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ONTOLOGY REPORT - ANNOTATIONS


Term:heparan sulfate proteoglycan biosynthetic process
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Accession:GO:0015012 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.
Synonyms:exact_synonym: heparan sulfate proteoglycan anabolism;   heparan sulfate proteoglycan biosynthesis;   heparan sulfate proteoglycan formation;   heparan sulfate proteoglycan synthesis;   heparan sulphate proteoglycan biosynthesis;   heparan sulphate proteoglycan biosynthetic process
 related_synonym: heparin proteoglycan biosynthetic process
 xref: RESID:AA0210


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heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B3gat3 beta-1,3-glucuronyltransferase 3 involved_in
acts_upstream_of_or_within
ISO (PMID:25893793)
(PMID:21763480)
UniProt
MGI
PMID:21763480 PMID:25893793 NCBI chrNW_004955599:573,982...578,032
Ensembl chrNW_004955599:573,426...578,032
JBrowse link
G Ext1 exostosin glycosyltransferase 1 involved_in
acts_upstream_of_or_within
ISO (PMID:10639137), (PMID:9620772)
(MGI:3687782|PMID:10639137)
(MGI:4431165|PMID:20080592)
BHF-UCL
UniProt
MGI
PMID:9620772 PMID:10639137 PMID:20080592 MGI:3687782 MGI:4431165 NCBI chrNW_004955417:23,798,044...24,067,759
Ensembl chrNW_004955417:23,798,393...24,067,100
JBrowse link
G Ext2 exostosin glycosyltransferase 2 involved_in
acts_upstream_of_or_within
ISO (PMID:17761672)
(MGI:3608483|PMID:16236767)
BHF-UCL
MGI
PMID:16236767 PMID:17761672 MGI:3608483 NCBI chrNW_004955422:3,303,948...3,438,381
Ensembl chrNW_004955422:3,304,842...3,447,908
JBrowse link
G Extl3 exostosin like glycosyltransferase 3 involved_in ISO (PMID:28132690), (PMID:28148688) UniProt PMID:28132690 PMID:28148688 NCBI chrNW_004955403:51,076,323...51,102,435
Ensembl chrNW_004955403:51,076,319...51,102,435
JBrowse link
G Glce glucuronic acid epimerase involved_in ISO (PMID:20118238), (PMID:30872481)
(MGI:2135754|PMID:11279150)
UniProt PMID:11279150 PMID:20118238 PMID:30872481 MGI:2135754 NCBI chrNW_004955450:7,149,721...7,226,835
Ensembl chrNW_004955450:7,149,721...7,227,524
JBrowse link
G Hs6st1 heparan sulfate 6-O-sulfotransferase 1 acts_upstream_of_or_within ISO (MGI:3715036|PMID:17405882) MGI PMID:17405882 MGI:3715036 NCBI chrNW_004955459:2,273,100...2,310,993
Ensembl chrNW_004955459:2,273,100...2,310,993
JBrowse link
G Lipc lipase C, hepatic type ISO RGD PMID:15102889 RGD:1580511 NCBI chrNW_004955450:15,947,869...16,062,449
Ensembl chrNW_004955450:15,948,187...16,048,766
JBrowse link
G Ndst1 N-deacetylase and N-sulfotransferase 1 involved_in ISO PMID:9915799 UniProt PMID:9915799 RGD:12907548 NCBI chrNW_004955415:4,017,142...4,078,927
Ensembl chrNW_004955415:3,999,473...4,060,998
JBrowse link
G Ndst2 N-deacetylase and N-sulfotransferase 2 acts_upstream_of_or_within ISO (MGI:1343737|PMID:10466727) MGI PMID:10466727 MGI:1343737 NCBI chrNW_004955437:18,090,198...18,099,328 JBrowse link
G Ndst3 N-deacetylase and N-sulfotransferase 3 involved_in ISO (PMID:9915799) UniProt PMID:9915799 NCBI chrNW_004955428:21,671,432...21,853,492
Ensembl chrNW_004955428:21,671,358...21,853,483
JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase involved_in ISO (MGI:2675908|PMID:14505572) UniProt PMID:14505572 MGI:2675908 NCBI chrNW_004955443:7,868,893...7,882,136
Ensembl chrNW_004955443:7,868,893...7,882,129
JBrowse link
G Vangl2 VANGL planar cell polarity protein 2 acts_upstream_of_or_within ISO (MGI:5498591|PMID:23760952) MGI PMID:23760952 MGI:5498591 NCBI chrNW_004955468:12,162,084...12,189,322
Ensembl chrNW_004955468:12,161,843...12,189,547
JBrowse link
G Xylt1 xylosyltransferase 1 involved_in ISO (PMID:17189265) UniProt PMID:17189265 NCBI chrNW_004955442:1,787,338...2,042,523
Ensembl chrNW_004955442:1,745,924...2,036,340
JBrowse link
G Xylt2 xylosyltransferase 2 involved_in ISO (PMID:17189265), (PMID:26027496) UniProt PMID:17189265 PMID:26027496 NCBI chrNW_004955451:11,347,254...11,354,489
Ensembl chrNW_004955451:11,344,780...11,354,489
JBrowse link
