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ONTOLOGY REPORT - ANNOTATIONS

Term:1-phosphatidylinositol-4-phosphate 5-kinase activity
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Accession:GO:0016308 term browser browse the term
Definition:Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H+.
Synonyms:exact_synonym: PIP5K
 narrow_synonym: 1-phosphatidylinositol-4-phosphate kinase, class IA;   1-phosphatidylinositol-4-phosphate kinase, class IB;   type I PIP kinase activity
 broad_synonym: 1-phosphatidylinositol-4-phosphate kinase activity;   PIP kinase activity;   diphosphoinositide kinase activity;   phosphatidylinositol 4-phosphate kinase activity
 related_synonym: ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase activity;   PI(4)5K;   PtdIns(4)P-5-kinase activity;   phosphatidylinositol-4-phosphate 5-kinase activity
 alt_id: GO:0004431;   GO:0045215
 xref: EC:2.7.1.68;   KEGG_REACTION:R03469;   MetaCyc:2.7.1.68-RXN;   RHEA:14425;   reactome:R-HSA-1676082 "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane";   reactome:R-HSA-3772436 "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2";   reactome:R-HSA-8868066 "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2"


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1-phosphatidylinositol-4-phosphate 5-kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pikfyve phosphoinositide kinase, FYVE-type zinc finger containing enables ISO (MGI:1321345|PMID:9858586) RGD PMID:9858586 MGI:1321345 NCBI chr 9:66,563,747...66,657,873
Ensembl chr 9:66,563,727...66,657,868 		JBrowse link
G Pip4k2a phosphatidylinositol-5-phosphate 4-kinase type 2 alpha enables ISO
ISS
IEA
IBA		 (PMID:26774281)
GO_REF:0000024
GO_REF:0000107
GO_REF:0000033		 RGD
UniProt
Ensembl
GO_Central		 PMID:26774281 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr17:81,496,669...81,668,180
Ensembl chr17:81,496,670...81,668,029 		JBrowse link
G Pip4k2b phosphatidylinositol-5-phosphate 4-kinase type 2 beta enables ISS
ISO
IEA
IBA		 GO_REF:0000024
(PMID:26774281), (PMID:9038203)
GO_REF:0000107
GO_REF:0000033		 UniProt
RGD
Ensembl
GO_Central		 PMID:9038203 PMID:26774281 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr10:82,706,016...82,734,938
Ensembl chr10:82,701,098...82,734,938 		JBrowse link
G Pip4k2c phosphatidylinositol-5-phosphate 4-kinase type 2 gamma enables IDA
ISO
IEA
IBA		 (PMID:26774281)
GO_REF:0000107
GO_REF:0000033
GO_REF:0000118		 RGD
Ensembl
GO_Central
TreeGrafter		 PMID:26774281 PMID:9685379 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118, RGD:633581 NCBI chr 7:63,020,004...63,035,086
Ensembl chr 7:63,020,000...63,035,078 		JBrowse link
G Pip5k1a phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha enables ISS
ISO
IEA
IBA		 GO_REF:0000024
(PMID:15157668), (PMID:21477596), (PMID:22942276)
GO_REF:0000107
GO_REF:0000118
GO_REF:0000033
MGI:1298224 (MGI:6201900|PMID:27739494), (PMID:20622009), (PMID:8798574)		 UniProt
RGD
Ensembl
TreeGrafter
GO_Central		 PMID:8798574 PMID:15157668 PMID:20622009 PMID:21477596 PMID:22942276 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 MGI:6201900 NCBI chr 2:182,628,299...182,671,584
Ensembl chr 2:182,628,300...182,671,598 		JBrowse link
G Pip5k1b phosphatidylinositol-4-phosphate 5-kinase type 1 beta enables ISS
IEA
IBA
ISO		 GO_REF:0000024
GO_REF:0000107
GO_REF:0000033
GO_REF:0000118
MGI:1298224 (MGI:6478055|PMID:22942276), (MGI:6478527|PMID:9367159), (PMID:20622009), (PMID:8798574)		 UniProt
Ensembl
GO_Central
TreeGrafter
RGD		 PMID:8798574 PMID:9367159 PMID:20622009 PMID:22942276 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 MGI:6478055 MGI:6478527 NCBI chr 1:221,907,220...222,183,672
Ensembl chr 1:221,914,159...222,183,672 		JBrowse link
G Pip5k1c phosphatidylinositol-4-phosphate 5-kinase type 1 gamma enables ISS
IEA
IBA
ISO		 GO_REF:0000024
GO_REF:0000118
GO_REF:0000033
MGI:3054978 (MGI:6478055|PMID:22942276), (PMID:14741049), (PMID:20622009), (PMID:9535851)		 UniProt
TreeGrafter
GO_Central
RGD		 PMID:9535851 PMID:14741049 PMID:20622009 PMID:22942276 GO_REF:0000024 GO_REF:0000033 GO_REF:0000118 MGI:6478055 NCBI chr 7:8,397,406...8,426,030
Ensembl chr 7:8,397,406...8,425,988 		JBrowse link
G Pip5kl1 phosphatidylinositol-4-phosphate 5-kinase-like 1 enables IBA
ISO		 GO_REF:0000033
(PMID:14701839)		 GO_Central
RGD		 PMID:14701839 GO_REF:0000033 NCBI chr 3:15,860,493...15,869,264
Ensembl chr 3:15,855,946...15,869,165 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21010
    catalytic activity 6145
      transferase activity 2451
        transferase activity, transferring phosphorus-containing groups 983
          phosphotransferase activity, alcohol group as acceptor 737
            phosphatidylinositol kinase activity 24
              1-phosphatidylinositol-4-phosphate 5-kinase activity 8
Path 2
Term Annotations click to browse term
  molecular_function 21010
    catalytic activity 6145
      transferase activity 2451
        transferase activity, transferring phosphorus-containing groups 983
          kinase activity 814
            lipid kinase activity 39
              phosphatidylinositol kinase activity 24
                1-phosphatidylinositol-4-phosphate 5-kinase activity 8
paths to the root