Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:iron-sulfur cluster assembly
go back to main search page
Accession:GO:0016226 term browser browse the term
Definition:The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
Synonyms:exact_synonym: iron-sulphur cluster assembly
 related_synonym: iron-sulfur cluster biosynthesis



show annotations for term's descendants           Sort by:
 
iron-sulfur cluster assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB7 ATP binding cassette subfamily B member 7 involved_in ISS
IEA
UniProt
Ensembl
UniProt
GO_REF:0000024 GO_REF:0000107 NCBI chr  X:75,051,048...75,156,283
Ensembl chr  X:75,051,048...75,156,732
JBrowse link
G AL109827.1 novel protein involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 Ensembl chr20:35,632,340...35,674,544 JBrowse link
G BOLA1 bolA family member 1 involved_in IC (PMID:27532772) ComplexPortal PMID:27532772 NCBI chr 1:149,899,568...149,900,795
Ensembl chr 1:149,887,890...149,900,798
JBrowse link
G BOLA2 bolA family member 2 involved_in IDA (PMID:27519415) ComplexPortal
ComplexPortal
PMID:27519415 NCBI chr16:29,453,588...29,454,964
Ensembl chr16:30,192,932...30,194,306
Ensembl chr16:30,192,932...30,194,306
JBrowse link
G BOLA2B bolA family member 2B involved_in IDA (PMID:27519415) ComplexPortal
ComplexPortal
PMID:27519415 NCBI chr16:30,192,932...30,193,666
Ensembl chr16:30,192,932...30,194,306
JBrowse link
G BOLA3 bolA family member 3 involved_in IC (PMID:27532772) ComplexPortal PMID:27532772 NCBI chr 2:74,135,400...74,147,912
Ensembl chr 2:74,135,400...74,147,912
JBrowse link
G CIAO1 cytosolic iron-sulfur assembly component 1 involved_in IBA
IEA
IMP
IGI
(PMID:21873635)
(PMID:23891004)
(PMID:17937914)
GO_Central
UniProt
GO_Central
InterPro
UniProt
PMID:17937914 PMID:21873635 PMID:23891004 GO_REF:0000002 GO_REF:0000104 NCBI chr 2:96,266,225...96,274,173
Ensembl chr 2:96,266,159...96,274,173
JBrowse link
G CIAO2A cytosolic iron-sulfur assembly component 2A involved_in IMP (PMID:23891004) UniProt
UniProt
PMID:23891004 NCBI chr15:64,072,565...64,093,838
Ensembl chr15:64,072,565...64,093,857
JBrowse link
G CIAO2B cytosolic iron-sulfur assembly component 2B involved_in IBA
IMP
(PMID:21873635)
(PMID:23891004)
GO_Central
UniProt
GO_Central
UniProt
PMID:21873635 PMID:23891004 NCBI chr16:66,932,065...66,934,402
Ensembl chr16:66,932,065...66,934,423
JBrowse link
G CIAO3 cytosolic iron-sulfur assembly component 3 involved_in
acts_upstream_of_or_within
IBA
IEA
IMP
ISO
(PMID:21873635)
(PMID:18270200)
(MGI:4946832|PMID:21367862)
GO_Central
Ensembl
UniProt
GO_Central
MGI
UniProt
PMID:18270200 PMID:21367862 PMID:21873635 GO_REF:0000107 MGI:4946832 NCBI chr16:729,765...740,997
Ensembl chr16:729,760...741,329
JBrowse link
G CIAPIN1 cytokine induced apoptosis inhibitor 1 involved_in IEA
IBA
(PMID:21873635) InterPro
UniProt
InterPro
GO_Central
GO_Central
PMID:21873635 GO_REF:0000002 GO_REF:0000104 NCBI chr16:57,428,187...57,447,385
Ensembl chr16:57,428,187...57,447,420
JBrowse link
G FDX2 ferredoxin 2 involved_in IC (PMID:29097656) ComplexPortal PMID:29097656 NCBI chr19:10,310,045...10,316,015
Ensembl chr19:10,310,045...10,316,015
JBrowse link
G FXN frataxin involved_in
acts_upstream_of_or_within
IEA
ISO
IC
IDA
(MGI:3611157|PMID:16278235)
(MGI:3770334|PMID:17597094)
(PMID:29097656)
(PMID:29491838)
InterPro
MGI
ComplexPortal
FlyBase
InterPro
Ensembl
FlyBase
PMID:16278235 PMID:17597094 PMID:29097656 PMID:29491838 GO_REF:0000002 GO_REF:0000107 MGI:3611157 MGI:3770334 NCBI chr 9:69,035,752...69,079,076
