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ONTOLOGY REPORT - ANNOTATIONS

Term:bile acid transmembrane transporter activity
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Accession:GO:0015125 term browser browse the term
Definition:Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.
Synonyms:xref: Reactome:R-HSA-5661184 "Defective SLCO1B1 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte)";   Reactome:R-HSA-5661198 "Defective SLCO1B3 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte)";   Reactome:R-HSA-9733964 "SLC51A:SLC51B transports bile salts from cytosol to extracellular region";   reactome:R-HSA-194079 "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol";   reactome:R-HSA-194083 "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol";   reactome:R-HSA-194130 "Transport (influx) of bile salts and acids by OATP-A"


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bile acid transmembrane transporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 enables ISO
IEA
IMP		 (PMID:20010382), (PMID:20398791), (PMID:29507376)
GO_REF:0000117
(PMID:20398791)
PMID:17082223		 RGD
UniProt		 PMID:20010382 PMID:20398791 PMID:29507376 PMID:17082223 PMID:20398791 GO_REF:0000117, RGD:30309920, RGD:30309945 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 enables IDA PMID:7518458 UniProt PMID:7518458 RGD:11059589 NCBI chr 1:90,171,401...90,187,810
Ensembl chr 1:81,043,595...81,059,992 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 enables IDA
ISO
IEA		 (PMID:22029531)
GO_REF:0000107		 RGD
Ensembl		 PMID:22029531 PMID:15297262 GO_REF:0000107, RGD:2317332 NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
G Slc10a7 solute carrier family 10, member 7 enables ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr19:46,087,440...46,311,753
Ensembl chr19:29,183,155...29,407,464 		JBrowse link
G Slc51a solute carrier family 51 member A enables ISO
IEA		 UniProtKB:Q80WK2 (PMID:16317684)
GO_REF:0000107		 RGD
Ensembl		 PMID:16317684 GO_REF:0000107 NCBI chr11:81,804,141...81,818,539
Ensembl chr11:68,299,086...68,313,485 		JBrowse link
G Slc51b SLC51 subunit beta enables ISO
IBA		 UniProtKB:Q8R000 (PMID:16317684)
GO_REF:0000033		 RGD
GO_Central		 PMID:16317684 GO_REF:0000033 NCBI chr 8:74,827,047...74,835,109
Ensembl chr 8:65,931,890...65,940,145 		JBrowse link
G Slco1a1 solute carrier organic anion transporter family, member 1a1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:176,606,924...176,682,027
Ensembl chr 4:174,876,593...174,950,873 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 enables IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:9294213 GO_REF:0000033, RGD:729806 NCBI chr 4:176,441,104...176,495,846
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Slco1a5 solute carrier organic anion transporter family, member 1A5 enables IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:11093941 GO_REF:0000033, RGD:70619 NCBI chr 4:176,903,387...176,985,589
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Slco1a6 solute carrier organic anion transporter family, member 1a6 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:176,803,025...176,848,311
Ensembl chr 4:175,072,143...175,117,263 		JBrowse link
G Slco1a8 solute carrier organic anion transporter family, member 1a8 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:176,706,205...176,749,723
Ensembl chr 4:174,975,122...175,014,586 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 enables IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:10500057 GO_REF:0000033, RGD:631887 NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Slco1c1 solute carrier organic anion transporter family, member 1c1 enables IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:11981753 GO_REF:0000033, RGD:634158 NCBI chr 4:176,197,736...176,244,401
Ensembl chr 4:174,466,631...174,513,289 		JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 enables IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:15345472 GO_REF:0000033, RGD:2316987 NCBI chr 1:163,371,410...163,419,412
Ensembl chr 1:153,959,293...154,007,353 		JBrowse link
ABC-type bile acid transporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 enables IMP
ISO
ISS
IDA
IBA
IEA		 PMID:15901796
(PMID:15791618), (PMID:15901796), (PMID:18985798), (PMID:32203132)
(PMID:18985798)
GO_REF:0000024
GO_REF:0000033
GO_REF:0000116		 RGD
UniProt
GO_Central
RHEA		 PMID:15791618 PMID:15901796 PMID:18985798 PMID:32203132 PMID:15901796 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000116, RGD:1598579, RGD:30309919 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 enables IDA PMID:10644759 UniProt PMID:10644759 RGD:40902972 NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 enables ISS
ISO
IEA		 GO_REF:0000024
(PMID:16282361)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:16282361 GO_REF:0000024 GO_REF:0000107 NCBI chr15:101,948,387...102,182,912
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
bile acid:sodium symporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENSRNOG00000062801 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr16:84,380,802...84,381,908 JBrowse link
G Slc10a1 solute carrier family 10 member 1 enables TAS
IBA
IDA		 GO_REF:0000033 GO_Central
RGD		 PMID:12105223 PMID:1961729 GO_REF:0000033, RGD:625479, RGD:729835 NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
G Slc10a2 solute carrier family 10 member 2 enables TAS
IBA
IDA		 GO_REF:0000033 GO_Central
RGD		 PMID:11509565 PMID:8770054 GO_REF:0000033, RGD:628456, RGD:729802 NCBI chr16:91,088,089...91,111,025
Ensembl chr16:84,374,862...84,409,475 		JBrowse link
G Slc10a3 solute carrier family 10, member 3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:157,306,043...157,309,849
Ensembl chr  X:152,151,076...152,162,958 		JBrowse link
G Slc10a4 solute carrier family 10, member 4 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:35,552,170...35,557,884
Ensembl chr14:35,197,886...35,203,729 		JBrowse link
G Slc10a5 solute carrier family 10, member 5 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:93,364,959...93,366,263
Ensembl chr 2:91,444,454...91,489,651 		JBrowse link
G Slc10a6 solute carrier family 10 member 6 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:6,385,348...6,407,532
Ensembl chr14:6,080,717...6,103,037 		JBrowse link
canalicular bile acid transmembrane transporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 enables IDA
ISO
IBA		 (PMID:23764895)
GO_REF:0000033
(PMID:22262466), (PMID:24711118), (PMID:32203132)		 RGD
GO_Central		 PMID:22262466 PMID:23764895 PMID:24711118 PMID:32203132 PMID:9545351 GO_REF:0000033, RGD:728120 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21100
    transporter activity 1274
      lipid transporter activity 184
        lipid transmembrane transporter activity 55
          bile acid transmembrane transporter activity 22
            ABC-type bile acid transporter activity 3
            bile acid:sodium symporter activity 7
            canalicular bile acid transmembrane transporter activity 1
Path 2
Term Annotations click to browse term
  molecular_function 21100
    transporter activity 1274
      transmembrane transporter activity 1165
        organic acid transmembrane transporter activity 196
          carboxylic acid transmembrane transporter activity 195
            monocarboxylic acid transmembrane transporter activity 71
              bile acid transmembrane transporter activity 22
                ABC-type bile acid transporter activity 3
                bile acid:sodium symporter activity 7
                canalicular bile acid transmembrane transporter activity 1
paths to the root