOLOGY REPORT - ANNOTATIONS

Term:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
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Accession:GO:0016709 term browser browse the term
Definition:Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor.
Synonyms:related_synonym: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
 xref: EC:1.14.13;   reactome:R-HSA-2162187 "DHB is hydroxylated to DHDB by COQ6";   reactome:R-HSA-2162194 "COQ9 dimer:COQ7:Fe2+ hydroxylates DMQ10H2 to DeMQ10H2"


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oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Coq6 coenzyme Q6 monooxygenase enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 6:104,007,814...104,019,888
Ensembl chr 6:104,007,872...104,024,657 		JBrowse link
G Coq7 coenzyme Q7, hydroxylase enables IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 1:172,836,359...172,851,173
Ensembl chr 1:172,835,188...172,851,158 		JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 enables ISO (PMID:26937021) RGD PMID:26937021 NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204 		JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 enables ISO
ISS		 (PMID:26937021)
GO_REF:0000024		 RGD
UniProt		 PMID:26937021 GO_REF:0000024 NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628 		JBrowse link
G Mical1 microtubule associated monooxygenase, calponin and LIM domain containing 1 enables ISO
ISS		 (PMID:21864500), (PMID:26845023)
(MGI:5513026|PMID:23911929), (MGI:6210614|PMID:26935886)
GO_REF:0000024		 RGD
UniProt		 PMID:21864500 PMID:23911929 PMID:26845023 PMID:26935886 GO_REF:0000024 MGI:5513026 MGI:6210614 NCBI chr20:44,974,137...44,986,089
Ensembl chr20:44,974,138...44,986,089 		JBrowse link
G Mical2 microtubule associated monooxygenase, calponin and LIM domain containing 2 enables ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:5513026|PMID:23911929), (MGI:5918009|PMID:23927065)		 UniProt
Ensembl
RGD		 PMID:23911929 PMID:23927065 GO_REF:0000024 GO_REF:0000107 MGI:5513026 MGI:5918009 NCBI chr 1:166,345,853...166,530,575
Ensembl chr 1:166,345,859...166,471,719
Ensembl chr 1:166,345,859...166,471,719 		JBrowse link
25-hydroxycholesterol 7alpha-hydroxylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 enables IEA GO_REF:0000116
GO_REF:0000003		 RHEA
UniProt		 GO_REF:0000003 GO_REF:0000116 NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698 		JBrowse link
27-hydroxycholesterol 7-alpha-monooxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 enables IEA GO_REF:0000116
GO_REF:0000003		 RHEA
UniProt		 GO_REF:0000003 GO_REF:0000116 NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698 		JBrowse link
4-nitrophenol 2-monooxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 enables ISO
IEA		 (PMID:9348445)
GO_REF:0000107		 RGD
Ensembl		 PMID:9348445 GO_REF:0000107 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
albendazole monooxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fmo3 flavin containing dimethylaniline monoxygenase 3 enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028 		JBrowse link
anandamide 11,12 epoxidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 enables ISO (PMID:21289075) RGD PMID:21289075 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 enables ISO (PMID:21289075) RGD PMID:21289075 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
anandamide 14,15 epoxidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 enables ISO (PMID:21289075) RGD PMID:21289075 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 enables ISO (PMID:21289075) RGD PMID:21289075 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp4x1 cytochrome P450, family 4, subfamily x, polypeptide 1 enables ISS
ISO		 GO_REF:0000024
(PMID:18549450)		 UniProt
RGD		 PMID:18549450 GO_REF:0000024 NCBI chr 5:128,651,681...128,683,338
Ensembl chr 5:128,651,776...128,682,779 		JBrowse link
anandamide 8,9 epoxidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 enables ISO (PMID:21289075) RGD PMID:21289075 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 enables ISO (PMID:21289075) RGD PMID:21289075 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
