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ONTOLOGY REPORT - ANNOTATIONS

Term:iron-sulfur cluster assembly
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Accession:GO:0016226 term browser browse the term
Definition:The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
Synonyms:exact_synonym: iron-sulphur cluster assembly
 related_synonym: iron-sulfur cluster biosynthesis
 xref: Reactome:R-HSA-1362409 "Mitochondrial iron-sulfur cluster biogenesis";   Reactome:R-HSA-2564830 "Cytosolic iron-sulfur cluster assembly"


show annotations for term's descendants           Sort by:
iron-sulfur cluster assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb7 ATP binding cassette subfamily B member 7 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:30765471)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:30765471 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:69,295,598...69,436,775
Ensembl chr  X:69,295,552...69,436,858 		JBrowse link
G Bola2 bolA family member 2 involved_in ISO (PMID:27519415) RGD PMID:27519415 NCBI chr 1:181,291,967...181,292,833
Ensembl chr 1:181,291,398...181,292,676 		JBrowse link
G Bola3 bolA family member 3 acts_upstream_of_or_within ISO (PMID:32313871) RGD PMID:32313871 NCBI chr 4:115,853,350...115,862,797
Ensembl chr 4:115,853,350...115,862,797 		JBrowse link
G Ciao1 cytosolic iron-sulfur assembly component 1 involved_in IEA
IBA		 GO_REF:0000104
GO_REF:0000002
GO_REF:0000033		 UniProt
InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 NCBI chr 3:114,458,671...114,465,928
Ensembl chr 3:114,458,655...114,467,009 		JBrowse link
G Ciao3 cytosolic iron-sulfur assembly component 3 involved_in
acts_upstream_of_or_within		 ISO
ISS		 (PMID:18270200)
MGI:4946833 (PMID:21367862)
GO_REF:0000024		 RGD
UniProt		 PMID:18270200 PMID:21367862 GO_REF:0000024 NCBI chr10:14,795,888...14,804,953
Ensembl chr10:14,795,961...14,804,950 		JBrowse link
G Ciapin1 cytokine induced apoptosis inhibitor 1 involved_in IEA
IBA		 GO_REF:0000104
GO_REF:0000002
GO_REF:0000033		 UniProt
InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 NCBI chr19:10,179,963...10,195,511
Ensembl chr19:10,180,100...10,195,503 		JBrowse link
G Fxn frataxin acts_upstream_of_or_within
involved_in		 ISO
IEA
IBA		 MGI:2176228|MGI:2177176 (PMID:16278235), (PMID:17597094)
(PMID:12785837)
GO_REF:0000002
GO_REF:0000033		 RGD
InterPro
GO_Central		 PMID:12785837 PMID:16278235 PMID:17597094 GO_REF:0000002 GO_REF:0000033 NCBI chr 1:221,874,007...221,897,543
Ensembl chr 1:221,872,420...221,897,540 		JBrowse link
G Glrx3 glutaredoxin 3 involved_in ISO
IEA		 (PMID:27519415)
GO_REF:0000107		 RGD
Ensembl		 PMID:27519415 GO_REF:0000107 NCBI chr 1:192,241,707...192,272,012
Ensembl chr 1:192,241,701...192,272,010 		JBrowse link
G Hscb HscB mitochondrial iron-sulfur cluster co-chaperone involved_in ISO (PMID:20668094) RGD PMID:20668094 NCBI chr12:45,821,527...45,831,902
Ensembl chr12:45,821,555...45,831,909 		JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 involved_in IEA
ISO
IBA
ISS		 GO_REF:0000107
(PMID:26702583)
GO_REF:0000033
GO_REF:0000024		 Ensembl
RGD
GO_Central
UniProt		 PMID:26702583 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr18:26,810,004...26,832,958
Ensembl chr18:26,535,798...26,554,292 		JBrowse link
G Iba57 iron-sulfur cluster assembly factor IBA57 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:43,942,017...43,950,807
Ensembl chr10:43,942,017...43,950,807 		JBrowse link
G Isca1 iron-sulfur cluster assembly 1 involved_in IEA
IBA		 GO_REF:0000002
GO_REF:0000033		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr17:4,905,291...4,917,955
Ensembl chr17:4,905,287...4,917,955 		JBrowse link
G Isca2 iron-sulfur cluster assembly 2 involved_in IBA
IEA		 GO_REF:0000033
GO_REF:0000002		 GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000033 NCBI chr 6:104,418,509...104,420,019
Ensembl chr 6:104,418,454...104,420,045
Ensembl chr14:104,418,454...104,420,045 		JBrowse link
G Iscu iron-sulfur cluster assembly enzyme involved_in ISO
IEA		 (PMID:16517407)
GO_REF:0000104
GO_REF:0000002		 RGD
UniProt
InterPro		 PMID:16517407 GO_REF:0000002 GO_REF:0000104 NCBI chr12:42,852,305...42,858,150
