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ONTOLOGY REPORT - ANNOTATIONS

Term:peptide hormone processing
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Accession:GO:0016486 term browser browse the term
Definition:The generation of a mature peptide hormone by posttranslational processing of a prohormone.

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peptide hormone processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Corin corin, serine peptidase involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004936482:13,782,571...13,999,561
Ensembl chrNW_004936482:13,743,433...13,999,348 		JBrowse link
G Ece1 endothelin converting enzyme 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936474:7,034,134...7,083,005
Ensembl chrNW_004936474:7,034,134...7,083,005 		JBrowse link
G Furin furin, paired basic amino acid cleaving enzyme involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936483:16,136,099...16,147,945
Ensembl chrNW_004936483:16,136,099...16,144,635 		JBrowse link
G LOC101959833 endothelin-converting enzyme 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936578:5,586,086...5,615,940
Ensembl chrNW_004936578:5,585,443...5,616,099 		JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 involved_in ISO
IEA		 pituitary adenylate cyclase-activating polypetide RGD
TreeGrafter
Ensembl		 PMID:10087454 PMID:16497799 GO_REF:0000107 GO_REF:0000118 RGD:1601276 RGD:2308913 NCBI chrNW_004936523:7,009,966...7,050,300
Ensembl chrNW_004936523:7,010,068...7,050,468 		JBrowse link
G Pcsk1n proprotein convertase subtilisin/kexin type 1 inhibitor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10632593) Ensembl
MGI		 PMID:10632593 GO_REF:0000107 NCBI chrNW_004936721:783,973...787,712
Ensembl chrNW_004936721:782,032...787,952 		JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:12859669) RGD
MGI
TreeGrafter
Ensembl		 PMID:12859669 PMID:16497799 GO_REF:0000107 GO_REF:0000118 RGD:1601276 NCBI chrNW_004936485:2,611,313...2,866,260
Ensembl chrNW_004936485:2,608,353...2,866,294 		JBrowse link
G Pcsk4 proprotein convertase subtilisin/kexin type 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936588:793,615...800,038
Ensembl chrNW_004936588:794,227...799,663 		JBrowse link
G Pcsk5 proprotein convertase subtilisin/kexin type 5 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936503:11,466,955...11,896,887
Ensembl chrNW_004936503:11,466,950...11,896,887 		JBrowse link
G Pcsk6 proprotein convertase subtilisin/kexin type 6 involved_in ISO
IEA		 RGD
TreeGrafter
Ensembl		 PMID:8070361 GO_REF:0000107 GO_REF:0000118 RGD:729476 NCBI chrNW_004936483:2,374,357...2,561,322
Ensembl chrNW_004936483:2,374,357...2,561,384 		JBrowse link
G Scg5 secretogranin V involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936673:1,312,183...1,367,205
Ensembl chrNW_004936673:1,311,861...1,367,237 		JBrowse link
angiotensin maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp6ap2 ATPase H+ transporting accessory protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936502:7,206,226...7,232,798
Ensembl chrNW_004936502:7,206,172...7,233,912 		JBrowse link
G LOC101968921 angiotensin-converting enzyme involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936541:4,157,847...4,178,156
Ensembl chrNW_004936541:4,157,393...4,178,177 		JBrowse link
G Ren renin acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:10617578) RGD
MGI
TreeGrafter
Ensembl		 PMID:10617578 PMID:21321306 GO_REF:0000107 GO_REF:0000118 RGD:5132599 NCBI chrNW_004936567:598,044...607,628
Ensembl chrNW_004936567:598,048...607,497 		JBrowse link
endothelin maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ece1 endothelin converting enzyme 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:7,034,134...7,083,005
Ensembl chrNW_004936474:7,034,134...7,083,005 		JBrowse link
enkephalin processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpe carboxypeptidase E ISO RGD PMID:6326144 RGD:6483103 NCBI chrNW_004936555:531,842...641,905
Ensembl chrNW_004936555:530,307...641,905 		JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936485:2,611,313...2,866,260
Ensembl chrNW_004936485:2,608,353...2,866,294 		JBrowse link
