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ONTOLOGY REPORT - ANNOTATIONS

Term:heparan sulfate proteoglycan biosynthetic process
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Accession:GO:0015012 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.
Synonyms:exact_synonym: heparan sulfate proteoglycan anabolism;   heparan sulfate proteoglycan biosynthesis;   heparan sulfate proteoglycan formation;   heparan sulfate proteoglycan synthesis;   heparan sulphate proteoglycan biosynthesis;   heparan sulphate proteoglycan biosynthetic process
 related_synonym: heparin proteoglycan biosynthetic process
 xref: RESID:AA0210

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heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B3gat3 beta-1,3-glucuronyltransferase 3 involved_in
acts_upstream_of_or_within		 ISO (PMID:25893793)
(PMID:21763480)		 RGD PMID:21763480 PMID:25893793 NCBI chr 1:225,120,061...225,126,579
Ensembl chr 1:225,120,061...225,126,579 		JBrowse link
G Ext1 exostosin glycosyltransferase 1 involved_in
acts_upstream_of_or_within		 ISO (PMID:10639137), (PMID:9620772)
(MGI:4431165|PMID:20080592)
(MGI:3687782|PMID:10639137)		 RGD PMID:9620772 PMID:10639137 PMID:20080592 MGI:3687782 MGI:4431165 NCBI chr 7:92,605,008...92,881,392
Ensembl chr 7:92,605,728...92,882,068 		JBrowse link
G Ext2 exostosin glycosyltransferase 2 involved_in
acts_upstream_of_or_within		 ISO (PMID:17761672)
MGI:3608690 (MGI:3608483|PMID:16236767)		 RGD PMID:16236767 PMID:17761672 MGI:3608483 NCBI chr 3:82,602,784...82,734,557
Ensembl chr 3:82,602,785...82,734,533 		JBrowse link
G Extl3 exostosin-like glycosyltransferase 3 involved_in ISO (PMID:28132690), (PMID:28148688) RGD PMID:28132690 PMID:28148688 NCBI chr15:48,420,419...48,465,171
Ensembl chr15:48,422,492...48,445,592 		JBrowse link
G Glce glucuronic acid epimerase involved_in ISO
IBA		 (PMID:20118238), (PMID:30872481)
(MGI:2135754|PMID:11279150)
PMID:21873635		 RGD PMID:11279150 PMID:20118238 PMID:30872481, PMID:21873635 MGI:2135754, RGD:13792537 NCBI chr 8:67,006,588...67,073,723
Ensembl chr 8:67,006,592...67,040,005 		JBrowse link
G Hs6st1 heparan sulfate 6-O-sulfotransferase 1 acts_upstream_of_or_within ISO MGI:3715259 (MGI:3715036|PMID:17405882) RGD PMID:17405882 MGI:3715036 NCBI chr 9:42,620,006...42,659,184
Ensembl chr 9:42,620,006...42,659,184 		JBrowse link
G Lipc lipase C, hepatic type IDA RGD PMID:15102889 RGD:1580511 NCBI chr 8:77,272,582...77,398,485
Ensembl chr 8:77,272,570...77,398,248 		JBrowse link
G Ndst1 N-deacetylase and N-sulfotransferase 1 involved_in IMP PMID:9915799 UniProt PMID:9915799 RGD:12907548 NCBI chr18:55,951,497...56,014,107
Ensembl chr18:55,955,389...55,992,885 		JBrowse link
G Ndst2 N-deacetylase and N-sulfotransferase 2 acts_upstream_of_or_within ISO MGI:1913285 (MGI:1343737|PMID:10466727) RGD PMID:10466727 MGI:1343737 NCBI chr15:3,995,797...4,006,491
Ensembl chr15:3,996,048...4,006,491
Ensembl chr15:3,996,048...4,006,491 		JBrowse link
G Ndst3 N-deacetylase and N-sulfotransferase 3 involved_in ISO (PMID:9915799) RGD PMID:9915799 NCBI chr 2:227,736,491...227,903,657
Ensembl chr 2:227,738,650...227,890,077 		JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase involved_in IEA
ISO
ISS		 GO_REF:0000107
(MGI:2675908|PMID:14505572)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:14505572 GO_REF:0000024 GO_REF:0000107 MGI:2675908 NCBI chr14:44,479,614...44,502,845
Ensembl chr14:44,479,614...44,502,845 		JBrowse link
G Vangl2 VANGL planar cell polarity protein 2 acts_upstream_of_or_within ISO MGI:1857642 (MGI:5498591|PMID:23760952) RGD PMID:23760952 MGI:5498591 NCBI chr13:90,379,203...90,405,627
Ensembl chr13:90,380,632...90,405,591 		JBrowse link
G Xylt1 xylosyltransferase 1 involved_in IEA
IBA
ISS
ISO		 GO_REF:0000041
PMID:21873635
GO_REF:0000024
(PMID:17189265)		 UniProt
RGD		 PMID:17189265, PMID:21873635 GO_REF:0000024 GO_REF:0000041, RGD:13792537 NCBI chr 1:186,939,698...187,264,758
Ensembl chr 1:187,149,453...187,261,632 		JBrowse link
G Xylt2 xylosyltransferase 2 involved_in ISS
IEA
ISO
IBA		 GO_REF:0000024
GO_REF:0000041
(PMID:17189265), (PMID:26027496)
PMID:21873635		 UniProt
RGD		 PMID:17189265 PMID:26027496, PMID:21873635 GO_REF:0000024 GO_REF:0000041, RGD:13792537 NCBI chr10:82,386,003...82,399,485
Ensembl chr10:82,386,005...82,399,485 		JBrowse link
heparan sulfate proteoglycan biosynthetic process, enzymatic modification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hs2st1 heparan sulfate 2-O-sulfotransferase 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:250,467,428...250,600,517
Ensembl chr 2:250,467,429...250,600,517 		JBrowse link
G Hs3st5 heparan sulfate-glucosamine 3-sulfotransferase 5 involved_in ISO (PMID:12138164) RGD PMID:12138164 NCBI chr20:40,236,437...40,545,502
