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ONTOLOGY REPORT - ANNOTATIONS


Term:synaptic vesicle priming
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Accession:GO:0016082 term browser browse the term
Definition:A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane.
Comment:Although this process can occur outside of synaptic transmission, by convention we treat it as a part of synaptic transmission. (dos, pvn, fk synapse project 2015)



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synaptic vesicle priming term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07053516.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Cadps calcium dependent secretion activator involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2443963 (MGI:4879076|PMID:21040848)
UniProtKB:Q8BYR5 (MGI:3773298|PMID:18022372), (MGI:5617001|PMID:25374362)
Ensembl
RGD
PMID:18022372 PMID:21040848 PMID:25374362 GO_REF:0000107 MGI:3773298 MGI:4879076 MGI:5617001 NCBI chr15:12,289,803...12,742,786
Ensembl chr15:12,290,262...12,742,779
JBrowse link
G Cadps2 calcium dependent secretion activator 2 acts_upstream_of_or_within
involved_in
ISO MGI:1350922 (MGI:4879076|PMID:21040848)
UniProtKB:Q80TJ1 (MGI:5617001|PMID:25374362), (MGI:6189303|PMID:25437547)
RGD PMID:21040848 PMID:25374362 PMID:25437547 MGI:4879076 MGI:5617001 MGI:6189303 NCBI chr 4:51,780,415...52,309,641
Ensembl chr 4:51,781,053...52,309,829
JBrowse link
G Erc1 ELKS/RAB6-interacting/CAST family member 1 involved_in ISO (MGI:5882646|PMID:27253063) RGD PMID:27253063 MGI:5882646 NCBI chr 4:152,763,664...153,055,706
Ensembl chr 4:152,767,419...153,055,639
JBrowse link
G Erc2 ELKS/RAB6-interacting/CAST family member 2 involved_in ISO (MGI:4415657|PMID:19874790) RGD PMID:19874790 MGI:4415657 NCBI chr16:2,812,712...3,673,624
Ensembl chr16:2,848,620...3,670,776
JBrowse link
G Napa NSF attachment protein alpha involved_in ISO (MGI:4879076|PMID:21040848) RGD PMID:21040848 MGI:4879076 NCBI chr 1:76,787,036...76,805,869
Ensembl chr 1:76,786,932...76,805,869
JBrowse link
G Otof otoferlin involved_in IBA
ISO
PMID:21873635
(MGI:4461353|PMID:20562868)
RGD PMID:20562868 PMID:21873635 MGI:4461353, RGD:13792537 NCBI chr 6:25,928,018...26,024,631
Ensembl chr 6:25,928,055...26,024,631
JBrowse link
G Rims1 regulating synaptic membrane exocytosis 1 involved_in ISO (MGI:4887275|PMID:21262469), (MGI:5432438|PMID:22753485) RGD PMID:21262469 PMID:22753485 MGI:4887275 MGI:5432438 NCBI chr 9:24,696,959...25,196,368
Ensembl chr 9:24,698,854...25,196,631
JBrowse link
G Rims2 regulating synaptic membrane exocytosis 2 involved_in ISO (MGI:5432438|PMID:22753485) RGD PMID:22753485 MGI:5432438 NCBI chr 7:70,248,104...70,759,134
Ensembl chr 7:70,243,872...70,757,491
JBrowse link
G Snap23 synaptosome associated protein 23 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:107,514,088...107,546,177 JBrowse link
G Snap25 synaptosome associated protein 25 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760
JBrowse link
G Snap29 synaptosome associated protein 29 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:83,578,479...83,608,953
Ensembl chr11:83,578,489...83,608,958
JBrowse link
G Snap47 synaptosome associated protein 47 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:44,192,886...44,234,435
Ensembl chr10:44,191,218...44,234,424
JBrowse link
G Snca synuclein alpha involved_in ISO (PMID:30404828) RGD PMID:30404828 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
G Stxbp1 syntaxin binding protein 1 involved_in ISO (MGI:3695670|PMID:17110441) RGD PMID:17110441 MGI:3695670 NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369
JBrowse link
G Sv2a synaptic vesicle glycoprotein 2a involved_in ISO (MGI:3831988|PMID:19176798) RGD PMID:19176798 MGI:3831988 NCBI chr 2:183,741,455...183,757,290
Ensembl chr 2:183,741,547...183,756,927
JBrowse link
G Synj1 synaptojanin 1 acts_upstream_of_or_within ISO MGI:2179801 (MGI:2447947|PMID:12481038) RGD PMID:12481038 MGI:2447947 NCBI chr11:30,192,629...30,269,277
Ensembl chr11:30,192,629...30,269,220
JBrowse link
G Unc13a unc-13 homolog A involved_in IDA
ISO
IEA
IBA
UniProtKB:Q9Z1N9 (MGI:2158113|PMID:11832228), (MGI:5617001|PMID:25374362)
GO_REF:0000002
PMID:21873635
RGD
InterPro
PMID:11832228 PMID:25374362 PMID:21499244 PMID:21873635 GO_REF:0000002 MGI:2158113 MGI:5617001, RGD:5686389, RGD:13792537 NCBI chr16:18,336,229...18,381,811
