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ONTOLOGY REPORT - ANNOTATIONS


Term:heparan sulfate proteoglycan biosynthetic process
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Accession:GO:0015012 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.
Synonyms:exact_synonym: heparan sulfate proteoglycan anabolism;   heparan sulfate proteoglycan biosynthesis;   heparan sulfate proteoglycan formation;   heparan sulfate proteoglycan synthesis;   heparan sulphate proteoglycan biosynthesis;   heparan sulphate proteoglycan biosynthetic process
 related_synonym: heparin proteoglycan biosynthetic process
 xref: RESID:AA0210


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heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B3GAT3 beta-1,3-glucuronyltransferase 3 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:21763480) Ensembl
MGI
PMID:21763480 GO_REF:0000107 NCBI chr 2:9,119,621...9,125,081
Ensembl chr 2:9,119,656...9,125,062
JBrowse link
G EXT1 exostosin glycosyltransferase 1 involved_in
acts_upstream_of_or_within
ISO (PMID:10639137), (PMID:9620772)
(MGI:3687782|PMID:10639137)
(MGI:4431165|PMID:20080592)
BHF-UCL
UniProt
MGI
PMID:9620772 PMID:10639137 PMID:20080592 MGI:3687782 MGI:4431165 NCBI chr 4:20,645,002...20,935,769
Ensembl chr 4:20,645,809...20,935,564
JBrowse link
G EXT2 exostosin glycosyltransferase 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3608483|PMID:16236767) InterPro
MGI
PMID:16236767 GO_REF:0000002 MGI:3608483 NCBI chr 2:18,099,790...18,239,229
Ensembl chr 2:18,100,379...18,232,025
JBrowse link
G EXTL3 exostosin like glycosyltransferase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:12,437,551...12,563,548
Ensembl chr14:12,437,515...12,563,544
JBrowse link
G GLCE glucuronic acid epimerase involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:167,007,930...167,122,196
Ensembl chr 1:167,007,964...167,122,185
JBrowse link
G HS6ST1 heparan sulfate 6-O-sulfotransferase 1 acts_upstream_of_or_within ISO (MGI:3715036|PMID:17405882) MGI PMID:17405882 MGI:3715036 NCBI chr15:59,066,448...59,108,780
Ensembl chr15:59,066,603...59,108,777
JBrowse link
G LIPC lipase C, hepatic type ISO RGD PMID:15102889 RGD:1580511 NCBI chr 1:113,433,684...113,604,139
Ensembl chr 1:113,433,679...113,604,306
JBrowse link
G NDST1 N-deacetylase and N-sulfotransferase 1 involved_in ISO
IEA
PMID:9915799 UniProt
UniProt
PMID:9915799 GO_REF:0000041 RGD:12907548 NCBI chr 2:151,433,925...151,525,909
Ensembl chr 2:151,489,521...151,522,751
JBrowse link
G NDST2 N-deacetylase and N-sulfotransferase 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:1343737|PMID:10466727) MGI
UniProt
PMID:10466727 GO_REF:0000041 MGI:1343737 NCBI chr14:76,525,998...76,534,695 JBrowse link
G NDST3 N-deacetylase and N-sulfotransferase 3 involved_in ISO
IEA
(PMID:9915799) UniProt
UniProt
PMID:9915799 GO_REF:0000041 NCBI chr 8:105,221,344...105,370,067
Ensembl chr 8:105,221,348...105,370,019
JBrowse link
G UGDH UDP-glucose 6-dehydrogenase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:30,725,281...30,759,359
Ensembl chr 8:30,725,288...30,759,326
JBrowse link
G VANGL2 VANGL planar cell polarity protein 2 acts_upstream_of_or_within ISO (MGI:5498591|PMID:23760952) MGI PMID:23760952 MGI:5498591 NCBI chr 4:90,051,994...90,080,701
Ensembl chr 4:90,053,380...90,080,656
JBrowse link
G XYLT1 xylosyltransferase 1 involved_in IEA
IBA
(PMID:21873635) UniProt
GO_Central
PMID:21873635 GO_REF:0000041 NCBI chr 3:27,158,438...27,492,629
Ensembl chr 3:27,158,874...27,492,892
JBrowse link
G XYLT2 xylosyltransferase 2 involved_in IEA
IBA
(PMID:21873635) UniProt
GO_Central
PMID:21873635 GO_REF:0000041 NCBI chr12:26,640,802...26,656,809
Ensembl chr12:26,640,899...26,663,520
JBrowse link
heparan sulfate proteoglycan biosynthetic process, enzymatic modification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HS2ST1 heparan sulfate 2-O-sulfotransferase 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 4:129,101,900...129,258,372 JBrowse link
G HS3ST5 heparan sulfate-glucosamine 3-sulfotransferase 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:79,956,485...80,140,140
Ensembl chr 1:79,955,657...80,243,797
JBrowse link
G HS6ST1 heparan sulfate 6-O-sulfotransferase 1 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:1353793|PMID:10644753)