calcidiol 1-monooxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 enables TAS
IEA
ISO
IDA		 GO_REF:0000107
(MGI:1097206|PMID:9295274), (MGI:3590419|PMID:15972816)
PMID:9333115
(PMID:15795327), (PMID:16549446), (PMID:17023519), (PMID:22862690), (PMID:9415400)		 Ensembl
RGD		 PMID:9295274 PMID:9415400 PMID:15795327 PMID:15972816 PMID:16549446 More... GO_REF:0000107 MGI:1097206 MGI:3590419, RGD:68680, RGD:69373, RGD:69372 NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241 		JBrowse link
cholestanetriol 26-monooxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 enables ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:11412116)		 UniProt
Ensembl
RGD		 PMID:11412116 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551 		JBrowse link
cholesterol 24-hydroxylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp46a1 cytochrome P450, family 46, subfamily a, polypeptide 1 enables ISO
IBA		 (PMID:14640697), (PMID:18621681), (PMID:25017465)
GO_REF:0000033
(MGI:1339884|PMID:10377398)		 RGD
GO_Central		 PMID:10377398 PMID:14640697 PMID:18621681 PMID:25017465 GO_REF:0000033 MGI:1339884 NCBI chr 6:127,247,543...127,274,765
Ensembl chr 6:127,243,315...127,274,760 		JBrowse link
cholesterol 7-alpha-monooxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 enables ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 enables IDA
ISO
IBA		 (PMID:11279518), (PMID:12114517), (PMID:15845870)
GO_REF:0000033
(PMID:12077124)
PMID:1694852		 RGD
GO_Central		 PMID:11279518 PMID:12077124 PMID:12114517 PMID:15845870 PMID:2335522 More... GO_REF:0000033, RGD:70535, RGD:70534 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
flavonoid 3'-monooxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 IDA RGD PMID:18057719 RGD:2301699 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
hypotaurine dehydrogenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fmo1 flavin containing dimethylaniline monoxygenase 1 enables ISO
ISS		 (PMID:32156684)
(MGI:6881635|PMID:32156684)
GO_REF:0000024		 RGD
UniProt		 PMID:32156684 GO_REF:0000024 MGI:6881635 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647 		JBrowse link
G Fmo13 flavin-containing monooxygenase 13 enables IEA GO_REF:0000003
GO_REF:0000116		 UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr13:78,726,398...78,738,178
Ensembl chr13:78,726,398...78,738,178 		JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308 		JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 enables ISO
IEA		 (PMID:32156684)
GO_REF:0000003		 RGD
UniProt		 PMID:32156684 GO_REF:0000003 NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028 		JBrowse link
G Fmo4 flavin containing dimethylaniline monoxygenase 4 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr13:75,154,683...75,172,874
Ensembl chr13:75,154,684...75,172,874 		JBrowse link
G Fmo5 flavin containing dimethylaniline monoxygenase 5 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 2:185,197,184...185,249,699
Ensembl chr 2:185,222,204...185,249,693 		JBrowse link
G Fmo6 flavin containing monooxygenase 6 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr13:75,256,617...75,288,167
Ensembl chr13:75,260,368...75,288,769 		JBrowse link
G Fmo9 flavin containing monooxygenase 9 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr13:78,820,080...78,841,075
Ensembl chr13:78,820,080...78,841,075 		JBrowse link
G Fmol flavin containing dimethylaniline monoxygenase like enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr13:78,789,759...78,804,900
Ensembl chr13:78,790,856...78,804,900 		JBrowse link
ketosteroid monooxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c1 aldo-keto reductase family 1, member C1 enables ISO
IBA		 (PMID:21232532)
GO_REF:0000033		 RGD
GO_Central		 PMID:21232532 GO_REF:0000033 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Akr1c12 aldo-keto reductase family 1, member C12 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:66,045,376...66,061,496
