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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of macroautophagy
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Accession:GO:0016242 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy.
Synonyms:exact_synonym: down regulation of macroautophagy;   downregulation of macroautophagy;   negative regulation of starvation-induced autophagy
 narrow_synonym: inhibition of macroautophagy


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negative regulation of macroautophagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmox1 heme oxygenase 1 acts_upstream_of_or_within ISO MGI:2429784 (MGI:5430482|PMID:20705711) RGD PMID:20705711 MGI:5430482 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 involved_in ISO (PMID:19640926) RGD PMID:19640926 NCBI chr 7:132,857,311...133,018,549
Ensembl chr 7:132,857,628...133,018,584
JBrowse link
G Lzts1 leucine zipper tumor suppressor 1 involved_in ISO (PMID:22354037) RGD PMID:22354037 NCBI chr16:22,250,452...22,306,667
Ensembl chr16:22,250,470...22,306,662
JBrowse link
G Mtor mechanistic target of rapamycin kinase involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(PMID:25327288)
(MGI:3690270|PMID:16714284), (MGI:5563734|PMID:23274896)
RGD PMID:16714284 PMID:23274896 PMID:25327288, PMID:21873635 MGI:3690270 MGI:5563734, RGD:13792537 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 acts_upstream_of_or_within ISO MGI:1857409|MGI:1891828 (MGI:3723543|PMID:17468177) RGD PMID:17468177 MGI:3723543 NCBI chr18:3,616,878...3,662,656
Ensembl chr18:3,616,878...3,662,683
JBrowse link
G Nrbp2 nuclear receptor binding protein 2 involved_in ISO (PMID:22354037) RGD PMID:22354037 NCBI chr 7:117,145,106...117,151,694
Ensembl chr 7:117,145,961...117,151,694
JBrowse link
G Pink1 PTEN induced kinase 1 involved_in ISO (PMID:19279012) RGD PMID:19279012 NCBI chr 5:156,677,146...156,689,258
Ensembl chr 5:156,677,146...156,689,415
JBrowse link
G Poldip2 DNA polymerase delta interacting protein 2 acts_upstream_of_or_within ISO MGI:4044390 (MGI:5588624|PMID:24797518) RGD PMID:24797518 MGI:5588624 NCBI chr10:65,781,994...65,790,833
Ensembl chr10:65,780,494...65,790,272
JBrowse link
G Qsox1 quiescin sulfhydryl oxidase 1 involved_in ISO (PMID:24475161) RGD PMID:24475161 NCBI chr13:73,423,396...73,460,890
Ensembl chr13:73,423,397...73,460,935
JBrowse link
G Smcr8 SMCR8-C9orf72 complex subunit involved_in ISO (PMID:28195531) RGD PMID:28195531 NCBI chr10:47,019,326...47,026,465
Ensembl chr10:47,018,974...47,026,465
JBrowse link
G Tsc1 TSC complex subunit 1 involved_in IMP PMID:23435171 ParkinsonsUK-UCL PMID:23435171 RGD:10448950 NCBI chr 3:7,219,955...7,269,063
Ensembl chr 3:7,237,192...7,265,145
JBrowse link
G Tsc2 TSC complex subunit 2 IMP RGD PMID:24599401 RGD:11568679 NCBI chr10:13,962,006...13,996,684
Ensembl chr10:13,961,947...13,996,584
JBrowse link
G Usp36 ubiquitin specific peptidase 36 involved_in ISO (PMID:22622177) RGD PMID:22622177 NCBI chr10:107,292,828...107,324,355
Ensembl chr10:107,292,828...107,324,355
JBrowse link
negative regulation of autophagosome assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn1 beclin 1 acts_upstream_of_or_within ISO MGI:2683833 (MGI:5888970|PMID:27994061) RGD PMID:27994061 MGI:5888970 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Chmp4b charged multivesicular body protein 4B involved_in ISO (PMID:21975012) RGD PMID:21975012 NCBI chr 3:150,188,275...150,227,453
Ensembl chr 3:150,188,455...150,227,405
JBrowse link
G Ehmt2 euchromatic histone lysine methyltransferase 2 acts_upstream_of_or_within ISO (MGI:5543871|PMID:23918802) RGD PMID:23918802 MGI:5543871 NCBI chr20:4,576,033...4,592,980
Ensembl chr20:4,576,057...4,592,980
JBrowse link
G Fez1 fasciculation and elongation protein zeta 1 involved_in ISO
ISS
(PMID:25495476)
GO_REF:0000024
RGD
GO_Central
PMID:25495476 GO_REF:0000024 NCBI chr 8:39,305,128...39,350,270
Ensembl chr 8:39,305,128...39,350,270
JBrowse link
G Fez2 fasciculation and elongation protein zeta 2 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:25495476)
GO_Central
Ensembl
RGD
PMID:25495476 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:963,903...1,003,955
Ensembl chr 6:963,907...1,004,001
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 involved_in IBA
ISO
PMID:21873635
(PMID:23916833)
RGD PMID:23916833, PMID:21873635 RGD:13792537 NCBI chr 7:132,857,311...133,018,549
Ensembl chr 7:132,857,628...133,018,584
JBrowse link
G Mtm1 myotubularin 1 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:2450997 (MGI:5510937|PMID:23695157)
RGD PMID:23695157, PMID:21873635 MGI:5510937, RGD:13792537 NCBI chr 6:18,821,821...18,840,449
Ensembl chr 6:18,821,815...18,839,409
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator involved_in ISS
ISO
GO_REF:0000024
(PMID:20181828)
UniProt
RGD
PMID:20181828 GO_REF:0000024 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G Phf23 PHD finger protein 23 involved_in ISO
IBA
ISS
(PMID:25484098)
PMID:21873635
GO_REF:0000024
RGD
GO_Central
PMID:25484098, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr10:56,605,078...56,609,236
