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ONTOLOGY REPORT - ANNOTATIONS


Term:peptide hormone processing
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Accession:GO:0016486 term browser browse the term
Definition:The generation of a mature peptide hormone by posttranslational processing of a prohormone.



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peptide hormone processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Corin corin, serine peptidase involved_in ISO
IEA
ISS
(PMID:10880574)
GO_REF:0000002
(PMID:21518754)
(MGI:3530681|PMID:15637153), (MGI:5319447|PMID:22437503), (MGI:5319621|PMID:11884416)
GO_REF:0000024
GO_REF:0000107
RGD
InterPro
UniProt
Ensembl
PMID:10880574 PMID:11884416 PMID:15637153 PMID:21518754 PMID:22437503 GO_REF:0000002 GO_REF:0000024 GO_REF:0000107 MGI:3530681 MGI:5319447 MGI:5319621 NCBI chr14:35,680,601...35,910,703
Ensembl chr14:35,681,304...35,909,503
JBrowse link
G Cpe carboxypeptidase E TAS RGD PMID:2784437 RGD:727682 NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233
JBrowse link
G Ece1 endothelin converting enzyme 1 involved_in ISO
IBA
(PMID:7864876)
GO_REF:0000033
RGD
GO_Central
PMID:7864876 GO_REF:0000033 NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371
JBrowse link
G Ece2 endothelin-converting enzyme 2 involved_in TAS
ISO
(PMID:11718899) RGD PMID:11718899 PMID:15060002 RGD:1303943 NCBI chr11:80,259,130...80,278,446
Ensembl chr11:80,263,162...80,278,428
JBrowse link
G Furin furin (paired basic amino acid cleaving enzyme) involved_in ISO
IBA
IEA
(PMID:9242664)
GO_REF:0000033
GO_REF:0000107
RGD
GO_Central
Ensembl
PMID:9242664 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:134,348,142...134,361,182
Ensembl chr 1:134,348,144...134,364,314
JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 involved_in IMP
IBA
ISO
IDA
GO_REF:0000033
(MGI:3773775|PMID:8262946), (MGI:3807770|PMID:9242664)
pituitary adenylate cyclase-activating polypetide
GO_Central
RGD
PMID:8262946 PMID:9242664 PMID:16497799 PMID:10087454 GO_REF:0000033 MGI:3773775 MGI:3807770, RGD:1601276, RGD:2308913 NCBI chr 2:4,395,543...4,442,434
Ensembl chr 2:4,395,543...4,442,434
JBrowse link
G Pcsk1n proprotein convertase subtilisin/kexin type 1 inhibitor involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:10632593)
Ensembl
RGD
PMID:10632593 GO_REF:0000107 NCBI chr  X:14,580,036...14,583,478
Ensembl chr  X:14,580,038...14,583,566
JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 acts_upstream_of_or_within
involved_in
IMP
ISO
IBA
ISS
MGI:1857445 (PMID:12859669)
GO_REF:0000033
(MGI:3807770|PMID:9242664)
GO_REF:0000024
(PMID:28719828)
RGD
GO_Central
UniProt
PMID:9242664 PMID:12859669 PMID:28719828 PMID:16497799 GO_REF:0000024 GO_REF:0000033 MGI:3807770, RGD:1601276 NCBI chr 3:130,880,422...131,183,127
Ensembl chr 3:130,880,422...131,183,127
JBrowse link
G Pcsk4 proprotein convertase subtilisin/kexin type 4 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:9,381,366...9,389,589
Ensembl chr 7:9,381,361...9,389,585
JBrowse link
G Pcsk5 proprotein convertase subtilisin/kexin type 5 involved_in ISO
IBA
IEA
(PMID:8901832)
GO_REF:0000033
GO_REF:0000107
(MGI:3795695|PMID:18519639), (MGI:3807770|PMID:9242664), (MGI:74959|PMID:8468318)
RGD
GO_Central
Ensembl
PMID:8468318 PMID:8901832 PMID:9242664 PMID:18519639 GO_REF:0000033 GO_REF:0000107 MGI:3795695 MGI:3807770 MGI:74959 NCBI chr 1:214,837,847...215,267,626
Ensembl chr 1:214,837,927...215,267,600
JBrowse link
G Pcsk6 proprotein convertase subtilisin/kexin type 6 involved_in IEP
IBA
IEA
ISO
GO_REF:0000033
GO_REF:0000107
(PMID:9242664)
GO_Central
Ensembl
RGD
PMID:9242664 PMID:8070361 GO_REF:0000033 GO_REF:0000107, RGD:729476 NCBI chr 1:119,428,978...119,627,626
Ensembl chr 1:119,429,265...119,627,596
JBrowse link
G Scg5 secretogranin V involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:1332331|PMID:10089884)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:10089884 GO_REF:0000024 GO_REF:0000107 MGI:1332331 NCBI chr 3:100,544,101...100,588,558
Ensembl chr 3:100,544,099...100,588,463
JBrowse link
angiotensin maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:3040566|PMID:14757757), (MGI:3793932|PMID:11303049)
(PMID:11432860), (PMID:1320019), (PMID:4322742), (PMID:6270633)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:1320019 PMID:4322742 PMID:6270633 PMID:11303049 PMID:11432860 More... GO_REF:0000024 GO_REF:0000107 MGI:3040566 MGI:3793932 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Atp6ap2 ATPase H+ transporting accessory protein 2 involved_in ISO
IEA
(PMID:12045255), (PMID:15746149)
GO_REF:0000107
RGD
Ensembl
PMID:12045255 PMID:15746149 GO_REF:0000107 NCBI chr  X:10,183,983...10,210,948
Ensembl chr  X:10,183,068...10,210,918
JBrowse link
G Ren renin acts_upstream_of_or_within
involved_in
IDA
ISO
IBA
MGI:2136642 (PMID:10617578)
GO_REF:0000033
(PMID:12045255)
RGD
GO_Central
PMID:10617578 PMID:12045255 PMID:21321306 GO_REF:0000033, RGD:5132599 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
endothelin maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ece1 endothelin converting enzyme 1 involved_in ISO
IEA
(PMID:7805846)
GO_REF:0000107
RGD
Ensembl