Ensembl chr17:66,045,378...66,108,329 		JBrowse link
G Akr1c12l1 aldo-keto reductase family 1, member C12-like 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:65,937,834...65,948,344
Ensembl chr17:65,937,814...65,997,595 		JBrowse link
G Akr1c13 aldo-keto reductase family 1, member C13 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:65,964,186...65,997,598
Ensembl chr17:65,964,975...65,997,591 		JBrowse link
G Akr1c14 aldo-keto reductase family 1, member C14 enables IBA
IEA		 GO_REF:0000033
GO_REF:0000118		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr17:66,156,286...66,173,277
Ensembl chr17:66,156,288...66,173,277 		JBrowse link
G Akr1c15 aldo-keto reductase family 1, member C15 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:66,181,493...66,208,090
Ensembl chr17:66,181,493...66,208,061 		JBrowse link
G Akr1c19 aldo-keto reductase family 1, member C19 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:66,001,358...66,027,226
Ensembl chr17:66,004,002...66,025,047 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 enables ISO
IBA
IEA		 (PMID:21232532)
GO_REF:0000033
GO_REF:0000118		 RGD
GO_Central
TreeGrafter		 PMID:21232532 GO_REF:0000033 GO_REF:0000118 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 enables ISO
IBA
IEA		 (PMID:21232532)
GO_REF:0000033
GO_REF:0000118		 RGD
GO_Central
TreeGrafter		 PMID:21232532 GO_REF:0000033 GO_REF:0000118 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G AKR1C3l1 aldo-keto reductase family 1 member C3-like 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:65,847,580...65,881,488
Ensembl chr17:65,835,634...65,881,488 		JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 enables IEA
IBA		 GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 4:66,154,246...66,187,505
Ensembl chr 4:66,154,248...66,186,372 		JBrowse link
G ENSRNOG00000063788 enables IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 Ensembl chr17:65,937,814...65,948,421 JBrowse link
kynurenine 3-monooxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kmo kynurenine 3-monooxygenase enables IDA
IEA
IBA
ISO		 GO_REF:0000118
GO_REF:0000033
GO_REF:0000104
(MGI:5780894|PMID:26752518)
PMID:1332540
(PMID:10672018), (PMID:23575632), (PMID:26752518), (PMID:29208702), (PMID:29429898), (PMID:9237672)		 TreeGrafter
GO_Central
UniProt
RGD		 PMID:9237672 PMID:10672018 PMID:23575632 PMID:26752518 PMID:29208702 More... GO_REF:0000033 GO_REF:0000104 GO_REF:0000118 MGI:5780894, RGD:2290309, RGD:8554522, RGD:11342439, RGD:2290313, RGD:2290310 NCBI chr13:87,557,080...87,589,334
Ensembl chr13:87,557,286...87,588,881 		JBrowse link
N,N-dimethylaniline monooxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fmo1 flavin containing dimethylaniline monoxygenase 1 enables IDA
IBA
ISO
IEA		 GO_REF:0000033
(PMID:15144220), (PMID:7758472)
GO_REF:0000104		 GO_Central
RGD
UniProt		 PMID:7758472 PMID:15144220 PMID:8504165 GO_REF:0000033 GO_REF:0000104, RGD:728615 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647 		JBrowse link
G Fmo13 flavin-containing monooxygenase 13 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:78,726,398...78,738,178
Ensembl chr13:78,726,398...78,738,178 		JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 enables IEA
IBA
ISO		 GO_REF:0000003
GO_REF:0000033
(PMID:11744609)		 UniProt
GO_Central
RGD		 PMID:11744609 GO_REF:0000003 GO_REF:0000033 NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308 		JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 enables IDA
IBA
IEA		 using alternative substrate L-selenomethionine, see EC 1.14.13.8
GO_REF:0000033
GO_REF:0000003
Renal location		 GO_Central
UniProt
RGD		 PMID:17173378 PMID:18775983 GO_REF:0000003 GO_REF:0000033, RGD:1626480, RGD:2325184 NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028 		JBrowse link
G Fmo4 flavin containing dimethylaniline monoxygenase 4 enables IEA
IBA		 GO_REF:0000003
GO_REF:0000033
GO_REF:0000104		 UniProt
GO_Central		 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104 NCBI chr13:75,154,683...75,172,874