Ensembl chr 9:69,035,751...69,079,076
JBrowse link
G GLRX3 glutaredoxin 3 involved_in IDA (PMID:27519415) ComplexPortal
ComplexPortal
PMID:27519415 NCBI chr10:130,136,391...130,180,377
Ensembl chr10:130,136,391...130,184,521
JBrowse link
G GLRX5 glutaredoxin 5 involved_in IC (PMID:27532772) ComplexPortal PMID:27532772 NCBI chr14:95,535,050...95,544,714
Ensembl chr14:95,533,503...95,544,724
JBrowse link
G HSCB HscB mitochondrial iron-sulfur cluster cochaperone involved_in IMP (PMID:20668094) UniProt
UniProt
PMID:20668094 NCBI chr22:28,742,032...28,757,510
Ensembl chr22:28,742,039...28,757,515
JBrowse link
G HSPA9 heat shock protein family A (Hsp70) member 9 involved_in IMP
IEA
(PMID:26702583) UniProt
UniProt
Ensembl
PMID:26702583 GO_REF:0000107 NCBI chr 5:138,553,756...138,575,401
Ensembl chr 5:138,553,756...138,575,675
JBrowse link
G IBA57 iron-sulfur cluster assembly factor IBA57 involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr 1:228,165,804...228,182,257
Ensembl chr 1:228,165,804...228,182,257
JBrowse link
G ISCA1 iron-sulfur cluster assembly 1 involved_in IBA
IEA
(PMID:21873635) GO_Central
GO_Central
InterPro
InterPro
PMID:21873635 GO_REF:0000002 NCBI chr 9:86,264,546...86,282,538
Ensembl chr 9:86,264,546...86,283,102
JBrowse link
G ISCA2 iron-sulfur cluster assembly 2 involved_in IBA
IEA
(PMID:21873635) GO_Central
GO_Central
InterPro
PMID:21873635 GO_REF:0000002 NCBI chr14:74,493,765...74,497,106
Ensembl chr14:74,493,756...74,497,106
JBrowse link
G ISCU iron-sulfur cluster assembly enzyme involved_in IEA
IMP
IC
TAS
(PMID:16517407)
(PMID:29097656)
(PMID:11060020)
InterPro
UniProt
ComplexPortal
InterPro
UniProt
PMID:11060020 PMID:16517407 PMID:29097656 GO_REF:0000002 GO_REF:0000104 NCBI chr12:108,561,463...108,569,384
Ensembl chr12:108,562,582...108,569,368
JBrowse link
G LYRM4 LYR motif containing 4 involved_in IBA
IC
IEA
(PMID:21873635)
(PMID:29097656)
GO_Central
ComplexPortal
InterPro
GO_Central
PMID:21873635 PMID:29097656 GO_REF:0000002 NCBI chr 6:5,031,753...5,260,950
Ensembl chr 6:5,103,629...5,260,950
JBrowse link
G MMS19 MMS19 homolog, cytosolic iron-sulfur assembly component involved_in IBA
IMP
IEA
(PMID:21873635)
(PMID:22678361), (PMID:22678362)
GO_Central
UniProt
GO_Central
UniProt
PMID:21873635 PMID:22678361 PMID:22678362 GO_REF:0000104 NCBI chr10:97,458,324...97,498,794
Ensembl chr10:97,458,324...97,498,794
JBrowse link
G NDOR1 NADPH dependent diflavin oxidoreductase 1 involved_in TAS
IEA
(PMID:23596212) ARUK-UCL
UniProt
ARUK-UCL
PMID:23596212 GO_REF:0000104 NCBI chr 9:137,205,700...137,219,361
Ensembl chr 9:137,205,685...137,219,361
JBrowse link
G NDUFAB1 NADH:ubiquinone oxidoreductase subunit AB1 involved_in IC (PMID:29097656) ComplexPortal PMID:29097656 NCBI chr16:23,581,014...23,596,316
Ensembl chr16:23,581,014...23,596,316
JBrowse link
G NFS1 NFS1 cysteine desulfurase involved_in IBA
IEA
IC
TAS
(PMID:21873635)
(PMID:29097656)
GO_Central
UniProt
ComplexPortal
GO_Central
Reactome
Reactome
PMID:21873635 PMID:29097656 GO_REF:0000117 Reactome:R-HSA-1362409 NCBI chr20:35,668,052...35,699,352
Ensembl chr20:35,668,052...35,699,355
JBrowse link
G NFU1 NFU1 iron-sulfur cluster scaffold involved_in IDA
IEA
IBA
(PMID:12886008), (PMID:28906594)
(PMID:21873635)
UniProt
InterPro
GO_Central
UniProt
InterPro
GO_Central
PMID:12886008 PMID:21873635 PMID:28906594 GO_REF:0000002 NCBI chr 2:69,395,750...69,439,567
Ensembl chr 2:69,396,113...69,437,628
