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ONTOLOGY REPORT - ANNOTATIONS


Term:procollagen-proline 4-dioxygenase complex
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Accession:GO:0016222 term browser browse the term
Definition:A protein complex that catalyzes the formation of procollagen trans-4-hydroxy-L-proline and succinate from procollagen L-proline and 2-oxoglutarate, requiring Fe2+ and ascorbate. Contains two alpha subunits that contribute to most parts of the catalytic sites, and two beta subunits that are identical to protein-disulfide isomerase.
Synonyms:broad_synonym: prolyl 4-hydroxylase complex
 related_synonym: procollagen-proline, 2-oxoglutarate-4-dioxygenase complex


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procollagen-proline 4-dioxygenase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P4ha1 prolyl 4-hydroxylase subunit alpha 1 part_of ISO (MGI:72931|PMID:7753822) RGD PMID:7753822 MGI:72931 NCBI chr20:27,302,046...27,352,098 JBrowse link
G P4ha2 prolyl 4-hydroxylase subunit alpha 2 part_of ISO (MGI:72931|PMID:7753822) RGD PMID:7753822 MGI:72931 NCBI chr10:38,243,047...38,271,989 JBrowse link
G P4ha3 prolyl 4-hydroxylase subunit alpha 3 TAS RGD PMID:14500733 RGD:731224 NCBI chr 1:154,628,723...154,663,779 JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta part_of ISO (PMID:7753822) RGD PMID:7753822 NCBI chr10:105,836,972...105,848,583 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20002
    protein-containing complex 6008
      endoplasmic reticulum protein-containing complex 139
        procollagen-proline 4-dioxygenase complex 4
          procollagen-proline 4-dioxygenase complex, alpha(I) type 0
          procollagen-proline 4-dioxygenase complex, alpha(II) type 0
          procollagen-proline 4-dioxygenase complex, alpha(III) type 0
Path 2
Term Annotations click to browse term
  cellular_component 20002
    cellular anatomical entity 19706
      organelle 13083
        membrane-bounded organelle 11649
          intracellular membrane-bounded organelle 11182
            endoplasmic reticulum 1753
              endoplasmic reticulum protein-containing complex 139
                procollagen-proline 4-dioxygenase complex 4
                  procollagen-proline 4-dioxygenase complex, alpha(I) type 0
                  procollagen-proline 4-dioxygenase complex, alpha(II) type 0
                  procollagen-proline 4-dioxygenase complex, alpha(III) type 0
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