Ensembl chr13:75,154,684...75,172,874 		JBrowse link
G Fmo5 flavin containing dimethylaniline monoxygenase 5 enables IDA
IBA
IEA		 GO_REF:0000033
GO_REF:0000003		 GO_Central
UniProt
RGD		 PMID:9711811 GO_REF:0000003 GO_REF:0000033, RGD:708323 NCBI chr 2:185,197,184...185,249,699
Ensembl chr 2:185,222,204...185,249,693 		JBrowse link
G Fmo6 flavin containing monooxygenase 6 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:75,256,617...75,288,167
Ensembl chr13:75,260,368...75,288,769 		JBrowse link
G Fmo9 flavin containing monooxygenase 9 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:78,820,080...78,841,075
Ensembl chr13:78,820,080...78,841,075 		JBrowse link
G Fmol flavin containing dimethylaniline monoxygenase like enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:78,789,759...78,804,900
Ensembl chr13:78,790,856...78,804,900 		JBrowse link
nitric-oxide synthase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nos1 nitric oxide synthase 1 enables TAS
IBA
IDA
ISO
IEA		 GO_REF:0000033
PMID:1712077
PMID:35772285
(PMID:1689048), (PMID:35772285)
GO_REF:0000117
(MGI:3807771|PMID:7545544), (MGI:5582183|PMID:11591728)
PMID:23549614
PMID:18591664
PMID:17029414
PMID:1383204
GO_REF:0000003
GO_REF:0000116		 GO_Central
RGD
UniProt
RHEA		 PMID:1689048 PMID:7545544 PMID:11591728 PMID:35772285 PMID:12526033 More... GO_REF:0000003 GO_REF:0000033 GO_REF:0000116 GO_REF:0000117 MGI:3807771 MGI:5582183, RGD:727494, RGD:401827139, RGD:329955539, RGD:14995314, RGD:8554165, RGD:1598372, RGD:8553334, RGD:1358520, RGD:1580263, RGD:1598372 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nos2 nitric oxide synthase 2 enables TAS
IBA
ISO
IEA
IDA		 GO_REF:0000033
(PMID:35772285), (PMID:7504305), (PMID:7682706)
GO_REF:0000117
(MGI:3807769|PMID:9271491), (MGI:3807772|PMID:1383204)
PMID:9851365
GO_REF:0000116
GO_REF:0000003		 GO_Central
RGD
UniProt
RHEA		 PMID:1383204 PMID:7504305 PMID:7682706 PMID:9271491 PMID:35772285 More... GO_REF:0000003 GO_REF:0000033 GO_REF:0000116 GO_REF:0000117 MGI:3807769 MGI:3807772, RGD:625548, RGD:8656011, RGD:1580262, RGD:70247 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 enables IMP
ISO
IBA
IEA
IDA		 MGI:1857229 (PMID:15647265)
GO_REF:0000033
(PMID:1378832), (PMID:19666465), (PMID:23707606), (PMID:35772285), (PMID:7488039)
GO_REF:0000117
GO_REF:0000116
GO_REF:0000003		 RGD
GO_Central
UniProt
RHEA		 PMID:1378832 PMID:7488039 PMID:15647265 PMID:19666465 PMID:23707606 More... GO_REF:0000003 GO_REF:0000033 GO_REF:0000116 GO_REF:0000117, RGD:628542, RGD:628542 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
phenanthrene 9,10-monooxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c1 aldo-keto reductase family 1, member C1 enables ISO (PMID:21851338) RGD PMID:21851338 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 enables ISO (PMID:21851338) RGD PMID:21851338 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 enables ISO (PMID:21851338) RGD PMID:21851338 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
squalene monooxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sqle squalene epoxidase enables IDA
IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000104
(PMID:30626872)		 GO_Central
UniProt
RGD		 PMID:30626872 PMID:7814369 GO_REF:0000033 GO_REF:0000104, RGD:70024 NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618 		JBrowse link
sterol 14-demethylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp51 cytochrome P450, family 51 enables IDA
ISO		 (PMID:20149798) RGD PMID:20149798 PMID:7665087 PMID:7581240 RGD:1298863, RGD:2316902 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410 		JBrowse link
trimethylamine monooxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fmo1 flavin containing dimethylaniline monoxygenase 1 enables IDA PMID:8504165 UniProt PMID:8504165 RGD:728615 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647 		JBrowse link
G Fmo13 flavin-containing monooxygenase 13 enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr13:78,726,398...78,738,178
