ONTOLOGY REPORT - ANNOTATIONS
Term: synaptic vesicle priming
Accession: GO:0016082
browse the term
Definition: A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane.
Comment: Although this process can occur outside of synaptic transmission, by convention we treat it as a part of synaptic transmission. (dos, pvn, fk synapse project 2015)
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Cadps
calcium dependent secretion activator
involved_in acts_upstream_of_or_within
ISO
UniProtKB:Q8BYR5 (MGI:3773298|PMID:18022372), (MGI:5617001|PMID:25374362) MGI:2443963 (MGI:4879076|PMID:21040848)
RGD
PMID:18022372 PMID:21040848 PMID:25374362
MGI:3773298 MGI:4879076 MGI:5617001
NCBI chr15:12,289,803...12,742,786
Ensembl chr15:12,290,262...12,742,779
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Cadps2
calcium dependent secretion activator 2
acts_upstream_of_or_within involved_in
ISO
MGI:1350922 (MGI:4879076|PMID:21040848) UniProtKB:Q80TJ1 (MGI:5617001|PMID:25374362), (MGI:6189303|PMID:25437547)
RGD
PMID:21040848 PMID:25374362 PMID:25437547
MGI:4879076 MGI:5617001 MGI:6189303
NCBI chr 4:51,780,415...52,309,641
Ensembl chr 4:51,781,053...52,309,829
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Erc1
ELKS/RAB6-interacting/CAST family member 1
involved_in
ISO
(MGI:5882646|PMID:27253063)
RGD
PMID:27253063
MGI:5882646
NCBI chr 4:152,763,664...153,055,706
Ensembl chr 4:152,767,419...153,055,639
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Erc2
ELKS/RAB6-interacting/CAST family member 2
involved_in
ISO
(MGI:4415657|PMID:19874790), (MGI:5882646|PMID:27253063)
RGD
PMID:19874790 PMID:27253063
MGI:4415657 MGI:5882646
NCBI chr16:2,812,712...3,673,624
Ensembl chr16:2,848,620...3,670,776
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Napa
NSF attachment protein alpha
involved_in
ISO
(MGI:4879076|PMID:21040848)
RGD
PMID:21040848
MGI:4879076
NCBI chr 1:76,787,036...76,805,869
Ensembl chr 1:76,786,932...76,805,869
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Otof
otoferlin
involved_in
IBA ISO
PMID:21873635 (MGI:4461353|PMID:20562868)
RGD
PMID:20562868 PMID:21873635
MGI:4461353 , RGD:13792537
NCBI chr 6:25,928,018...26,024,631
Ensembl chr 6:25,928,055...26,024,631
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Rims1
regulating synaptic membrane exocytosis 1
involved_in
ISO
(MGI:4887275|PMID:21262469), (MGI:5432438|PMID:22753485)
RGD
PMID:21262469 PMID:22753485
MGI:4887275 MGI:5432438
NCBI chr 9:24,696,959...25,196,368
Ensembl chr 9:24,698,854...25,196,631
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Rims2
regulating synaptic membrane exocytosis 2
involved_in
ISO
(MGI:4887275|PMID:21262469), (MGI:5432438|PMID:22753485)
RGD
PMID:21262469 PMID:22753485
MGI:4887275 MGI:5432438
NCBI chr 7:70,248,104...70,759,134
Ensembl chr 7:70,243,872...70,757,491
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Rph3a
rabphilin 3A
involved_in
ISO IEA
(MGI:7316519|PMID:16763567) GO_REF:0000107
RGD Ensembl
PMID:16763567
GO_REF:0000107 MGI:7316519
NCBI chr12:35,542,389...35,618,901
Ensembl chr12:35,542,728...35,617,592
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Snap23
synaptosome associated protein 23
involved_in
IBA
PMID:21873635
GO_Central
PMID:21873635
RGD:13792537
NCBI chr 3:107,514,088...107,546,177
Ensembl chr 3:107,514,131...107,544,320
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Snap25
synaptosome associated protein 25
involved_in
IBA
PMID:21873635
GO_Central
PMID:21873635
RGD:13792537
NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760
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Snap29
synaptosome associated protein 29
involved_in
IBA
PMID:21873635
GO_Central
PMID:21873635
RGD:13792537
NCBI chr11:83,578,479...83,608,953
Ensembl chr11:83,578,489...83,608,958
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Snap47
synaptosome associated protein 47
involved_in
IBA
PMID:21873635
GO_Central
PMID:21873635
RGD:13792537
NCBI chr10:44,192,886...44,234,435
Ensembl chr10:44,191,218...44,234,424
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Snca
synuclein alpha
involved_in
ISO
(PMID:30404828)
RGD
PMID:30404828
NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
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Stxbp1
syntaxin binding protein 1
involved_in
ISO
(MGI:3695670|PMID:17110441)
RGD
PMID:17110441
MGI:3695670
NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369
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Sv2a
synaptic vesicle glycoprotein 2a
involved_in
ISO
