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ONTOLOGY REPORT - ANNOTATIONS

Term:mediator complex
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Accession:GO:0016592 term browser browse the term
Definition:A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
Synonyms:exact_synonym: L mediator complex;   Srb-mediator complex
 narrow_synonym: TRAP complex
 related_synonym: CDK8-containing TRAP/mediator complex
 alt_id: GO:0000119
 xref: Wikipedia:Mediator_(coactivator)


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mediator complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bclaf1 BCL2-associated transcription factor 1 part_of IBA GO_Central GO_REF:0000033 NCBI chr10:20,187,897...20,218,390
Ensembl chr10:20,188,215...20,220,359 		JBrowse link
G Bclaf3 Bclaf1 and Thrap3 family member 3 part_of IBA GO_Central GO_REF:0000033 NCBI chr  X:158,315,639...158,376,077
Ensembl chr  X:158,309,684...158,376,077 		JBrowse link
G Ccnc cyclin C part_of IDA
IBA		 (PMID:15340084) MGI
GO_Central		 PMID:15340084 GO_REF:0000033 NCBI chr 4:21,727,705...21,759,917
Ensembl chr 4:21,727,701...21,759,922 		JBrowse link
G Cdk8 cyclin dependent kinase 8 part_of IDA
ISO
IBA		 (PMID:15340084)
(PMID:14638676)		 MGI
GO_Central		 PMID:14638676 PMID:15340084 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 5:146,167,432...146,239,684
Ensembl chr 5:146,168,040...146,239,684 		JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 part_of IBA GO_Central GO_REF:0000033 NCBI chr11:46,345,758...46,372,082
Ensembl chr11:46,345,762...46,372,082 		JBrowse link
G Med1 mediator complex subunit 1 part_of IBA
ISO
IDA		 (PMID:14638676)
(PMID:12093747), (PMID:15340084)		 GO_Central
MGI		 PMID:12093747 PMID:14638676 PMID:15340084 GO_REF:0000008 GO_REF:0000033 NCBI chr11:98,042,980...98,084,121
Ensembl chr11:98,042,980...98,084,119 		JBrowse link
G Med10 mediator complex subunit 10 part_of IDA
IBA		 (PMID:15340084) MGI
GO_Central		 PMID:15340084 GO_REF:0000033 NCBI chr13:69,950,467...69,964,221
Ensembl chr13:69,950,514...69,964,223 		JBrowse link
G Med11 mediator complex subunit 11 part_of ISO
IBA		 (PMID:14638676) MGI
GO_Central		 PMID:14638676 GO_REF:0000033 NCBI chr11:70,342,744...70,344,558
Ensembl chr11:70,342,745...70,344,553 		JBrowse link
G Med12 mediator complex subunit 12 part_of IDA
ISO
IBA		 (PMID:15340084) MGI
GO_Central		 PMID:15340084 GO_REF:0000008 GO_REF:0000033 NCBI chr  X:100,317,697...100,342,540
Ensembl chr  X:100,317,636...100,341,071 		JBrowse link
G Med12l mediator complex subunit 12-like part_of IBA GO_Central GO_REF:0000033 NCBI chr 3:58,912,820...59,225,867
Ensembl chr 3:58,913,246...59,226,103 		JBrowse link
G Med13 mediator complex subunit 13 part_of ISO
IBA
IDA		 (PMID:15340084) MGI
GO_Central		 PMID:15340084 GO_REF:0000008 GO_REF:0000033 NCBI chr11:86,157,859...86,248,422
Ensembl chr11:86,157,859...86,248,428 		JBrowse link
G Med13l mediator complex subunit 13-like part_of IDA (PMID:12093747) MGI PMID:12093747 NCBI chr 5:118,698,363...118,903,503
Ensembl chr 5:118,698,744...118,903,503 		JBrowse link
G Med14 mediator complex subunit 14 part_of ISO
IDA
IBA		 (PMID:15340084) MGI
GO_Central		 PMID:15340084 GO_REF:0000008 GO_REF:0000033 NCBI chr  X:12,541,607...12,628,813
Ensembl chr  X:12,541,608...12,628,312 		JBrowse link
G Med16 mediator complex subunit 16 part_of ISO
IBA
IDA		 (PMID:12093747), (PMID:15340084) MGI
GO_Central		 PMID:12093747 PMID:15340084 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr10:79,730,543...79,744,757
Ensembl chr10:79,730,542...79,744,757 		JBrowse link
G Med17 mediator complex subunit 17 part_of ISO
IBA
IDA		 (PMID:14638676)
(PMID:15340084)		 MGI
GO_Central		 PMID:14638676 PMID:15340084 GO_REF:0000008 GO_REF:0000033 NCBI chr 9:15,171,647...15,194,576
Ensembl chr 9:15,171,647...15,191,227 		JBrowse link
G Med18 mediator complex subunit 18 part_of IBA
ISO		 (PMID:14638676) GO_Central
MGI		 PMID:14638676 GO_REF:0000033 NCBI chr 4:132,186,040...132,191,232
Ensembl chr 4:132,186,042...132,191,232 		JBrowse link
G Med19 mediator complex subunit 19 part_of IDA
IBA		 (PMID:14638676) MGI
GO_Central		 PMID:14638676 GO_REF:0000033 NCBI chr 2:84,508,769...84,519,330
Ensembl chr 2:84,508,746...84,518,559 		JBrowse link
G Med20 mediator complex subunit 20 part_of IDA
IBA		 (PMID:15340084) MGI
GO_Central		 PMID:15340084 GO_REF:0000033 NCBI chr17:47,922,510...47,935,176
Ensembl chr17:47,922,507...47,935,343 		JBrowse link
