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ONTOLOGY REPORT - ANNOTATIONS


Term:superoxide-generating NADPH oxidase activity
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Accession:GO:0016175 term browser browse the term
Definition:Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-.
Synonyms:related_synonym: cytochrome B-245
 xref: EC:1.6.3;   reactome:R-HSA-1222376 "NOX2 generates superoxide from oxygen";   reactome:R-HSA-1236967 "Alkalization of the phagosomal lumen by NOX2";   reactome:R-HSA-1497810 "Uncoupled eNOS favours the formation of superoxide";   reactome:R-HSA-5218841 "NADPH oxidase 2 generates superoxide from oxygen";   reactome:R-HSA-5668629 "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP";   reactome:R-HSA-5668718 "NOX1 complex:RAC1:GTP generates superoxide from oxygen";   reactome:R-HSA-5668731 "NOX3 complex:RAC1:GTP generates superoxide from oxygen";   reactome:R-HSA-6789092 "NOX2 generates superoxide anion from oxygen";   reactome:R-HSA-6807557 "NOX4, NOX5 reduce O2 to O2.-"


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superoxide-generating NADPH oxidase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyba cytochrome b-245 alpha chain JBrowse link 19 55,249,634 55,257,824 RGD:1624291
RGD:2317869
G Cybb cytochrome b-245 beta chain JBrowse link X 14,578,330 14,610,049 RGD:1624291
RGD:13792537
G Duox1 dual oxidase 1 JBrowse link 3 114,251,794 114,286,827 RGD:13792537
G Duox2 dual oxidase 2 JBrowse link 3 114,218,187 114,237,808 RGD:13792537
G Ncf1 neutrophil cytosolic factor 1 JBrowse link 12 25,497,104 25,506,300 RGD:1600566
RGD:1624291
RGD:1600115
RGD:1600567
G Ncf2 neutrophil cytosolic factor 2 JBrowse link 13 70,226,441 70,259,019 RGD:1624291
G Ncf4 neutrophil cytosolic factor 4 JBrowse link 7 119,481,711 119,499,426 RGD:1624291
RGD:1600115
G Nox1 NADPH oxidase 1 JBrowse link X 104,909,328 104,932,508 RGD:625378
RGD:13792537
RGD:1624291
RGD:1600115
G Nox3 NADPH oxidase 3 JBrowse link 1 44,550,994 44,615,760 RGD:1624291
RGD:13792537
G Nox4 NADPH oxidase 4 JBrowse link 1 150,796,359 150,976,186 RGD:1624291
RGD:13792537

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Term Annotations click to browse term
  molecular_function 19526
    catalytic activity 6039
      oxidoreductase activity 844
        oxidoreductase activity, acting on NAD(P)H 89
          oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 16
            superoxide-generating NADPH oxidase activity 10
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.