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ONTOLOGY REPORT - ANNOTATIONS

Term:synaptic vesicle priming
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Accession:GO:0016082 term browser browse the term
Definition:A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane.
Comment:Although this process can occur outside of synaptic transmission, by convention we treat it as a part of synaptic transmission. (dos, pvn, fk synapse project 2015)

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synaptic vesicle priming term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07053516.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 Ensembl chr 3:112,346,627...112,361,216 JBrowse link
G Cadps calcium dependent secretion activator acts_upstream_of_or_within
involved_in		 IEA
ISO		 GO_REF:0000107
MGI:2443963 (MGI:4879076|PMID:21040848)
UniProtKB:Q8BYR5 (MGI:3773298|PMID:18022372), (MGI:5617001|PMID:25374362)
MGI:2443963|UniProtKB:Q8BYR5 (MGI:3773298|PMID:18022372), (MGI:4879076|PMID:21040848), (MGI:5617001|PMID:25374362)		 Ensembl
RGD		 PMID:18022372 PMID:21040848 PMID:25374362 GO_REF:0000107 MGI:3773298 MGI:4879076 MGI:5617001 NCBI chr15:15,275,489...15,690,575
Ensembl chr15:15,275,541...15,667,778 		JBrowse link
G Cadps2 calcium dependent secretion activator 2 involved_in
acts_upstream_of_or_within		 ISO MGI:1350922|UniProtKB:Q80TJ1 (MGI:4879076|PMID:21040848), (MGI:5617001|PMID:25374362), (MGI:6189303|PMID:25437547)
UniProtKB:Q80TJ1 (MGI:5617001|PMID:25374362), (MGI:6189303|PMID:25437547)
MGI:1350922 (MGI:4879076|PMID:21040848)		 RGD PMID:21040848 PMID:25374362 PMID:25437547 MGI:4879076 MGI:5617001 MGI:6189303 NCBI chr 4:50,326,447...50,861,161
Ensembl chr 4:50,326,442...50,860,756 		JBrowse link
G Erc1 ELKS/RAB6-interacting/CAST family member 1 involved_in ISO (MGI:5882646|PMID:27253063) RGD PMID:27253063 MGI:5882646 NCBI chr 4:152,087,393...152,380,023
Ensembl chr 4:152,087,379...152,380,184 		JBrowse link
G Erc2 ELKS/RAB6-interacting/CAST family member 2 involved_in ISO (MGI:4415657|PMID:19874790) RGD PMID:19874790 MGI:4415657 NCBI chr16:3,258,580...4,283,592
Ensembl chr16:3,293,599...3,679,222 		JBrowse link
G Napa NSF attachment protein alpha involved_in ISO (MGI:4879076|PMID:21040848) RGD PMID:21040848 MGI:4879076 NCBI chr 1:77,994,227...78,012,846
Ensembl chr 1:77,994,203...78,012,845 		JBrowse link
G Otof otoferlin involved_in ISO
IBA		 (MGI:4461353|PMID:20562868)
PMID:21873635		 RGD PMID:20562868, PMID:21873635, PMID:21873635 MGI:4461353, RGD:13792537, RGD:13792537 NCBI chr 6:27,328,343...27,424,864
Ensembl chr 6:27,328,406...27,424,864 		JBrowse link
G Rims1 regulating synaptic membrane exocytosis 1 involved_in ISO (MGI:4887275|PMID:21262469), (MGI:5432438|PMID:22753485) RGD PMID:21262469 PMID:22753485 MGI:4887275 MGI:5432438 NCBI chr 9:28,440,408...28,973,246
Ensembl chr 9:28,442,229...28,973,246 		JBrowse link
G Rims2 regulating synaptic membrane exocytosis 2 involved_in ISO (MGI:5432438|PMID:22753485) RGD PMID:22753485 MGI:5432438 NCBI chr 7:78,091,998...78,594,164
Ensembl chr 7:78,092,037...78,594,138 		JBrowse link
G Snap23 synaptosome associated protein 23 involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr 3:112,333,972...112,362,960 JBrowse link
