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ONTOLOGY REPORT - ANNOTATIONS

Term:iron-sulfur cluster assembly
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Accession:GO:0016226 term browser browse the term
Definition:The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
Synonyms:exact_synonym: iron-sulphur cluster assembly
 related_synonym: iron-sulfur cluster biosynthesis

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iron-sulfur cluster assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb7 ATP binding cassette subfamily B member 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936683:1,224,703...1,326,761 JBrowse link
G Bola2b bolA family member 2B involved_in ISO (PMID:27519415) ComplexPortal PMID:27519415 NCBI chrNW_004936501:12,335,330...12,335,941 JBrowse link
G Ciao1 cytosolic iron-sulfur assembly component 1 involved_in IEA UniProt
Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 NCBI chrNW_004936744:359,234...364,649 JBrowse link
G Ciao2a cytosolic iron-sulfur assembly component 2A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:24,547,862...24,568,003 JBrowse link
G Ciao2b cytosolic iron-sulfur assembly component 2B involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936475:17,181,766...17,184,266 JBrowse link
G Ciao3 cytosolic iron-sulfur assembly component 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:4946832|PMID:21367862) MGI
Ensembl		 PMID:21367862 GO_REF:0000107 MGI:4946832 NCBI chrNW_004936501:277,525...286,929 JBrowse link
G Ciapin1 cytokine induced apoptosis inhibitor 1 involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chrNW_004936475:9,485,214...9,502,619 JBrowse link
G Fxn frataxin involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3770334|PMID:17597094)
(MGI:3611157|PMID:16278235)		 InterPro
MGI		 PMID:16278235 PMID:17597094 GO_REF:0000002 MGI:3611157 MGI:3770334 NCBI chrNW_004936503:5,323,206...5,343,228 JBrowse link
G Glrx3 glutaredoxin 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936486:17,201,838...17,233,171 JBrowse link
G Hscb HscB mitochondrial iron-sulfur cluster cochaperone involved_in ISO (PMID:20668094) UniProt PMID:20668094 NCBI chrNW_004936657:2,848,282...2,860,115 JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936531:7,702,186...7,716,428 JBrowse link
G Isca1 iron-sulfur cluster assembly 1 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936680:1,673,666...1,689,646 JBrowse link
G Isca2 iron-sulfur cluster assembly 2 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936488:3,676,752...3,678,741 JBrowse link
G Iscu iron-sulfur cluster assembly enzyme involved_in IEA InterPro
Ensembl
UniProt		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 NCBI chrNW_004936769:492,024...498,587 JBrowse link
G Lyrm4 LYR motif containing 4 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936534:7,205,538...7,350,114 JBrowse link
G Mms19 MMS19 homolog, cytosolic iron-sulfur assembly component involved_in IEA UniProt
Ensembl		 GO_REF:0000104 GO_REF:0000107 NCBI chrNW_004936636:2,191,748...2,221,027 JBrowse link
G Ndor1 NADPH dependent diflavin oxidoreductase 1 involved_in IEA UniProt GO_REF:0000104 NCBI chrNW_004936669:773,494...782,286 JBrowse link
G Nfu1 NFU1 iron-sulfur cluster scaffold involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004936491:13,680,669...13,712,924 JBrowse link
G Nubp1 NUBP iron-sulfur cluster assembly factor 1, cytosolic involved_in IEA InterPro
Ensembl
UniProt		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 NCBI chrNW_004936530:8,970,963...8,985,925 JBrowse link
G Nubp2 NUBP iron-sulfur cluster assembly factor 2, cytosolic involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chrNW_004936694:2,208,102...2,211,910 JBrowse link
G Nubpl NUBP iron-sulfur cluster assembly factor, mitochondrial involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936494:6,141,444...6,365,537 JBrowse link
G Xdh xanthine dehydrogenase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3770334|PMID:17597094) MGI
Ensembl		 PMID:17597094 GO_REF:0000107 MGI:3770334 NCBI chrNW_004936493:1,762,814...1,824,501 JBrowse link
[2Fe-2S] cluster assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bola2b bolA family member 2B involved_in ISO (PMID:27519415) UniProt PMID:27519415 NCBI chrNW_004936501:12,335,330...12,335,941 JBrowse link