Ensembl chr13:78,726,398...78,738,178 		JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 enables IEA GO_REF:0000116
GO_REF:0000003		 RHEA
UniProt		 GO_REF:0000003 GO_REF:0000116 NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20890
    catalytic activity 6118
      oxidoreductase activity 872
        oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 240
          oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 43
            (+)-abscisic acid 8'-hydroxylase activity 0
            (+)-delta-cadinene-8-hydroxylase activity 0
            (+)-menthofuran synthase activity 0
            (+)-taxifolin 5'-hydroxylase activity 0
            (-)-menthol monooxygenase activity 0
            (11Z)-eicosenoate 14-hydroxylase activity 0
            (22S)-22-hydroxy-5alpha-campestan-3-one C-23 hydroxylase activity 0
            (22S)-22-hydroxy-campest-4-en-3-one C-23 hydroxylase activity 0
            (22S)-22-hydroxy-campesterol C-23 hydroxylase activity 0
            (3E)-4,8-dimethyl-1,3,7-nonatriene synthase activity 0
            (5alpha)-campestan-3-one hydroxylase activity 0
            1,8-cineole 2-exo-monooxygenase activity 0
            1-deoxy-11-oxopentalenate oxygenase activity 0
            1-hydroxy-2-naphthoate hydroxylase activity 0
            1-hydroxy-2-oxolimonene 1,2-monooxygenase activity 0
            1-methylnaphthalene hydroxylase activity 0
            11-oxo-beta-amyrin 30-oxidase activity 0
            11alpha-hydroxy-beta-amyrin dehydrogenase activity 0
            2,2',3-trihydroxybiphenyl monooxygenase activity 0
            2,2'-hydroxybiphenyl monooxygenase activity 0
            2,4-dichlorophenol 6-monooxygenase activity 0
            2,6-dihydroxypyridine 3-monooxygenase activity 0
            2-alpha-hydroxytaxusin 7-beta-hydroxylase activity 0
            2-heptyl-3-hydroxy-4(1H)-quinolone synthase activity 0
            2-hydroxy-1,4-benzoxazin-3-one monooxygenase activity 0
            2-hydroxy-phenylacetate hydroxylase activity 0
            2-hydroxybiphenyl 3-monooxygenase activity 0
            2-hydroxycyclohexanone 2-monooxygenase activity 0
            2-hydroxyquinoline 8-monooxygenase activity 0
            2-isopropylphenol monooxygenase activity 0
            2-methylbutyronitrile hydroxylase activity 0
            2-methylnaphthalene hydroxylase activity 0
            2-methylpropionitrile hydroxylase activity 0
            2-nitrophenol 2-monooxygenase activity 0
            2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity 0
            2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity 0
            2-propylphenol monooxygenase activity 0
            24-ethylidenelophenol 4alpha-methyl oxidase activity 0
            24-methylenecycloartanol 4alpha-methyl oxidase activity 0
            24-methylenelophenol methyl oxidase activity 0
            25-hydroxycholesterol 7alpha-hydroxylase activity 1
            27-hydroxycholesterol 7-alpha-monooxygenase activity 1
            3,5-xylenol methylhydroxylase activity 0
            3,9-dihydroxypterocarpan 6a-monooxygenase activity 0
            3-(3-hydroxyphenyl)propionate hydroxylase activity 0
            3-HSA hydroxylase activity 0
            3-chlorotoluene monooxygenase activity 0
            3-epi-6-deoxocathasterone C-23 hydroxylase activity 0
            3-geranylgeranylindole NADPH:oxygen oxidoreductase (10,11-epoxidizing) activity 0
            3-hydroxybenzoate 4-monooxygenase activity 0
            3-hydroxybenzoate 6-monooxygenase activity 0
            3-hydroxyindolin-2-one monooxygenase activity 0
            3-hydroxyphenylacetate 6-hydroxylase activity 0
            3-ketosteroid 9-alpha-monooxygenase activity 0
            3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity 0
            30-hydroxy-beta-amyrin 11-hydroxylase activity 0
            3alpha-hydroxy-ent-sandaracopimardiene 7-beta-monooxygenase activity 0
            3alpha-hydroxy-ent-sandaracopimardiene 9-beta-monooxygenase activity 0
