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ONTOLOGY REPORT - ANNOTATIONS

Term:NuRD complex
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Accession:GO:0016581 term browser browse the term
Definition:An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins.
Synonyms:exact_synonym: NRD complex;   nucleosome remodeling and histone deacetylation complex
 narrow_synonym: Mi-2 complex


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NuRD complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDK2AP1 cyclin dependent kinase 2 associated protein 1 part_of IEA Ensembl GO_REF:0000107 NCBI chr14:29,631,084...29,642,262
Ensembl chr14:29,631,084...29,642,253 		JBrowse link
G CDK2AP2 cyclin dependent kinase 2 associated protein 2 part_of IEA Ensembl GO_REF:0000107 NCBI chr 2:5,025,256...5,027,766
Ensembl chr 2:5,025,600...5,027,764 		JBrowse link
G CHD3 chromodomain helicase DNA binding protein 3 part_of IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr12:53,135,767...53,163,244
Ensembl chr12:53,139,366...53,163,243 		JBrowse link
G CHD4 chromodomain helicase DNA binding protein 4 part_of IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:64,071,627...64,105,212
Ensembl chr 5:64,065,992...64,105,173 		JBrowse link
G CHD5 chromodomain helicase DNA binding protein 5 part_of ISO (MGI:5559665|PMID:21931736) UniProt PMID:21931736 MGI:5559665 NCBI chr 6:67,017,410...67,086,685
Ensembl chr 6:67,017,417...67,086,711 		JBrowse link
G GATAD2A GATA zinc finger domain containing 2A part_of IEA
IBA		 Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 2:58,415,749...58,517,308
Ensembl chr 2:58,415,750...58,517,162 		JBrowse link
G GATAD2B GATA zinc finger domain containing 2B part_of IEA
IBA		 Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 4:95,766,989...95,864,502
Ensembl chr 4:95,766,490...95,864,435 		JBrowse link
G HDAC1 histone deacetylase 1 part_of IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:88,749,611...88,785,220
Ensembl chr 6:88,749,634...88,785,411 		JBrowse link
G HDAC2 histone deacetylase 2 part_of IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:79,867,713...79,901,597
Ensembl chr 1:79,863,094...79,901,585 		JBrowse link
G MBD2 methyl-CpG binding domain protein 2 part_of IEA Ensembl GO_REF:0000107 NCBI chr 1:103,683,077...103,768,372
Ensembl chr 1:103,735,192...103,752,402 		JBrowse link
G MBD3 methyl-CpG binding domain protein 3 part_of IEA Ensembl GO_REF:0000107 NCBI chr 2:76,913,880...76,923,435
Ensembl chr 2:76,906,644...76,923,432 		JBrowse link
G MTA1 metastasis associated 1 part_of IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118
G MTA2 metastasis associated 1 family member 2 part_of IEA
IBA		 Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 2:9,137,818...9,146,966
Ensembl chr 2:9,137,946...9,146,961 		JBrowse link
G MTA3 metastasis associated 1 family member 3 part_of IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:97,601,403...97,782,868
Ensembl chr 3:97,601,412...97,782,863 		JBrowse link
G RBBP4 RB binding protein 4, chromatin remodeling factor part_of IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 6:88,987,092...89,006,815 JBrowse link
G RBBP7 RB binding protein 7, chromatin remodeling factor part_of IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr  X:13,293,278...13,317,074
Ensembl chr  X:13,280,977...13,317,031 		JBrowse link
G SALL1 spalt like transcription factor 1 part_of ISO (PMID:11836251) MGI PMID:11836251 NCBI chr 6:33,731,666...33,748,698
Ensembl chr 6:33,732,025...33,748,704 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 18685
    protein-containing complex 6006
      transcription regulator complex 526
        NuRD complex 17
          SHREC complex 0
Path 2
Term Annotations click to browse term
  cellular_component 18685
    cellular anatomical entity 18463
      organelle 12421
        membrane-bounded organelle 11396
          intracellular membrane-bounded organelle 10852
            nucleus 6842
              nuclear lumen 3884
                nucleoplasm 3447
                  histone deacetylase complex 78
                    NuRD complex 17
                      SHREC complex 0
paths to the root