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ONTOLOGY REPORT - ANNOTATIONS


Term:peptide hormone processing
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Accession:GO:0016486 term browser browse the term
Definition:The generation of a mature peptide hormone by posttranslational processing of a prohormone.


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peptide hormone processing term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Corin corin, serine peptidase IEA
ISO
ISS
GO_REF:0000107
(MGI:MGI:3530681|PMID:15637153), (MGI:MGI:5319447|PMID:22437503), (MGI:MGI:5319621|PMID:11884416)
(PMID:10880574), (PMID:21518754)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:10880574, PMID:11884416, PMID:15637153, PMID:21518754, PMID:22437503 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3530681, MGI:MGI:5319447, MGI:MGI:5319621 NCBI chr14:38,247,379...38,474,931
Ensembl chr14:38,247,791...38,473,648
JBrowse link
G Cpe carboxypeptidase E TAS RGD PMID:2784437 RGD:727682 NCBI chr16:26,906,716...27,014,811
Ensembl chr16:26,906,716...27,014,813
JBrowse link
G Ece1 endothelin converting enzyme 1 ISO (PMID:7864876) RGD PMID:7864876 NCBI chr 5:156,215,469...156,318,652
Ensembl chr 5:156,215,417...156,318,671
JBrowse link
G Ece2 endothelin-converting enzyme 2 TAS
ISO
(PMID:11718899) RGD PMID:11718899, PMID:15060002 RGD:1303943 NCBI chr11:83,948,896...83,985,429
Ensembl chr11:83,948,230...83,964,055
JBrowse link
G Furin furin (paired basic amino acid cleaving enzyme) ISO
IBA
IEA
(PMID:9242664)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:9242664, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 1:142,185,092...142,198,167
Ensembl chr 1:142,185,094...142,197,182
JBrowse link
G LOC103690091 proSAAS ISO (MGI:MGI:1351397|PMID:10632593) RGD PMID:10632593 MGI:MGI:1351397 NCBI chr  X:15,324,261...15,328,617 JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 IMP
IBA
ISO
IDA
PMID:21873635
(MGI:MGI:3773775|PMID:8262946), (MGI:MGI:3807770|PMID:9242664)
pituitary adenylate cyclase-activating polypetide
RGD PMID:8262946, PMID:9242664, PMID:16497799, PMID:21873635, PMID:10087454 MGI:MGI:3773775, MGI:MGI:3807770, RGD:1601276, RGD:13792537, RGD:2308913 NCBI chr 2:91,450,162...91,497,091
Ensembl chr 2:91,450,162...91,497,091
JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 IMP
IBA
ISO
ISS
PMID:21873635
MGI:MGI:1857445 (MGI:MGI:2668770|PMID:12859669), (MGI:MGI:3807770|PMID:9242664)
GO_REF:0000024
(PMID:28719828)
RGD
UniProt
PMID:9242664, PMID:12859669, PMID:28719828, PMID:16497799, PMID:21873635 GO_REF:0000024, MGI:MGI:2668770, MGI:MGI:3807770, RGD:1601276, RGD:13792537 NCBI chr 3:137,618,891...137,923,385
Ensembl chr 3:137,618,898...137,925,605
JBrowse link
G Pcsk4 proprotein convertase subtilisin/kexin type 4 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:12,247,498...12,255,721
Ensembl chr 7:12,247,498...12,255,719
JBrowse link
G Pcsk5 proprotein convertase subtilisin/kexin type 5 ISO
IBA
(PMID:8901832)
PMID:21873635
(MGI:MGI:3795695|PMID:18519639), (MGI:MGI:3807770|PMID:9242664), (MGI:MGI:74959|PMID:8468318)
RGD PMID:8468318, PMID:8901832, PMID:9242664, PMID:18519639, PMID:21873635 MGI:MGI:3795695, MGI:MGI:3807770, MGI:MGI:74959, RGD:13792537 NCBI chr 1:236,031,988...236,313,858
Ensembl chr 1:236,031,988...236,313,858
JBrowse link
G Pcsk6 proprotein convertase subtilisin/kexin type 6 IEP
IBA
IEA
ISO
PMID:21873635
GO_REF:0000107
(PMID:9242664)
Ensembl
RGD
PMID:9242664, PMID:8070361, PMID:21873635 GO_REF:0000107, RGD:729476, RGD:13792537 NCBI chr 1:126,749,508...126,947,392
Ensembl chr 1:126,749,508...126,947,392
JBrowse link
G Scg5 secretogranin V IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:1332331|PMID:10089884)
Ensembl
UniProt
RGD
PMID:10089884 GO_REF:0000024, GO_REF:0000107, MGI:MGI:1332331 NCBI chr 3:105,235,065...105,279,475
Ensembl chr 3:105,235,050...105,279,462
JBrowse link
angiotensin maturation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp6ap2 ATPase H+ transporting accessory protein 2 ISO (PMID:12045255), (PMID:15746149) RGD PMID:12045255, PMID:15746149 NCBI chr  X:11,137,889...11,164,854
Ensembl chr  X:11,136,939...11,164,915
JBrowse link
