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ONTOLOGY REPORT - ANNOTATIONS

Term:superoxide-generating NAD(P)H oxidase activity
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Accession:GO:0016175 term browser browse the term
Definition:Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-.
Synonyms:related_synonym: cytochrome B-245
 xref: Reactome:R-HSA-9673797 "NOX1 complex:pp-DVL:RAC1:GTP generates superoxide from oxygen";   reactome:R-HSA-1222376 "NOX2 generates superoxide from oxygen";   reactome:R-HSA-1236967 "Alkalization of the phagosomal lumen by NOX2";   reactome:R-HSA-1497810 "Uncoupled eNOS favours the formation of superoxide";   reactome:R-HSA-5218841 "NADPH oxidase 2 generates superoxide from oxygen";   reactome:R-HSA-5668629 "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP";   reactome:R-HSA-5668718 "NOX1 complex:RAC1:GTP generates superoxide from oxygen";   reactome:R-HSA-5668731 "NOX3 complex:RAC1:GTP generates superoxide from oxygen";   reactome:R-HSA-6789092 "NOX2 generates superoxide anion from oxygen";   reactome:R-HSA-6807557 "NOX4, NOX5 reduce O2 to O2.-"


show annotations for term's descendants           Sort by:
superoxide-generating NAD(P)H oxidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyba cytochrome b-245 alpha chain contributes_to
enables		 ISO
IMP
IEA		 (PMID:1763037)
PMID:8798532
GO_REF:0000107		 RGD
Ensembl		 PMID:1763037 PMID:8798532 GO_REF:0000107, RGD:2317869 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Cybb cytochrome b-245 beta chain contributes_to
enables		 ISO
IBA		 (PMID:12042318)
GO_REF:0000033
(PMID:22493499)		 RGD
GO_Central		 PMID:12042318 PMID:22493499 GO_REF:0000033 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Duox1 dual oxidase 1 enables IEA
IBA		 GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 3:109,260,526...109,295,588
Ensembl chr 3:109,262,397...109,295,563 		JBrowse link
G Duox2 dual oxidase 2 enables IBA
IEA		 GO_REF:0000033
GO_REF:0000118		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 3:109,223,809...109,247,023
Ensembl chr 3:109,226,924...109,245,902 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 enables ISO (PMID:26514923) RGD PMID:26514923 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Ncf2 neutrophil cytosolic factor 2 enables
contributes_to		 IEA
ISO		 GO_REF:0000107
(PMID:9490028)		 Ensembl
RGD		 PMID:9490028 GO_REF:0000107 NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277 		JBrowse link
G Nox1 NADPH oxidase 1 enables TAS
ISO
IBA
IEA
IDA
IMP		 MGI:3616995 (MGI:7539450|PMID:16724959), (PMID:18397177)
GO_REF:0000033
GO_REF:0000118
GO_REF:0000107
PMID:10485709
PMID:25228390
(PMID:14617635), (PMID:16329988), (PMID:18023288)		 RGD
GO_Central
TreeGrafter
Ensembl		 PMID:14617635 PMID:16329988 PMID:16724959 PMID:18023288 PMID:18397177 More... GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 MGI:7539450, RGD:625378, RGD:633401, RGD:401827135 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236 		JBrowse link
G Nox3 NADPH oxidase 3 enables ISS
ISO
IBA		 GO_REF:0000024
(MGI:3512869|PMID:15326186), (MGI:3709963|PMID:17140397)
GO_REF:0000033
(PMID:15181005), (PMID:15824103)		 UniProt
RGD
GO_Central		 PMID:15181005 PMID:15326186 PMID:15824103 PMID:17140397 GO_REF:0000024 GO_REF:0000033 MGI:3512869 MGI:3709963 NCBI chr 1:44,238,012...44,302,851
Ensembl chr 1:44,236,992...44,302,851 		JBrowse link
G Nox4 NADPH oxidase 4 enables
NOT|enables		 IEA
ISO
IBA
IDA		 GO_REF:0000107
(MGI:5009390|PMID:17942966), (MGI:7539454|PMID:15638999), (PMID:11098048)
GO_REF:0000118
GO_REF:0000033
(PMID:15721269)
(PMID:10869423), (PMID:11032835), (PMID:15155719), (PMID:15927447), (PMID:16019190), (PMID:16179589), (PMID:16230378), (PMID:16324151), (PMID:25062272)
(PMID:15721269), (PMID:23393389)
PMID:16135519
PMID:15322091		 Ensembl
RGD
TreeGrafter
GO_Central		 PMID:10869423 PMID:11032835 PMID:11098048 PMID:15155719 PMID:15638999 More... GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 MGI:5009390 MGI:7539454, RGD:2324673, RGD:1580287 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
superoxide-generating NADPH oxidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nox1 NADPH oxidase 1 enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236 		JBrowse link
G Nox3 NADPH oxidase 3 enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr 1:44,238,012...44,302,851
Ensembl chr 1:44,236,992...44,302,851 		JBrowse link
G Nox4 NADPH oxidase 4 enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21010
    catalytic activity 6145
      oxidoreductase activity 871
        oxidoreductase activity, acting on NAD(P)H 57
          oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 17
            superoxide-generating NAD(P)H oxidase activity 9
              superoxide-generating NADH oxidase activity 0
              superoxide-generating NADPH oxidase activity 3
paths to the root