JBrowse link
G NUBP1 NUBP iron-sulfur cluster assembly factor 1, cytosolic involved_in IEA
IBA
IMP
(PMID:21873635)
(PMID:18573874)
InterPro
InterPro
GO_Central
UniProt
UniProt
GO_Central
PMID:18573874 PMID:21873635 GO_REF:0000002 GO_REF:0000104 NCBI chr16:10,743,842...10,769,351
Ensembl chr16:10,743,786...10,769,351
JBrowse link
G NUBP2 NUBP iron-sulfur cluster assembly factor 2, cytosolic involved_in IBA
IEA
(PMID:21873635) GO_Central
UniProt
GO_Central
InterPro
InterPro
PMID:21873635 GO_REF:0000002 GO_REF:0000104 NCBI chr16:1,782,960...1,789,186
Ensembl chr16:1,782,932...1,789,186
JBrowse link
G NUBPL NUBP iron-sulfur cluster assembly factor, mitochondrial involved_in IBA
IEA
(PMID:21873635) GO_Central
InterPro
GO_Central
InterPro
PMID:21873635 GO_REF:0000002 NCBI chr14:31,561,404...31,861,224
Ensembl chr14:31,489,956...31,861,224
JBrowse link
G XDH xanthine dehydrogenase involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3770334|PMID:17597094) Ensembl
Ensembl
MGI
PMID:17597094 GO_REF:0000107 MGI:3770334 NCBI chr 2:31,334,321...31,414,742
Ensembl chr 2:31,334,321...31,414,742
JBrowse link
[2Fe-2S] cluster assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AL109827.1 novel protein involved_in IEA InterPro
InterPro
GO_REF:0000002 Ensembl chr20:35,632,340...35,674,544 JBrowse link
G BOLA2 bolA family member 2 involved_in IDA (PMID:27519415) UniProt
UniProt
PMID:27519415 NCBI chr16:29,453,588...29,454,964
Ensembl chr16:30,192,932...30,194,306
Ensembl chr16:30,192,932...30,194,306
JBrowse link
G BOLA2B bolA family member 2B involved_in IDA (PMID:27519415) UniProt
UniProt
PMID:27519415 NCBI chr16:30,192,932...30,193,666
Ensembl chr16:30,192,932...30,194,306
JBrowse link
G FXN frataxin involved_in IDA (PMID:24971490), (PMID:29576242) UniProt PMID:24971490 PMID:29576242 NCBI chr 9:69,035,752...69,079,076
Ensembl chr 9:69,035,751...69,079,076
JBrowse link
G GLRX3 glutaredoxin 3 involved_in IDA (PMID:27519415) UniProt
UniProt
PMID:27519415 NCBI chr10:130,136,391...130,180,377
Ensembl chr10:130,136,391...130,184,521
JBrowse link
G GLRX5 glutaredoxin 5 involved_in IGI (PMID:23615440) UniProt
UniProt
PMID:23615440 NCBI chr14:95,535,050...95,544,714
Ensembl chr14:95,533,503...95,544,724
JBrowse link
G HSCB HscB mitochondrial iron-sulfur cluster cochaperone involved_in IBA
IEA
(PMID:21873635) GO_Central
InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr22:28,742,032...28,757,510
Ensembl chr22:28,742,039...28,757,515
JBrowse link
G ISCU iron-sulfur cluster assembly enzyme involved_in IMP
IDA
(PMID:29309586)
(PMID:23940031), (PMID:24971490), (PMID:29576242)
UniProt PMID:23940031 PMID:24971490 PMID:29309586 PMID:29576242 NCBI chr12:108,561,463...108,569,384
Ensembl chr12:108,562,582...108,569,368
JBrowse link
G NFS1 NFS1 cysteine desulfurase involved_in IEA
IDA
(PMID:24971490) InterPro
UniProt
InterPro
PMID:24971490 GO_REF:0000002 NCBI chr20:35,668,052...35,699,352
Ensembl chr20:35,668,052...35,699,355
JBrowse link
[4Fe-4S] cluster assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FXN frataxin acts_upstream_of
involved_in
IDA
IEA
ISS
(PMID:29576242) UniProt
Ensembl
PMID:29576242 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:69,035,752...69,079,076
Ensembl chr 9:69,035,751...69,079,076
JBrowse link
G ISCU iron-sulfur cluster assembly enzyme acts_upstream_of_positive_effect
involved_in
IMP
IDA
(PMID:29309586)
(PMID:23940031)
(PMID:16527810), (PMID:29576242)
