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ONTOLOGY REPORT - ANNOTATIONS


Term:mediator complex
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Accession:GO:0016592 term browser browse the term
Definition:A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
Synonyms:exact_synonym: L mediator complex;   Srb-mediator complex
 narrow_synonym: TRAP complex
 related_synonym: CDK8-containing TRAP/mediator complex
 alt_id: GO:0000119
 xref: Wikipedia:Mediator_(coactivator)


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mediator complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bclaf3 BCLAF1 and THRAP3 family member 3 JBrowse link X 38,294,009 38,353,525 RGD:13792537
G Ccnc cyclin C JBrowse link 5 35,865,598 35,883,732 RGD:1624291
RGD:13792537
RGD:1600115
G Cdk19 cyclin-dependent kinase 19 JBrowse link 20 45,458,499 45,598,799 RGD:13792537
G Cdk4 cyclin-dependent kinase 4 JBrowse link 7 70,345,971 70,352,689 RGD:13792537
G Cdk6 cyclin-dependent kinase 6 JBrowse link 4 27,781,728 27,969,653 RGD:13792537
G Cdk8 cyclin-dependent kinase 8 JBrowse link 12 10,496,273 10,561,335 RGD:1624291
G Cdk9 cyclin-dependent kinase 9 JBrowse link 3 11,742,269 11,747,117 RGD:13792537
G LOC100911917 mediator of RNA polymerase II transcription subunit 22-like JBrowse link 3 4,861,753 4,867,005 RGD:13792537
G Med1 mediator complex subunit 1 JBrowse link 10 86,101,560 86,145,271 RGD:1600115
RGD:13792537
RGD:1624291
G Med10 mediator complex subunit 10 JBrowse link 1 36,107,249 36,118,887 RGD:1624291
RGD:13792537
G Med11 mediator complex subunit 11 JBrowse link 10 57,057,272 57,059,415 RGD:1624291
RGD:13792537
G Med12 mediator complex subunit 12 JBrowse link X 71,174,653 71,197,812 RGD:1624291
RGD:13792537
G Med12l mediator complex subunit 12-like JBrowse link 2 149,213,134 149,316,569 RGD:13792537
G Med13 mediator complex subunit 13 JBrowse link 10 73,702,327 73,787,084 RGD:1624291
RGD:13792537
G Med13l mediator complex subunit 13-like JBrowse link 12 43,421,317 43,576,859 RGD:1624291
RGD:13792537
G Med14 mediator complex subunit 14 JBrowse link X 10,964,035 11,082,403 RGD:1624291
RGD:13792537
G Med15 mediator complex subunit 15 JBrowse link 11 87,553,868 87,628,631 RGD:1600115
G Med16 mediator complex subunit 16 JBrowse link 7 12,619,739 12,632,241 RGD:1624291
RGD:13792537
G Med17 mediator complex subunit 17 JBrowse link 8 13,522,257 13,835,302 RGD:1624291
RGD:13792537
G Med18 mediator complex subunit 18 JBrowse link 5 150,649,136 150,654,123 RGD:1624291
RGD:13792537
G Med19 mediator complex subunit 19 JBrowse link 3 72,080,630 72,091,150 RGD:1624291
RGD:13792537
G Med20 mediator complex subunit 20 JBrowse link 9 15,379,379 15,393,131 RGD:1600115
RGD:13792537
RGD:1624291
G Med21 mediator complex subunit 21 JBrowse link 4 180,961,194 180,968,155 RGD:1624291
RGD:13792537
G Med22 mediator complex subunit 22 JBrowse link 3 5,453,678 5,458,760 RGD:1624291
RGD:13792537
G Med23 mediator complex subunit 23 JBrowse link 1 21,539,765 21,587,675 RGD:1624291
RGD:13792537
G Med24 mediator complex subunit 24 JBrowse link 10 86,620,166 86,658,014 RGD:1624291
RGD:13792537
G Med25 mediator complex subunit 25 JBrowse link 1 100,872,240 100,887,864 RGD:13792537
G Med26 mediator complex subunit 26 JBrowse link 16 19,001,061 19,050,874 RGD:1624291
RGD:13792537
G Med27 mediator complex subunit 27 JBrowse link 3 7,884,793 8,059,003 RGD:1624291
G Med28 mediator complex subunit 28 JBrowse link 14 70,089,225 70,098,021 RGD:1624291
RGD:13792537
G Med29 mediator complex subunit 29 JBrowse link 1 85,368,288 85,373,691 RGD:1624291
G Med30 mediator complex subunit 30 JBrowse link 7 92,234,584 92,260,019 RGD:1624291
RGD:13792537
G Med31 mediator complex subunit 31 JBrowse link 10 58,780,987 58,784,369 RGD:1624291
RGD:13792537
G Med4 mediator complex subunit 4 JBrowse link 15 55,406,543 55,416,816 RGD:1624291
G Med6 mediator complex subunit 6 JBrowse link 6 105,302,558 105,316,024 RGD:1624291
RGD:13792537
G Med7 mediator complex subunit 7 JBrowse link 10 31,532,190 31,536,405 RGD:1624291
RGD:13792537
G Med9 mediator complex subunit 9 JBrowse link 10 46,314,639 46,329,374 RGD:1624291
RGD:13792537
G Ppargc1b PPARG coactivator 1 beta JBrowse link 18 56,626,725 56,650,524 RGD:1624291
G Thrap3 thyroid hormone receptor associated protein 3 JBrowse link 5 144,178,248 144,221,318 RGD:1624291
RGD:13792537
G Uxt ubiquitously-expressed, prefoldin-like chaperone JBrowse link X 1,275,402 1,287,781 RGD:13792537

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20300
    protein-containing complex 6095
      mediator complex 40
Path 2
Term Annotations click to browse term
  cellular_component 20300
    cellular anatomical entity 19956
      organelle 12976
        intracellular organelle 12440
          intracellular membrane-bounded organelle 10250
            nucleus 6971
              nuclear lumen 4052
                nucleoplasm 3399
                  mediator complex 40
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.