            3beta-hydroxy-12,15-cassadiene-11-one 2-hydroxylase activity 0
            4'-methoxyisoflavone 2'-hydroxylase activity 0
            4,8,12-trimethyltrideca-1,3,7,11-tetraene synthase activity 0
            4-aminobenzoate 1-monooxygenase activity 0
            4-chlorobenzaldehyde oxidase activity 0
            4-hydroxyacetophenone monooxygenase activity 0
            4-hydroxybenzoate 1-hydroxylase activity 0
            4-hydroxybenzoate 3-monooxygenase [NAD(P)H] activity + 0
            4-hydroxybenzoate 3-monooxygenase activity 0
            4-hydroxyphenylacetaldehyde oxime monooxygenase activity 0
            4-hydroxyphenylacetate 1-monooxygenase activity 0
            4-hydroxypyridine-3-hydroxylase activity 0
            4-hydroxyquinoline 3-monooxygenase activity 0
            4-nitrophenol 2-monooxygenase activity 1
            4-nitrophenol 4-monooxygenase activity 0
            4-nitrotoluene monooxygenase activity 0
            4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol-4alpha-methyl oxidase activity 0
            4alpha-formyl-ergosta-7,24(241)-dien-3beta-ol-methyl oxidase activity 0
            4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol-methyl oxidase activity 0
            4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol-4alpha-methyl oxidase activity 0
            4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol-methyl oxidase activity 0
            5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase activity 0
            5-epi-aristolochene-1,3-dihydroxylase activity 0
            5-pyridoxate dioxygenase activity 0
            6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity 0
            6-hydroxynicotinate 3-monooxygenase activity 0
            6-oxocampestanol hydroxylase activity 0
            6-oxocineole dehydrogenase activity 0
            7-beta-hydroxytaxusin 2-alpha-hydroxylase activity 0
            7-oxateasterone synthase activity 0
            7-oxatyphasterol synthase activity 0
            9,10-dihydroxystearate hydroxylase activity 0
            9,10-epoxystearate hydroxylase activity 0
            9beta-pimara-7,15-diene oxidase activity 0
            CYP79F1 dihomomethionine monooxygenase activity 0
            CYP79F1 tetrahomomethionine monooxygenase activity 0
            CYP79F1 trihomomethionine monooxygenase activity 0
            DMNT synthase activity 0
            Delta12-linoleate epoxygenase activity 0
            FAD-dependent urate hydroxylase activity 0
            L-lysine 6-monooxygenase (NADPH) activity 0
            L-phenylalanine N-monooxygenase activity 0
            L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating) 0
            L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating, decarboxylating) 0
            N,N-dimethylaniline monooxygenase activity 9
            N-hydroxy-L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating) 0
            N-methylcoclaurine 3'-monooxygenase activity 0
            abieta-7,13-dien-18-ol hydroxylase activity 0
            abieta-7,13-diene hydroxylase activity 0
            abietadienal hydroxylase activity 0
            albendazole monooxygenase activity 1
            alkene monooxygenase activity 0
            allocryptopine 6-hydroxylase activity 0
            alpha-amyrin 28-monooxygenase activity 0
            alpha-humulene 10-hydroxylase activity 0
            alpha-pinene monooxygenase [NADH] activity 0
            anandamide epoxidase activity + 3
            angelicin synthase activity 0
            anhydrotetracycline monooxygenase activity 0
            anthranilate 3-monooxygenase (deaminating) activity 0
            anthraniloyl-CoA monooxygenase activity 0
            apigenin-7,4'-dimethyl ether 6-hydroxylase activity 0
            aurachin C monooxygenase activity 0
            benzoate 4-monooxygenase activity 0
            benzoyl-CoA 3-monooxygenase activity 0
            beta-amyrin 11-oxidase activity 0
            beta-amyrin 30-monooxygenase activity 0
            beta-amyrin monooxygenase activity 0
