Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:heparan sulfate proteoglycan biosynthetic process
go back to main search page
Accession:GO:0015012 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of heparan sulfate proteoglycans, which consist of a core protein linked to a heparan sulfate glycosaminoglycan. The heparan sulfate chain is composed of the repeating disaccharide unit beta-(1,4)-N-acetyl-D-glucosamine-alpha-(1,4)-hexuronic acid, the former being either sulfated or deacetylated on its amino group as well as sulfated on one of its hydroxyl groups, and the latter being e a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids. Heparan sulfate chains are covalently linked to serine/threonine residues (O-linked) of the core protein via a tetrasaccharide linker sequence (xylose-galactose-galactose-glucuronate).
Synonyms:exact_synonym: heparan sulfate proteoglycan anabolism;   heparan sulfate proteoglycan biosynthesis;   heparan sulfate proteoglycan formation;   heparan sulfate proteoglycan synthesis;   heparan sulphate proteoglycan biosynthesis;   heparan sulphate proteoglycan biosynthetic process
 related_synonym: heparin proteoglycan biosynthetic process
 xref: MetaCyc:PWY-6558;   Reactome:R-HSA-2022928 "HS-GAG biosynthesis"


show annotations for term's descendants           Sort by:
heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B3galt6 Beta-1,3-galactosyltransferase 6 involved_in ISO (PMID:23664118) RGD PMID:23664118 NCBI chr 5:171,866,428...171,868,564
Ensembl chr 5:171,864,094...171,874,789 		JBrowse link
G B3gat3 beta-1,3-glucuronyltransferase 3 involved_in
acts_upstream_of_or_within 		ISO (PMID:25893793)
(PMID:21763480) 		RGD PMID:21763480 PMID:25893793 NCBI chr 1:215,246,453...215,253,033
Ensembl chr 1:215,246,482...215,266,876 		JBrowse link
G Ext1 exostosin glycosyltransferase 1 acts_upstream_of_or_within
involved_in 		ISO
IEA 		(PMID:20080592), (PMID:29415886)
(PMID:10639137), (PMID:30377379)
GO_REF:0000117
GO_REF:0000107
(PMID:10639137), (PMID:17761672), (PMID:36593275), (PMID:9620772) 		RGD
UniProt
Ensembl		 PMID:9620772 PMID:10639137 PMID:17761672 PMID:20080592 PMID:29415886 More... GO_REF:0000107 GO_REF:0000117 NCBI chr 7:86,265,651...86,544,488
Ensembl chr 7:86,259,900...86,544,567 		JBrowse link
G Ext2 exostosin glycosyltransferase 2 acts_upstream_of_or_within
involved_in 		ISO
IEA 		MGI:3608690 (PMID:16236767)
MGI:894663 (PMID:10639137)
GO_REF:0000117
GO_REF:0000107
(PMID:17761672), (PMID:36593275) 		RGD
UniProt
Ensembl		 PMID:10639137 PMID:16236767 PMID:17761672 PMID:36593275 GO_REF:0000107 GO_REF:0000117 NCBI chr 3:100,120,776...100,253,424
Ensembl chr 3:100,120,776...100,253,596 		JBrowse link
G Extl1 exostosin-like glycosyltransferase 1 involved_in ISO
IEA 		(PMID:11390981)
GO_REF:0000107
GO_REF:0000117 		RGD
Ensembl
UniProt		 PMID:11390981 GO_REF:0000107 GO_REF:0000117 NCBI chr 5:151,857,629...151,872,830
Ensembl chr 5:151,857,629...151,872,830 		JBrowse link
G Extl3 exostosin-like glycosyltransferase 3 involved_in ISO
IEA 		(PMID:19336225)
GO_REF:0000107
GO_REF:0000117
(PMID:11390981), (PMID:17761672), (PMID:28132690), (PMID:28148688), (PMID:35676258) 		RGD
Ensembl
