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ONTOLOGY REPORT - ANNOTATIONS


Term:heparan sulfate proteoglycan biosynthetic process
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Accession:GO:0015012 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.
Synonyms:exact_synonym: heparan sulfate proteoglycan anabolism;   heparan sulfate proteoglycan biosynthesis;   heparan sulfate proteoglycan formation;   heparan sulfate proteoglycan synthesis;   heparan sulphate proteoglycan biosynthesis;   heparan sulphate proteoglycan biosynthetic process
 related_synonym: heparin proteoglycan biosynthetic process
 xref: RESID:AA0210


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heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B3gat3 beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I) acts_upstream_of_or_within
involved_in
ISO (MGI:2154388|PMID:11731273) MGI PMID:11731273 GO_REF:0000096 MGI:2154388 MGI:4834177 NCBI chr19:8,920,374...8,927,236
Ensembl chr19:8,920,374...8,927,236
JBrowse link
G Ext1 exostosin glycosyltransferase 1 involved_in
acts_upstream_of_or_within
ISO
IDA
IMP
(MGI:3687782|PMID:10639137)
(MGI:4431165|PMID:20080592)
MGI
UniProt
PMID:10639137 PMID:20080592 GO_REF:0000096 MGI:3687782 MGI:4431165 MGI:4834177 NCBI chr15:53,068,261...53,346,183
Ensembl chr15:53,064,038...53,346,159
JBrowse link
G Ext2 exostosin glycosyltransferase 2 acts_upstream_of_or_within
involved_in
IMP
ISO
(MGI:3608483|PMID:16236767) MGI PMID:16236767 GO_REF:0000096 MGI:3608483 MGI:4834177 NCBI chr 2:93,695,631...93,822,568
Ensembl chr 2:93,661,028...93,822,568
JBrowse link
G Extl3 exostosin-like glycosyltransferase 3 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr14:65,052,059...65,149,899
Ensembl chr14:65,052,060...65,149,855
JBrowse link
G Glce glucuronyl C5-epimerase involved_in ISO
IDA
IBA
(MGI:2135754|PMID:11279150)
(MGI:6201960|PMID:21873635)
MGI
UniProt
GO_Central
PMID:11279150 PMID:21873635 GO_REF:0000096 MGI:2135754 MGI:4834177 MGI:6201960 NCBI chr 9:62,057,244...62,122,609
Ensembl chr 9:62,057,248...62,122,655
JBrowse link
G Hs6st1 heparan sulfate 6-O-sulfotransferase 1 acts_upstream_of_or_within IMP (MGI:3715036|PMID:17405882) MGI PMID:17405882 MGI:3715036 NCBI chr 1:36,068,400...36,106,446
Ensembl chr 1:36,068,400...36,106,446
JBrowse link
G Lipc lipase, hepatic involved_in ISO RGD
MGI
PMID:15102889 GO_REF:0000096 MGI:4417868 RGD:1580511 NCBI chr 9:70,798,128...70,952,221
Ensembl chr 9:70,798,128...70,952,226
JBrowse link
G Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr18:60,684,494...60,749,035
Ensembl chr18:60,684,494...60,748,650
JBrowse link
G Ndst2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 acts_upstream_of_or_within IMP (MGI:1343737|PMID:10466727) MGI PMID:10466727 MGI:1343737 NCBI chr14:20,723,730...20,734,570
Ensembl chr14:20,723,730...20,734,562
JBrowse link
G Ndst3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 3:123,526,166...123,691,174
Ensembl chr 3:123,526,166...123,690,853
JBrowse link
G Ugdh UDP-glucose dehydrogenase involved_in IMP (MGI:2675908|PMID:14505572) UniProt PMID:14505572 MGI:2675908 NCBI chr 5:65,413,207...65,435,842
Ensembl chr 5:65,413,221...65,435,949
JBrowse link
G Vangl2 VANGL planar cell polarity 2 acts_upstream_of_or_within IMP (MGI:5498591|PMID:23760952) MGI PMID:23760952 MGI:5498591 NCBI chr 1:172,000,960...172,027,318
Ensembl chr 1:172,000,960...172,028,444
JBrowse link
G Xylt1 xylosyltransferase 1 involved_in ISO
IBA
(MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096 MGI:4834177 MGI:6201960 NCBI chr 7:117,380,979...117,667,630
Ensembl chr 7:117,380,979...117,673,580
JBrowse link
G Xylt2 xylosyltransferase II involved_in IBA
ISO
(MGI:6201960|PMID:21873635) GO_Central
MGI
PMID:21873635 GO_REF:0000096 MGI:4834177 MGI:6201960 NCBI chr11:94,663,845...94,677,518
Ensembl chr11:94,663,851...94,677,515
JBrowse link
heparan sulfate proteoglycan biosynthetic process, enzymatic modification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hs2st1 heparan sulfate 2-O-sulfotransferase 1 involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 3:144,429,701...144,570,216
Ensembl chr 3:144,429,706...144,570,181
JBrowse link
G Hs3st5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr10:36,506,590...36,834,397
Ensembl chr10:36,506,814...36,834,397
JBrowse link
G Hs6st1 heparan sulfate 6-O-sulfotransferase 1 acts_upstream_of_or_within
involved_in
IDA
IBA
(MGI:1353793|PMID:10644753)
(MGI:6201960|PMID:21873635)
MGI
GO_Central
PMID:10644753 PMID:21873635 MGI:1353793 MGI:6201960 NCBI chr 1:36,068,400...36,106,446
