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ONTOLOGY REPORT - ANNOTATIONS

Term:peptide hormone processing
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Accession:GO:0016486 term browser browse the term
Definition:The generation of a mature peptide hormone by posttranslational processing of a prohormone.


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peptide hormone processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chst8 carbohydrate sulfotransferase 8 acts_upstream_of_or_within TAS (PMID:10988300) MGI PMID:10988300 NCBI chr 7:34,373,893...34,512,136
Ensembl chr 7:34,373,893...34,512,136 		JBrowse link
G Corin corin, serine peptidase involved_in IMP
ISO		 (MGI:3530681|PMID:15637153), (MGI:5319447|PMID:22437503), (MGI:5319621|PMID:11884416) UniProt
MGI		 PMID:11884416 PMID:15637153 PMID:22437503 GO_REF:0000119 MGI:3530681 MGI:4834177 MGI:5319447 MGI:5319621 NCBI chr 5:72,457,291...72,661,884
Ensembl chr 5:72,457,368...72,661,816 		JBrowse link
G Ece1 endothelin converting enzyme 1 involved_in
acts_upstream_of_or_within		 ISO
IBA
ISS		 (PMID:8062389) MGI
GO_Central		 PMID:8062389 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 4:137,589,548...137,692,540
Ensembl chr 4:137,589,548...137,692,540 		JBrowse link
G Ece2 endothelin converting enzyme 2 acts_upstream_of_or_within ISS (PMID:7797512) MGI PMID:7797512 NCBI chr16:20,448,601...20,464,665
Ensembl chr16:20,448,578...20,465,235 		JBrowse link
G Eef1ece2 Eef1akmt4-endothelin converting enzyme 2 readthrough involved_in ISO (PMID:11718899) UniProt PMID:11718899 NCBI chr16:20,430,351...20,464,665
Ensembl chr16:20,430,360...20,464,670 		JBrowse link
G Furin furin, paired basic amino acid cleaving enzyme involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 7:80,038,942...80,055,188
Ensembl chr 7:80,038,333...80,055,184 		JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 involved_in IDA
IBA
ISO		 (MGI:3773775|PMID:8262946), (MGI:3807770|PMID:9242664)
pituitary adenylate cyclase-activating polypetide		 BHF-UCL
GO_Central
MGI
RGD		 PMID:8262946 PMID:9242664 PMID:10087454 PMID:16497799 GO_REF:0000033 GO_REF:0000096 MGI:3773775 MGI:3807770 MGI:4417868 RGD:1601276 RGD:2308913 NCBI chr13:75,237,407...75,282,980
Ensembl chr13:75,237,945...75,282,980 		JBrowse link
G Pcsk1n proprotein convertase subtilisin/kexin type 1 inhibitor acts_upstream_of_or_within IDA (PMID:10632593) MGI PMID:10632593 NCBI chr  X:7,786,061...7,790,649
Ensembl chr  X:7,786,061...7,790,649 		JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 involved_in
acts_upstream_of_or_within		 IDA
IBA
IMP
ISO		 (MGI:3807770|PMID:9242664)
(PMID:12859669)		 BHF-UCL
GO_Central
MGI
RGD		 PMID:9242664 PMID:12859669 PMID:16497799 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:3807770 MGI:4417868 MGI:4834177 RGD:1601276 NCBI chr 2:143,388,053...143,658,204
Ensembl chr 2:143,388,076...143,658,205 		JBrowse link
G Pcsk4 proprotein convertase subtilisin/kexin type 4 involved_in IBA GO_Central GO_REF:0000033 NCBI chr10:80,157,117...80,165,583
Ensembl chr10:80,157,117...80,165,332 		JBrowse link
G Pcsk5 proprotein convertase subtilisin/kexin type 5 involved_in IDA
IBA
ISO		 (MGI:3795695|PMID:18519639), (MGI:3807770|PMID:9242664), (MGI:74959|PMID:8468318) BHF-UCL
GO_Central
MGI		 PMID:8468318 PMID:9242664 PMID:18519639 GO_REF:0000033 GO_REF:0000119 MGI:3795695 MGI:3807770 MGI:4834177 MGI:74959 NCBI chr19:17,409,678...17,815,076
Ensembl chr19:17,409,683...17,814,996 		JBrowse link
G Pcsk6 proprotein convertase subtilisin/kexin type 6 involved_in ISO
IBA		 RGD
GO_Central
MGI		 PMID:8070361 GO_REF:0000033 GO_REF:0000119 MGI:4834177 RGD:729476 NCBI chr 7:65,511,884...65,700,134
Ensembl chr 7:65,511,482...65,700,134 		JBrowse link
G Scg5 secretogranin V involved_in IDA (MGI:1332331|PMID:10089884) UniProt PMID:10089884 MGI:1332331 NCBI chr 2:113,606,708...113,659,423
Ensembl chr 2:113,606,707...113,659,466 		JBrowse link
angiotensin maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme involved_in IMP
IDA
ISO		 (MGI:3040566|PMID:14757757)
(MGI:3793932|PMID:11303049)		 UniProt
MGI		 PMID:11303049 PMID:14757757 GO_REF:0000119 MGI:3040566 MGI:3793932 MGI:4834177 NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790 		JBrowse link
G Atp6ap2 ATPase, H+ transporting, lysosomal accessory protein 2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr  X:12,453,998...12,483,290
Ensembl chr  X:12,454,040...12,483,288 		JBrowse link
G Ren1 renin 1 structural acts_upstream_of_or_within
involved_in		 ISO
IMP
IBA		 (PMID:10617578) RGD
MGI
GO_Central		 PMID:10617578 PMID:21321306 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:5132599 NCBI chr 1:133,278,412...133,288,058
Ensembl chr 1:133,278,248...133,288,063 		JBrowse link
G Ren2 renin 2 tandem duplication of Ren1 involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177
endothelin maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ece1 endothelin converting enzyme 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 4:137,589,548...137,692,540
Ensembl chr 4:137,589,548...137,692,540 		JBrowse link
enkephalin processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpe carboxypeptidase E involved_in ISO RGD
MGI		 PMID:6326144 GO_REF:0000096 MGI:4417868 RGD:6483103 NCBI chr 8:65,045,576...65,146,143
