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ONTOLOGY REPORT - ANNOTATIONS

Term:protein-disulfide reductase activity
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Accession:GO:0015035 term browser browse the term
Definition:Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds.
Synonyms:exact_synonym: peptide disulfide oxidoreductase activity;   peptide disulphide oxidoreductase activity;   protein disulfide oxidoreductase activity;   protein disulphide oxidoreductase activity
 narrow_synonym: haem lyase disulphide oxidoreductase activity;   heme lyase disulfide oxidoreductase activity
 alt_id: GO:0008895;   GO:0015037
 xref: MetaCyc:DISULFOXRED-RXN;   Reactome:R-HSA-264997 "P4HB mediates disulfide bond formation in Proinsulin";   Reactome:R-HSA-9817575 "ERO1B oxidizes P4HB";   reactome:R-HSA-1307802 "MIA40:ERV1 (CHCHD4:GFER) oxidizes cysteine residues to cystine disulfide bonds";   reactome:R-HSA-3299753 "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1"


show annotations for term's descendants           Sort by:
protein-disulfide reductase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chchd4 coiled-coil-helix-coiled-coil-helix domain containing 4 enables ISS
ISO
IBA
IEA		 GO_REF:0000024
(PMID:19182799), (PMID:26387864), (PMID:37159021)
GO_REF:0000033
GO_REF:0000002		 UniProt
RGD
GO_Central
InterPro		 PMID:19182799 PMID:26387864 PMID:37159021 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 NCBI chr 4:123,968,264...123,977,398
Ensembl chr 4:123,968,265...123,977,414
Ensembl chr 1:123,968,265...123,977,414 		JBrowse link
G Chchd4l1 coiled-coil-helix-coiled-coil-helix domain containing 4 like 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr  X:58,696,582...58,702,716
Ensembl chr  X:58,696,582...58,702,713 		JBrowse link
G Dnajc10 DnaJ heat shock protein family (Hsp40) member C10 enables ISS
ISO
IBA
IEA		 GO_REF:0000024
(PMID:21329881)
GO_REF:0000033
GO_REF:0000104
(PMID:23769672)		 UniProt
RGD
GO_Central		 PMID:21329881 PMID:23769672 GO_REF:0000024 GO_REF:0000033 GO_REF:0000104 NCBI chr 3:65,232,031...65,272,732
Ensembl chr 3:65,232,697...65,272,719 		JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha enables IEA
ISO
IBA		 GO_REF:0000002
(PMID:20308425)
GO_REF:0000033		 InterPro
RGD
GO_Central		 PMID:20308425 GO_REF:0000002 GO_REF:0000033 NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478 		JBrowse link
G Ero1b endoplasmic reticulum oxidoreductase 1 beta enables ISO
IBA		 (PMID:11707400), (PMID:16407158), (PMID:21091435)
(PMID:20308425)
GO_REF:0000033		 RGD
GO_Central		 PMID:11707400 PMID:16407158 PMID:20308425 PMID:21091435 GO_REF:0000033 NCBI chr17:85,861,086...86,003,244
Ensembl chr17:85,929,618...86,003,398 		JBrowse link
G Gfer growth factor, augmenter of liver regeneration enables ISO
ISS		 (PMID:22224850)
GO_REF:0000024		 RGD
UniProt		 PMID:22224850 GO_REF:0000024 NCBI chr10:13,718,489...13,721,782
Ensembl chr10:13,718,489...13,720,869 		JBrowse link
G Glrx2 glutaredoxin 2 enables IBA
ISO		 GO_REF:0000033
(PMID:23872354)		 GO_Central
RGD		 PMID:23872354 GO_REF:0000033 NCBI chr13:55,481,875...55,504,737
Ensembl chr13:55,482,694...55,492,831 		JBrowse link
G LOC120094797 mitochondrial intermembrane space import and assembly protein 40-like enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:60,584,841...60,585,260
Ensembl chr 9:60,584,841...60,585,260 		JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta enables ISO (PMID:16677074), (PMID:21308844)
MGI:5504624 (PMID:31184304)		 RGD PMID:16677074 PMID:21308844 PMID:31184304 NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500 		JBrowse link