            beta-carotene 2,2'-beta-hydroxylase activity 0
            bisphenol A hydroxylase A activity 0
            branched-chain dodecylbenzene sulfonate monooxygenase activity 0
            brassinolide synthase activity 0
            calcidiol 1-monooxygenase activity 1
            campest-4-en-3-one hydroxylase activity 0
            campestanol hydroxylase activity 0
            campesterol,NADPH:oxygen oxidoreductase activity 0
            carbon disulfide oxygenase activity 0
            chlorophenol 4-monooxygenase activity 0
            cholest-4-en-3-one 26-monooxygenase activity 0
            cholestanetriol 26-monooxygenase activity 1
            cholestanol hydroxylase activity 0
            cholesterol 24-hydroxylase activity 1
            cholesterol 7-alpha-monooxygenase activity 2
            coniferyl aldehyde 5-hydroxylase activity 0
            costunolide 3beta-hydroxylase activity 0
            costunolide synthase activity 0
            cyclohexanone monooxygenase activity 0
            cyclooctat-9-en-5,7-diol C18-monooxygenase activity 0
            cyclopentanone monooxygenase activity 0
            cytochrome P450 dependent 12,13beta-epoxy-beta-amyrin hydroxylase activity 0
            cytochrome P450 dependent 16beta-hydroxy-beta-amyrin epoxidase activity 0
            cytochrome P450 dependent beta-amyrin 12,13beta-epoxidase activity 0
            cytochrome P450 dependent beta-amyrin 16beta-hydroxylase activity 0
            cytochrome P450 dependent ent-sandaracopimaradiene 3-hydroxylase activity 0
            dammarenediol 12-hydroxylase activity 0
            dehydroabietadienal hydroxylase activity 0
            dehydroabietadienol hydroxylase activity 0
            deoxysarpagine hydroxylase activity 0
            dibenzothiophene monooxygenase activity 0
            dihydrochelirubine 12-monooxygenase activity 0
            dihydrosanguinarine 10-monooxygenase activity 0
            dimethyl sulfide monooxygenase activity 0
            dimethylsulfoxide oxygenase activity 0
            emindole-SB NADPH:oxygen oxidoreductase (14,15-epoxidizing) activity 0
            ent-7-alpha-hydroxykaurenoate oxidase activity 0
            ent-cassa-12,15-diene 11-hydroxylase activity 0
            ent-cassadiene-C2-hydroxylase activity 0
            ent-isokaurene C2-hydroxylase activity 0
            ent-kaur-16-en-19-al oxidase activity 0
            ent-kaur-16-en-19-ol oxidase activity 0
            ent-kaurene oxidase activity 0
            ent-kaurenoate oxidase activity 0
            eriodictyol 2-hydroxylase activity 0
            eriodictyol,NADPH:oxygen oxidoreductase activity 0
            flaviolin monooxygenase activity 0
            flavonoid 3',5'-hydroxylase activity 0
            flavonoid 3'-monooxygenase activity 1
            fluorescent chlorophyll catabolite monooxygenase (deformylase) activity 0
            fraxetin 5-hydroxylase activity 0
            genkwanin 6-hydroxylase activity 0
            geraniol 10-hydroxylase activity 0
            germacrene A acid 8beta-hydroxylase activity 0
            gibberellin 12-aldehyde oxidase activity 0
            hydroxyphenylacetonitrile 2-monooxygenase activity 0
            hypotaurine dehydrogenase activity 9
            imidazoleacetate 4-monooxygenase activity 0
            indole-2-monooxygenase activity 0
            indole-3-carbonyl nitrile 4-hydroxylase activity 0
            indole-3-pyruvate monooxygenase activity 0
            indolin-2-one monooxygenase activity 0
            isobutylamine N-hydroxylase activity 0
            isoflavone 3'-hydroxylase activity 0
            isofucosterol hydroxylase activity 0
            isoleucine N-monooxygenase (oxime forming) activity 0
            isopimaradienal hydroxylase activity 0
            isopimaradienol hydroxylase activity 0
            ketosteroid monooxygenase activity 12
            kynurenine 3-monooxygenase activity 1
            leukotriene-E4 20-monooxygenase activity 0