Ensembl chr12:42,852,305...42,858,150 		JBrowse link
G Lyrm4 LYR motif containing 4 involved_in IBA
IEA		 GO_REF:0000033
GO_REF:0000002		 GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000033 NCBI chr17:28,746,457...28,861,849
Ensembl chr17:28,746,469...28,861,750 		JBrowse link
G Mms19 MMS19 homolog, cytosolic iron-sulfur assembly component involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 1:240,757,279...240,794,291
Ensembl chr 1:240,757,282...240,794,288 		JBrowse link
G Ndor1 NADPH dependent diflavin oxidoreductase 1 involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 3:8,062,629...8,070,873
Ensembl chr 3:8,062,630...8,070,860 		JBrowse link
G Nfs1 NFS1 cysteine desulfurase involved_in IBA
ISO
IEA		 GO_REF:0000033
(PMID:16847322)
GO_REF:0000107
GO_REF:0000117		 GO_Central
RGD
Ensembl
UniProt		 PMID:16847322 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr 3:144,637,309...144,659,660
Ensembl chr 3:144,637,309...144,659,666 		JBrowse link
G Nfu1 NFU1 iron-sulfur cluster scaffold involved_in ISO
IEA		 (PMID:12886008), (PMID:28906594)
GO_REF:0000107
GO_REF:0000002		 RGD
Ensembl
InterPro		 PMID:12886008 PMID:28906594 GO_REF:0000002 GO_REF:0000107 NCBI chr 4:119,458,981...119,480,162
Ensembl chr 4:119,459,061...119,480,373 		JBrowse link
G Nubp1 NUBP iron-sulfur cluster assembly factor 1 involved_in ISO
IEA
IBA
ISS		 (PMID:18573874)
GO_REF:0000107
GO_REF:0000104
GO_REF:0000002
GO_REF:0000033
GO_REF:0000024		 RGD
Ensembl
UniProt
InterPro
GO_Central		 PMID:18573874 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 NCBI chr10:5,259,328...5,270,848 JBrowse link
G Nubp2 NUBP iron-sulfur cluster assembly factor 2 involved_in IEA
IBA		 GO_REF:0000002
GO_REF:0000104
GO_REF:0000033		 InterPro
UniProt
GO_Central		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 NCBI chr10:13,903,224...13,906,928
Ensembl chr10:13,903,224...13,906,969 		JBrowse link
G Nubpl NUBP iron-sulfur cluster assembly factor like involved_in IBA
IEA		 GO_REF:0000033
GO_REF:0000002		 GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000033 NCBI chr 6:69,559,278...69,781,254
Ensembl chr 6:69,559,291...69,781,253 		JBrowse link
G Tst thiosulfate sulfurtransferase NAS RGD PMID:2018478 RGD:729953 NCBI chr 7:109,948,061...109,955,378
Ensembl chr 7:109,948,062...109,957,216 		JBrowse link
G Xdh xanthine dehydrogenase acts_upstream_of_or_within ISO
IEA		 (PMID:17597094)
GO_REF:0000107		 RGD
Ensembl		 PMID:17597094 GO_REF:0000107 NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
[2Fe-2S] cluster assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bola2 bolA family member 2 involved_in ISO (PMID:27519415) RGD PMID:27519415 NCBI chr 1:181,291,967...181,292,833
Ensembl chr 1:181,291,398...181,292,676 		JBrowse link
G Fdx2 ferredoxin 2 involved_in IEA
ISO		 GO_REF:0000107
(PMID:28001042), (PMID:38627381)		 Ensembl
RGD		 PMID:28001042 PMID:38627381 GO_REF:0000107 NCBI chr 8:19,604,916...19,609,832
Ensembl chr 8:19,604,916...19,609,849 		JBrowse link
G Fxn frataxin involved_in ISS
ISO		 GO_REF:0000024
(PMID:24971490), (PMID:29491838), (PMID:29576242), (PMID:38627381)		 UniProt
RGD		 PMID:24971490 PMID:29491838 PMID:29576242 PMID:38627381 GO_REF:0000024 NCBI chr 1:221,874,007...221,897,543
Ensembl chr 1:221,872,420...221,897,540 		JBrowse link
G Glrx3 glutaredoxin 3 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:27519415)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:27519415 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:192,241,707...192,272,012
Ensembl chr 1:192,241,701...192,272,010 		JBrowse link
G Glrx5 glutaredoxin 5 involved_in ISO
IEA		 UniProtKB:Q02784 (PMID:23615440)
GO_REF:0000107		 RGD
Ensembl		 PMID:23615440 GO_REF:0000107 NCBI chr 6:123,988,461...123,998,545
Ensembl chr 6:123,988,134...123,998,545 		JBrowse link
G Hscb HscB mitochondrial iron-sulfur cluster co-chaperone involved_in IBA
IEA		 GO_REF:0000033
GO_REF:0000002		 GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000033 NCBI chr12:45,821,527...45,831,902
Ensembl chr12:45,821,555...45,831,909 		JBrowse link
G Iscu iron-sulfur cluster assembly enzyme involved_in ISO
