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ONTOLOGY REPORT - ANNOTATIONS


Term:heparan sulfate proteoglycan biosynthetic process
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Accession:GO:0015012 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.
Synonyms:exact_synonym: heparan sulfate proteoglycan anabolism;   heparan sulfate proteoglycan biosynthesis;   heparan sulfate proteoglycan formation;   heparan sulfate proteoglycan synthesis;   heparan sulphate proteoglycan biosynthesis;   heparan sulphate proteoglycan biosynthetic process
 related_synonym: heparin proteoglycan biosynthetic process
 xref: RESID:AA0210


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heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B3GAT3 beta-1,3-glucuronyltransferase 3 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:21763480) Ensembl
MGI
PMID:21763480 GO_REF:0000107 NCBI chr18:54,020,547...54,025,264
Ensembl chr18:54,020,736...54,024,910
JBrowse link
G EXT1 exostosin glycosyltransferase 1 involved_in
acts_upstream_of_or_within
ISO (PMID:10639137), (PMID:9620772)
(MGI:4431165|PMID:20080592)
(MGI:3687782|PMID:10639137)
BHF-UCL
MGI
UniProt
PMID:9620772 PMID:10639137 PMID:20080592 MGI:3687782 MGI:4431165 NCBI chr13:17,172,497...17,457,084
Ensembl chr13:17,172,705...17,456,469
JBrowse link
G EXT2 exostosin glycosyltransferase 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3608483|PMID:16236767) InterPro
MGI
PMID:16236767 GO_REF:0000002 MGI:3608483 NCBI chr18:44,987,310...45,122,339
Ensembl chr18:44,987,748...45,129,974
JBrowse link
G EXTL3 exostosin like glycosyltransferase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:28,788,803...28,833,964
Ensembl chr25:28,790,506...28,937,647
JBrowse link
G GLCE glucuronic acid epimerase involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr30:33,093,318...33,208,754
Ensembl chr30:33,110,947...33,206,095
JBrowse link
G HS6ST1 heparan sulfate 6-O-sulfotransferase 1 acts_upstream_of_or_within ISO (MGI:3715036|PMID:17405882) MGI PMID:17405882 MGI:3715036 NCBI chr19:22,343,193...22,372,464
Ensembl chr19:22,368,942...22,369,652
JBrowse link
G LIPC lipase C, hepatic type ISO RGD PMID:15102889 RGD:1580511 NCBI chr30:23,432,460...23,584,037
Ensembl chr30:23,432,493...23,584,037
JBrowse link
G NDST1 N-deacetylase and N-sulfotransferase 1 involved_in ISO
IEA
PMID:9915799 UniProt
UniProt
PMID:9915799 GO_REF:0000041 RGD:12907548 NCBI chr 4:58,580,231...58,639,750
Ensembl chr 4:58,532,148...58,640,191
JBrowse link
G NDST2 N-deacetylase and N-sulfotransferase 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:1343737|PMID:10466727) MGI
UniProt
PMID:10466727 GO_REF:0000041 MGI:1343737 NCBI chr 4:24,235,051...24,243,411
Ensembl chr 4:24,231,492...24,243,455
JBrowse link
G NDST3 N-deacetylase and N-sulfotransferase 3 involved_in ISO
IEA
(PMID:9915799) UniProt
UniProt
PMID:9915799 GO_REF:0000041 NCBI chr32:37,309,829...37,487,977
Ensembl chr32:37,309,718...37,485,796
JBrowse link
G NDST4 N-deacetylase and N-sulfotransferase 4 involved_in IEA UniProt GO_REF:0000041 NCBI chr32:34,347,865...34,606,763
Ensembl chr32:34,351,162...34,631,039
JBrowse link
G SMIM14 small integral membrane protein 14 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:72,839,897...72,934,335
Ensembl chr 3:72,839,920...72,963,208
JBrowse link
G UGDH UDP-glucose 6-dehydrogenase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:72,935,532...72,964,151
Ensembl chr 3:72,839,920...72,963,208
JBrowse link
G VANGL2 VANGL planar cell polarity protein 2 acts_upstream_of_or_within ISO (MGI:5498591|PMID:23760952) MGI PMID:23760952 MGI:5498591 NCBI chr38:21,822,873...21,824,537 JBrowse link
G XYLT1 xylosyltransferase 1 involved_in ISS
IBA
IEA
(PMID:21873635) UniProt
GO_Central
PMID:21873635 GO_REF:0000024 GO_REF:0000041 NCBI chr 6:26,742,853...27,041,666
Ensembl chr 6:26,742,853...27,041,666
JBrowse link
G XYLT2 xylosyltransferase 2 involved_in ISS
IBA
IEA
(PMID:21873635) UniProt
GO_Central
PMID:21873635 GO_REF:0000024 GO_REF:0000041 NCBI chr 9:26,316,812...26,329,333
Ensembl chr 9:26,316,774...26,329,511
JBrowse link
heparan sulfate proteoglycan biosynthetic process, enzymatic modification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HS2ST1 heparan sulfate 2-O-sulfotransferase 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:61,124,393...61,298,912 JBrowse link
G HS3ST5 heparan sulfate-glucosamine 3-sulfotransferase 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:70,137,232...70,387,797
Ensembl chr12:70,140,802...70,388,174