G Fxn frataxin involved_in ISO (PMID:24971490), (PMID:29576242) UniProt PMID:24971490 PMID:29576242 NCBI chrNW_004936503:5,323,206...5,343,228 JBrowse link
G Glrx3 glutaredoxin 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936486:17,201,838...17,233,171 JBrowse link
G Iscu iron-sulfur cluster assembly enzyme involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936769:492,024...498,587 JBrowse link
G Nfs1 NFS1 cysteine desulfurase involved_in ISO (PMID:24971490) UniProt PMID:24971490 NCBI chrNW_004936561:5,136,692...5,158,266 JBrowse link
[4Fe-4S] cluster assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fxn frataxin acts_upstream_of
acts_upstream_of_or_within		 ISO (PMID:29576242)
(PMID:25597503)		 UniProt PMID:25597503 PMID:29576242 NCBI chrNW_004936503:5,323,206...5,343,228 JBrowse link
G Iscu iron-sulfur cluster assembly enzyme acts_upstream_of_positive_effect
acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:29309586)
(PMID:25597503)
(PMID:16527810), (PMID:29576242)		 UniProt
Ensembl		 PMID:16527810 PMID:25597503 PMID:29309586 PMID:29576242 GO_REF:0000107 NCBI chrNW_004936769:492,024...498,587 JBrowse link
G Lyrm4 LYR motif containing 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25597503) Ensembl
UniProt		 PMID:25597503 GO_REF:0000107 NCBI chrNW_004936534:7,205,538...7,350,114 JBrowse link
G Nfs1 NFS1 cysteine desulfurase acts_upstream_of
acts_upstream_of_or_within		 ISO (PMID:16527810)
(PMID:25597503)		 UniProt PMID:16527810 PMID:25597503 NCBI chrNW_004936561:5,136,692...5,158,266 JBrowse link
iron incorporation into metallo-sulfur cluster term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fxn frataxin involved_in ISO (PMID:12785837) BHF-UCL PMID:12785837 NCBI chrNW_004936503:5,323,206...5,343,228 JBrowse link
G Nfs1 NFS1 cysteine desulfurase involved_in ISO (PMID:16847322)
(MGI:3763294|PMID:16847322)		 HGNC-UCL PMID:16847322 MGI:3763294 NCBI chrNW_004936561:5,136,692...5,158,266 JBrowse link
positive regulation of iron-sulfur cluster assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb7 ATP binding cassette subfamily B member 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936683:1,224,703...1,326,761 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 14984
    metabolic process 9441
      cellular metabolic process 7930
        sulfur compound metabolic process 273
          iron-sulfur cluster assembly 23
            [2Fe-2S] cluster assembly + 5
            [4Fe-4S] cluster assembly + 4
            iron incorporation into metallo-sulfur cluster + 2
            iron-sulfur-molybdenum cofactor assembly + 0
            molybdenum incorporation into iron-sulfur cluster + 0
            negative regulation of iron-sulfur cluster assembly + 0
            nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide + 0
            nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide 0
            nickel incorporation into nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide 0
            nitrogenase P cluster assembly 0
            positive regulation of iron-sulfur cluster assembly + 1
            regulation of iron-sulfur cluster assembly + 1
Path 2
Term Annotations click to browse term
  biological_process 14984
    cellular process 13982
      cellular component organization or biogenesis 5557
        cellular component organization 5414
          cellular component assembly 2569
            metallo-sulfur cluster assembly 23
              iron-sulfur cluster assembly 23
                [2Fe-2S] cluster assembly + 5
                [4Fe-4S] cluster assembly + 4
                iron incorporation into metallo-sulfur cluster + 2
                iron-sulfur-molybdenum cofactor assembly + 0
                molybdenum incorporation into iron-sulfur cluster + 0
                negative regulation of iron-sulfur cluster assembly + 0
                nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide + 0
                nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide 0
                nickel incorporation into nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide 0
                nitrogenase P cluster assembly 0
                positive regulation of iron-sulfur cluster assembly + 1
                regulation of iron-sulfur cluster assembly + 1
paths to the root