G Snap25 synaptosome associated protein 25 involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr 3:129,697,408...129,788,417
Ensembl chr 3:129,599,353...129,788,400 		JBrowse link
G Snap29 synaptosome associated protein 29 involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr11:87,827,633...87,858,107
Ensembl chr11:87,827,651...87,858,107 		JBrowse link
G Snap47 synaptosome associated protein 47 involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr10:45,757,196...45,798,734
Ensembl chr10:45,757,197...45,798,715 		JBrowse link
G Snca synuclein alpha involved_in ISO (PMID:30404828) RGD PMID:30404828 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285 		JBrowse link
G Stxbp1 syntaxin binding protein 1 involved_in ISO (MGI:3695670|PMID:17110441) RGD PMID:17110441 MGI:3695670 NCBI chr 3:11,823,779...11,885,479
Ensembl chr 3:11,823,785...11,885,417 		JBrowse link
G Sv2a synaptic vesicle glycoprotein 2a involved_in ISO (MGI:3831988|PMID:19176798) RGD PMID:19176798 MGI:3831988 NCBI chr 2:198,321,100...198,336,889
Ensembl chr 2:198,321,142...198,336,913 		JBrowse link
G Synj1 synaptojanin 1 acts_upstream_of_or_within ISO MGI:2179801 (MGI:2447947|PMID:12481038) RGD PMID:12481038 MGI:2447947 NCBI chr11:31,105,784...31,181,573
Ensembl chr11:31,104,787...31,180,642 		JBrowse link
G Unc13a unc-13 homolog A involved_in IDA
ISO
IEA
IBA		 UniProtKB:Q9Z1N9 (MGI:2158113|PMID:11832228), (MGI:5617001|PMID:25374362)
GO_REF:0000002
PMID:21873635		 RGD
InterPro		 PMID:11832228 PMID:25374362, PMID:21499244, PMID:21873635, PMID:21873635 GO_REF:0000002 MGI:2158113 MGI:5617001, RGD:5686389, RGD:13792537, RGD:13792537 NCBI chr16:20,056,398...20,103,951
Ensembl chr16:20,056,765...20,097,287 		JBrowse link
G Unc13b unc-13 homolog B involved_in
acts_upstream_of_or_within		 IMP
ISO
IBA
ISS		 PMID:22966208
UniProtKB:Q4KUS2 (MGI:2158113|PMID:11832228), (MGI:5617001|PMID:25374362)
MGI:2449706 (MGI:2181453|PMID:12070347)
PMID:21873635
GO_REF:0000024
MGI:2449706|UniProtKB:Q4KUS2 (MGI:2158113|PMID:11832228), (MGI:2181453|PMID:12070347), (MGI:5617001|PMID:25374362)		 RGD
ParkinsonsUK-UCL		 PMID:11832228 PMID:12070347 PMID:25374362, PMID:22966208, PMID:21873635, PMID:22966208, PMID:21873635 GO_REF:0000024 MGI:2158113 MGI:2181453 MGI:5617001, RGD:11535109, RGD:13792537, RGD:11535109, RGD:13792537 NCBI chr 5:58,505,449...58,714,396
Ensembl chr 5:58,505,500...58,715,576 		JBrowse link
G Unc13c unc-13 homolog C involved_in IMP
IBA		 PMID:22966208
PMID:21873635		 ParkinsonsUK-UCL
GO_Central		 PMID:22966208, PMID:21873635, PMID:22966208, PMID:21873635 RGD:11535109, RGD:13792537, RGD:11535109, RGD:13792537 NCBI chr 8:80,202,736...80,656,363
Ensembl chr 8:80,203,609...80,631,926 		JBrowse link
positive regulation of synaptic vesicle priming term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rims1 regulating synaptic membrane exocytosis 1 involved_in IGI PMID:21262469 ParkinsonsUK-UCL PMID:21262469, PMID:21262469 RGD:10047275, RGD:10047275 NCBI chr 9:28,440,408...28,973,246
Ensembl chr 9:28,442,229...28,973,246 		JBrowse link
G Unc13b unc-13 homolog B involved_in IGI PMID:21262469 ParkinsonsUK-UCL PMID:21262469, PMID:21262469, PMID:21262469, PMID:21262469 RGD:10047275, RGD:10047275, RGD:10047275, RGD:10047275 NCBI chr 5:58,505,449...58,714,396
