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ONTOLOGY REPORT - ANNOTATIONS


Term:heparan sulfate proteoglycan biosynthetic process
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Accession:GO:0015012 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.
Synonyms:exact_synonym: heparan sulfate proteoglycan anabolism;   heparan sulfate proteoglycan biosynthesis;   heparan sulfate proteoglycan formation;   heparan sulfate proteoglycan synthesis;   heparan sulphate proteoglycan biosynthesis;   heparan sulphate proteoglycan biosynthetic process
 related_synonym: heparin proteoglycan biosynthetic process
 xref: RESID:AA0210


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heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B3gat3 beta-1,3-glucuronyltransferase 3 involved_in
acts_upstream_of_or_within
ISO (PMID:25893793)
(PMID:21763480)
UniProt
MGI
PMID:21763480 PMID:25893793 NCBI chrNW_004936581:636,648...642,138 JBrowse link
G Ext1 exostosin glycosyltransferase 1 involved_in
acts_upstream_of_or_within
ISO (PMID:10639137), (PMID:9620772)
(MGI:3687782|PMID:10639137)
(MGI:4431165|PMID:20080592)
BHF-UCL
UniProt
MGI
PMID:9620772 PMID:10639137 PMID:20080592 MGI:3687782 MGI:4431165 NCBI chrNW_004936470:28,303,213...28,566,470 JBrowse link
G Ext2 exostosin glycosyltransferase 2 involved_in
acts_upstream_of_or_within
ISO (PMID:17761672)
(MGI:3608483|PMID:16236767)
BHF-UCL
MGI
PMID:16236767 PMID:17761672 MGI:3608483 NCBI chrNW_004936562:4,345,146...4,489,180 JBrowse link
G Extl3 exostosin like glycosyltransferase 3 involved_in ISO (PMID:28132690), (PMID:28148688) UniProt PMID:28132690 PMID:28148688 NCBI chrNW_004936675:1,448,381...1,479,735 JBrowse link
G Glce glucuronic acid epimerase involved_in ISO (PMID:20118238), (PMID:30872481)
(MGI:2135754|PMID:11279150)
UniProt PMID:11279150 PMID:20118238 PMID:30872481 MGI:2135754 NCBI chrNW_004936471:28,984,777...29,035,878 JBrowse link
G Hs6st1 heparan sulfate 6-O-sulfotransferase 1 acts_upstream_of_or_within ISO (MGI:3715036|PMID:17405882) MGI PMID:17405882 MGI:3715036 NCBI chrNW_004936469:43,039,494...43,086,041 JBrowse link
G Lipc lipase C, hepatic type ISO RGD PMID:15102889 RGD:1580511 NCBI chrNW_004936471:19,604,083...19,733,721 JBrowse link
G LOC101971473 N-deacetylase and N-sulfotransferase 3 involved_in ISO (PMID:9915799) UniProt PMID:9915799 NCBI chrNW_004936932:259,847...414,472 JBrowse link
G Ndst1 N-deacetylase and N-sulfotransferase 1 involved_in ISO PMID:9915799 UniProt PMID:9915799 RGD:12907548 NCBI chrNW_004936504:4,413,549...4,495,933 JBrowse link
G Ndst2 N-deacetylase and N-sulfotransferase 2 acts_upstream_of_or_within ISO (MGI:1343737|PMID:10466727) MGI PMID:10466727 MGI:1343737 NCBI chrNW_004936521:5,336,658...5,346,704 JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase involved_in ISO (MGI:2675908|PMID:14505572) UniProt PMID:14505572 MGI:2675908 NCBI chrNW_004936482:7,090,241...7,118,315 JBrowse link
G Vangl2 VANGL planar cell polarity protein 2 acts_upstream_of_or_within ISO (MGI:5498591|PMID:23760952) MGI PMID:23760952 MGI:5498591 NCBI chrNW_004936740:228,377...242,318 JBrowse link
G Xylt1 xylosyltransferase 1 involved_in ISO (PMID:17189265) UniProt PMID:17189265 NCBI chrNW_004936501:4,164,714...4,337,604 JBrowse link
G Xylt2 xylosyltransferase 2 involved_in ISO (PMID:17189265), (PMID:26027496) UniProt PMID:17189265 PMID:26027496 NCBI chrNW_004936490:11,327,654...11,340,417 JBrowse link
heparan sulfate proteoglycan biosynthetic process, enzymatic modification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hs3st5 heparan sulfate-glucosamine 3-sulfotransferase 5 involved_in ISO (PMID:12138164) UniProt PMID:12138164 NCBI chrNW_004936679:2,540,894...2,737,462 JBrowse link