JBrowse link
G HS6ST1 heparan sulfate 6-O-sulfotransferase 1 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:1353793|PMID:10644753)
GO_Central
MGI
PMID:10644753 PMID:21873635 MGI:1353793 NCBI chr19:22,343,193...22,372,464
Ensembl chr19:22,368,942...22,369,652
JBrowse link
G HS6ST2 heparan sulfate 6-O-sulfotransferase 2 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:1353793|PMID:10644753)
GO_Central
MGI
PMID:10644753 PMID:21873635 MGI:1353793 NCBI chr  X:103,529,705...103,816,049
Ensembl chr  X:103,531,378...103,815,538
JBrowse link
G HS6ST3 heparan sulfate 6-O-sulfotransferase 3 involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
(MGI:1353793|PMID:10644753)
(PMID:21873635)
Ensembl
MGI
GO_Central
PMID:10644753 PMID:21873635 GO_REF:0000107 MGI:1353793 NCBI chr22:47,257,641...47,265,143
Ensembl chr22:47,117,757...47,259,351
JBrowse link
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EXT1 exostosin glycosyltransferase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:17,172,497...17,457,084
Ensembl chr13:17,172,705...17,456,469
JBrowse link
G EXT2 exostosin glycosyltransferase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:44,987,310...45,122,339
Ensembl chr18:44,987,748...45,129,974
JBrowse link
G HS2ST1 heparan sulfate 2-O-sulfotransferase 1 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:2150438|PMID:11457822)
GO_Central
MGI
PMID:11457822 PMID:21873635 MGI:2150438 NCBI chr 6:61,124,393...61,298,912 JBrowse link
G NDST1 N-deacetylase and N-sulfotransferase 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 4:58,580,231...58,639,750
Ensembl chr 4:58,532,148...58,640,191
JBrowse link
G NDST2 N-deacetylase and N-sulfotransferase 2 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 4:24,235,051...24,243,411
Ensembl chr 4:24,231,492...24,243,455
JBrowse link
G NDST3 N-deacetylase and N-sulfotransferase 3 involved_in IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr32:37,309,829...37,487,977
Ensembl chr32:37,309,718...37,485,796
JBrowse link
G NDST4 N-deacetylase and N-sulfotransferase 4 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr32:34,347,865...34,606,763
Ensembl chr32:34,351,162...34,631,039
JBrowse link
positive regulation of heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTNNB1 catenin beta 1 involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr23:10,559,722...10,572,933
Ensembl chr23:10,559,718...10,572,927
JBrowse link
G PXYLP1 2-phosphoxylose phosphatase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:37,145,065...37,197,808
Ensembl chr23:37,145,086...37,196,427
JBrowse link
G TCF7L2 transcription factor 7 like 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr28:23,966,079...24,162,775
Ensembl chr28:23,966,073...24,163,737
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16235
    metabolic process 10501
      primary metabolic process 9359
        protein metabolic process 5218
          glycoprotein metabolic process 366
            proteoglycan metabolic process 76
              proteoglycan biosynthetic process 54
                heparan sulfate proteoglycan biosynthetic process 23
                  heparan sulfate proteoglycan biosynthetic process, enzymatic modification 5
                  heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide 0
                  heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process 7
                  positive regulation of heparan sulfate proteoglycan biosynthetic process + 3
                  regulation of heparan sulfate proteoglycan biosynthetic process + 3
Path 2
Term Annotations click to browse term
  biological_process 16235
    metabolic process 10501
      organic substance metabolic process 10085
        macromolecule metabolic process 8735
          cellular macromolecule metabolic process 7361
            cellular macromolecule biosynthetic process 4402
              glycoprotein biosynthetic process 301
                proteoglycan biosynthetic process 54
                  heparan sulfate proteoglycan biosynthetic process 23
                    heparan sulfate proteoglycan biosynthetic process, enzymatic modification 5
                    heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide 0
                    heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process 7
                    positive regulation of heparan sulfate proteoglycan biosynthetic process + 3
                    regulation of heparan sulfate proteoglycan biosynthetic process + 3
paths to the root