epidermal growth factor receptor ligand maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam10 ADAM metallopeptidase domain 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:19,760,709...19,911,759
Ensembl chrNW_004936471:19,758,118...19,911,759 		JBrowse link
G Mep1a meprin A subunit alpha involved_in ISO (PMID:22923609) MGI PMID:22923609 NCBI chrNW_004936476:13,514,965...13,553,209 JBrowse link
insulin processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpe carboxypeptidase E acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:7663508) RGD
MGI
Ensembl		 PMID:2822027 PMID:7663508 GO_REF:0000107 RGD:1626225 NCBI chrNW_004936555:531,842...641,905
Ensembl chrNW_004936555:530,307...641,905 		JBrowse link
G Ero1b endoplasmic reticulum oxidoreductase 1 beta involved_in
acts_upstream_of_or_within		 ISO (PMID:20308425) MGI PMID:20308425 NCBI chrNW_004936484:16,495,953...16,537,716
Ensembl chrNW_004936484:16,502,828...16,534,887 		JBrowse link
G Ins insulin involved_in ISO (PMID:20424817) MGI PMID:20424817 NCBI chrNW_004936816:1,002,137...1,003,357
Ensembl chrNW_004936816:1,002,137...1,003,357 		JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936594:5,368,199...5,379,215
Ensembl chrNW_004936594:5,367,816...5,379,252 		JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936523:7,009,966...7,050,300
Ensembl chrNW_004936523:7,010,068...7,050,468 		JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936485:2,611,313...2,866,260
Ensembl chrNW_004936485:2,608,353...2,866,294 		JBrowse link
G Slc30a8 solute carrier family 30 member 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936470:29,114,713...29,151,993
Ensembl chrNW_004936470:29,114,713...29,151,993 		JBrowse link
G Yipf5 Yip1 domain family member 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936504:10,265,506...10,278,522
Ensembl chrNW_004936504:10,265,477...10,282,108 		JBrowse link
islet amyloid polypeptide processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pcsk2 proprotein convertase subtilisin/kexin type 2 involved_in ISO PMID:15983213 BHF-UCL PMID:15983213 RGD:8554260 NCBI chrNW_004936485:2,611,313...2,866,260
Ensembl chrNW_004936485:2,608,353...2,866,294 		JBrowse link
patched ligand maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Disp1 dispatched RND transporter family member 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12421714) Ensembl
MGI		 PMID:12421714 GO_REF:0000107 NCBI chrNW_004936526:111,742...303,381
Ensembl chrNW_004936526:86,854...303,290 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15871
    metabolic process 9527
      hormone metabolic process 209
        peptide hormone processing 23
          angiotensin maturation 3
          endothelin maturation 1
          enkephalin processing 2
          epidermal growth factor receptor ligand maturation 2
          glucagon processing 0
          insulin processing 8
          islet amyloid polypeptide processing 1
          negative regulation of peptide hormone processing 0
          nerve growth factor processing 0
          patched ligand maturation 1
          positive regulation of peptide hormone processing 0
          regulation of peptide hormone processing + 0
Path 2
Term Annotations click to browse term
  biological_process 15871
    metabolic process 9527
      cellular metabolic process 8291
        cellular biosynthetic process 6489
          macromolecule biosynthetic process 5732
            gene expression 5323
              protein maturation 466
                protein processing 223
                  signaling receptor ligand precursor processing 29
                    peptide hormone processing 23
                      angiotensin maturation 3
                      endothelin maturation 1
                      enkephalin processing 2
                      epidermal growth factor receptor ligand maturation 2
                      glucagon processing 0
                      insulin processing 8
                      islet amyloid polypeptide processing 1
                      negative regulation of peptide hormone processing 0
                      nerve growth factor processing 0
                      patched ligand maturation 1
                      positive regulation of peptide hormone processing 0
                      regulation of peptide hormone processing + 0
paths to the root