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ONTOLOGY REPORT - ANNOTATIONS


Term:NuRD complex
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Accession:GO:0016581 term browser browse the term
Definition:An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins.
Synonyms:exact_synonym: Mi-2 complex;   NRD complex;   nucleosome remodeling and histone deacetylation complex


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NuRD complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chd3 chromodomain helicase DNA binding protein 3 ISO (MGI:MGI:1333986|PMID:10204490)
UniProtKB:O94776|UniProtKB:O95983|UniProtKB:Q09028|UniProtKB:Q92769 (PMID:17827154), (PMID:27068747)
RGD PMID:10204490, PMID:17827154, PMID:27068747 MGI:MGI:1333986 NCBI chr10:55,943,467...55,970,417
Ensembl chr10:55,943,446...55,965,216
JBrowse link
G Chd4 chromodomain helicase DNA binding protein 4 ISO (MGI:MGI:5429837|PMID:22075476)
(PMID:19644445)
RGD PMID:19644445, PMID:22075476 MGI:MGI:5429837 NCBI chr 4:157,612,531...157,645,660
Ensembl chr 4:157,612,536...157,645,659
JBrowse link
G Chd5 chromodomain helicase DNA binding protein 5 ISO
ISS
(MGI:MGI:5559665|PMID:21931736)
GO_REF:0000024
RGD
UniProt
PMID:21931736 GO_REF:0000024, MGI:MGI:5559665 NCBI chr 5:169,519,212...169,572,059
Ensembl chr 5:169,519,212...169,567,107
JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 ISO (PMID:17827154) RGD PMID:17827154 NCBI chr 3:147,713,808...147,760,375
Ensembl chr 3:147,713,821...147,757,862
JBrowse link
G Gatad2a GATA zinc finger domain containing 2A ISO
IBA
(PMID:12183469)
PMID:21873635
RGD PMID:12183469, PMID:21873635 RGD:13792537 NCBI chr16:21,177,793...21,267,768
Ensembl chr16:21,178,138...21,268,504
JBrowse link
G Gatad2b GATA zinc finger domain containing 2B IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:189,654,871...189,735,056
Ensembl chr 2:189,655,702...189,733,540
JBrowse link
G Hdac1 histone deacetylase 1 ISO PR:Q8K4B0|PR:Q9R190|PR:Q9Z2D8 (MGI:MGI:2178733|PMID:11836251), (MGI:MGI:2683041|PMID:14645126), (MGI:MGI:3619832|PMID:16462733), (MGI:MGI:5429837|PMID:22075476)
(PMID:17827154), (PMID:19644445), (PMID:22926524)
RGD PMID:11836251, PMID:14645126, PMID:16462733, PMID:17827154, PMID:19644445, PMID:22075476, PMID:22926524 MGI:MGI:2178733, MGI:MGI:2683041, MGI:MGI:3619832, MGI:MGI:5429837 NCBI chr 5:147,716,664...147,743,723
Ensembl chr 5:147,716,664...147,743,723
JBrowse link
G Hdac2 histone deacetylase 2 ISO (PMID:17827154), (PMID:19644445), (PMID:22926524) RGD PMID:17827154, PMID:19644445, PMID:22926524 NCBI chr20:43,084,870...43,108,198
Ensembl chr20:43,084,870...43,108,198
JBrowse link
G Mbd3 methyl-CpG binding domain protein 3 ISO PR:O09106|PR:Q8K4B0|PR:Q9R190 (MGI:MGI:3619832|PMID:16462733) RGD PMID:16462733 MGI:MGI:3619832 NCBI chr 7:12,179,046...12,186,251
Ensembl chr 7:12,179,203...12,186,656
JBrowse link
G Mta1 metastasis associated 1 ISO
IBA
IEA
PR:O09106|PR:Q9R190|PR:Q9Z2D8 (MGI:MGI:3619832|PMID:16462733)
PMID:21873635
(PMID:22926524)
GO_REF:0000107
RGD
Ensembl
PMID:16462733, PMID:22926524, PMID:21873635 GO_REF:0000107, MGI:MGI:3619832, RGD:13792537 NCBI chr 6:137,911,302...137,950,066
Ensembl chr 6:137,924,293...137,950,075
JBrowse link
G Mta2 metastasis associated 1 family, member 2 ISO
IBA
PR:O09106|PR:Q8K4B0|PR:Q9Z2D8 (MGI:MGI:2683041|PMID:14645126), (MGI:MGI:3619832|PMID:16462733)
PMID:21873635
(PMID:19644445), (PMID:22926524)
RGD PMID:14645126, PMID:16462733, PMID:19644445, PMID:22926524, PMID:21873635 MGI:MGI:2683041, MGI:MGI:3619832, RGD:13792537 NCBI chr 1:225,140,863...225,149,584
Ensembl chr 1:225,140,863...225,149,583
JBrowse link
G Mta3 metastasis associated 1 family, member 3 ISO
IBA
(PMID:22926524)
PMID:21873635
RGD PMID:22926524, PMID:21873635 RGD:13792537 NCBI chr 6:6,904,449...7,036,929
Ensembl chr 6:6,908,684...7,031,828
JBrowse link
G Rbbp4 RB binding protein 4, chromatin remodeling factor ISO (MGI:MGI:2683041|PMID:14645126)
(PMID:19644445), (PMID:22926524)
RGD PMID:14645126, PMID:19644445, PMID:22926524 MGI:MGI:2683041 NCBI chr 5:147,499,880...147,535,240
Ensembl chr 5:147,499,882...147,535,240
JBrowse link
G Rbbp7 RB binding protein 7, chromatin remodeling factor ISO
ISS
(MGI:MGI:2683041|PMID:14645126)
(PMID:19644445), (PMID:22926524)
GO_REF:0000024
RGD
UniProt
PMID:14645126, PMID:19644445, PMID:22926524 GO_REF:0000024, MGI:MGI:2683041 NCBI chr  X:33,648,682...33,665,821
Ensembl chr  X:33,648,682...33,665,821
JBrowse link
G Sall1 spalt-like transcription factor 1 ISO (MGI:MGI:2178733|PMID:11836251) RGD PMID:11836251 MGI:MGI:2178733 NCBI chr19:23,387,737...23,405,025
Ensembl chr19:23,389,375...23,405,039
JBrowse link
G Zbtb7a zinc finger and BTB domain containing 7a colocalizes_with ISS
ISO
IEA
GO_REF:0000024
(PMID:26816381)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:26816381 GO_REF:0000024, GO_REF:0000107 NCBI chr 7:11,429,266...11,446,119
Ensembl chr 7:11,432,049...11,444,786
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20609
    cellular anatomical entity 20358
      nucleoplasm 3399
        histone deacetylase complex 81
          NuRD complex 16
Path 2
Term Annotations click to browse term
  cellular_component 20609
    cellular anatomical entity 20358
      intracellular anatomical structure 14706
        intracellular organelle 12912
          intracellular membrane-bounded organelle 10704
            nucleus 7183
              nuclear lumen 4262
                nuclear chromosome 963
                  nuclear chromatin 753
                    SWI/SNF superfamily-type complex 78
                      CHD-type complex 16
                        NuRD complex 16
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.