            levopimaradienol hydroxylase activity 0
            limonene hydroxylase activity 0
            limonene monooxygenase activity + 0
            lithocholate 6beta-hydroxylase activity 0
            lupeol 28-monooxygenase activity 0
            lupeol 28-oxidase activity 0
            magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity 0
            melilotate 3-monooxygenase activity 0
            methane monooxygenase activity + 0
            methanesulfonate monooxygenase activity 0
            methyltetrahydroprotoberberine 14-monooxygenase activity 0
            naringenin 2-hydroxylase activity 0
            nitric-oxide synthase activity 3
            octat-9-en-7-ol 5-monooxygenase activity 0
            oleate 12-hydroxylase activity 0
            orcinol 2-monooxygenase activity 0
            parthenolide 3beta-hydroxylase activity 0
            parthenolide synthase activity 0
            paspalicine synthase activity 0
            paspalinine synthase activity 0
            pentachlorophenol monooxygenase activity 0
            phenanthrene 1,2-monooxygenase activity 0
            phenanthrene 3,4-monooxygenase activity 0
            phenanthrene 9,10-monooxygenase activity 3
            phenol 2-monooxygenase activity 0
            phenylacetate hydroxylase activity 0
            phenylacetone monooxygenase activity 0
            phenylacetyl-CoA 1,2-epoxidase activity 0
            phosphatidylcholine 12-monooxygenase activity 0
            pinocembrin 2-hydroxylase activity 0
            piperitol synthase activity 0
            precorrin-3B synthase activity 0
            protopanaxadiol 6-hydroxylase activity 0
            protopine 6-monooxygenase activity 0
            psoralen synthase activity 0
            pyocyanin hydroxylase activity 0
            questin monooxygenase activity 0
            quinine 3-monooxygenase activity 0
            sakuranetin 6-hydroxylase activity 0
            salicylate 1-monooxygenase activity 0
            salicylate 5-hydroxylase activity 0
            scopoletin 8-hydroxylase activity 0
            senecionine N-oxygenase activity 0
            sesamin synthase activity 0
            sitosterol hydroxylase activity 0
            squalene monooxygenase activity 1
            sterol 14-demethylase activity 1
            styrene monooxygenase activity 0
            syn-pimaradiene 6beta-hydroxylase activity 0
            tabersonine 16-hydroxylase activity 0
            taurochenodeoxycholate 6alpha-hydroxylase activity 0
            taxane 10-beta-hydroxylase activity 0
            taxane 13-alpha-hydroxylase activity 0
            taxifolin 8-monooxygenase activity 0
            taxoid 14-beta-hydroxylase activity 0
            taxoid 7beta-hydroxylase activity 0
            taxusin 2-alpha-hydroxylase activity 0
            tetrahydrofuran hydroxylase activity 0
            tocopherol omega-hydroxylase activity + 0
            tocotrienol omega-hydroxylase activity 0
            toluene 2-monooxygenase activity 0
            toluene 4-monooxygenase activity 0
            toluene-4-sulfonate monooxygenase activity 0
            toluene-sulfonate methyl-monooxygenase activity 0
            trans-cinnamate 2-monooxygenase activity 0
            trans-cinnamate 4-monooxygenase activity 0
            tri-(coumaroyl or caffeoyl) spermidine meta-hydroxylase activity + 0
            tri-(feruloyl or hydroxyferuloyl) spermidine meta-hydroxylase activity + 0
            trimethylamine monooxygenase activity 3
            trimethyluric acid monooxygenase activity 0
            tyrosine N-monooxygenase activity 0
            ursolic aldehyde 28-monooxygenase activity 0
            valine N-monooxygenase (oxime forming) activity 0
            vanillate monooxygenase activity 0
            vinorine hydroxylase activity 0
            xylene monooxygenase activity 0
            zeaxanthin 2,2'-beta-hydroxylase activity 0
            zeaxanthin 2-beta-hydroxylase activity 0
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