IEA		 (PMID:29576242)
(PMID:23940031), (PMID:24971490), (PMID:38627381)
GO_REF:0000107		 RGD
Ensembl		 PMID:23940031 PMID:24971490 PMID:29576242 PMID:38627381 GO_REF:0000107 NCBI chr12:42,852,305...42,858,150
Ensembl chr12:42,852,305...42,858,150 		JBrowse link
G Lyrm4 LYR motif containing 4 involved_in ISO (PMID:17331979), (PMID:31664822) RGD PMID:17331979 PMID:31664822 NCBI chr17:28,746,457...28,861,849
Ensembl chr17:28,746,469...28,861,750 		JBrowse link
G Ndufab1 NADH:ubiquinone oxidoreductase subunit AB1 involved_in ISO (PMID:31664822), (PMID:38627381) RGD PMID:31664822 PMID:38627381 NCBI chr 1:186,075,933...186,091,843
Ensembl chr 1:176,644,703...176,658,099 		JBrowse link
G Nfs1 NFS1 cysteine desulfurase involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:24971490), (PMID:31664822), (PMID:38627381)
GO_REF:0000002
GO_REF:0000024		 Ensembl
RGD
InterPro
UniProt		 PMID:24971490 PMID:31664822 PMID:38627381 GO_REF:0000002 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:144,637,309...144,659,660
Ensembl chr 3:144,637,309...144,659,666 		JBrowse link
[4Fe-4S] cluster assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fdx2 ferredoxin 2 acts_upstream_of ISO
IEA		 (PMID:28001042)
GO_REF:0000107		 RGD
Ensembl		 PMID:28001042 GO_REF:0000107 NCBI chr 8:19,604,916...19,609,832
Ensembl chr 8:19,604,916...19,609,849 		JBrowse link
G Fxn frataxin acts_upstream_of
involved_in		 ISO
ISS		 (PMID:29576242)
(PMID:25597503)
GO_REF:0000024		 RGD
UniProt		 PMID:25597503 PMID:29576242 GO_REF:0000024 NCBI chr 1:221,874,007...221,897,543
Ensembl chr 1:221,872,420...221,897,540 		JBrowse link
G Iscu iron-sulfur cluster assembly enzyme acts_upstream_of_positive_effect
involved_in		 ISO
IEA		 (PMID:29309586)
GO_REF:0000107
(PMID:25597503)
(PMID:23940031)
(PMID:16527810)
(PMID:29576242)		 RGD
Ensembl		 PMID:16527810 PMID:23940031 PMID:25597503 PMID:29309586 PMID:29576242 GO_REF:0000107 NCBI chr12:42,852,305...42,858,150
Ensembl chr12:42,852,305...42,858,150 		JBrowse link
G Lyrm4 LYR motif containing 4 acts_upstream_of ISO (PMID:25597503) RGD PMID:25597503 NCBI chr17:28,746,457...28,861,849
Ensembl chr17:28,746,469...28,861,750 		JBrowse link
G Nfs1 NFS1 cysteine desulfurase involved_in
acts_upstream_of		 IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:16527810)
(PMID:25597503)		 Ensembl
UniProt
RGD		 PMID:16527810 PMID:25597503 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:144,637,309...144,659,660
Ensembl chr 3:144,637,309...144,659,666 		JBrowse link
iron incorporation into metallo-sulfur cluster term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nfs1 NFS1 cysteine desulfurase involved_in ISO (PMID:16847322) RGD PMID:16847322 NCBI chr 3:144,637,309...144,659,660
Ensembl chr 3:144,637,309...144,659,666 		JBrowse link
positive regulation of iron-sulfur cluster assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb7 ATP binding cassette subfamily B member 7 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:17192393)
(PMID:16467350)		 UniProt
Ensembl
RGD		 PMID:16467350 PMID:17192393 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:69,295,598...69,436,775
Ensembl chr  X:69,295,552...69,436,858 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    cellular process 19550
      cellular component organization or biogenesis 7104
        cellular component biogenesis 3559
          cellular component assembly 3214
            metallo-sulfur cluster assembly 27
              iron-sulfur cluster assembly 27
                [2Fe-2S] cluster assembly + 10
                [4Fe-4S] cluster assembly + 5
                iron incorporation into metallo-sulfur cluster 1
                iron-sulfur-molybdenum cofactor assembly + 0
                molybdenum incorporation into iron-sulfur cluster 0
                negative regulation of iron-sulfur cluster assembly + 0
                nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide 0
                nitrogenase P cluster assembly 0
                positive regulation of iron-sulfur cluster assembly + 1
                regulation of iron-sulfur cluster assembly + 1
paths to the root