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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of macroautophagy
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Accession:GO:0016242 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy.
Synonyms:exact_synonym: down regulation of macroautophagy;   downregulation of macroautophagy;   negative regulation of starvation-induced autophagy
 narrow_synonym: inhibition of macroautophagy



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negative regulation of macroautophagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmox1 heme oxygenase 1 acts_upstream_of_or_within ISO MGI:2429784 (MGI:5430482|PMID:20705711) RGD PMID:20705711 MGI:5430482 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 involved_in ISO (PMID:19640926) RGD PMID:19640926 NCBI chr 7:122,826,712...122,987,711
Ensembl chr 7:122,826,696...122,987,703
JBrowse link
G Lzts1 leucine zipper tumor suppressor 1 involved_in ISO (PMID:22354037) RGD PMID:22354037 NCBI chr16:20,542,756...20,598,204
Ensembl chr16:20,542,809...20,598,203
JBrowse link
G Mtor mechanistic target of rapamycin kinase acts_upstream_of_or_within
involved_in
ISO
IBA
(MGI:3690270|PMID:16714284), (MGI:5563734|PMID:23274896)
PMID:21873635
(PMID:25327288)
RGD PMID:16714284 PMID:23274896 PMID:25327288 PMID:21873635 MGI:3690270 MGI:5563734, RGD:13792537 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 acts_upstream_of_or_within ISO MGI:1857409|MGI:1891828 (MGI:3723543|PMID:17468177) RGD PMID:17468177 MGI:3723543 NCBI chr18:3,379,482...3,425,100
Ensembl chr18:3,379,482...3,425,049
JBrowse link
G Nrbp2 nuclear receptor binding protein 2 involved_in ISO (PMID:22354037) RGD PMID:22354037 NCBI chr 7:107,798,642...107,805,230
Ensembl chr 7:107,799,497...107,805,230
JBrowse link
G Pink1 PTEN induced kinase 1 involved_in ISO (PMID:19279012) RGD PMID:19279012 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
JBrowse link
G Poldip2 DNA polymerase delta interacting protein 2 acts_upstream_of_or_within ISO MGI:4044390 (MGI:5588624|PMID:24797518) RGD PMID:24797518 MGI:5588624 NCBI chr10:63,408,766...63,417,605
Ensembl chr10:63,407,213...63,417,605
JBrowse link
G Qsox1 quiescin sulfhydryl oxidase 1 involved_in ISO (PMID:24475161) RGD PMID:24475161 NCBI chr13:67,949,780...67,987,434
Ensembl chr13:67,949,780...67,987,459
JBrowse link
G Smcr8 SMCR8-C9orf72 complex subunit involved_in ISO (PMID:28195531) RGD PMID:28195531 NCBI chr10:45,457,962...45,465,101
Ensembl chr10:45,457,605...45,468,876
JBrowse link
G Tsc1 TSC complex subunit 1 involved_in IMP PMID:23435171 ParkinsonsUK-UCL PMID:23435171 RGD:10448950 NCBI chr 3:11,969,547...12,018,591
Ensembl chr 3:11,979,729...12,015,674
JBrowse link
G Tsc2 TSC complex subunit 2 IMP RGD PMID:24599401 RGD:11568679 NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951
JBrowse link
G Usp36 ubiquitin specific peptidase 36 involved_in ISO (PMID:22622177) RGD PMID:22622177 NCBI chr10:103,497,349...103,528,877
Ensembl chr10:103,497,349...103,528,877
JBrowse link
negative regulation of autophagosome assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn1 beclin 1 acts_upstream_of_or_within ISO MGI:2683833 (MGI:5888970|PMID:27994061) RGD PMID:27994061 MGI:5888970 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Chmp4b charged multivesicular body protein 4B involved_in ISO (PMID:21975012) RGD PMID:21975012 NCBI chr 3:143,170,822...143,211,376
Ensembl chr 3:143,170,902...143,210,844
JBrowse link
G Ehmt2 euchromatic histone lysine methyltransferase 2 acts_upstream_of_or_within ISO (MGI:5543871|PMID:23918802) RGD PMID:23918802 MGI:5543871 NCBI chr20:3,919,623...3,936,751
Ensembl chr20:3,919,624...3,941,547
JBrowse link
G Fez1 fasciculation and elongation protein zeta 1 involved_in ISO
ISS
(PMID:25495476)
GO_REF:0000024
RGD
GO_Central
PMID:25495476 GO_REF:0000024 NCBI chr 8:36,544,462...36,589,684
Ensembl chr 8:36,544,535...36,589,683
JBrowse link
G Fez2 fasciculation and elongation protein zeta 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:25495476)
GO_Central
RGD
PMID:25495476 GO_REF:0000024 NCBI chr 6:16,654,572...16,694,628
Ensembl chr 6:16,654,614...16,694,626
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 involved_in IBA
ISO
PMID:21873635
(PMID:23916833)
RGD PMID:23916833 PMID:21873635 RGD:13792537 NCBI chr 7:122,826,712...122,987,711
Ensembl chr 7:122,826,696...122,987,703
JBrowse link
G Mtm1 myotubularin 1 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:2450997 (MGI:5510937|PMID:23695157)
RGD PMID:23695157 PMID:21873635 MGI:5510937, RGD:13792537 NCBI chr 6:488,691...506,964
Ensembl chr 6:488,969...506,860
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator involved_in ISS
ISO
GO_REF:0000024
(PMID:20181828)
UniProt
RGD
PMID:20181828 GO_REF:0000024 NCBI chr 1:181,213,292...181,215,327 JBrowse link
G Phf23 PHD finger protein 23 involved_in ISO
ISS
IBA
(PMID:25484098)
GO_REF:0000024
PMID:21873635
RGD
GO_Central
PMID:25484098 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr10:54,718,608...54,722,784
Ensembl chr10:54,717,724...54,722,782
JBrowse link