UniProt PMID:16527810 PMID:23940031 PMID:29309586 PMID:29576242 NCBI chr12:108,561,463...108,569,384
Ensembl chr12:108,562,582...108,569,368
JBrowse link
G LYRM4 LYR motif containing 4 involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 6:5,031,753...5,260,950
Ensembl chr 6:5,103,629...5,260,950
JBrowse link
G NFS1 NFS1 cysteine desulfurase involved_in
acts_upstream_of
IEA
IDA
(PMID:16527810) Ensembl
UniProt
PMID:16527810 GO_REF:0000107 NCBI chr20:35,668,052...35,699,352
Ensembl chr20:35,668,052...35,699,355
JBrowse link
iron incorporation into metallo-sulfur cluster term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FXN frataxin involved_in IDA
IBA
(PMID:12785837)
(PMID:21873635)
BHF-UCL
GO_Central
BHF-UCL
GO_Central
PMID:12785837 PMID:21873635 NCBI chr 9:69,035,752...69,079,076
Ensembl chr 9:69,035,751...69,079,076
JBrowse link
G NFS1 NFS1 cysteine desulfurase involved_in IDA
IEA
(PMID:16847322) HGNC-UCL
HGNC-UCL
Ensembl
PMID:16847322 GO_REF:0000107 NCBI chr20:35,668,052...35,699,352
Ensembl chr20:35,668,052...35,699,355
JBrowse link
positive regulation of iron-sulfur cluster assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB7 ATP binding cassette subfamily B member 7 involved_in ISS
IMP
IEA
(PMID:17192393) UniProt
UniProt
Ensembl
PMID:17192393 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:75,051,048...75,156,283
Ensembl chr  X:75,051,048...75,156,732
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19690
    metabolic process 13120
      cellular metabolic process 11013
        sulfur compound metabolic process 389
          iron-sulfur cluster assembly 31
            [2Fe-2S] cluster assembly + 9
            [4Fe-4S] cluster assembly + 4
            iron incorporation into metallo-sulfur cluster + 2
            iron-sulfur-molybdenum cofactor assembly + 0
            molybdenum incorporation into iron-sulfur cluster + 0
            negative regulation of iron-sulfur cluster assembly + 0
            nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide + 0
            nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide 0
            nickel incorporation into nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide 0
            nitrogenase P cluster assembly 0
            positive regulation of iron-sulfur cluster assembly + 1
            regulation of iron-sulfur cluster assembly + 1
Path 2
Term Annotations click to browse term
  biological_process 19690
    cellular process 18197
      cellular component organization or biogenesis 7294
        cellular component organization 7089
          cellular component assembly 3397
            metallo-sulfur cluster assembly 31
              iron-sulfur cluster assembly 31
                [2Fe-2S] cluster assembly + 9
                [4Fe-4S] cluster assembly + 4
                iron incorporation into metallo-sulfur cluster + 2
                iron-sulfur-molybdenum cofactor assembly + 0
                molybdenum incorporation into iron-sulfur cluster + 0
                negative regulation of iron-sulfur cluster assembly + 0
                nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide + 0
                nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide 0
                nickel incorporation into nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide 0
                nitrogenase P cluster assembly 0
                positive regulation of iron-sulfur cluster assembly + 1
                regulation of iron-sulfur cluster assembly + 1
paths to the root