Ensembl chr10:56,605,140...56,609,233
JBrowse link
G Pink1 PTEN induced kinase 1 involved_in ISO (PMID:19279012) RGD PMID:19279012 NCBI chr 5:156,677,146...156,689,258
Ensembl chr 5:156,677,146...156,689,415
JBrowse link
G Scfd1 sec1 family domain containing 1 involved_in ISO (PMID:21242315) RGD PMID:21242315 NCBI chr 6:72,124,408...72,202,703
Ensembl chr 6:72,124,417...72,202,713
JBrowse link
G Sec22b SEC22 homolog B, vesicle trafficking protein involved_in ISO (PMID:21242315) RGD PMID:21242315 NCBI chr 2:200,076,079...200,096,861
Ensembl chr 2:200,076,054...200,098,076
JBrowse link
G Smcr8 SMCR8-C9orf72 complex subunit involved_in ISO (PMID:28195531) RGD PMID:28195531 NCBI chr10:47,019,326...47,026,465
Ensembl chr10:47,018,974...47,026,465
JBrowse link
G Tmem39a transmembrane protein 39a involved_in IBA
ISS
ISO
PMID:21873635
GO_REF:0000024
(PMID:31806350)
UniProt
RGD
PMID:31806350, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr11:64,723,181...64,752,514
Ensembl chr11:64,723,186...64,752,544
JBrowse link
negative regulation of autophagosome maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec16a C-type lectin domain containing 16A involved_in ISO (PMID:28223137) RGD PMID:28223137 NCBI chr10:5,002,196...5,196,914
Ensembl chr10:5,009,826...5,196,892
JBrowse link
G Phf23 PHD finger protein 23 involved_in ISO
ISS
IBA
(PMID:25484098)
GO_REF:0000024
PMID:21873635
RGD
GO_Central
PMID:25484098, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr10:56,605,078...56,609,236
Ensembl chr10:56,605,140...56,609,233
JBrowse link
G Rubcn rubicon autophagy regulator involved_in IBA
ISO
PMID:21873635
(PMID:21062745)
RGD PMID:21062745, PMID:21873635 RGD:13792537 NCBI chr11:71,150,506...71,199,254
Ensembl chr11:71,151,132...71,197,035
JBrowse link
G Tmem39a transmembrane protein 39a involved_in ISO
IBA
ISS
(PMID:31806350)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:31806350, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr11:64,723,181...64,752,514
Ensembl chr11:64,723,186...64,752,544
JBrowse link
G Ubqln4 ubiquilin 4 involved_in ISO (PMID:23459205) RGD PMID:23459205 NCBI chr 2:187,915,701...187,931,035
Ensembl chr 2:187,915,751...187,931,035
JBrowse link
negative regulation of macroautophagy by TORC1 signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec16a C-type lectin domain containing 16A involved_in ISO (PMID:28223137) RGD PMID:28223137 NCBI chr10:5,002,196...5,196,914
Ensembl chr10:5,009,826...5,196,892
JBrowse link
negative regulation of mitophagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec16a C-type lectin domain containing 16A acts_upstream_of_or_within ISO MGI:5648633 (MGI:5603233|PMID:24949970) RGD PMID:24949970 MGI:5603233 NCBI chr10:5,002,196...5,196,914
Ensembl chr10:5,009,826...5,196,892
JBrowse link
G Rnf41 ring finger protein 41 acts_upstream_of_or_within ISO MGI:1921624 (MGI:5603233|PMID:24949970) RGD PMID:24949970 MGI:5603233 NCBI chr 7:2,827,242...2,854,230
Ensembl chr 7:2,827,247...2,852,681
JBrowse link
G Tigar TP53 induced glycolysis regulatory phosphatase acts_upstream_of_or_within ISO MGI:5319187 (MGI:5319065|PMID:22044588) RGD PMID:22044588 MGI:5319065 NCBI chr 4:159,635,145...159,654,108
Ensembl chr 4:159,635,153...159,654,063
JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within ISO MGI:1857263 (MGI:5319065|PMID:22044588) RGD PMID:22044588 MGI:5319065 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Usp30 ubiquitin specific peptidase 30 IMP RGD PMID:24896179 RGD:13208875 NCBI chr12:48,262,663...48,316,580
Ensembl chr12:48,262,658...48,316,722
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19491
    cellular process 18343
      process utilizing autophagic mechanism 460
        autophagy 460
          macroautophagy 237
            negative regulation of macroautophagy 31
              negative regulation of aggrephagy 0
              negative regulation of autophagosome assembly 14
              negative regulation of autophagosome maturation 5
              negative regulation of lipophagy 0
              negative regulation of macroautophagy by TORC1 signaling 1
              negative regulation of mitophagy 5
              negative regulation of xenophagy 0
Path 2
Term Annotations click to browse term
  biological_process 19491
    biological regulation 13515
      regulation of biological process 12773
        regulation of metabolic process 6744
          regulation of catabolic process 926
            regulation of cellular catabolic process 770
              regulation of autophagy 261
                negative regulation of autophagy 76
                  negative regulation of macroautophagy 31
                    negative regulation of aggrephagy 0
                    negative regulation of autophagosome assembly 14
                    negative regulation of autophagosome maturation 5
                    negative regulation of lipophagy 0
                    negative regulation of macroautophagy by TORC1 signaling 1
                    negative regulation of mitophagy 5
                    negative regulation of xenophagy 0
paths to the root