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ONTOLOGY REPORT - ANNOTATIONS

Term:ABC-type vitamin B12 transporter activity
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Accession:GO:0015420 term browser browse the term
Definition:Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: vitamin B12(out) + ATP + H2O = ADP + an vitamin B12(in) + H+ + phosphate. Vitamin B12 is alkylcob(III)alamin.
Synonyms:exact_synonym: ATP-dependent vitamin B12 transmembrane transporter activity;   ATPase-coupled cobalamin transmembrane transporter activity;   cobalamin porter activity;   vitamin B12 ABC transporter activity;   vitamin B12 porter activity;   vitamin B12-transporting ATPase activity
 narrow_synonym: cobalamin ABC transporter
 broad_synonym: cobalamin transporter activity;   vitamin B12 transporter activity
 related_synonym: ATP-dependent cobalamin transmembrane transporter activity;   ATPase-coupled vitamin B12 transmembrane transporter activity;   cobalamin-transporting ATPase activity
 alt_id: GO:0015235;   GO:0102023
 xref: EC:7.6.2.8;   MetaCyc:3.6.3.33-RXN;   RHEA:17873;   Reactome:R-HSA-3095901 "ABCC1 transports cytosolic RCbl to extracellular region";   Reactome:R-HSA-5223313 "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells)";   Reactome:R-HSA-5683325 "Defective ABCD4:LMBRD1 does not transport Cbl from lysosomal lumen to cytosol";   Reactome:R-HSA-9759206 "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol"


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ABC-type vitamin B12 transporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 enables IEA
ISO		 GO_REF:0000107
(PMID:21511966), (PMID:22547309)
MGI:2155908 (PMID:19897579)		 Ensembl
RGD		 PMID:19897579 PMID:21511966 PMID:22547309 GO_REF:0000107 NCBI chr10:1,022,041...1,162,431
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcd4 ATP binding cassette subfamily D member 4 enables ISO
IEA		 (PMID:33845046)
GO_REF:0000107		 RGD
Ensembl		 PMID:33845046 GO_REF:0000107 NCBI chr 6:109,977,541...109,992,050
Ensembl chr 6:104,246,468...104,280,276 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21102
    transporter activity 1395
      transmembrane transporter activity 1278
        vitamin transmembrane transporter activity 36
          ABC-type vitamin B12 transporter activity 2
Path 2
Term Annotations click to browse term
  molecular_function 21102
    transporter activity 1395
      transmembrane transporter activity 1278
        active transmembrane transporter activity 449
          primary active transmembrane transporter activity 168
            ATPase-coupled transmembrane transporter activity 119
              ABC-type transporter activity 56
                ABC-type vitamin B12 transporter activity 2
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