heparan sulfate proteoglycan biosynthetic process, enzymatic modification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hs3st5 heparan sulfate-glucosamine 3-sulfotransferase 5 involved_in ISO (PMID:12138164) UniProt PMID:12138164 NCBI chrNW_004955526:2,418,217...2,652,025
Ensembl chrNW_004955526:2,636,579...2,652,405
JBrowse link
G Hs6st1 heparan sulfate 6-O-sulfotransferase 1 acts_upstream_of_or_within ISO (MGI:1353793|PMID:10644753) MGI PMID:10644753 MGI:1353793 NCBI chrNW_004955459:2,273,100...2,310,993
Ensembl chrNW_004955459:2,273,100...2,310,993
JBrowse link
G Hs6st2 heparan sulfate 6-O-sulfotransferase 2 acts_upstream_of_or_within ISO (MGI:1353793|PMID:10644753) MGI PMID:10644753 MGI:1353793 NCBI chrNW_004955473:2,002,475...2,291,868
Ensembl chrNW_004955473:2,002,725...2,289,662
JBrowse link
G Hs6st3 heparan sulfate 6-O-sulfotransferase 3 acts_upstream_of_or_within ISO (MGI:1353793|PMID:10644753) MGI PMID:10644753 MGI:1353793 NCBI chrNW_004955404:13,461,906...14,129,089
Ensembl chrNW_004955404:13,468,128...14,128,707
JBrowse link
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ext1 exostosin glycosyltransferase 1 involved_in ISO (PMID:17761672) BHF-UCL PMID:17761672 NCBI chrNW_004955417:23,798,044...24,067,759
Ensembl chrNW_004955417:23,798,393...24,067,100
JBrowse link
G Ext2 exostosin glycosyltransferase 2 involved_in ISO (PMID:17761672) BHF-UCL PMID:17761672 NCBI chrNW_004955422:3,303,948...3,438,381
Ensembl chrNW_004955422:3,304,842...3,447,908
JBrowse link
G Hs2st1 heparan sulfate 2-O-sulfotransferase 1 acts_upstream_of_or_within ISO (MGI:2150438|PMID:11457822) MGI PMID:11457822 MGI:2150438 NCBI chrNW_004955423:7,090,246...7,253,608 JBrowse link
G Ndst3 N-deacetylase and N-sulfotransferase 3 involved_in ISO (PMID:9915799) UniProt PMID:9915799 NCBI chrNW_004955428:21,671,432...21,853,492
Ensembl chrNW_004955428:21,671,358...21,853,483
JBrowse link
positive regulation of heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnnb1 catenin beta 1 involved_in ISO (PMID:15853773) BHF-UCL PMID:15853773 NCBI chrNW_004955420:29,030,716...29,047,447
Ensembl chrNW_004955420:29,030,716...29,047,449
JBrowse link
G Pxylp1 2-phosphoxylose phosphatase 1 involved_in ISO (PMID:24425863) UniProt PMID:24425863 NCBI chrNW_004955508:4,390,647...4,449,782
Ensembl chrNW_004955508:4,390,455...4,449,782
JBrowse link
G Tcf7l2 transcription factor 7 like 2 involved_in ISO (PMID:15853773) BHF-UCL PMID:15853773 NCBI chrNW_004955431:18,020,309...18,207,926
Ensembl chrNW_004955431:18,020,409...18,209,134
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11940
    metabolic process 7525
      primary metabolic process 6662
        protein metabolic process 3698
          glycoprotein metabolic process 257
            proteoglycan metabolic process 64
              proteoglycan biosynthetic process 41
                heparan sulfate proteoglycan biosynthetic process 21
                  heparan sulfate proteoglycan biosynthetic process, enzymatic modification 4
                  heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide 0
                  heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process 4
                  positive regulation of heparan sulfate proteoglycan biosynthetic process + 3
                  regulation of heparan sulfate proteoglycan biosynthetic process + 3
Path 2
Term Annotations click to browse term
  biological_process 11940
    metabolic process 7525
      organic substance metabolic process 7255
        macromolecule metabolic process 6254
          cellular macromolecule metabolic process 5357
            cellular macromolecule biosynthetic process 3132
              glycoprotein biosynthetic process 201
                proteoglycan biosynthetic process 41
                  heparan sulfate proteoglycan biosynthetic process 21
                    heparan sulfate proteoglycan biosynthetic process, enzymatic modification 4
                    heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide 0
                    heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process 4
                    positive regulation of heparan sulfate proteoglycan biosynthetic process + 3
                    regulation of heparan sulfate proteoglycan biosynthetic process + 3
paths to the root