G Ren renin IDA
IBA
ISO
PMID:21873635
MGI:MGI:2136642 (MGI:MGI:1351364|PMID:10617578)
(PMID:12045255)
RGD PMID:10617578, PMID:12045255, PMID:21321306, PMID:21873635 MGI:MGI:1351364, RGD:5132599, RGD:13792537 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
endothelin maturation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ece1 endothelin converting enzyme 1 ISO
IEA
(PMID:7805846)
GO_REF:0000107
RGD
Ensembl
PMID:7805846 GO_REF:0000107 NCBI chr 5:156,215,469...156,318,652
Ensembl chr 5:156,215,417...156,318,671
JBrowse link
enkephalin processing term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpe carboxypeptidase E IDA RGD PMID:6326144 RGD:6483103 NCBI chr16:26,906,716...27,014,811
Ensembl chr16:26,906,716...27,014,813
JBrowse link
G Ctsl cathepsin L ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279
JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 ISO (MGI:MGI:3773775|PMID:8262946) RGD PMID:8262946 MGI:MGI:3773775 NCBI chr 3:137,618,891...137,923,385
Ensembl chr 3:137,618,898...137,925,605
JBrowse link
insulin processing term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpe carboxypeptidase E IDA
IEA
ISO
GO_REF:0000107
MGI:MGI:1856395 (MGI:MGI:73445|PMID:7663508)
Ensembl
RGD
PMID:7663508, PMID:2822027 GO_REF:0000107, MGI:MGI:73445, RGD:1626225 NCBI chr16:26,906,716...27,014,811
Ensembl chr16:26,906,716...27,014,813
JBrowse link
G Ero1b endoplasmic reticulum oxidoreductase 1 beta ISO MGI:MGI:3864866 (MGI:MGI:4440670|PMID:20308425) RGD PMID:20308425 MGI:MGI:4440670 NCBI chr17:90,709,394...90,783,110
Ensembl chr17:90,710,555...90,756,048
JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 ISO (PMID:7626024) RGD PMID:7626024 NCBI chr 3:137,618,891...137,923,385
Ensembl chr 3:137,618,898...137,925,605
JBrowse link
islet amyloid polypeptide processing term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pcsk2 proprotein convertase subtilisin/kexin type 2 IMP PMID:15983213 BHF-UCL PMID:15983213 RGD:8554260 NCBI chr 3:137,618,891...137,923,385
Ensembl chr 3:137,618,898...137,925,605
JBrowse link
patched ligand maturation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Disp1 dispatched RND transporter family member 1 ISO MGI:MGI:2429759 (MGI:MGI:2389012|PMID:12421714) RGD PMID:12421714 MGI:MGI:2389012 NCBI chr13:101,451,932...101,597,570
Ensembl chr13:101,451,932...101,597,570
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    metabolic process 12256
      hormone metabolic process 215
        peptide hormone processing 17
          angiotensin maturation 2
          endothelin maturation 1
          enkephalin processing 3
          epidermal growth factor receptor ligand maturation 0
          glucagon processing 0
          insulin processing 3
          islet amyloid polypeptide processing 1
          negative regulation of peptide hormone processing 0
          nerve growth factor processing 0
          patched ligand maturation 1
          positive regulation of peptide hormone processing 0
          regulation of peptide hormone processing + 0
Path 2
Term Annotations click to browse term
  biological_process 20014
    metabolic process 12256
      organic substance metabolic process 11636
        macromolecule metabolic process 10081
          protein metabolic process 6214
            proteolysis 1893
              protein processing 237
                signaling receptor ligand precursor processing 20
                  peptide hormone processing 17
                    angiotensin maturation 2
                    endothelin maturation 1
                    enkephalin processing 3
                    epidermal growth factor receptor ligand maturation 0
                    glucagon processing 0
                    insulin processing 3
                    islet amyloid polypeptide processing 1
                    negative regulation of peptide hormone processing 0
                    nerve growth factor processing 0
                    patched ligand maturation 1
                    positive regulation of peptide hormone processing 0
                    regulation of peptide hormone processing + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.