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ONTOLOGY REPORT - ANNOTATIONS

Term:striated muscle hypertrophy
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Accession:GO:0014897 term browser browse the term
Definition:The enlargement or overgrowth of all or part of an organ due to an increase in size of muscle cells without cell division. In the case of striated muscle, this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils.


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cardiac muscle hypertrophy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ang2 angiogenin, ribonuclease A family, member 2 acts_upstream_of_or_within ISO (MGI:5920524|PMID:29065170) RGD PMID:29065170 MGI:5920524 NCBI chr15:24,398,383...24,415,837
Ensembl chr15:24,398,419...24,398,922 		JBrowse link
G Cav3 caveolin 3 acts_upstream_of ISO MGI:2180558 (MGI:3804582|PMID:18552160) RGD PMID:18552160 MGI:3804582 NCBI chr 4:145,582,168...145,598,142
Ensembl chr 4:145,582,060...145,598,137 		JBrowse link
G Csrp3 cysteine and glycine rich protein 3 involved_in ISO (PMID:12507422) RGD PMID:12507422 NCBI chr 1:98,528,067...98,546,647
Ensembl chr 1:98,528,068...98,546,653 		JBrowse link
G Hdac2 histone deacetylase 2 IEP RGD PMID:19713680 RGD:9590231 NCBI chr20:40,548,250...40,571,609
Ensembl chr20:40,548,250...40,571,609 		JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 acts_upstream_of_or_within ISO MGI:2447620 (MGI:4454633|PMID:20382855) RGD PMID:20382855 MGI:4454633 NCBI chr 1:26,822,131...26,832,218
Ensembl chr 1:26,822,131...26,832,218 		JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B involved_in IEA
ISO
ISS		 GO_REF:0000107
(MGI:4420536|PMID:19023134)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:19023134 GO_REF:0000024 GO_REF:0000107 MGI:4420536 NCBI chr 9:86,735,793...86,756,640
Ensembl chr 9:86,742,102...86,755,108 		JBrowse link
G Lep leptin IDA RGD PMID:20738325 RGD:8693628 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Npm1 nucleophosmin 1 IEP RGD PMID:21444791 RGD:11535018 NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645 		JBrowse link
G Pak2 p21 (RAC1) activated kinase 2 IEP RGD PMID:22564263 RGD:9835036 NCBI chr11:68,708,070...68,766,622
Ensembl chr11:68,707,969...68,768,816 		JBrowse link
G Rap1gds1 Rap1 GTPase-GDP dissociation stimulator 1 acts_upstream_of_or_within ISO MGI:3613572 (MGI:6480257|PMID:26975711) RGD PMID:26975711 MGI:6480257 NCBI chr 2:227,500,366...227,645,243
Ensembl chr 2:227,500,367...227,645,169 		JBrowse link
G Ryr2 ryanodine receptor 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3713774 (MGI:3713015|PMID:17431507)		 Ensembl
RGD		 PMID:17431507 GO_REF:0000107 MGI:3713015 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142 		JBrowse link
G Tcap titin-cap involved_in ISO (PMID:15582318) RGD PMID:15582318 NCBI chr10:83,381,719...83,382,887
Ensembl chr10:83,381,719...83,382,887 		JBrowse link
G Tiam1 TIAM Rac1 associated GEF 1 IMP RGD PMID:22564263 RGD:9835036 NCBI chr11:29,031,347...29,380,153
Ensembl chr11:29,031,348...29,159,901 		JBrowse link
G Ttn titin involved_in ISO (PMID:11846417) RGD PMID:11846417 NCBI chr 3:61,652,432...61,924,912
Ensembl chr 3:61,652,439...61,924,741 		JBrowse link
G Zfp418 zinc finger protein 418 acts_upstream_of_or_within ISO MGI:3050453|MGI:6369036|MGI:6369039 (MGI:5920524|PMID:29065170) RGD PMID:29065170 MGI:5920524 NCBI chr 1:66,581,406...66,594,247
Ensembl chr 1:66,581,287...66,594,242 		JBrowse link
cardiac muscle hypertrophy in response to stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 acts_upstream_of_or_within ISO (MGI:5576864|PMID:24137001) RGD PMID:24137001 MGI:5576864 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
G Camta2 calmodulin binding transcription activator 2 acts_upstream_of_or_within ISO (PMID:16678093) RGD PMID:16678093 NCBI chr10:55,383,450...55,401,838