G Pink1 PTEN induced kinase 1 involved_in ISO (PMID:19279012) RGD PMID:19279012 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
JBrowse link
G Scfd1 sec1 family domain containing 1 involved_in ISO (PMID:21242315) RGD PMID:21242315 NCBI chr 6:68,795,810...68,874,076
Ensembl chr 6:68,795,878...68,874,078
JBrowse link
G Sec22b SEC22 homolog B, vesicle trafficking protein involved_in ISO (PMID:21242315) RGD PMID:21242315 NCBI chr 2:185,500,029...185,520,811
Ensembl chr 2:185,500,004...185,522,026
JBrowse link
G Smcr8 SMCR8-C9orf72 complex subunit involved_in ISO (PMID:28195531) RGD PMID:28195531 NCBI chr10:45,457,962...45,465,101
Ensembl chr10:45,457,605...45,468,876
JBrowse link
G Tmem39a transmembrane protein 39a involved_in IBA
ISS
ISO
PMID:21873635
GO_REF:0000024
(PMID:31806350)
UniProt
RGD
PMID:31806350 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr11:62,160,631...62,189,964
Ensembl chr11:62,160,631...62,189,964
JBrowse link
negative regulation of autophagosome maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec16a C-type lectin domain containing 16A involved_in ISO (PMID:28223137) RGD PMID:28223137 NCBI chr10:4,927,804...5,123,749
Ensembl chr10:4,928,030...5,123,578
JBrowse link
G Phf23 PHD finger protein 23 involved_in ISO
ISS
IBA
(PMID:25484098)
GO_REF:0000024
PMID:21873635
RGD
GO_Central
PMID:25484098 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr10:54,718,608...54,722,784
Ensembl chr10:54,717,724...54,722,782
JBrowse link
G Rubcn rubicon autophagy regulator involved_in IBA
ISO
PMID:21873635
(PMID:21062745)
RGD PMID:21062745 PMID:21873635 RGD:13792537 NCBI chr11:67,907,534...67,964,347
Ensembl chr11:67,907,516...67,964,314
JBrowse link
G Tmem39a transmembrane protein 39a involved_in ISO
IBA
ISS
(PMID:31806350)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:31806350 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr11:62,160,631...62,189,964
Ensembl chr11:62,160,631...62,189,964
JBrowse link
G Ubqln4 ubiquilin 4 involved_in ISO (PMID:23459205) RGD PMID:23459205 NCBI chr 2:174,012,726...174,028,062
Ensembl chr 2:174,012,777...174,028,059
JBrowse link
negative regulation of macroautophagy by TORC1 signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec16a C-type lectin domain containing 16A involved_in ISO (PMID:28223137) RGD PMID:28223137 NCBI chr10:4,927,804...5,123,749
Ensembl chr10:4,928,030...5,123,578
JBrowse link
negative regulation of mitophagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec16a C-type lectin domain containing 16A acts_upstream_of_or_within ISO MGI:5648633 (MGI:5603233|PMID:24949970) RGD PMID:24949970 MGI:5603233 NCBI chr10:4,927,804...5,123,749
Ensembl chr10:4,928,030...5,123,578
JBrowse link
G Pink1 PTEN induced kinase 1 involved_in ISO (PMID:19279012) RGD PMID:19279012 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
JBrowse link
G Rnf41 ring finger protein 41 acts_upstream_of_or_within ISO MGI:1921624 (MGI:5603233|PMID:24949970) RGD PMID:24949970 MGI:5603233 NCBI chr 7:838,160...876,869
Ensembl chr 7:838,203...865,511
JBrowse link
G Tigar TP53 induced glycolysis regulatory phosphatase acts_upstream_of_or_within ISO MGI:5319187 (MGI:5319065|PMID:22044588) RGD PMID:22044588 MGI:5319065 NCBI chr 4:159,927,138...159,946,094
Ensembl chr 4:159,927,139...159,946,029
JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within ISO MGI:1857263 (MGI:5319065|PMID:22044588) RGD PMID:22044588 MGI:5319065 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Usp30 ubiquitin specific peptidase 30 IMP RGD PMID:24896179 RGD:13208875 NCBI chr12:42,501,345...42,555,311
Ensembl chr12:42,501,348...42,555,616
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20091
    cellular process 18675
      process utilizing autophagic mechanism 508
        autophagy 508
          macroautophagy 269
            negative regulation of macroautophagy 31
              negative regulation of aggrephagy 0
              negative regulation of autophagosome assembly 14
              negative regulation of autophagosome maturation 5
              negative regulation of lipophagy 0
              negative regulation of macroautophagy by TORC1 signaling 1
              negative regulation of mitophagy 6
              negative regulation of xenophagy 0
Path 2
Term Annotations click to browse term
  biological_process 20091
    biological regulation 13996
      regulation of biological process 13218
        regulation of metabolic process 7044
          regulation of catabolic process 1008
            regulation of cellular catabolic process 780
              regulation of autophagy 294
                negative regulation of autophagy 79
                  negative regulation of macroautophagy 31
                    negative regulation of aggrephagy 0
                    negative regulation of autophagosome assembly 14
                    negative regulation of autophagosome maturation 5
                    negative regulation of lipophagy 0
                    negative regulation of macroautophagy by TORC1 signaling 1
                    negative regulation of mitophagy 6
                    negative regulation of xenophagy 0
paths to the root