G Pdia2 protein disulfide isomerase family A, member 2 enables ISO (PMID:16677074) RGD PMID:16677074 NCBI chr10:15,215,824...15,218,937
Ensembl chr10:15,215,824...15,220,931 		JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 enables IEA
ISO		 GO_REF:0000107
(PMID:16677074)		 Ensembl
RGD		 PMID:16677074 GO_REF:0000107 NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236 		JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 enables ISO
IEA		 (PMID:16677074)
GO_REF:0000107		 RGD
Ensembl		 PMID:16677074 GO_REF:0000107 NCBI chr 4:76,803,198...76,822,245
Ensembl chr 4:76,803,198...76,822,107 		JBrowse link
G Pdia5 protein disulfide isomerase family A, member 5 enables ISO (PMID:16677074) RGD PMID:16677074 NCBI chr11:65,272,152...65,359,087
Ensembl chr11:65,272,155...65,359,084 		JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 enables ISO
IBA
IEA		 (PMID:16677074)
(PMID:24508390)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:16677074 PMID:24508390 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:40,062,980...40,080,223
Ensembl chr 6:40,062,926...40,080,613 		JBrowse link
G Tmx1 thioredoxin-related transmembrane protein 1 enables ISO (PMID:22228764) RGD PMID:22228764 NCBI chr 6:88,960,691...88,971,744
Ensembl chr 6:88,960,695...88,971,301 		JBrowse link
G Tmx3 thioredoxin-related transmembrane protein 3 enables ISO (PMID:15623505) RGD PMID:15623505 NCBI chr18:83,731,777...83,764,719
Ensembl chr18:83,731,868...83,762,263 		JBrowse link
G Txn1 thioredoxin 1 enables ISO (PMID:17182577), (PMID:19032234), (PMID:2176490)
(PMID:18555775)		 RGD PMID:2176490 PMID:17182577 PMID:18555775 PMID:19032234 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
G Txn2 thioredoxin 2 contributes_to IDA RGD PMID:9006939 RGD:70610 NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359 		JBrowse link
G Txndc12 thioredoxin domain containing 12 enables ISO (PMID:18628206) RGD PMID:18628206 NCBI chr 5:123,587,854...123,612,886
Ensembl chr 5:123,586,781...123,612,870 		JBrowse link
G Txndc5 thioredoxin domain containing 5 enables ISO (PMID:14971039) RGD PMID:14971039 NCBI chr17:26,289,880...26,318,025
Ensembl chr17:26,289,880...26,318,025 		JBrowse link
G Txndc8 thioredoxin domain containing 8 NOT|enables ISO (PMID:15181017) RGD PMID:15181017 NCBI chr 5:72,749,708...72,785,858
Ensembl chr 5:72,749,725...72,785,931 		JBrowse link
G Txnl1 thioredoxin-like 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr18:57,125,362...57,155,167
Ensembl chr18:57,125,369...57,165,266 		JBrowse link
G Tymp thymidine phosphorylase enables IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874 		JBrowse link
flavin-dependent sulfhydryl oxidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gfer growth factor, augmenter of liver regeneration enables IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:11346147 GO_REF:0000033, RGD:9685721 NCBI chr10:13,718,489...13,721,782
Ensembl chr10:13,718,489...13,720,869 		JBrowse link
G Qsox1 quiescin sulfhydryl oxidase 1 enables ISO
IBA
ISS
IDA		 (PMID:17331072), (PMID:18393449)
GO_REF:0000033
GO_REF:0000024
PMID:11278790		 RGD
GO_Central
UniProt		 PMID:17331072 PMID:18393449 PMID:11278790 GO_REF:0000024 GO_REF:0000033, RGD:67932 NCBI chr13:67,949,780...67,987,434
Ensembl chr13:67,949,780...67,987,459 		JBrowse link
G Qsox2 quiescin sulfhydryl oxidase 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:9,034,994...9,064,649
Ensembl chr 3:9,034,994...9,064,664 		JBrowse link
protein-disulfide reductase (glutathione) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clic3 chloride intracellular channel 3 enables ISO (PMID:28198360) RGD PMID:28198360 NCBI chr 3:8,271,416...8,274,023
