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ONTOLOGY REPORT - ANNOTATIONS

Term:heparan sulfate proteoglycan biosynthetic process
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Accession:GO:0015012 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.
Synonyms:exact_synonym: heparan sulfate proteoglycan anabolism;   heparan sulfate proteoglycan biosynthesis;   heparan sulfate proteoglycan formation;   heparan sulfate proteoglycan synthesis;   heparan sulphate proteoglycan biosynthesis;   heparan sulphate proteoglycan biosynthetic process
 related_synonym: heparin proteoglycan biosynthetic process
 xref: MetaCyc:PWY-6558;   RESID:AA0210


show annotations for term's descendants           Sort by:
heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B3gat3 beta-1,3-glucuronyltransferase 3 involved_in
acts_upstream_of_or_within		 ISO (PMID:25893793)
(PMID:21763480)		 RGD PMID:21763480 PMID:25893793 NCBI chr 1:205,817,374...205,823,928
Ensembl chr 1:205,817,378...205,837,807 		JBrowse link
G Ext1 exostosin glycosyltransferase 1 involved_in
acts_upstream_of_or_within		 ISO (PMID:10639137), (PMID:9620772)
(MGI:3687782|PMID:10639137), (PMID:10639137), (PMID:30377379)
(PMID:20080592), (PMID:29415886)		 RGD PMID:9620772 PMID:10639137 PMID:20080592 PMID:29415886 PMID:30377379 MGI:3687782 NCBI chr 7:84,375,769...84,654,625
Ensembl chr 7:84,375,784...84,655,357 		JBrowse link
G Ext2 exostosin glycosyltransferase 2 involved_in
acts_upstream_of_or_within		 ISO (PMID:17761672)
MGI:894663 (PMID:10639137)
MGI:3608690 (PMID:16236767)		 RGD PMID:10639137 PMID:16236767 PMID:17761672 NCBI chr 3:79,665,414...79,798,077
Ensembl chr 3:79,665,415...79,798,059 		JBrowse link
G Extl1 exostosin-like glycosyltransferase 1 involved_in ISO (PMID:11390981) RGD PMID:11390981 NCBI chr 5:146,573,911...146,589,115
Ensembl chr 5:146,573,912...146,589,115 		JBrowse link
G Extl3 exostosin-like glycosyltransferase 3 involved_in ISO (PMID:11390981), (PMID:28132690), (PMID:28148688), (PMID:35676258)
(MGI:3844390|PMID:19336225)		 RGD PMID:11390981 PMID:19336225 PMID:28132690 PMID:28148688 PMID:35676258 MGI:3844390 NCBI chr15:39,294,033...39,384,086
Ensembl chr15:39,293,605...39,338,898 		JBrowse link
G Glce glucuronic acid epimerase involved_in ISO
IBA		 (PMID:20118238), (PMID:30872481)
(PMID:11279150), (PMID:30377379)
GO_REF:0000033		 RGD
GO_Central		 PMID:11279150 PMID:20118238 PMID:30377379 PMID:30872481 GO_REF:0000033 NCBI chr 8:62,546,104...62,612,144
Ensembl chr 8:62,546,107...62,612,040 		JBrowse link
G Hs2st1 heparan sulfate 2-O-sulfotransferase 1 involved_in ISO MGI:4439258 (PMID:19889634), (PMID:30377379) RGD PMID:19889634 PMID:30377379 NCBI chr 2:233,508,018...233,641,769
Ensembl chr 2:233,508,021...233,641,769 		JBrowse link
G Hs3st1 heparan sulfate-glucosamine 3-sulfotransferase 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:24247246), (PMID:30377379), (PMID:9346953)		 Ensembl
RGD		 PMID:9346953 PMID:24247246 PMID:30377379 GO_REF:0000107 NCBI chr14:71,185,826...71,223,263
Ensembl chr14:71,185,682...71,223,248 		JBrowse link
G Hs3st2 heparan sulfate-glucosamine 3-sulfotransferase 2 involved_in ISO MGI:5566804 (PMID:26731579) RGD PMID:26731579 NCBI chr 1:175,956,161...176,077,400
Ensembl chr 1:175,956,157...176,077,399 		JBrowse link
G Hs3st3a1 heparan sulfate-glucosamine 3-sulfotransferase 3A1 involved_in ISO MGI:5312610 (PMID:34653670) RGD PMID:34653670 NCBI chr10:49,092,850...49,180,676
Ensembl chr10:49,094,026...49,180,676 		JBrowse link
G Hs3st3b1 heparan sulfate-glucosamine 3-sulfotransferase 3B1 involved_in ISO (PMID:10520990) RGD PMID:10520990 NCBI chr10:48,561,473...48,593,970
Ensembl chr10:48,561,473...48,593,970 		JBrowse link
G Hs3st4 heparan sulfate-glucosamine 3-sulfotransferase 4 involved_in ISO (PMID:30377379) RGD PMID:30377379 NCBI chr 1:178,539,078...178,944,850
Ensembl chr 1:178,539,093...178,944,107 		JBrowse link
G Hs3st6 heparan sulfate-glucosamine 3-sulfotransferase 6 involved_in ISO (PMID:15303968) RGD PMID:15303968 NCBI chr10:13,781,999...13,788,133
Ensembl chr10:13,781,993...13,788,133 		JBrowse link
G Hs6st1 heparan sulfate 6-O-sulfotransferase 1 involved_in
