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ONTOLOGY REPORT - ANNOTATIONS

Term:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
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Accession:GO:0016702 term browser browse the term
Definition:Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor.
Synonyms:xref: EC:1.13.11;   Reactome:R-HSA-2161775 "ALOX12 oxidises LTA4 to LXA4";   Reactome:R-HSA-9916401 "ALOX12 oxidises LTA4 to LXB4";   reactome:R-HSA-2161907 "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4";   reactome:R-HSA-2161917 "ALOX5 oxidises 15S-HpETE to LXA4/B4";   reactome:R-HSA-5164399 "BCO2:Fe2+ cleaves betaC to APO10al and bION";   reactome:R-HSA-9018880 "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE";   reactome:R-HSA-9020274 "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA";   reactome:R-HSA-9026408 "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3";   reactome:R-HSA-9026918 "Lipoxygenase oxidises 17(S)-Hp-DHA to 7(S),17(S)-diHp-DHA"

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oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADO 2-aminoethanethiol dioxygenase enables IEA InterPro GO_REF:0000002 NCBI chr 9:68,483,110...68,486,866
Ensembl chr 9:68,485,720...68,486,532 		JBrowse link
G ALOX12 arachidonate 12-lipoxygenase, 12S type enables IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000117 NCBI chr16:6,355,795...6,370,051
Ensembl chr16:6,356,058...6,369,738 		JBrowse link
G ALOX12B arachidonate 12-lipoxygenase, 12R type enables IEA InterPro
Ensembl
UniProt		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000117 NCBI chr16:7,454,950...7,470,949
Ensembl chr16:7,455,044...7,469,934 		JBrowse link
G ALOX15 arachidonate 15-lipoxygenase enables IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000117 NCBI chr16:4,112,795...4,121,764
Ensembl chr16:4,111,151...4,121,645 		JBrowse link
G ALOX15B arachidonate 15-lipoxygenase type B enables IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000117 NCBI chr16:7,425,533...7,435,896
Ensembl chr16:7,425,990...7,435,327 		JBrowse link
G ALOX5 arachidonate 5-lipoxygenase enables IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000117 NCBI chr 9:41,085,257...41,145,760
Ensembl chr 9:41,085,361...41,145,331 		JBrowse link
G ALOXE3 arachidonate epidermal lipoxygenase 3 NOT|enables ISO
IEA 		(PMID:12881489) UniProt
UniProt
InterPro
Ensembl		 PMID:12881489 GO_REF:0000002 GO_REF:0000107 GO_REF:0000117 NCBI chr16:7,478,775...7,500,931
Ensembl chr16:7,478,793...7,500,428 		JBrowse link
G BCO1 beta-carotene oxygenase 1 enables IEA InterPro GO_REF:0000002 NCBI chr 5:66,681,756...66,730,832
Ensembl chr 5:66,681,513...66,733,604 		JBrowse link
G BCO2 beta-carotene oxygenase 2 enables IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr 1:103,511,730...103,566,526
Ensembl chr 1:103,521,658...103,565,659 		JBrowse link
G CDO1 cysteine dioxygenase type 1 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr23:19,049,612...19,061,783
Ensembl chr23:19,049,262...19,061,740 		JBrowse link
G IDO1 indoleamine 2,3-dioxygenase 1 enables IEA UniProt GO_REF:0000117 NCBI chr 8:37,930,910...37,950,790
Ensembl chr 8:37,930,562...37,946,505 		JBrowse link
G IDO2 indoleamine 2,3-dioxygenase 2 enables IEA UniProt GO_REF:0000117 NCBI chr 8:37,951,810...38,027,689
Ensembl chr 8:37,959,078...38,027,632 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 enables IEA TreeGrafter GO_REF:0000118 NCBI chr12:17,195,403...17,218,450
Ensembl chr12:17,192,628...17,218,315 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 enables ISO
IEA 		RGD
TreeGrafter		 PMID:8203528 GO_REF:0000118 RGD:1642604 NCBI chr25:42,733,535...42,742,463
Ensembl chr25:42,734,771...42,742,429 		JBrowse link
G RPE65 retinoid isomerohydrolase RPE65 enables IEA InterPro GO_REF:0000002 NCBI chr20:64,662,777...64,684,178
Ensembl chr20:64,664,358...64,683,211 		JBrowse link
G TMLHE trimethyllysine hydroxylase, epsilon enables ISO (PMID:12121276) MGI PMID:12121276 NCBI chr  X:129,628,788...129,729,616
Ensembl chr  X:129,626,286...129,729,592 		JBrowse link
3-hydroxyanthranilate 3,4-dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HAAO 3-hydroxyanthranilate 3,4-dioxygenase enables ISO