Ensembl chr 3:8,272,097...8,274,018 		JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 IMP RGD PMID:12032078 RGD:9999151 NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236 		JBrowse link
G Txndc12 thioredoxin domain containing 12 enables ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:12761212)		 UniProt
Ensembl
RGD		 PMID:12761212 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:123,587,854...123,612,886
Ensembl chr 5:123,586,781...123,612,870 		JBrowse link
protein-disulfide reductase (NAD(P)H) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pgk1 phosphoglycerate kinase 1 enables ISO (PMID:11130727) RGD PMID:11130727 NCBI chr  X:71,271,454...71,287,429
Ensembl chr  X:71,271,440...71,287,418 		JBrowse link
G Txn1 thioredoxin 1 enables IEA
ISO		 GO_REF:0000107
(PMID:17182577)		 Ensembl
RGD		 PMID:17182577 GO_REF:0000107 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
G Txndc17 thioredoxin domain containing 17 enables ISO (PMID:14607844), (PMID:15355959), (PMID:18579519) RGD PMID:14607844 PMID:15355959 PMID:18579519 NCBI chr10:56,832,749...56,835,721 JBrowse link
thioredoxin-disulfide reductase (NADPH) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nxn nucleoredoxin enables IBA
ISO		 GO_REF:0000033
(PMID:9119370)		 GO_Central
RGD		 PMID:9119370 GO_REF:0000033 NCBI chr10:61,109,322...61,247,578
Ensembl chr10:61,110,020...61,248,251 		JBrowse link
G Selenot selenoprotein T enables IDA
IBA		 PMID:26866473
GO_REF:0000033		 GO_Central PMID:26866473 GO_REF:0000033, RGD:12793008 NCBI chr 2:142,804,387...142,821,438
Ensembl chr 2:142,804,405...142,821,427 		JBrowse link
G Txn1 thioredoxin 1 TAS RGD PMID:12011048 RGD:727213 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
G Txndc2 thioredoxin domain containing 2 enables ISO (PMID:11399755) RGD PMID:11399755 NCBI chr 9:105,230,575...105,235,131
Ensembl chr 9:105,230,578...105,235,126 		JBrowse link
G Txnrd1 thioredoxin reductase 1 enables IDA
ISO
IBA
IEA		 (PMID:11259642)
GO_REF:0000033
(PMID:8577704)
PMID:10849437
GO_REF:0000003		 RGD
GO_Central
UniProt		 PMID:8577704 PMID:11259642 PMID:12435734 PMID:10849437 GO_REF:0000003 GO_REF:0000033, RGD:634375, RGD:634378 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Txnrd2 thioredoxin reductase 2 enables TAS
IBA
IDA
IEA		 GO_REF:0000033
PMID:9988709
GO_REF:0000003		 GO_Central
UniProt
RGD		 PMID:9988709 PMID:9988709 GO_REF:0000003 GO_REF:0000033, RGD:61776, RGD:61776 NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156 		JBrowse link
G Txnrd3 thioredoxin reductase 3 enables IBA
ISO		 GO_REF:0000033
(PMID:11259642)		 GO_Central
RGD		 PMID:11259642 GO_REF:0000033 NCBI chr 4:122,072,548...122,112,493
Ensembl chr 4:122,072,548...122,112,491 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20634
    catalytic activity 6032
      catalytic activity, acting on a protein 2509
        protein-disulfide reductase activity 34
          flavin-dependent sulfhydryl oxidase activity 3
          protein-disulfide reductase (NAD(P)H) activity + 9
          protein-disulfide reductase (glutathione) activity 3
Path 2
Term Annotations click to browse term
  molecular_function 20634
    catalytic activity 6032
      oxidoreductase activity 854
        oxidoreductase activity, acting on a sulfur group of donors 56
          disulfide oxidoreductase activity 42
            protein-disulfide reductase activity 34
              flavin-dependent sulfhydryl oxidase activity 3
              protein-disulfide reductase (NAD(P)H) activity + 9
              protein-disulfide reductase (glutathione) activity 3
paths to the root