Ensembl chr 5:58,505,500...58,715,576 		JBrowse link
regulation of synaptic vesicle priming term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Napa NSF attachment protein alpha acts_upstream_of_or_within
involved_in		 ISO
IBA		 MGI:104562 (MGI:4879076|PMID:21040848)
PMID:21873635		 RGD PMID:21040848, PMID:21873635, PMID:21873635 MGI:4879076, RGD:13792537, RGD:13792537 NCBI chr 1:77,994,227...78,012,846
Ensembl chr 1:77,994,203...78,012,845 		JBrowse link
G Napb NSF attachment protein beta acts_upstream_of_or_within
involved_in		 IEA
ISO
IBA		 GO_REF:0000107
MGI:104563 (MGI:4879076|PMID:21040848)
PMID:21873635		 Ensembl
RGD		 PMID:21040848, PMID:21873635, PMID:21873635 GO_REF:0000107 MGI:4879076, RGD:13792537, RGD:13792537 NCBI chr 3:143,017,571...143,063,904
Ensembl chr 3:143,020,454...143,063,983 		JBrowse link
G Rab3a RAB3A, member RAS oncogene family involved_in IDA PMID:21689256 UniProt PMID:21689256, PMID:21689256 RGD:14390056, RGD:14390056 NCBI chr16:20,435,098...20,439,206
Ensembl chr16:20,435,101...20,439,206 		JBrowse link
G Stx1a syntaxin 1A involved_in ISO UniProtKB:O35526|UniProtKB:P61264 (MGI:5521403|PMID:24133272) RGD PMID:24133272 MGI:5521403 NCBI chr12:24,682,050...24,710,002
Ensembl chr12:24,682,041...24,710,019 		JBrowse link
G Stx1b syntaxin 1B involved_in ISS
ISO		 GO_REF:0000024
UniProtKB:O35526 (MGI:5521403|PMID:24133272)		 ParkinsonsUK-UCL
RGD		 PMID:24133272 GO_REF:0000024 MGI:5521403 NCBI chr 1:199,251,842...199,270,465
Ensembl chr 1:199,251,844...199,270,627 		JBrowse link
G Stxbp1 syntaxin binding protein 1 involved_in IMP
IDA		 PMID:21689256 RGD
UniProt		 PMID:19255244, PMID:21689256, PMID:21689256 RGD:2311128, RGD:14390056, RGD:14390056 NCBI chr 3:11,823,779...11,885,479
Ensembl chr 3:11,823,785...11,885,417 		JBrowse link
G Stxbp5 syntaxin binding protein 5 involved_in ISO (MGI:3814264|PMID:18936251) RGD PMID:18936251 MGI:3814264 NCBI chr 1:3,858,917...4,011,684
Ensembl chr 1:3,858,909...4,011,511 		JBrowse link
G Unc13a unc-13 homolog A involved_in IDA PMID:21689256 UniProt PMID:21689256, PMID:21689256 RGD:14390056, RGD:14390056 NCBI chr16:20,056,398...20,103,951
Ensembl chr16:20,056,765...20,097,287 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20082
    cellular process 18900
      exocytic process 99
        synaptic vesicle priming 25
          negative regulation of synaptic vesicle priming 0
          positive regulation of synaptic vesicle priming 2
          regulation of synaptic vesicle priming + 10
Path 2
Term Annotations click to browse term
  biological_process 20082
    localization 6506
      establishment of localization 4918
        transport 4755
          export from cell 1018
            secretion by cell 967
              signal release 621
                signal release from synapse 208
                  neurotransmitter secretion 208
                    synaptic vesicle exocytosis 155
                      synaptic vesicle priming 25
                        negative regulation of synaptic vesicle priming 0
                        positive regulation of synaptic vesicle priming 2
                        regulation of synaptic vesicle priming + 10
paths to the root