(MGI:3831988|PMID:19176798)
RGD
PMID:19176798
MGI:3831988
NCBI chr 2:183,741,455...183,757,290
Ensembl chr 2:183,741,547...183,756,927
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Synj1
synaptojanin 1
acts_upstream_of_or_within
ISO
MGI:2179801 (MGI:2447947|PMID:12481038)
RGD
PMID:12481038
MGI:2447947
NCBI chr11:30,192,629...30,269,277
Ensembl chr11:30,192,629...30,269,220
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Unc13a
unc-13 homolog A
involved_in
IDA IBA ISO
PMID:21873635 UniProtKB:Q9Z1N9 (MGI:2158113|PMID:11832228), (MGI:5617001|PMID:25374362)
RGD
PMID:11832228 PMID:25374362 PMID:21499244 PMID:21873635
MGI:2158113 MGI:5617001 , RGD:5686389 , RGD:13792537
NCBI chr16:18,336,229...18,381,811
Ensembl chr16:18,336,229...18,381,872
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Unc13b
unc-13 homolog B
involved_in acts_upstream_of_or_within
ISS IMP IBA ISO
GO_REF:0000024 PMID:22966208 PMID:21873635 MGI:2449706 (MGI:2181453|PMID:12070347) UniProtKB:Q4KUS2 (MGI:2158113|PMID:11832228), (MGI:5617001|PMID:25374362)
ParkinsonsUK-UCL RGD
PMID:11832228 PMID:12070347 PMID:25374362 PMID:22966208 PMID:21873635
GO_REF:0000024 MGI:2158113 MGI:2181453 MGI:5617001 , RGD:11535109 , RGD:13792537
NCBI chr 5:57,288,999...57,504,110
Ensembl chr 5:57,289,227...57,502,926
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Unc13c
unc-13 homolog C
involved_in
IMP IBA
PMID:22966208 PMID:21873635
ParkinsonsUK-UCL GO_Central
PMID:22966208 PMID:21873635
RGD:11535109 , RGD:13792537
NCBI chr 8:74,247,026...74,697,629
Ensembl chr 8:74,247,899...74,673,223
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Vamp1
vesicle-associated membrane protein 1
involved_in
ISO
(MGI:6189249|PMID:24944211)
RGD
PMID:24944211
MGI:6189249
NCBI chr 4:158,012,634...158,019,350
Ensembl chr 4:158,012,663...158,019,349
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Rims1
regulating synaptic membrane exocytosis 1
involved_in
IGI
PMID:21262469
ParkinsonsUK-UCL
PMID:21262469
RGD:10047275
NCBI chr 9:24,696,959...25,196,368
Ensembl chr 9:24,698,854...25,196,631
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Unc13b
unc-13 homolog B
involved_in
IGI
PMID:21262469
ParkinsonsUK-UCL
PMID:21262469 PMID:21262469
RGD:10047275 , RGD:10047275
NCBI chr 5:57,288,999...57,504,110
Ensembl chr 5:57,289,227...57,502,926
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Napa
NSF attachment protein alpha
involved_in acts_upstream_of_or_within
IBA ISO
PMID:21873635 MGI:104562 (MGI:4879076|PMID:21040848)
RGD
PMID:21040848 PMID:21873635
MGI:4879076 , RGD:13792537
NCBI chr 1:76,787,036...76,805,869
Ensembl chr 1:76,786,932...76,805,869
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Napb
NSF attachment protein beta
involved_in acts_upstream_of_or_within
IEA ISO IBA
GO_REF:0000107 MGI:104563 (MGI:4879076|PMID:21040848) PMID:21873635
Ensembl RGD
PMID:21040848 PMID:21873635
GO_REF:0000107 MGI:4879076 , RGD:13792537
NCBI chr 3:136,132,248...136,179,225
Ensembl chr 3:136,133,428...136,179,345
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Rab3a
RAB3A, member RAS oncogene family
involved_in
IDA
PMID:21689256
UniProt
PMID:21689256
RGD:14390056
NCBI chr16:18,684,185...18,688,297
Ensembl chr16:18,684,188...18,688,336
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Stx1a
syntaxin 1A
involved_in
ISO
UniProtKB:O35526|UniProtKB:P61264 (MGI:5521403|PMID:24133272)
RGD
PMID:24133272
MGI:5521403
NCBI chr12:21,641,971...21,670,022
Ensembl chr12:21,641,969...21,669,930
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Stx1b
syntaxin 1B
involved_in
ISS ISO
GO_REF:0000024 UniProtKB:O35526 (MGI:5521403|PMID:24133272)
ParkinsonsUK-UCL RGD
PMID:24133272
GO_REF:0000024 MGI:5521403
NCBI chr 1:182,415,544...182,434,385
Ensembl chr 1:182,415,546...182,441,280
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Stxbp1
syntaxin binding protein 1
involved_in
IMP IDA
PMID:21689256
RGD UniProt
PMID:19255244 PMID:21689256
RGD:2311128 , RGD:14390056
NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369
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Stxbp5
syntaxin binding protein 5
involved_in
ISO
(MGI:3814264|PMID:18936251)
RGD
PMID:18936251
MGI:3814264
NCBI chr 1:4,182,489...4,335,271
Ensembl chr 1:4,185,529...4,335,101
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Unc13a
unc-13 homolog A
involved_in
IDA
PMID:21689256
UniProt
PMID:21689256
RGD:14390056
NCBI chr16:18,336,229...18,381,811
Ensembl chr16:18,336,229...18,381,872
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