IEA 		RGD
TreeGrafter
Ensembl
UniProt
RHEA
InterPro		 PMID:2940338 PMID:3112306 PMID:9870556 GO_REF:0000002 GO_REF:0000003 GO_REF:0000104 GO_REF:0000107 GO_REF:0000116 GO_REF:0000118 RGD:2290301 RGD:2290302 RGD:2290370 NCBI chr14:64,460,553...64,485,731
Ensembl chr14:64,460,703...64,485,378 		JBrowse link
4-hydroxymandelate synthase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HPDL 4-hydroxyphenylpyruvate dioxygenase like enables IEA Ensembl GO_REF:0000107 NCBI chr20:87,463,202...87,465,467
Ensembl chr20:87,463,636...87,464,748 		JBrowse link
4-hydroxyphenylpyruvate dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HPD 4-hydroxyphenylpyruvate dioxygenase enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr11:117,203,844...117,246,249
Ensembl chr11:117,203,307...117,224,038 		JBrowse link
G HPDL 4-hydroxyphenylpyruvate dioxygenase like enables IEA InterPro GO_REF:0000002 NCBI chr20:87,463,202...87,465,467
Ensembl chr20:87,463,636...87,464,748 		JBrowse link
acireductone dioxygenase (Ni2+-requiring) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADI1 acireductone dioxygenase 1 enables IEA UniProt
RHEA		 GO_REF:0000104 GO_REF:0000116 NCBI chr14:104,140,027...104,172,782
Ensembl chr14:104,139,952...104,172,271 		JBrowse link
acireductone dioxygenase [iron(II)-requiring] activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADI1 acireductone dioxygenase 1 enables IEA UniProt
TreeGrafter
InterPro
RHEA		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000104 GO_REF:0000116 GO_REF:0000118 NCBI chr14:104,140,027...104,172,782
Ensembl chr14:104,139,952...104,172,271 		JBrowse link
arachidonate 12(S)-lipoxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX12 arachidonate 12-lipoxygenase, 12S type enables IEA Ensembl GO_REF:0000107 NCBI chr16:6,355,795...6,370,051
Ensembl chr16:6,356,058...6,369,738 		JBrowse link
G ALOX12B arachidonate 12-lipoxygenase, 12R type enables IEA Ensembl GO_REF:0000107 NCBI chr16:7,454,950...7,470,949
Ensembl chr16:7,455,044...7,469,934 		JBrowse link
G ALOX15 arachidonate 15-lipoxygenase enables ISO
IEA 		RGD
Ensembl		 PMID:8117750 GO_REF:0000107 RGD:70288 NCBI chr16:4,112,795...4,121,764
Ensembl chr16:4,111,151...4,121,645 		JBrowse link
arachidonate 15-lipoxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX12 arachidonate 12-lipoxygenase, 12S type enables IEA Ensembl GO_REF:0000107 NCBI chr16:6,355,795...6,370,051
Ensembl chr16:6,356,058...6,369,738 		JBrowse link
G ALOX15 arachidonate 15-lipoxygenase enables ISO
IEA 		RGD
Ensembl		 PMID:8444196 GO_REF:0000107 RGD:70287 NCBI chr16:4,112,795...4,121,764
Ensembl chr16:4,111,151...4,121,645 		JBrowse link
G ALOX15B arachidonate 15-lipoxygenase type B enables IEA Ensembl GO_REF:0000107 NCBI chr16:7,425,533...7,435,896
Ensembl chr16:7,425,990...7,435,327 		JBrowse link
arachidonate 5-lipoxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5 arachidonate 5-lipoxygenase enables IEA Ensembl GO_REF:0000107 NCBI chr 9:41,085,257...41,145,760
Ensembl chr 9:41,085,361...41,145,331 		JBrowse link
G ALOX5AP arachidonate 5-lipoxygenase activating protein contributes_to ISO RGD PMID:2300173 RGD:69749 NCBI chr 3:9,618,030...9,642,990
Ensembl chr 3:9,617,949...9,643,184 		JBrowse link
arachidonate 8(R)-lipoxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX12B arachidonate 12-lipoxygenase, 12R type enables IEA Ensembl GO_REF:0000107 NCBI chr16:7,454,950...7,470,949
Ensembl chr16:7,455,044...7,469,934 		JBrowse link
arachidonate 8(S)-lipoxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX15B arachidonate 15-lipoxygenase type B enables IEA Ensembl GO_REF:0000107 NCBI chr16:7,425,533...7,435,896
Ensembl chr16:7,425,990...7,435,327 		JBrowse link
beta,beta-carotene-9',10'-cleaving oxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCO2 beta-carotene oxygenase 2 enables IEA Ensembl GO_REF:0000107 NCBI chr 1:103,511,730...103,566,526
Ensembl chr 1:103,521,658...103,565,659 		JBrowse link
beta-carotene 15,15'-dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCO1 beta-carotene oxygenase 1 enables ISO
IEA 		RGD
TreeGrafter