Ensembl chr 1:36,068,400...36,106,446
JBrowse link
G Hs6st2 heparan sulfate 6-O-sulfotransferase 2 acts_upstream_of_or_within
involved_in
IDA
IBA
(MGI:1353793|PMID:10644753)
(MGI:6201960|PMID:21873635)
MGI
GO_Central
PMID:10644753 PMID:21873635 MGI:1353793 MGI:6201960 NCBI chr  X:51,386,637...51,681,705
Ensembl chr  X:51,387,212...51,681,856
JBrowse link
G Hs6st3 heparan sulfate 6-O-sulfotransferase 3 acts_upstream_of_or_within
involved_in
IDA
IBA
(MGI:1353793|PMID:10644753)
(MGI:6201960|PMID:21873635)
MGI
GO_Central
PMID:10644753 PMID:21873635 MGI:1353793 MGI:6201960 NCBI chr14:119,137,516...119,869,815
Ensembl chr14:119,138,341...119,869,815
JBrowse link
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ext1 exostosin glycosyltransferase 1 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr15:53,068,261...53,346,183
Ensembl chr15:53,064,038...53,346,159
JBrowse link
G Ext2 exostosin glycosyltransferase 2 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 2:93,695,631...93,822,568
Ensembl chr 2:93,661,028...93,822,568
JBrowse link
G Hs2st1 heparan sulfate 2-O-sulfotransferase 1 acts_upstream_of_or_within
involved_in
IMP
IBA
(MGI:2150438|PMID:11457822)
(MGI:6201960|PMID:21873635)
MGI
GO_Central
PMID:11457822 PMID:21873635 MGI:2150438 MGI:6201960 NCBI chr 3:144,429,701...144,570,216
Ensembl chr 3:144,429,706...144,570,181
JBrowse link
G Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr18:60,684,494...60,749,035
Ensembl chr18:60,684,494...60,748,650
JBrowse link
G Ndst2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr14:20,723,730...20,734,570
Ensembl chr14:20,723,730...20,734,562
JBrowse link
G Ndst3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 involved_in IBA
ISO
(MGI:6201960|PMID:21873635) GO_Central
MGI
PMID:21873635 GO_REF:0000096 MGI:4834177 MGI:6201960 NCBI chr 3:123,526,166...123,691,174
Ensembl chr 3:123,526,166...123,690,853
JBrowse link
G Ndst4 N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4 involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 3:125,404,029...125,728,351
Ensembl chr 3:125,404,076...125,728,899
JBrowse link
positive regulation of heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnnb1 catenin (cadherin associated protein), beta 1 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 9:120,933,400...120,960,507
Ensembl chr 9:120,929,216...120,960,507
JBrowse link
G Pxylp1 2-phosphoxylose phosphatase 1 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 9:96,823,336...96,892,688
Ensembl chr 9:96,823,336...96,892,669
JBrowse link
G Tcf7l2 transcription factor 7 like 2, T cell specific, HMG box involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr19:55,741,797...55,933,659
Ensembl chr19:55,741,820...55,933,654
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28578
    metabolic process 11202
      primary metabolic process 9905
        protein metabolic process 5246
          glycoprotein metabolic process 332
            proteoglycan metabolic process 76
              proteoglycan biosynthetic process 52
                heparan sulfate proteoglycan biosynthetic process 22
                  heparan sulfate proteoglycan biosynthetic process, enzymatic modification 5
                  heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide 0
                  heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process 7
                  positive regulation of heparan sulfate proteoglycan biosynthetic process + 3
                  regulation of heparan sulfate proteoglycan biosynthetic process + 3
Path 2
Term Annotations click to browse term
  biological_process 28578
    metabolic process 11202
      organic substance metabolic process 10784
        macromolecule metabolic process 9261
          cellular macromolecule metabolic process 7676
            cellular macromolecule biosynthetic process 4624
              glycoprotein biosynthetic process 267
                proteoglycan biosynthetic process 52
                  heparan sulfate proteoglycan biosynthetic process 22
                    heparan sulfate proteoglycan biosynthetic process, enzymatic modification 5
                    heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide 0
                    heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process 7
                    positive regulation of heparan sulfate proteoglycan biosynthetic process + 3
                    regulation of heparan sulfate proteoglycan biosynthetic process + 3
paths to the root