acts_upstream_of_or_within		 ISO (PMID:12611590), (PMID:15226404), (PMID:30377379)
MGI:3715259 (PMID:17405882)		 RGD PMID:12611590 PMID:15226404 PMID:17405882 PMID:30377379 NCBI chr 9:38,283,502...38,322,684
Ensembl chr 9:38,282,395...38,322,683 		JBrowse link
G Hs6st2 heparan sulfate 6-O-sulfotransferase 2 involved_in ISO (PMID:12611590), (PMID:15226404), (PMID:30377379) RGD PMID:12611590 PMID:15226404 PMID:30377379 NCBI chr  X:130,966,547...131,261,629
Ensembl chr  X:130,968,385...131,261,492 		JBrowse link
G Hs6st3 heparan sulfate 6-O-sulfotransferase 3 involved_in ISO (PMID:12611590), (PMID:15226404) RGD PMID:12611590 PMID:15226404 NCBI chr15:96,281,502...97,000,804
Ensembl chr15:96,281,646...97,000,462 		JBrowse link
G Lipc lipase C, hepatic type IDA RGD PMID:15102889 RGD:1580511 NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464 		JBrowse link
G Ndst1 N-deacetylase and N-sulfotransferase 1 involved_in IMP
ISO		 PMID:9915799
MGI:3589211|MGI:3589383 (PMID:18385133), (PMID:18487608), (PMID:23846497), (PMID:30377379)		 RGD PMID:18385133 PMID:18487608 PMID:23846497 PMID:30377379 PMID:9915799 RGD:12907548 NCBI chr18:54,136,887...54,199,545
Ensembl chr18:54,140,779...54,178,191 		JBrowse link
G Ndst2 N-deacetylase and N-sulfotransferase 2 involved_in
acts_upstream_of_or_within		 ISO (PMID:18487608), (PMID:27387504), (PMID:30377379), (PMID:8294485)
MGI:1913285 (PMID:10466727)		 RGD PMID:8294485 PMID:10466727 PMID:18487608 PMID:27387504 PMID:30377379 NCBI chr15:3,563,515...3,573,801
Ensembl chr15:3,563,358...3,573,801 		JBrowse link
G Ndst3 N-deacetylase and N-sulfotransferase 3 involved_in ISO (PMID:9915799)
MGI:3806156 (PMID:18385133)		 RGD PMID:9915799 PMID:18385133 NCBI chr 2:211,702,728...211,868,159
Ensembl chr 2:211,704,898...211,854,584 		JBrowse link
G Slc35d2 solute carrier family 35 member D2 acts_upstream_of_positive_effect ISO (PMID:15082721) RGD PMID:15082721 NCBI chr17:987,899...1,019,747
Ensembl chr17:988,157...1,019,743 		JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase involved_in IEA
ISO
ISS		 GO_REF:0000107
(MGI:2675908|PMID:14505572)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:14505572 GO_REF:0000024 GO_REF:0000107 MGI:2675908 NCBI chr14:42,848,704...42,872,351
Ensembl chr14:42,848,854...42,872,354 		JBrowse link
G Vangl2 VANGL planar cell polarity protein 2 acts_upstream_of_or_within ISO MGI:1857642 (PMID:23760952) RGD PMID:23760952 NCBI chr13:84,462,731...84,489,404
Ensembl chr13:84,465,527...84,489,378 		JBrowse link
G Xylt1 xylosyltransferase 1 involved_in IEA
IBA
ISS
ISO		 GO_REF:0000041
GO_REF:0000033
GO_REF:0000024
(PMID:17189265)		 UniProt
GO_Central
RGD		 PMID:17189265 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 NCBI chr 1:171,643,925...171,929,774
Ensembl chr 1:171,643,925...171,926,783 		JBrowse link
G Xylt2 xylosyltransferase 2 involved_in ISS
IBA
IEA
ISO		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000041
(PMID:17189265), (PMID:26027496)		 UniProt
GO_Central
RGD		 PMID:17189265 PMID:26027496 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 NCBI chr10:79,605,910...79,619,482
Ensembl chr10:79,606,007...79,619,391 		JBrowse link
heparan sulfate proteoglycan biosynthetic process, enzymatic modification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hs2st1 heparan sulfate 2-O-sulfotransferase 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:233,508,018...233,641,769
Ensembl chr 2:233,508,021...233,641,769 		JBrowse link
G Hs3st5 heparan sulfate-glucosamine 3-sulfotransferase 5 involved_in ISO (PMID:12138164) RGD PMID:12138164 NCBI chr20:40,106,876...40,417,661
Ensembl chr20:40,106,876...40,417,653 		JBrowse link
G Hs6st1 heparan sulfate 6-O-sulfotransferase 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:10644753)		 GO_Central
RGD		 PMID:10644753 GO_REF:0000033 NCBI chr 9:38,283,502...38,322,684
Ensembl chr 9:38,282,395...38,322,683 		JBrowse link
G Hs6st2 heparan sulfate 6-O-sulfotransferase 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:130,966,547...131,261,629
Ensembl chr  X:130,968,385...131,261,492 		JBrowse link
G Hs6st3 heparan sulfate 6-O-sulfotransferase 3 acts_upstream_of_or_within ISO (PMID:10644753) RGD PMID:10644753 NCBI chr15:96,281,502...97,000,804