PMID:7805846 GO_REF:0000107 NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371
JBrowse link
enkephalin processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpe carboxypeptidase E IDA RGD PMID:6326144 RGD:6483103 NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233
JBrowse link
G Ctsl cathepsin L involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 involved_in ISO (MGI:3773775|PMID:8262946) RGD PMID:8262946 MGI:3773775 NCBI chr 3:130,880,422...131,183,127
Ensembl chr 3:130,880,422...131,183,127
JBrowse link
epidermal growth factor receptor ligand maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam10 ADAM metallopeptidase domain 10 involved_in IEA
ISO
GO_REF:0000107
(PMID:14993236), (PMID:17079736)
Ensembl
RGD
PMID:14993236 PMID:17079736 GO_REF:0000107 NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889
JBrowse link
G Mep1a meprin A subunit alpha involved_in ISO (PMID:22923609) RGD PMID:22923609 NCBI chr 9:17,474,634...17,504,147
Ensembl chr 9:17,474,619...17,504,147
JBrowse link
insulin processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpe carboxypeptidase E involved_in
acts_upstream_of_or_within
IDA
IMP
ISO
IEA
MGI:1856395 (PMID:9348219)
MGI:1856395 (PMID:7663508)
GO_REF:0000107
RGD
Ensembl
PMID:7663508 PMID:9348219 PMID:2822027 PMID:12829804 GO_REF:0000107, RGD:1626225, RGD:405650689 NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233
JBrowse link
G Ero1b endoplasmic reticulum oxidoreductase 1 beta acts_upstream_of_or_within
involved_in
ISO MGI:3864866 (PMID:20308425) RGD PMID:20308425 NCBI chr17:85,861,086...86,003,244
Ensembl chr17:85,929,618...86,003,398
JBrowse link
G Ins2 insulin 2 involved_in IEA
ISO
GO_REF:0000107
MGI:2442682 (PMID:20424817)
Ensembl
RGD
PMID:20424817 GO_REF:0000107 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta involved_in ISO MGI:5504624 (PMID:31184304) RGD PMID:31184304 NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500
JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 involved_in ISO MGI:2384741 (PMID:12136131) RGD PMID:12136131 NCBI chr 2:4,395,543...4,442,434
Ensembl chr 2:4,395,543...4,442,434
JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 involved_in ISO (PMID:7626024)
MGI:1857445 (PMID:9452465)
RGD PMID:7626024 PMID:9452465 NCBI chr 3:130,880,422...131,183,127
Ensembl chr 3:130,880,422...131,183,127
JBrowse link
G Slc30a8 solute carrier family 30 member 8 involved_in ISO MGI:4362061 (PMID:19542200), (PMID:19706465) RGD PMID:19542200 PMID:19706465 NCBI chr 7:83,591,993...83,627,786
Ensembl chr 7:83,591,993...83,626,305
JBrowse link
G Yipf5 Yip1 domain family, member 5 involved_in ISO
ISS
(PMID:33164986)
GO_REF:0000024
RGD
UniProt
PMID:33164986 GO_REF:0000024 NCBI chr18:32,123,814...32,136,947
Ensembl chr18:32,123,842...32,157,642
JBrowse link
islet amyloid polypeptide processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pcsk2 proprotein convertase subtilisin/kexin type 2 involved_in IMP PMID:15983213 BHF-UCL PMID:15983213 RGD:8554260 NCBI chr 3:130,880,422...131,183,127
Ensembl chr 3:130,880,422...131,183,127
JBrowse link
patched ligand maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Disp1 dispatched RND transporter family member 1 acts_upstream_of_or_within ISO MGI:2429759 (PMID:12421714) RGD PMID:12421714 NCBI chr13:94,720,928...94,866,695
Ensembl chr13:94,720,928...94,866,702
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19872
    metabolic process 11602
      hormone metabolic process 251
        peptide hormone processing 24
          angiotensin maturation 3
          endothelin maturation 1
          enkephalin processing 3
          epidermal growth factor receptor ligand maturation 2
          glucagon processing 0
          insulin processing 8
          islet amyloid polypeptide processing 1
          negative regulation of peptide hormone processing 0
          nerve growth factor processing 0
          patched ligand maturation 1
          positive regulation of peptide hormone processing 0
          regulation of peptide hormone processing + 0
Path 2
Term Annotations click to browse term
  biological_process 19872
    cellular process 18312
      cellular metabolic process 9669
        cellular biosynthetic process 7844
          macromolecule biosynthetic process 7299
            gene expression 6861
              protein maturation 537
                protein processing 254
                  signaling receptor ligand precursor processing 31
                    peptide hormone processing 24
                      angiotensin maturation 3
                      endothelin maturation 1
                      enkephalin processing 3
                      epidermal growth factor receptor ligand maturation 2
                      glucagon processing 0
                      insulin processing 8
                      islet amyloid polypeptide processing 1
                      negative regulation of peptide hormone processing 0
                      nerve growth factor processing 0
                      patched ligand maturation 1
                      positive regulation of peptide hormone processing 0
                      regulation of peptide hormone processing + 0
paths to the root