Ensembl chr16:18,336,229...18,381,872
JBrowse link
G Unc13b unc-13 homolog B involved_in
acts_upstream_of_or_within
ISS
ISO
IBA
IMP
GO_REF:0000024
UniProtKB:Q4KUS2 (MGI:2158113|PMID:11832228), (MGI:5617001|PMID:25374362)
MGI:2449706 (MGI:2181453|PMID:12070347)
PMID:21873635
PMID:22966208
ParkinsonsUK-UCL
RGD
PMID:11832228 PMID:12070347 PMID:25374362 PMID:21873635 PMID:22966208 GO_REF:0000024 MGI:2158113 MGI:2181453 MGI:5617001, RGD:13792537, RGD:11535109 NCBI chr 5:57,288,999...57,504,110
Ensembl chr 5:57,289,227...57,502,926
JBrowse link
G Unc13c unc-13 homolog C involved_in IMP
IBA
PMID:22966208
PMID:21873635
ParkinsonsUK-UCL
GO_Central
PMID:22966208 PMID:21873635 RGD:11535109, RGD:13792537 NCBI chr 8:74,247,026...74,697,629
Ensembl chr 8:74,247,899...74,673,223
JBrowse link
positive regulation of synaptic vesicle priming term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rims1 regulating synaptic membrane exocytosis 1 involved_in IGI PMID:21262469 ParkinsonsUK-UCL PMID:21262469 RGD:10047275 NCBI chr 9:24,696,959...25,196,368
Ensembl chr 9:24,698,854...25,196,631
JBrowse link
G Unc13b unc-13 homolog B involved_in IGI PMID:21262469 ParkinsonsUK-UCL PMID:21262469 PMID:21262469 RGD:10047275, RGD:10047275 NCBI chr 5:57,288,999...57,504,110
Ensembl chr 5:57,289,227...57,502,926
JBrowse link
regulation of synaptic vesicle priming term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Napa NSF attachment protein alpha involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:104562 (MGI:4879076|PMID:21040848)
RGD PMID:21040848 PMID:21873635 MGI:4879076, RGD:13792537 NCBI chr 1:76,787,036...76,805,869
Ensembl chr 1:76,786,932...76,805,869
JBrowse link
G Napb NSF attachment protein beta involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
GO_REF:0000107
MGI:104563 (MGI:4879076|PMID:21040848)
PMID:21873635
Ensembl
RGD
PMID:21040848 PMID:21873635 GO_REF:0000107 MGI:4879076, RGD:13792537 NCBI chr 3:136,132,248...136,179,225
Ensembl chr 3:136,133,428...136,179,345
JBrowse link
G Rab3a RAB3A, member RAS oncogene family involved_in IDA PMID:21689256 UniProt PMID:21689256 RGD:14390056 NCBI chr16:18,684,185...18,688,297
Ensembl chr16:18,684,188...18,688,336
JBrowse link
G Stx1a syntaxin 1A involved_in ISO UniProtKB:O35526|UniProtKB:P61264 (MGI:5521403|PMID:24133272) RGD PMID:24133272 MGI:5521403 NCBI chr12:21,641,971...21,670,022
Ensembl chr12:21,641,969...21,669,930
JBrowse link
G Stx1b syntaxin 1B involved_in ISS
ISO
GO_REF:0000024
UniProtKB:O35526 (MGI:5521403|PMID:24133272)
ParkinsonsUK-UCL
RGD
PMID:24133272 GO_REF:0000024 MGI:5521403 NCBI chr 1:182,415,544...182,434,385
Ensembl chr 1:182,415,546...182,441,280
JBrowse link
G Stxbp1 syntaxin binding protein 1 involved_in IMP
IDA
PMID:21689256 RGD
UniProt
PMID:19255244 PMID:21689256 RGD:2311128, RGD:14390056 NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369
JBrowse link
G Stxbp5 syntaxin binding protein 5 involved_in ISO (MGI:3814264|PMID:18936251) RGD PMID:18936251 MGI:3814264 NCBI chr 1:4,182,489...4,335,271
Ensembl chr 1:4,185,529...4,335,101
JBrowse link
G Unc13a unc-13 homolog A involved_in IDA PMID:21689256 UniProt PMID:21689256 RGD:14390056 NCBI chr16:18,336,229...18,381,811
Ensembl chr16:18,336,229...18,381,872
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19497
    cellular process 18359
      exocytic process 95
        synaptic vesicle priming 25
          negative regulation of synaptic vesicle priming 0
          positive regulation of synaptic vesicle priming 2
          regulation of synaptic vesicle priming + 10
Path 2
Term Annotations click to browse term
  biological_process 19497
    localization 6488
      establishment of localization 4887
        transport 4725
          export from cell 1020
            secretion by cell 966
              signal release 624
                signal release from synapse 206
                  neurotransmitter secretion 206
                    synaptic vesicle exocytosis 154
                      synaptic vesicle priming 25
                        negative regulation of synaptic vesicle priming 0
                        positive regulation of synaptic vesicle priming 2
                        regulation of synaptic vesicle priming + 10
paths to the root