GO_Central
MGI
PMID:10644753 PMID:21873635 MGI:1353793 NCBI chr15:59,066,448...59,108,780
Ensembl chr15:59,066,603...59,108,777
JBrowse link
G HS6ST2 heparan sulfate 6-O-sulfotransferase 2 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:1353793|PMID:10644753)
GO_Central
MGI
PMID:10644753 PMID:21873635 MGI:1353793 NCBI chr  X:108,755,577...109,043,976
Ensembl chr  X:108,757,821...109,044,695
JBrowse link
G HS6ST3 heparan sulfate 6-O-sulfotransferase 3 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:1353793|PMID:10644753)
GO_Central
MGI
PMID:10644753 PMID:21873635 MGI:1353793 NCBI chr11:65,516,180...66,193,410
Ensembl chr11:65,516,296...66,186,846
JBrowse link
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EXT1 exostosin glycosyltransferase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:20,645,002...20,935,769
Ensembl chr 4:20,645,809...20,935,564
JBrowse link
G EXT2 exostosin glycosyltransferase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:18,099,790...18,239,229
Ensembl chr 2:18,100,379...18,232,025
JBrowse link
G HS2ST1 heparan sulfate 2-O-sulfotransferase 1 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:2150438|PMID:11457822)
GO_Central
MGI
PMID:11457822 PMID:21873635 MGI:2150438 NCBI chr 4:129,101,900...129,258,372 JBrowse link
G NDST1 N-deacetylase and N-sulfotransferase 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:151,433,925...151,525,909
Ensembl chr 2:151,489,521...151,522,751
JBrowse link
G NDST2 N-deacetylase and N-sulfotransferase 2 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr14:76,525,998...76,534,695 JBrowse link
G NDST3 N-deacetylase and N-sulfotransferase 3 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:105,221,344...105,370,067
Ensembl chr 8:105,221,348...105,370,019
JBrowse link
G NDST4 N-deacetylase and N-sulfotransferase 4 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:107,882,088...108,129,785
Ensembl chr 8:107,910,973...108,123,325
JBrowse link
positive regulation of heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTNNB1 catenin beta 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:25,163,550...25,208,314
Ensembl chr13:25,137,173...25,208,311
JBrowse link
G PXYLP1 2-phosphoxylose phosphatase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:81,951,336...82,049,385
Ensembl chr13:81,970,447...82,046,032
JBrowse link
G TCF7L2 transcription factor 7 like 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:123,343,695...123,547,332
Ensembl chr14:123,343,694...123,546,417
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16567
    metabolic process 10397
      primary metabolic process 9275
        protein metabolic process 5129
          glycoprotein metabolic process 353
            proteoglycan metabolic process 74
              proteoglycan biosynthetic process 52
                heparan sulfate proteoglycan biosynthetic process 22
                  heparan sulfate proteoglycan biosynthetic process, enzymatic modification 5
                  heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide 0
                  heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process 7
                  positive regulation of heparan sulfate proteoglycan biosynthetic process + 3
                  regulation of heparan sulfate proteoglycan biosynthetic process + 3
Path 2
Term Annotations click to browse term
  biological_process 16567
    metabolic process 10397
      organic substance metabolic process 9962
        macromolecule metabolic process 8623
          cellular macromolecule metabolic process 7287
            cellular macromolecule biosynthetic process 4331
              glycoprotein biosynthetic process 288
                proteoglycan biosynthetic process 52
                  heparan sulfate proteoglycan biosynthetic process 22
                    heparan sulfate proteoglycan biosynthetic process, enzymatic modification 5
                    heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide 0
                    heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process 7
                    positive regulation of heparan sulfate proteoglycan biosynthetic process + 3
                    regulation of heparan sulfate proteoglycan biosynthetic process + 3
paths to the root