Ensembl		 PMID:12468597 GO_REF:0000107 GO_REF:0000118 RGD:634627 NCBI chr 5:66,681,756...66,730,832
Ensembl chr 5:66,681,513...66,733,604 		JBrowse link
G BCO2 beta-carotene oxygenase 2 enables IEA TreeGrafter GO_REF:0000118 NCBI chr 1:103,511,730...103,566,526
Ensembl chr 1:103,521,658...103,565,659 		JBrowse link
G RPE65 retinoid isomerohydrolase RPE65 enables IEA TreeGrafter GO_REF:0000118 NCBI chr20:64,662,777...64,684,178
Ensembl chr20:64,664,358...64,683,211 		JBrowse link
carotenoid dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCO1 beta-carotene oxygenase 1 enables IEA TreeGrafter GO_REF:0000118 NCBI chr 5:66,681,756...66,730,832
Ensembl chr 5:66,681,513...66,733,604 		JBrowse link
G BCO2 beta-carotene oxygenase 2 enables IEA TreeGrafter GO_REF:0000118 NCBI chr 1:103,511,730...103,566,526
Ensembl chr 1:103,521,658...103,565,659 		JBrowse link
cysteamine dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADO 2-aminoethanethiol dioxygenase enables IEA Ensembl GO_REF:0000107 NCBI chr 9:68,483,110...68,486,866
Ensembl chr 9:68,485,720...68,486,532 		JBrowse link
cysteine dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDO1 cysteine dioxygenase type 1 enables ISO
IEA 		RGD
TreeGrafter
Ensembl
UniProt
RHEA		 PMID:16611641 GO_REF:0000003 GO_REF:0000104 GO_REF:0000107 GO_REF:0000116 GO_REF:0000118 RGD:2301357 NCBI chr23:19,049,612...19,061,783
Ensembl chr23:19,049,262...19,061,740 		JBrowse link
homogentisate 1,2-dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HGD homogentisate 1,2-dioxygenase enables IEA InterPro
Ensembl
TreeGrafter
UniProt		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 NCBI chr22:60,136,293...60,192,275
Ensembl chr22:60,137,532...60,192,430 		JBrowse link
indoleamine 2,3-dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IDO1 indoleamine 2,3-dioxygenase 1 enables ISO
IEA 		RGD
TreeGrafter
Ensembl		 PMID:3400092 PMID:10719243 PMID:11513477 GO_REF:0000107 GO_REF:0000118 RGD:2290190 RGD:2290313 RGD:2290543 NCBI chr 8:37,930,910...37,950,790
Ensembl chr 8:37,930,562...37,946,505 		JBrowse link
G IDO2 indoleamine 2,3-dioxygenase 2 enables IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:37,951,810...38,027,689
Ensembl chr 8:37,959,078...38,027,632 		JBrowse link
linoleate 13S-lipoxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX12 arachidonate 12-lipoxygenase, 12S type enables IEA Ensembl GO_REF:0000107 NCBI chr16:6,355,795...6,370,051
Ensembl chr16:6,356,058...6,369,738 		JBrowse link
G ALOX15 arachidonate 15-lipoxygenase enables IEA Ensembl GO_REF:0000107 NCBI chr16:4,112,795...4,121,764
Ensembl chr16:4,111,151...4,121,645 		JBrowse link
G ALOX15B arachidonate 15-lipoxygenase type B enables IEA Ensembl GO_REF:0000107 NCBI chr16:7,425,533...7,435,896
Ensembl chr16:7,425,990...7,435,327 		JBrowse link
linoleate 9S-lipoxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX12B arachidonate 12-lipoxygenase, 12R type enables IEA Ensembl GO_REF:0000107 NCBI chr16:7,454,950...7,470,949
Ensembl chr16:7,455,044...7,469,934 		JBrowse link
G ALOX15B arachidonate 15-lipoxygenase type B enables IEA Ensembl GO_REF:0000107 NCBI chr16:7,425,533...7,435,896
Ensembl chr16:7,425,990...7,435,327 		JBrowse link
quercetin 2,3-dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIR pirin enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr  X:13,854,356...13,966,554
Ensembl chr  X:13,854,236...13,966,506 		JBrowse link
sulfur dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ETHE1 ETHE1 persulfide dioxygenase enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:37,024,015...37,045,628
Ensembl chr 6:37,024,014...37,045,737 		JBrowse link
tryptophan 2,3-dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IDO1 indoleamine 2,3-dioxygenase 1 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:37,930,910...37,950,790
Ensembl chr 8:37,930,562...37,946,505 		JBrowse link
G IDO2 indoleamine 2,3-dioxygenase 2 enables IEA TreeGrafter GO_REF:0000118 NCBI chr 8:37,951,810...38,027,689
Ensembl chr 8:37,959,078...38,027,632 		JBrowse link
G TDO2 tryptophan 2,3-dioxygenase enables ISO
IEA 		RGD
Ensembl
TreeGrafter
UniProt
InterPro