Ensembl chr10:55,383,450...55,401,558 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit acts_upstream_of_or_within ISO (MGI:5576864|PMID:24137001) RGD PMID:24137001 MGI:5576864 NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362 		JBrowse link
G Gata4 GATA binding protein 4 acts_upstream_of_or_within ISO MGI:3054171|MGI:3778685 (MGI:5002493|PMID:20705924) RGD PMID:20705924 MGI:5002493 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636 		JBrowse link
G Gata6 GATA binding protein 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3054171|MGI:3654150 (MGI:5002493|PMID:20705924)		 Ensembl
RGD		 PMID:20705924 GO_REF:0000107 MGI:5002493 NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532 		JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 acts_upstream_of_or_within ISO (MGI:3624193|PMID:16603706) RGD PMID:16603706 MGI:3624193 NCBI chr 1:26,822,131...26,832,218
Ensembl chr 1:26,822,131...26,832,218 		JBrowse link
G Inpp5f inositol polyphosphate-5-phosphatase F acts_upstream_of_or_within ISO MGI:4128518 (MGI:4943859|PMID:19875726) RGD PMID:19875726 MGI:4943859 NCBI chr 1:183,190,480...183,270,276
Ensembl chr 1:183,190,480...183,270,276 		JBrowse link
G Kdm4a lysine demethylase 4A acts_upstream_of_or_within ISO (MGI:5050547|PMID:21555854) RGD PMID:21555854 MGI:5050547 NCBI chr 5:131,672,754...131,719,534
Ensembl chr 5:131,672,754...131,719,501 		JBrowse link
G Klf15 Kruppel-like factor 15 involved_in ISO (MGI:3709247|PMID:17438289) RGD PMID:17438289 MGI:3709247 NCBI chr 4:122,965,718...122,978,403
Ensembl chr 4:122,965,807...122,978,374 		JBrowse link
G Mef2c myocyte enhancer factor 2C acts_upstream_of_or_within ISO (MGI:1346950|PMID:10531040) RGD PMID:10531040 MGI:1346950 NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880 		JBrowse link
G Mir208b microRNA 208b acts_upstream_of_or_within ISO (MGI:5576864|PMID:24137001) RGD PMID:24137001 MGI:5576864 NCBI chr15:28,451,638...28,451,749
Ensembl chr15:28,451,638...28,451,749 		JBrowse link
G Myh6 myosin heavy chain 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(MGI:5576864|PMID:24137001)		 Ensembl
RGD		 PMID:24137001 GO_REF:0000107 MGI:5576864 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720 		JBrowse link
G Myh7 myosin heavy chain 7 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5576864|PMID:24137001)
GO_REF:0000107		 RGD
Ensembl		 PMID:24137001 GO_REF:0000107 MGI:5576864 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217 		JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 acts_upstream_of_or_within ISO MGI:107164 (MGI:2388546|PMID:12370307) RGD PMID:12370307 MGI:2388546 NCBI chr19:33,960,643...34,035,150
Ensembl chr19:33,960,852...34,035,150 		JBrowse link
G Nppa natriuretic peptide A acts_upstream_of_or_within ISO MGI:1857231 (MGI:3606834|PMID:14985074), (MGI:3610438|PMID:15452027), (MGI:5576864|PMID:24137001) RGD PMID:14985074 PMID:15452027 PMID:24137001 MGI:3606834 MGI:3610438 MGI:5576864 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B acts_upstream_of_or_within ISO (MGI:5576864|PMID:24137001) RGD PMID:24137001 MGI:5576864 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha acts_upstream_of_or_within ISO MGI:103296 (MGI:2388546|PMID:12370307) RGD PMID:12370307 MGI:2388546 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974 		JBrowse link
G Tcap titin-cap involved_in ISO (PMID:12507422) RGD PMID:12507422 NCBI chr10:83,381,719...83,382,887
Ensembl chr10:83,381,719...83,382,887 		JBrowse link
cell growth involved in cardiac muscle cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A acts_upstream_of_or_within ISO MGI:104774 (MGI:2664013|PMID:12782680) RGD PMID:12782680 MGI:2664013 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500 		JBrowse link
G Adra1b adrenoceptor alpha 1B acts_upstream_of_or_within ISO MGI:104773 (MGI:2664013|PMID:12782680) RGD PMID:12782680 MGI:2664013 NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919 		JBrowse link
G Agt angiotensinogen IDA RGD PMID:21376054 RGD:5129173 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 IMP RGD PMID:21173078 RGD:6903878 NCBI chr  X:112,119,673...112,124,060