Ensembl chr15:96,281,646...97,000,462 		JBrowse link
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ext1 exostosin glycosyltransferase 1 involved_in ISO (PMID:17761672), (PMID:36593275) RGD PMID:17761672 PMID:36593275 NCBI chr 7:84,375,769...84,654,625
Ensembl chr 7:84,375,784...84,655,357 		JBrowse link
G Ext2 exostosin glycosyltransferase 2 involved_in ISO (PMID:17761672), (PMID:36593275) RGD PMID:17761672 PMID:36593275 NCBI chr 3:79,665,414...79,798,077
Ensembl chr 3:79,665,415...79,798,059 		JBrowse link
G Hs2st1 heparan sulfate 2-O-sulfotransferase 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:1934916 (PMID:11457822)		 GO_Central
RGD		 PMID:11457822 GO_REF:0000033 NCBI chr 2:233,508,018...233,641,769
Ensembl chr 2:233,508,021...233,641,769 		JBrowse link
G Ndst1 N-deacetylase and N-sulfotransferase 1 involved_in IDA
ISO
IBA		 PMID:1379236
PMID:8483907
(MGI:6870964|PMID:10758005)
GO_REF:0000033		 RGD
GO_Central		 PMID:10758005 PMID:1379236 PMID:8483907 GO_REF:0000033 MGI:6870964, RGD:68801, RGD:151356652 NCBI chr18:54,136,887...54,199,545
Ensembl chr18:54,140,779...54,178,191 		JBrowse link
G Ndst2 N-deacetylase and N-sulfotransferase 2 involved_in ISO
IBA		 (MGI:6870964|PMID:10758005)
GO_REF:0000033		 RGD
GO_Central		 PMID:10758005 GO_REF:0000033 MGI:6870964 NCBI chr15:3,563,515...3,573,801
Ensembl chr15:3,563,358...3,573,801 		JBrowse link
G Ndst3 N-deacetylase and N-sulfotransferase 3 involved_in ISO
IBA		 (PMID:9915799)
GO_REF:0000033		 RGD
GO_Central		 PMID:9915799 GO_REF:0000033 NCBI chr 2:211,702,728...211,868,159
Ensembl chr 2:211,704,898...211,854,584 		JBrowse link
G Ndst4 N-deacetylase and N-sulfotransferase 4 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:213,787,010...214,119,514
Ensembl chr 2:213,787,006...214,115,373 		JBrowse link
positive regulation of heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnnb1 catenin beta 1 involved_in ISO
IEA
ISS		 (PMID:15853773)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:15853773 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Pxylp1 2-phosphoxylose phosphatase 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:24425863)		 UniProt
RGD		 PMID:24425863 GO_REF:0000024 NCBI chr 8:97,419,766...97,485,163
Ensembl chr 8:97,419,776...97,485,064 		JBrowse link
G Tcf7l2 transcription factor 7 like 2 involved_in ISO (PMID:15853773) RGD PMID:15853773 NCBI chr 1:254,785,956...254,978,967
Ensembl chr 1:254,786,091...254,978,967 		JBrowse link
regulation of heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tm9sf2 transmembrane 9 superfamily member 2 involved_in ISO (PMID:28404855) RGD PMID:28404855 NCBI chr15:99,201,556...99,254,054
Ensembl chr15:99,201,489...99,254,049 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20115
    metabolic process 12289
      cellular metabolic process 10293
        sulfur compound metabolic process 324
          sulfur compound biosynthetic process 144
            heparan sulfate proteoglycan biosynthetic process 31
              heparan sulfate proteoglycan biosynthetic process, enzymatic modification 5
              heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process 7
              positive regulation of heparan sulfate proteoglycan biosynthetic process 3
              regulation of heparan sulfate proteoglycan biosynthetic process + 4
Path 2
Term Annotations click to browse term
  biological_process 20115
    metabolic process 12289
      macromolecule metabolic process 10146
        protein metabolic process 5693
          glycoprotein metabolic process 387
            proteoglycan metabolic process 91
              proteoglycan biosynthetic process 66
                heparan sulfate proteoglycan biosynthetic process 31
                  heparan sulfate proteoglycan biosynthetic process, enzymatic modification 5
                  heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process 7
                  positive regulation of heparan sulfate proteoglycan biosynthetic process 3
                  regulation of heparan sulfate proteoglycan biosynthetic process + 4
paths to the root