Ensembl chr 8:65,045,576...65,146,088 		JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 involved_in IDA (MGI:3773775|PMID:8262946) BHF-UCL PMID:8262946 MGI:3773775 NCBI chr 2:143,388,053...143,658,204
Ensembl chr 2:143,388,076...143,658,205 		JBrowse link
epidermal growth factor receptor ligand maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam10 a disintegrin and metallopeptidase domain 10 involved_in IMP (PMID:14993236), (PMID:17079736) MGI PMID:14993236 PMID:17079736 NCBI chr 9:70,586,133...70,687,511
Ensembl chr 9:70,586,279...70,687,511 		JBrowse link
G Mep1a meprin 1 alpha involved_in ISO (PMID:22923609) MGI PMID:22923609 NCBI chr17:43,785,215...43,815,034
Ensembl chr17:43,785,215...43,813,703 		JBrowse link
insulin processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpe carboxypeptidase E acts_upstream_of_or_within
involved_in		 ISO
IMP		 (PMID:7663508)
(PMID:9348219)		 RGD
MGI		 PMID:2822027 PMID:7663508 PMID:9348219 GO_REF:0000096 MGI:4417868 RGD:1626225 NCBI chr 8:65,045,576...65,146,143
Ensembl chr 8:65,045,576...65,146,088 		JBrowse link
G Ero1b endoplasmic reticulum oxidoreductase 1 beta involved_in
acts_upstream_of_or_within		 IMP (PMID:20308425) MGI PMID:20308425 NCBI chr13:12,580,701...12,624,422
Ensembl chr13:12,580,755...12,626,285 		JBrowse link
G Hsp90b1 heat shock protein 90, beta (Grp94), member 1 involved_in ISO (PMID:30670477) MGI PMID:30670477 NCBI chr10:86,526,705...86,541,308
Ensembl chr10:86,526,073...86,541,373 		JBrowse link
G Ins2 insulin II involved_in IGI
ISO		 (PMID:20424817)
(PMID:35529069)		 MGI PMID:20424817 PMID:35529069 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118 		JBrowse link
G P4hb prolyl 4-hydroxylase, beta polypeptide involved_in IMP (PMID:31184304) MGI PMID:31184304 NCBI chr11:120,451,124...120,464,079
Ensembl chr11:120,451,124...120,464,079 		JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 involved_in IMP (PMID:12136131) MGI PMID:12136131 NCBI chr13:75,237,407...75,282,980
Ensembl chr13:75,237,945...75,282,980 		JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 involved_in ISO
IMP		 (PMID:9452465) MGI PMID:9452465 GO_REF:0000119 MGI:4834177 NCBI chr 2:143,388,053...143,658,204
Ensembl chr 2:143,388,076...143,658,205 		JBrowse link
G Slc30a5 solute carrier family 30 (zinc transporter), member 5 involved_in ISO (PMID:11904301) MGI PMID:11904301 NCBI chr13:100,939,153...100,969,988
Ensembl chr13:100,939,156...100,969,935 		JBrowse link
G Slc30a8 solute carrier family 30 (zinc transporter), member 8 involved_in IMP (PMID:19542200), (PMID:19706465) MGI PMID:19542200 PMID:19706465 NCBI chr15:52,158,949...52,199,194
Ensembl chr15:52,158,949...52,199,194 		JBrowse link
G Yipf5 Yip1 domain family, member 5 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr18:40,337,918...40,352,452
Ensembl chr18:40,336,949...40,352,482 		JBrowse link
islet amyloid polypeptide processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pcsk2 proprotein convertase subtilisin/kexin type 2 involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr 2:143,388,053...143,658,204
Ensembl chr 2:143,388,076...143,658,205 		JBrowse link
patched ligand maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Disp1 dispatched RND transporter family member 1 acts_upstream_of_or_within IMP
IDA		 (PMID:12421714) MGI PMID:12421714 NCBI chr 1:182,867,828...183,010,257
Ensembl chr 1:182,867,830...183,003,086 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28573
    metabolic process 11001
      hormone metabolic process 257
        peptide hormone processing 28
          angiotensin maturation 4
          endothelin maturation 1
          enkephalin processing 2
          epidermal growth factor receptor ligand maturation 2
          glucagon processing 0
          insulin processing 10
          islet amyloid polypeptide processing 1
          negative regulation of peptide hormone processing 0
          nerve growth factor processing 0
          patched ligand maturation 1
          positive regulation of peptide hormone processing 0
          regulation of peptide hormone processing + 0
Path 2
Term Annotations click to browse term
  biological_process 28573
    metabolic process 11001
      cellular metabolic process 9207
        cellular biosynthetic process 7432
          macromolecule biosynthetic process 6879
            gene expression 6461
              protein maturation 502
                protein processing 263
                  signaling receptor ligand precursor processing 35
                    peptide hormone processing 28
                      angiotensin maturation 4
                      endothelin maturation 1
                      enkephalin processing 2
                      epidermal growth factor receptor ligand maturation 2
                      glucagon processing 0
                      insulin processing 10
                      islet amyloid polypeptide processing 1
                      negative regulation of peptide hormone processing 0
                      nerve growth factor processing 0
                      patched ligand maturation 1
                      positive regulation of peptide hormone processing 0
                      regulation of peptide hormone processing + 0
paths to the root