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Akap13 A-kinase anchoring protein 13 IMP RGD PMID:18951085 RGD:2312638 NCBI chr 1:129,313,183...129,619,647
Ensembl chr 1:129,314,402...129,619,646 		JBrowse link
G Ang2 angiogenin, ribonuclease A family, member 2 acts_upstream_of_or_within ISO (MGI:5920524|PMID:29065170) RGD PMID:29065170 MGI:5920524 NCBI chr15:24,398,383...24,415,837
Ensembl chr15:24,398,419...24,398,922 		JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II delta IMP RGD PMID:21554860 RGD:6907064 NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178 		JBrowse link
G Gata4 GATA binding protein 4 IDA RGD PMID:20971938 RGD:5131529 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta IDA RGD PMID:27854077 RGD:13792737 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 IMP RGD PMID:9769323 RGD:7495831 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993 		JBrowse link
G Myl2 myosin light chain 2 IEP RGD PMID:7657802 RGD:1580138 NCBI chr12:34,454,223...34,468,554
Ensembl chr12:34,454,218...34,468,983 		JBrowse link
G Myocd myocardin IMP RGD PMID:18772130 RGD:5132877 NCBI chr10:49,833,219...49,928,806
Ensembl chr10:49,836,641...49,927,627 		JBrowse link
G Nppa natriuretic peptide A IEP RGD PMID:7657802 RGD:1580138 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B IEP RGD PMID:7657802 RGD:1580138 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Pdlim5 PDZ and LIM domain 5 involved_in IGI PMID:24743145 BHF-UCL PMID:24743145 RGD:10054083 NCBI chr 2:230,952,251...231,120,329
Ensembl chr 2:230,952,248...231,120,275 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 IMP RGD PMID:19542178 RGD:7775063 NCBI chr 1:228,409,883...229,638,794
Ensembl chr 1:228,408,947...229,639,080 		JBrowse link
G Sorbs2 sorbin and SH3 domain containing 2 involved_in IGI PMID:24743145 BHF-UCL PMID:24743145 RGD:10054083 NCBI chr16:46,435,220...46,748,743
Ensembl chr16:46,435,237...46,626,514 		JBrowse link
negative regulation of cardiac muscle hypertrophy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akap1 A-kinase anchoring protein 1 IMP RGD PMID:19358331 RGD:2312604 NCBI chr10:73,621,021...73,654,123
Ensembl chr10:73,621,883...73,653,896 		JBrowse link
G Bmp10 bone morphogenetic protein 10 involved_in IEA
ISO		 GO_REF:0000107
(MGI:3695247|PMID:16798733)		 Ensembl
RGD		 PMID:16798733 GO_REF:0000107 MGI:3695247 NCBI chr 4:119,872,066...119,877,694
Ensembl chr 4:119,872,045...119,878,627 		JBrowse link
G Cav3 caveolin 3 involved_in
acts_upstream_of_or_within		 ISO (PMID:12847114)
MGI:2180558 (MGI:3804582|PMID:18552160)		 RGD PMID:12847114 PMID:18552160 MGI:3804582 NCBI chr 4:145,582,168...145,598,142
Ensembl chr 4:145,582,060...145,598,137 		JBrowse link
G Fbxo32 F-box protein 32 involved_in IMP PMID:24117217 BHF-UCL PMID:24117217 RGD:11079185 NCBI chr 7:89,731,626...89,764,761
Ensembl chr 7:89,730,232...89,765,436 		JBrowse link
G Gata5 GATA binding protein 5 involved_in ISO (MGI:5286818|PMID:21633169) RGD PMID:21633169 MGI:5286818 NCBI chr 3:167,418,563...167,426,751
Ensembl chr 3:167,418,565...167,426,751 		JBrowse link
G Glrx3 glutaredoxin 3 involved_in ISO (MGI:4461873|PMID:18258855) RGD PMID:18258855 MGI:4461873 NCBI chr 1:192,241,707...192,272,012
Ensembl chr 1:192,241,701...192,272,010 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta acts_upstream_of_or_within ISO (MGI:2157270|PMID:11782539) RGD PMID:11782539 MGI:2157270 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Jarid2 jumonji and AT-rich interaction domain containing 2 involved_in IGI
IMP		 PMID:24657879 BHF-UCL PMID:24657879 PMID:24657879 RGD:11344938, RGD:11344938 NCBI chr17:19,777,487...19,957,696
Ensembl chr17:19,777,266...19,955,690 		JBrowse link
G Mir1 microRNA 1 involved_in ISO (PMID:19933931) RGD PMID:19933931 NCBI chr18:1,887,537...1,887,623 JBrowse link
G Mir1b microRNA 1b involved_in ISO (PMID:19933931) RGD PMID:19933931 NCBI chr 3:167,487,117...167,487,201