UniProt		 PMID:11390981 PMID:17761672 PMID:19336225 PMID:28132690 PMID:28148688 More... GO_REF:0000107 GO_REF:0000117 NCBI chr15:43,469,293...43,559,760
Ensembl chr15:43,471,366...43,495,356 		JBrowse link
G Glce glucuronic acid epimerase involved_in ISO
IBA
IEA 		(PMID:20118238), (PMID:30872481)
GO_REF:0000033
(PMID:11279150), (PMID:30377379)
GO_REF:0000107
GO_REF:0000002 		RGD
GO_Central
Ensembl
InterPro		 PMID:11279150 PMID:20118238 PMID:30377379 PMID:30872481 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:71,441,607...71,507,639
Ensembl chr 8:71,441,616...71,507,587 		JBrowse link
G Hs2st1 heparan sulfate 2-O-sulfotransferase 1 involved_in
acts_upstream_of_or_within 		ISO
IEA
IBA 		MGI:4439258 (PMID:19889634), (PMID:30377379)
GO_REF:0000107
MGI:1934916 (PMID:11457822)
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:11457822 PMID:19889634 PMID:30377379 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:236,168,391...236,302,186
Ensembl chr 2:236,168,392...236,302,133 		JBrowse link
G Hs3st1 heparan sulfate-glucosamine 3-sulfotransferase 1 involved_in IEA
ISO 		GO_REF:0000107
(PMID:24247246), (PMID:30377379), (PMID:9346953) 		Ensembl
RGD		 PMID:9346953 PMID:24247246 PMID:30377379 GO_REF:0000107 NCBI chr14:75,398,101...75,429,628
Ensembl chr14:75,398,026...75,436,848 		JBrowse link
G Hs3st2 heparan sulfate-glucosamine 3-sulfotransferase 2 involved_in ISO
IEA 		MGI:5566804 (PMID:26731579)
GO_REF:0000107 		RGD
Ensembl		 PMID:26731579 GO_REF:0000107 NCBI chr 1:185,387,445...185,508,700
Ensembl chr 1:185,386,761...185,508,700 		JBrowse link
G Hs3st3a1 heparan sulfate-glucosamine 3-sulfotransferase 3A1 involved_in ISO
IEA 		MGI:5312610 (PMID:34653670)
GO_REF:0000107 		RGD
Ensembl		 PMID:34653670 GO_REF:0000107 NCBI chr10:49,593,208...49,679,854
Ensembl chr10:49,593,009...49,679,854 		JBrowse link
G Hs3st3b1 heparan sulfate-glucosamine 3-sulfotransferase 3B1 involved_in ISO
IEA 		(PMID:10520990)
GO_REF:0000107 		RGD
Ensembl		 PMID:10520990 GO_REF:0000107 NCBI chr10:49,060,693...49,093,185
Ensembl chr10:49,060,693...49,093,185 		JBrowse link
G Hs3st4 heparan sulfate-glucosamine 3-sulfotransferase 4 involved_in ISO
IEA 		(PMID:30377379)
GO_REF:0000107 		RGD
Ensembl		 PMID:30377379 GO_REF:0000107 NCBI chr 1:187,970,127...188,375,869
Ensembl chr 1:187,969,943...188,375,465 		JBrowse link
G Hs3st5 heparan sulfate-glucosamine 3-sulfotransferase 5 involved_in IEA
ISO 		GO_REF:0000107
(PMID:12138164) 		Ensembl
RGD		 PMID:12138164 GO_REF:0000107 NCBI chr20:41,661,785...41,972,550
Ensembl chr20:41,773,601...41,972,542 		JBrowse link
G Hs3st6 heparan sulfate-glucosamine 3-sulfotransferase 6 involved_in ISO
IEA 		(PMID:15303968)
GO_REF:0000107 		RGD
Ensembl		 PMID:15303968 GO_REF:0000107 NCBI chr10:14,286,555...14,292,660
Ensembl chr10:14,286,507...14,292,660 		JBrowse link
G Hs6st1 heparan sulfate 6-O-sulfotransferase 1 involved_in
acts_upstream_of_or_within 		ISO
IBA
IEA 		(PMID:12611590), (PMID:15226404), (PMID:30377379)
MGI:3715259 (PMID:10644753), (PMID:17405882)
GO_REF:0000033
GO_REF:0000107 		RGD
GO_Central
Ensembl		 PMID:10644753 PMID:12611590 PMID:15226404 PMID:17405882 PMID:30377379 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:45,779,402...45,818,583
Ensembl chr 9:45,779,019...45,818,582 		JBrowse link