RHEA		 PMID:3400092 PMID:3899109 PMID:7236232 PMID:10719243 GO_REF:0000002 GO_REF:0000003 GO_REF:0000104 GO_REF:0000107 GO_REF:0000116 GO_REF:0000117 GO_REF:0000118 RGD:2290190 RGD:2290313 RGD:2291804 RGD:2303721 NCBI chr 7:102,467,075...102,485,434
Ensembl chr 7:102,467,640...102,485,394 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19734
    catalytic activity 5499
      oxidoreductase activity 700
        dioxygenase activity 91
          oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 25
            1-hydroxy-2-naphthoate 1,2-dioxygenase activity 0
            2,3-dihydroxy-p-cumate dioxygenase activity 0
            2,3-dihydroxybenzoate 2,3-dioxygenase activity 0
            2,3-dihydroxybenzoate 3,4-dioxygenase activity 0
            2,3-dihydroxybiphenyl 1,2-dioxygenase activity 0
            2,3-dihydroxyindole 2,3-dioxygenase activity 0
            2,4'-dihydroxyacetophenone dioxygenase activity 0
            2,5-dihydroxypyridine 5,6-dioxygenase activity 0
            3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity 0
            3,4-dihydroxyphenylacetate 2,3-dioxygenase activity 0
            3-carboxyethylcatechol 2,3-dioxygenase activity 0
            3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase activity 0
            3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity 0
            3-hydroxyanthranilate 3,4-dioxygenase activity 1
            4-hydroxycatechol 1,2-dioxygenase activity 0
            4-hydroxymandelate synthase activity 1
            4-hydroxyphenylpyruvate dioxygenase activity 2
            5,6-dimethylbenzimidazole synthase activity 0
            7,8-dihydroxykynurenate 8,8a-dioxygenase activity 0
            9-cis-10'-apo-beta-carotenal cleavage oxygenase activity 0
            9-cis-beta-carotene 9',10'-cleavage oxygenase activity 0
            acetylacetone-cleaving enzyme activity 0
            acireductone dioxygenase (Ni2+-requiring) activity 1
            acireductone dioxygenase [iron(II)-requiring] activity 1
            all-trans-8'-apo-beta-carotenal 15,15'-oxygenase activity 0
            all-trans-beta-apo-10'-carotenal cleavage oxygenase activity 0
            arachidonate 12(R)-lipoxygenase activity 0
            arachidonate 12(S)-lipoxygenase activity 3
            arachidonate 15-lipoxygenase activity 3
            arachidonate 5-lipoxygenase activity 2
            arachidonate 8(R)-lipoxygenase activity 1
            arachidonate 8(S)-lipoxygenase activity 1
            beta,beta-carotene-9',10'-cleaving oxygenase activity 1
            beta-carotene 15,15'-dioxygenase activity 3
            biphenyl-2,3-diol 1,2-dioxygenase activity 0
            caffeate 3,4-dioxygenase activity 0
            carotenoid dioxygenase activity + 2
            catechol 1,2-dioxygenase activity 0
            catechol 2,3-dioxygenase activity 0
            chloridazon-catechol dioxygenase activity 0
            chlorite O2-lyase activity 0
            cysteamine dioxygenase activity 1
            cysteine dioxygenase activity 1
            fatty acid alpha-dioxygenase activity 0
            gallate dioxygenase activity 0
            gentisate 1,2-dioxygenase activity 0
            homogentisate 1,2-dioxygenase activity 1
            hydroxyquinol 1,2-dioxygenase activity 0
            indole 2,3-dioxygenase activity 0
            indoleamine 2,3-dioxygenase activity 2
            lignostilbene alpha beta-dioxygenase activity 0
            linoleate 11-lipoxygenase activity 0
            linoleate 13S-lipoxygenase activity 3
            linoleate 8R-lipoxygenase activity 0
            linoleate 9S-lipoxygenase activity 2
            linolenate 9R-lipoxygenase activity 0
            p-cumate 2,3-dioxygenase activity 0
            protocatechuate 3,4-dioxygenase activity 0
            protocatechuate 4,5-dioxygenase activity 0
            pyrogallol 1,2-oxygenase activity 0
            quercetin 2,3-dioxygenase activity 1
            stizolobate synthase activity 0
            stizolobinate synthase activity 0
            sulfur dioxygenase activity 1
            sulfur oxygenase/reductase activity 0
            tryptophan 2,3-dioxygenase activity 3
            violaxanthin oxygenase activity 0
paths to the root