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ONTOLOGY REPORT - ANNOTATIONS

Term:synaptic vesicle priming
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Accession:GO:0016082 term browser browse the term
Definition:A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane.
Comment:Although this process can occur outside of synaptic transmission, by convention we treat it as a part of synaptic transmission. (dos, pvn, fk synapse project 2015)


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synaptic vesicle priming term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cadps calcium dependent secretion activator involved_in
acts_upstream_of_or_within		 ISO UniProtKB:Q8BYR5 (MGI:3773298|PMID:18022372), (MGI:5617001|PMID:25374362)
MGI:2443963 (MGI:4879076|PMID:21040848)		 RGD PMID:18022372 PMID:21040848 PMID:25374362 MGI:3773298 MGI:4879076 MGI:5617001 NCBI chr15:12,289,803...12,742,786
Ensembl chr15:12,290,262...12,742,779 		JBrowse link
G Cadps2 calcium dependent secretion activator 2 acts_upstream_of_or_within
involved_in		 ISO MGI:1350922 (MGI:4879076|PMID:21040848)
UniProtKB:Q80TJ1 (MGI:5617001|PMID:25374362), (MGI:6189303|PMID:25437547)		 RGD PMID:21040848 PMID:25374362 PMID:25437547 MGI:4879076 MGI:5617001 MGI:6189303 NCBI chr 4:51,780,415...52,309,641
Ensembl chr 4:51,781,053...52,309,829 		JBrowse link
G Erc1 ELKS/RAB6-interacting/CAST family member 1 involved_in ISO (MGI:5882646|PMID:27253063) RGD PMID:27253063 MGI:5882646 NCBI chr 4:152,763,664...153,055,706
Ensembl chr 4:152,767,419...153,055,639 		JBrowse link
G Erc2 ELKS/RAB6-interacting/CAST family member 2 involved_in ISO (MGI:4415657|PMID:19874790), (MGI:5882646|PMID:27253063) RGD PMID:19874790 PMID:27253063 MGI:4415657 MGI:5882646 NCBI chr16:2,812,712...3,673,624
Ensembl chr16:2,848,620...3,670,776 		JBrowse link
G Napa NSF attachment protein alpha involved_in ISO (MGI:4879076|PMID:21040848) RGD PMID:21040848 MGI:4879076 NCBI chr 1:76,787,036...76,805,869
Ensembl chr 1:76,786,932...76,805,869 		JBrowse link
G Otof otoferlin involved_in IBA
ISO		 PMID:21873635
(MGI:4461353|PMID:20562868)		 RGD PMID:20562868 PMID:21873635 MGI:4461353, RGD:13792537 NCBI chr 6:25,928,018...26,024,631
Ensembl chr 6:25,928,055...26,024,631 		JBrowse link
G Rims1 regulating synaptic membrane exocytosis 1 involved_in ISO (MGI:4887275|PMID:21262469), (MGI:5432438|PMID:22753485) RGD PMID:21262469 PMID:22753485 MGI:4887275 MGI:5432438 NCBI chr 9:24,696,959...25,196,368
Ensembl chr 9:24,698,854...25,196,631 		JBrowse link
G Rims2 regulating synaptic membrane exocytosis 2 involved_in ISO (MGI:4887275|PMID:21262469), (MGI:5432438|PMID:22753485) RGD PMID:21262469 PMID:22753485 MGI:4887275 MGI:5432438 NCBI chr 7:70,248,104...70,759,134
Ensembl chr 7:70,243,872...70,757,491 		JBrowse link
G Rph3a rabphilin 3A involved_in ISO
IEA		 (MGI:7316519|PMID:16763567)
GO_REF:0000107		 RGD
Ensembl		 PMID:16763567 GO_REF:0000107 MGI:7316519 NCBI chr12:35,542,389...35,618,901
Ensembl chr12:35,542,728...35,617,592 		JBrowse link
G Snap23 synaptosome associated protein 23 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:107,514,088...107,546,177
Ensembl chr 3:107,514,131...107,544,320 		JBrowse link
G Snap25 synaptosome associated protein 25 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760 		JBrowse link
G Snap29 synaptosome associated protein 29 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:83,578,479...83,608,953
Ensembl chr11:83,578,489...83,608,958 		JBrowse link
G Snap47 synaptosome associated protein 47 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:44,192,886...44,234,435
Ensembl chr10:44,191,218...44,234,424 		JBrowse link
G Snca synuclein alpha involved_in ISO (PMID:30404828) RGD PMID:30404828 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Stxbp1 syntaxin binding protein 1 involved_in ISO (MGI:3695670|PMID:17110441) RGD PMID:17110441 MGI:3695670 NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369 		JBrowse link
G Sv2a synaptic vesicle glycoprotein 2a involved_in ISO (MGI:3831988|PMID:19176798) RGD PMID:19176798 MGI:3831988 NCBI chr 2:183,741,455...183,757,290
Ensembl chr 2:183,741,547...183,756,927 		JBrowse link
G Synj1 synaptojanin 1 acts_upstream_of_or_within ISO MGI:2179801 (MGI:2447947|PMID:12481038) RGD PMID:12481038 MGI:2447947 NCBI chr11:30,192,629...30,269,277
Ensembl chr11:30,192,629...30,269,220 		JBrowse link
G Unc13a unc-13 homolog A involved_in IDA
IBA
ISO		 PMID:21873635
UniProtKB:Q9Z1N9 (MGI:2158113|PMID:11832228), (MGI:5617001|PMID:25374362)		 RGD PMID:11832228 PMID:25374362 PMID:21499244 PMID:21873635 MGI:2158113 MGI:5617001, RGD:5686389, RGD:13792537 NCBI chr16:18,336,229...18,381,811