G Hs6st2 heparan sulfate 6-O-sulfotransferase 2 involved_in ISO
IEA
IBA 		(PMID:12611590), (PMID:15226404), (PMID:30377379)
GO_REF:0000107
GO_REF:0000033
GO_REF:0000117 		RGD
Ensembl
GO_Central
UniProt		 PMID:12611590 PMID:15226404 PMID:30377379 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr  X:135,887,224...136,182,388
Ensembl chr  X:135,888,472...136,182,353 		JBrowse link
G Hs6st3 heparan sulfate 6-O-sulfotransferase 3 involved_in
acts_upstream_of_or_within 		ISO
IEA
IBA 		(PMID:12611590), (PMID:15226404)
(PMID:10644753)
GO_REF:0000107
GO_REF:0000033
GO_REF:0000117 		RGD
Ensembl
GO_Central
UniProt		 PMID:10644753 PMID:12611590 PMID:15226404 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr15:102,688,420...103,407,725
Ensembl chr15:102,688,365...103,408,384 		JBrowse link
G Lipc lipase C, hepatic type IDA RGD PMID:15102889 RGD:1580511 NCBI chr 8:80,390,470...80,516,463
Ensembl chr 8:80,390,471...80,516,285 		JBrowse link
G Ndst1 N-deacetylase and N-sulfotransferase 1 involved_in IMP
IDA
IEA
ISO
IBA 		PMID:9915799
PMID:8483907
PMID:1379236
GO_REF:0000041
GO_REF:0000107
MGI:3589211|MGI:3589383 (PMID:10758005), (PMID:18385133), (PMID:18487608), (PMID:23846497), (PMID:30377379)
GO_REF:0000033 		UniProt
Ensembl
RGD
GO_Central		 PMID:10758005 PMID:18385133 PMID:18487608 PMID:23846497 PMID:30377379 More... GO_REF:0000033 GO_REF:0000041 GO_REF:0000107, RGD:12907548, RGD:151356652, RGD:68801 NCBI chr18:56,407,308...56,470,007
Ensembl chr18:56,411,200...56,448,612 		JBrowse link
G Ndst2 N-deacetylase and N-sulfotransferase 2 acts_upstream_of_or_within
involved_in 		ISO
IEA
IBA 		MGI:1913285 (PMID:10466727)
GO_REF:0000041
GO_REF:0000107
(PMID:10758005), (PMID:18487608), (PMID:27387504), (PMID:30377379), (PMID:8294485)
GO_REF:0000033 		RGD
UniProt
Ensembl
GO_Central		 PMID:8294485 PMID:10466727 PMID:10758005 PMID:18487608 PMID:27387504 More... GO_REF:0000033 GO_REF:0000041 GO_REF:0000107 NCBI chr15:3,612,775...3,623,061
Ensembl chr15:3,612,775...3,623,061 		JBrowse link
G Ndst3 N-deacetylase and N-sulfotransferase 3 involved_in ISO
IEA
IBA 		(PMID:9915799)
MGI:3806156 (PMID:18385133)
GO_REF:0000041
GO_REF:0000107
GO_REF:0000033 		RGD
UniProt
Ensembl
GO_Central		 PMID:9915799 PMID:18385133 GO_REF:0000033 GO_REF:0000041 GO_REF:0000107 NCBI chr 2:214,386,804...214,552,739
Ensembl chr 2:214,389,447...214,539,164 		JBrowse link
G Ndst4 N-deacetylase and N-sulfotransferase 4 involved_in IEA
IBA 		GO_REF:0000041
GO_REF:0000033 		UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000041 NCBI chr 2:216,461,542...216,794,035
Ensembl chr 2:216,461,543...216,794,035 		JBrowse link
G Slc35d2 solute carrier family 35 member D2 acts_upstream_of_positive_effect ISO
IEA 		(PMID:15082721)
GO_REF:0000107 		RGD
Ensembl		 PMID:15082721 GO_REF:0000107 NCBI chr17:992,153...1,025,476
Ensembl chr17:993,646...1,025,475 		JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase involved_in IEA
ISS
ISO 		GO_REF:0000107
GO_REF:0000024
(PMID:14505572) 		Ensembl
UniProt
RGD		 PMID:14505572 GO_REF:0000024 GO_REF:0000107 NCBI chr14:43,202,480...43,226,002
Ensembl chr14:43,202,356...43,226,629 		JBrowse link
G Vangl2 VANGL planar cell polarity protein 2 acts_upstream_of_or_within ISO
IEA 		MGI:1857642 (PMID:23760952)
GO_REF:0000107 		RGD