Ensembl chr20:40,236,437...40,545,494 		JBrowse link
G Hs6st1 heparan sulfate 6-O-sulfotransferase 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(MGI:1353793|PMID:10644753)		 RGD PMID:10644753, PMID:21873635 MGI:1353793, RGD:13792537 NCBI chr 9:42,620,006...42,659,184
Ensembl chr 9:42,620,006...42,659,184 		JBrowse link
G Hs6st2 heparan sulfate 6-O-sulfotransferase 2 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(MGI:1353793|PMID:10644753)		 RGD PMID:10644753, PMID:21873635 MGI:1353793, RGD:13792537 NCBI chr  X:138,675,326...138,972,774
Ensembl chr  X:138,677,580...138,972,684 		JBrowse link
G Hs6st3 heparan sulfate 6-O-sulfotransferase 3 acts_upstream_of_or_within ISO (MGI:1353793|PMID:10644753) RGD PMID:10644753 MGI:1353793 NCBI chr15:104,448,479...105,254,540
Ensembl chr15:104,448,600...105,254,214 		JBrowse link
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ext1 exostosin glycosyltransferase 1 involved_in ISO (PMID:17761672) RGD PMID:17761672 NCBI chr 7:92,605,008...92,881,392
Ensembl chr 7:92,605,728...92,882,068 		JBrowse link
G Ext2 exostosin glycosyltransferase 2 involved_in ISO (PMID:17761672) RGD PMID:17761672 NCBI chr 3:82,602,784...82,734,557
Ensembl chr 3:82,602,785...82,734,533 		JBrowse link
G Hs2st1 heparan sulfate 2-O-sulfotransferase 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
MGI:1934916 (MGI:2150438|PMID:11457822)		 RGD PMID:11457822, PMID:21873635 MGI:2150438, RGD:13792537 NCBI chr 2:250,467,428...250,600,517
Ensembl chr 2:250,467,429...250,600,517 		JBrowse link
G Ndst1 N-deacetylase and N-sulfotransferase 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr18:55,951,497...56,014,107
Ensembl chr18:55,955,389...55,992,885 		JBrowse link
G Ndst2 N-deacetylase and N-sulfotransferase 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:3,995,797...4,006,491
Ensembl chr15:3,996,048...4,006,491
Ensembl chr15:3,996,048...4,006,491 		JBrowse link
G Ndst3 N-deacetylase and N-sulfotransferase 3 involved_in IBA
ISO		 PMID:21873635
(PMID:9915799)		 RGD PMID:9915799, PMID:21873635 RGD:13792537 NCBI chr 2:227,736,491...227,903,657
Ensembl chr 2:227,738,650...227,890,077 		JBrowse link
G Ndst4 N-deacetylase and N-sulfotransferase 4 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:229,170,781...229,496,732
Ensembl chr 2:229,196,616...229,496,516 		JBrowse link
positive regulation of heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnnb1 catenin beta 1 involved_in ISO
IEA
ISS		 (PMID:15853773)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:15853773 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Pxylp1 2-phosphoxylose phosphatase 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:24425863)		 UniProt
RGD		 PMID:24425863 GO_REF:0000024 NCBI chr 8:104,724,728...104,790,639
Ensembl chr 8:104,724,743...104,790,639 		JBrowse link
G Tcf7l2 transcription factor 7 like 2 involved_in ISO (PMID:15853773) RGD PMID:15853773 NCBI chr 1:276,686,911...276,730,517
Ensembl chr 1:276,659,542...276,730,514
Ensembl chr 1:276,659,542...276,730,514 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19612
    metabolic process 11881
      primary metabolic process 10638
        protein metabolic process 5986
          glycoprotein metabolic process 362
            proteoglycan metabolic process 78
              proteoglycan biosynthetic process 53
                heparan sulfate proteoglycan biosynthetic process 22
                  heparan sulfate proteoglycan biosynthetic process, enzymatic modification 5
                  heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide 0
                  heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process 7
                  positive regulation of heparan sulfate proteoglycan biosynthetic process + 3
                  regulation of heparan sulfate proteoglycan biosynthetic process + 3
Path 2
Term Annotations click to browse term
  biological_process 19612
    metabolic process 11881
      organic substance metabolic process 11416
        macromolecule metabolic process 9872
          cellular macromolecule metabolic process 8317
            cellular macromolecule biosynthetic process 5053
              glycoprotein biosynthetic process 295
                proteoglycan biosynthetic process 53
                  heparan sulfate proteoglycan biosynthetic process 22
                    heparan sulfate proteoglycan biosynthetic process, enzymatic modification 5
                    heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide 0
                    heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process 7
                    positive regulation of heparan sulfate proteoglycan biosynthetic process + 3
                    regulation of heparan sulfate proteoglycan biosynthetic process + 3
paths to the root