G Med21 mediator complex subunit 21 part_of ISO
IBA
IDA		 (PMID:12093747), (PMID:15340084) MGI
GO_Central		 PMID:12093747 PMID:15340084 GO_REF:0000008 GO_REF:0000033 NCBI chr 6:146,544,077...146,552,098
Ensembl chr 6:146,544,045...146,552,230 		JBrowse link
G Med22 mediator complex subunit 22 part_of IBA
ISO		 (PMID:14638676) GO_Central
MGI		 PMID:14638676 GO_REF:0000033 NCBI chr 2:26,795,279...26,800,654
Ensembl chr 2:26,795,274...26,800,689 		JBrowse link
G Med23 mediator complex subunit 23 part_of IBA
IDA		 (PMID:15340084) GO_Central
MGI		 PMID:15340084 GO_REF:0000033 NCBI chr10:24,745,889...24,789,358
Ensembl chr10:24,745,884...24,789,579 		JBrowse link
G Med24 mediator complex subunit 24 part_of IDA
IBA		 (PMID:12093747), (PMID:15340084) MGI
GO_Central		 PMID:12093747 PMID:15340084 GO_REF:0000033 NCBI chr11:98,595,423...98,620,245
Ensembl chr11:98,595,417...98,620,261 		JBrowse link
G Med25 mediator complex subunit 25 part_of IBA GO_Central GO_REF:0000033 NCBI chr 7:44,526,189...44,544,771
Ensembl chr 7:44,526,189...44,542,136 		JBrowse link
G Med26 mediator complex subunit 26 part_of ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 8:73,248,402...73,302,154
Ensembl chr 8:73,248,405...73,302,114 		JBrowse link
G Med27 mediator complex subunit 27 part_of IBA GO_Central GO_REF:0000033 NCBI chr 2:29,236,822...29,414,802
Ensembl chr 2:29,236,831...29,414,805 		JBrowse link
G Med28 mediator complex subunit 28 part_of IBA GO_Central GO_REF:0000033 NCBI chr 5:45,677,571...45,686,626
Ensembl chr 5:45,677,571...45,686,618 		JBrowse link
G Med29 mediator complex subunit 29 part_of IBA
ISO		 (PMID:14638676) GO_Central
MGI		 PMID:14638676 GO_REF:0000033 NCBI chr 7:28,084,667...28,092,126
Ensembl chr 7:28,085,571...28,092,133 		JBrowse link
G Med30 mediator complex subunit 30 part_of ISO
IDA
IBA		 (PMID:15340084) MGI
GO_Central		 PMID:15340084 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr15:52,575,841...52,593,827
Ensembl chr15:52,575,804...52,593,960 		JBrowse link
G Med31 mediator complex subunit 31 part_of IBA GO_Central GO_REF:0000033 NCBI chr11:72,102,550...72,106,418
Ensembl chr11:72,102,550...72,106,418 		JBrowse link
G Med4 mediator complex subunit 4 part_of IDA
ISO		 (PMID:15340084)
(PMID:14638676)		 MGI PMID:14638676 PMID:15340084 GO_REF:0000119 MGI:4834177 NCBI chr14:73,747,489...73,755,985
Ensembl chr14:73,747,465...73,756,289 		JBrowse link
G Med6 mediator complex subunit 6 part_of IDA
ISO
IBA		 (PMID:15340084)
(PMID:14638676)		 MGI
GO_Central		 PMID:14638676 PMID:15340084 GO_REF:0000008 GO_REF:0000033 NCBI chr12:81,620,331...81,641,782
Ensembl chr12:81,620,331...81,641,782 		JBrowse link
G Med7 mediator complex subunit 7 part_of IBA
IDA		 (PMID:15340084) GO_Central
MGI		 PMID:15340084 GO_REF:0000033 NCBI chr11:46,327,742...46,333,548
Ensembl chr11:46,327,752...46,333,548 		JBrowse link
G Med8 mediator complex subunit 8 part_of IBA
ISO		 (PMID:14638676) GO_Central
MGI		 PMID:14638676 GO_REF:0000033 NCBI chr 4:118,266,495...118,273,021
Ensembl chr 4:118,266,534...118,272,979 		JBrowse link
G Med9 mediator complex subunit 9 part_of IDA
IBA		 (PMID:14638676) MGI
GO_Central		 PMID:14638676 GO_REF:0000033 NCBI chr11:59,839,040...59,854,132
Ensembl chr11:59,839,032...59,853,031 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 part_of
is_active_in		 ISO (PMID:32727915) MGI
DisProt		 PMID:32727915 GO_REF:0000119 MGI:4834177 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Ppargc1b peroxisome proliferative activated receptor, gamma, coactivator 1 beta part_of ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr18:61,424,516...61,533,846
Ensembl chr18:61,431,207...61,533,502 		JBrowse link
G Thrap3 thyroid hormone receptor associated protein 3 part_of ISO
IDA
IBA		 (PMID:12093747), (PMID:15340084) MGI
GO_Central		 PMID:12093747 PMID:15340084 GO_REF:0000008 GO_REF:0000033 NCBI chr 4:126,057,875...126,096,548
Ensembl chr 4:126,057,875...126,096,553 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 28585
    protein-containing complex 6184
      nuclear protein-containing complex 1285
        mediator complex 37
Path 2
Term Annotations click to browse term
  cellular_component 28585
    cellular anatomical entity 19618
      organelle 13534
        membrane-bounded organelle 12550
          intracellular membrane-bounded organelle 12003
            nucleus 7487
              nuclear protein-containing complex 1285
                mediator complex 37
paths to the root