Ensembl		 PMID:23760952 GO_REF:0000107 NCBI chr13:86,995,124...87,021,770
Ensembl chr13:86,997,920...87,021,770 		JBrowse link
G Xylt1 xylosyltransferase 1 involved_in IEA
ISO
ISS
IBA 		GO_REF:0000041
(PMID:17189265)
GO_REF:0000024
GO_REF:0000033 		UniProt
RGD
GO_Central		 PMID:17189265 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 NCBI chr 1:181,078,222...181,361,047
Ensembl chr 1:181,078,222...181,361,047 		JBrowse link
G Xylt2 xylosyltransferase 2 involved_in ISS
ISO
IEA
IBA 		GO_REF:0000024
(PMID:17189265), (PMID:26027496)
GO_REF:0000041
GO_REF:0000033
GO_REF:0000107 		UniProt
RGD
GO_Central
Ensembl		 PMID:17189265 PMID:26027496 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000107 NCBI chr10:80,102,776...80,116,346
Ensembl chr10:80,102,873...80,116,257 		JBrowse link
positive regulation of heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnnb1 catenin beta 1 involved_in ISO
IEA
ISS 		(PMID:15853773)
GO_REF:0000107
GO_REF:0000024 		RGD
Ensembl
UniProt		 PMID:15853773 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Pxylp1 2-phosphoxylose phosphatase 1 involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:24425863) 		UniProt
Ensembl
RGD		 PMID:24425863 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:106,299,303...106,364,603
Ensembl chr 8:106,299,304...106,364,603 		JBrowse link
G Tcf7l2 transcription factor 7 like 2 involved_in ISO
IEA 		(PMID:15853773)
GO_REF:0000107 		RGD
Ensembl		 PMID:15853773 GO_REF:0000107 NCBI chr 1:264,791,335...264,984,225
Ensembl chr 1:264,791,335...264,984,225 		JBrowse link
regulation of heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tm9sf2 transmembrane 9 superfamily member 2 involved_in ISO (PMID:28404855) RGD PMID:28404855 NCBI chr15:105,606,082...105,660,715
Ensembl chr15:105,606,118...105,660,714 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20668
    cellular process 19605
      metabolic process 12252
        carbohydrate derivative metabolic process 1055
          glycoprotein metabolic process 362
            glycoprotein biosynthetic process 295
              proteoglycan biosynthetic process 69
                heparan sulfate proteoglycan biosynthetic process 32
                  glycosaminoglycan-protein linkage region biosynthetic process 0
                  positive regulation of heparan sulfate proteoglycan biosynthetic process 3
                  regulation of heparan sulfate proteoglycan biosynthetic process + 4
Path 2
Term Annotations click to browse term
  biological_process 20668
    cellular process 19605
      metabolic process 12252
        macromolecule metabolic process 10074
          protein metabolic process 5265
            glycoprotein metabolic process 362
              glycoprotein biosynthetic process 295
                protein O-linked glycosylation 142
                  protein O-linked xylosylation 56
                    heparan sulfate proteoglycan biosynthetic process 32
                      glycosaminoglycan-protein linkage region biosynthetic process 0
                      positive regulation of heparan sulfate proteoglycan biosynthetic process 3
                      regulation of heparan sulfate proteoglycan biosynthetic process + 4
paths to the root