Ensembl chr16:18,336,229...18,381,872 		JBrowse link
G Unc13b unc-13 homolog B involved_in
acts_upstream_of_or_within		 ISS
IMP
IBA
ISO		 GO_REF:0000024
PMID:22966208
PMID:21873635
MGI:2449706 (MGI:2181453|PMID:12070347)
UniProtKB:Q4KUS2 (MGI:2158113|PMID:11832228), (MGI:5617001|PMID:25374362)		 ParkinsonsUK-UCL
RGD		 PMID:11832228 PMID:12070347 PMID:25374362 PMID:22966208 PMID:21873635 GO_REF:0000024 MGI:2158113 MGI:2181453 MGI:5617001, RGD:11535109, RGD:13792537 NCBI chr 5:57,288,999...57,504,110
Ensembl chr 5:57,289,227...57,502,926 		JBrowse link
G Unc13c unc-13 homolog C involved_in IMP
IBA		 PMID:22966208
PMID:21873635		 ParkinsonsUK-UCL
GO_Central		 PMID:22966208 PMID:21873635 RGD:11535109, RGD:13792537 NCBI chr 8:74,247,026...74,697,629
Ensembl chr 8:74,247,899...74,673,223 		JBrowse link
G Vamp1 vesicle-associated membrane protein 1 involved_in ISO (MGI:6189249|PMID:24944211) RGD PMID:24944211 MGI:6189249 NCBI chr 4:158,012,634...158,019,350
Ensembl chr 4:158,012,663...158,019,349 		JBrowse link
positive regulation of synaptic vesicle priming term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rims1 regulating synaptic membrane exocytosis 1 involved_in IGI PMID:21262469 ParkinsonsUK-UCL PMID:21262469 RGD:10047275 NCBI chr 9:24,696,959...25,196,368
Ensembl chr 9:24,698,854...25,196,631 		JBrowse link
G Unc13b unc-13 homolog B involved_in IGI PMID:21262469 ParkinsonsUK-UCL PMID:21262469 PMID:21262469 RGD:10047275, RGD:10047275 NCBI chr 5:57,288,999...57,504,110
Ensembl chr 5:57,289,227...57,502,926 		JBrowse link
regulation of synaptic vesicle priming term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Napa NSF attachment protein alpha involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
MGI:104562 (MGI:4879076|PMID:21040848)		 RGD PMID:21040848 PMID:21873635 MGI:4879076, RGD:13792537 NCBI chr 1:76,787,036...76,805,869
Ensembl chr 1:76,786,932...76,805,869 		JBrowse link
G Napb NSF attachment protein beta involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000107
MGI:104563 (MGI:4879076|PMID:21040848)
PMID:21873635		 Ensembl
RGD		 PMID:21040848 PMID:21873635 GO_REF:0000107 MGI:4879076, RGD:13792537 NCBI chr 3:136,132,248...136,179,225
Ensembl chr 3:136,133,428...136,179,345 		JBrowse link
G Rab3a RAB3A, member RAS oncogene family involved_in IDA PMID:21689256 UniProt PMID:21689256 RGD:14390056 NCBI chr16:18,684,185...18,688,297
Ensembl chr16:18,684,188...18,688,336 		JBrowse link
G Stx1a syntaxin 1A involved_in ISO UniProtKB:O35526|UniProtKB:P61264 (MGI:5521403|PMID:24133272) RGD PMID:24133272 MGI:5521403 NCBI chr12:21,641,971...21,670,022
Ensembl chr12:21,641,969...21,669,930 		JBrowse link
G Stx1b syntaxin 1B involved_in ISS
ISO		 GO_REF:0000024
UniProtKB:O35526 (MGI:5521403|PMID:24133272)		 ParkinsonsUK-UCL
RGD		 PMID:24133272 GO_REF:0000024 MGI:5521403 NCBI chr 1:182,415,544...182,434,385
Ensembl chr 1:182,415,546...182,441,280 		JBrowse link
G Stxbp1 syntaxin binding protein 1 involved_in IMP
IDA		 PMID:21689256 RGD
UniProt		 PMID:19255244 PMID:21689256 RGD:2311128, RGD:14390056 NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369 		JBrowse link
G Stxbp5 syntaxin binding protein 5 involved_in ISO (MGI:3814264|PMID:18936251) RGD PMID:18936251 MGI:3814264 NCBI chr 1:4,182,489...4,335,271
Ensembl chr 1:4,185,529...4,335,101 		JBrowse link
G Unc13a unc-13 homolog A involved_in IDA PMID:21689256 UniProt PMID:21689256 RGD:14390056 NCBI chr16:18,336,229...18,381,811
Ensembl chr16:18,336,229...18,381,872 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19748
    cellular process 18161
      exocytic process 101
        synaptic vesicle priming 26
          negative regulation of synaptic vesicle priming 0
          positive regulation of synaptic vesicle priming 2
          regulation of synaptic vesicle priming + 10
Path 2
Term Annotations click to browse term
  biological_process 19748
    biological regulation 13456
      regulation of biological process 13044
        signaling 7559
          cell-cell signaling 1805
            synaptic signaling 961
              trans-synaptic signaling 926
                anterograde trans-synaptic signaling 919
                  chemical synaptic transmission 919
                    neurotransmitter secretion 186
                      synaptic vesicle exocytosis 126
                        synaptic vesicle priming 26
                          negative regulation of synaptic vesicle priming 0
                          positive regulation of synaptic vesicle priming 2
                          regulation of synaptic vesicle priming + 10
paths to the root