G Hs6st1 heparan sulfate 6-O-sulfotransferase 1 acts_upstream_of_or_within ISO (MGI:1353793|PMID:10644753) MGI PMID:10644753 MGI:1353793 NCBI chrNW_004936469:43,039,494...43,086,041 JBrowse link
G Hs6st2 heparan sulfate 6-O-sulfotransferase 2 acts_upstream_of_or_within ISO (MGI:1353793|PMID:10644753) MGI PMID:10644753 MGI:1353793 NCBI chrNW_004936691:1,976,449...2,257,303 JBrowse link
G Hs6st3 heparan sulfate 6-O-sulfotransferase 3 acts_upstream_of_or_within ISO (MGI:1353793|PMID:10644753) MGI PMID:10644753 MGI:1353793 NCBI chrNW_004936472:13,157,669...13,811,747 JBrowse link
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ext1 exostosin glycosyltransferase 1 involved_in ISO (PMID:17761672) BHF-UCL PMID:17761672 NCBI chrNW_004936470:28,303,213...28,566,470 JBrowse link
G Ext2 exostosin glycosyltransferase 2 involved_in ISO (PMID:17761672) BHF-UCL PMID:17761672 NCBI chrNW_004936562:4,345,146...4,489,180 JBrowse link
G Hs2st1 heparan sulfate 2-O-sulfotransferase 1 acts_upstream_of_or_within ISO (MGI:2150438|PMID:11457822) MGI PMID:11457822 MGI:2150438 NCBI chrNW_004936732:1,773,043...1,947,081 JBrowse link
G LOC101971473 N-deacetylase and N-sulfotransferase 3 involved_in ISO (PMID:9915799) UniProt PMID:9915799 NCBI chrNW_004936932:259,847...414,472 JBrowse link
positive regulation of heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnnb1 catenin beta 1 involved_in ISO (PMID:15853773) BHF-UCL PMID:15853773 NCBI chrNW_004936473:29,999,542...30,034,610 JBrowse link
G Pxylp1 2-phosphoxylose phosphatase 1 involved_in ISO (PMID:24425863) UniProt PMID:24425863 NCBI chrNW_004936540:3,075,618...3,133,554 JBrowse link
G Tcf7l2 transcription factor 7 like 2 involved_in ISO (PMID:15853773) BHF-UCL PMID:15853773 NCBI chrNW_004936486:3,473,877...3,660,565 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12135
    metabolic process 7611
      primary metabolic process 6727
        protein metabolic process 3740
          glycoprotein metabolic process 256
            proteoglycan metabolic process 63
              proteoglycan biosynthetic process 41
                heparan sulfate proteoglycan biosynthetic process 21
                  heparan sulfate proteoglycan biosynthetic process, enzymatic modification 4
                  heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide 0
                  heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process 4
                  positive regulation of heparan sulfate proteoglycan biosynthetic process + 3
                  regulation of heparan sulfate proteoglycan biosynthetic process + 3
Path 2
Term Annotations click to browse term
  biological_process 12135
    metabolic process 7611
      organic substance metabolic process 7336
        macromolecule metabolic process 6313
          cellular macromolecule metabolic process 5402
            cellular macromolecule biosynthetic process 3157
              glycoprotein biosynthetic process 200
                proteoglycan biosynthetic process 41
                  heparan sulfate proteoglycan biosynthetic process 21
                    heparan sulfate proteoglycan biosynthetic process, enzymatic modification 4
                    heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide 0
                    heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process 4
                    positive regulation of heparan sulfate proteoglycan biosynthetic process + 3
                    regulation of heparan sulfate proteoglycan biosynthetic process + 3
paths to the root