Ensembl chr 3:167,487,117...167,487,201 		JBrowse link
G Mlip muscular LMNA-interacting protein involved_in
acts_upstream_of_or_within		 ISS
ISO		 GO_REF:0000024
(MGI:5581934|PMID:22343712)		 UniProt
RGD		 PMID:22343712 GO_REF:0000024 MGI:5581934 NCBI chr 8:77,935,087...78,204,725
Ensembl chr 8:77,935,079...78,204,254 		JBrowse link
G Notch1 notch receptor 1 involved_in ISO (MGI:6158728|PMID:26491108) RGD PMID:26491108 MGI:6158728 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G P2rx4 purinergic receptor P2X 4 involved_in ISO (PMID:15130891) RGD PMID:15130891 NCBI chr12:33,844,609...33,862,265
Ensembl chr12:33,844,396...33,862,253 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 involved_in ISO (MGI:3836877|PMID:19127022) RGD PMID:19127022 MGI:3836877 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385 		JBrowse link
G Smad4 SMAD family member 4 involved_in IEA
ISO		 GO_REF:0000107
(MGI:3689643|PMID:16151019)		 Ensembl
RGD		 PMID:16151019 GO_REF:0000107 MGI:3689643 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A involved_in ISO UniProtKB:P25119 (MGI:6158728|PMID:26491108) RGD PMID:26491108 MGI:6158728 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B involved_in ISO UniProtKB:P25118 (MGI:6158728|PMID:26491108) RGD PMID:26491108 MGI:6158728 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206 		JBrowse link
G Trim63 tripartite motif containing 63 involved_in IMP PMID:24117217 BHF-UCL PMID:24117217 RGD:11079185 NCBI chr 5:146,533,492...146,547,332
Ensembl chr 5:146,533,507...146,547,322 		JBrowse link
negative regulation of cardiac muscle hypertrophy in response to stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 involved_in ISO (PMID:19287093)
(MGI:3848765|PMID:19287093)		 RGD PMID:19287093 MGI:3848765 NCBI chr13:45,156,137...45,255,292
Ensembl chr13:45,156,146...45,255,246 		JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 IDA RGD PMID:19204184 RGD:9685562 NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282 		JBrowse link
G Foxo1 forkhead box O1 involved_in IMP PMID:26436652 UniProt PMID:26436652 RGD:13210548 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Lmna lamin A/C involved_in IEA
ISO
ISS		 GO_REF:0000107
(MGI:5700584|PMID:26436652)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:26436652 GO_REF:0000024 GO_REF:0000107 MGI:5700584 NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423 		JBrowse link
G Mlip muscular LMNA-interacting protein involved_in ISO (MGI:5700584|PMID:26436652), (MGI:5908525|PMID:26359501) RGD PMID:26359501 PMID:26436652 MGI:5700584 MGI:5908525 NCBI chr 8:77,935,087...78,204,725
Ensembl chr 8:77,935,079...78,204,254 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma acts_upstream_of_or_within IDA PMID:29695452 BHF-UCL PMID:29695452 RGD:150521636 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Smad3 SMAD family member 3 involved_in IGI PMID:27038547 BHF-UCL PMID:27038547 RGD:11535100 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
negative regulation of cell growth involved in cardiac muscle cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav3 caveolin 3 IMP RGD PMID:21170593 RGD:6784534 NCBI chr 4:145,582,168...145,598,142
Ensembl chr 4:145,582,060...145,598,137 		JBrowse link
G Ctdp1 CTD phosphatase subunit 1 IMP RGD PMID:22569295 RGD:9686371 NCBI chr18:73,854,277...73,916,232
Ensembl chr18:73,854,282...73,916,457 		JBrowse link
G Foxp1 forkhead box P1 IMP RGD PMID:26333362 RGD:11561912 NCBI chr 4:131,559,599...132,155,092
Ensembl chr 4:131,564,756...132,112,258 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase IMP RGD PMID:24190878 RGD:10449133 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha involved_in ISO (MGI:4829580|PMID:20516643) RGD PMID:20516643 MGI:4829580 NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802 		JBrowse link
G Mir451a microRNA 451a IMP RGD PMID:25209900 RGD:11558015 NCBI chr10:62,961,520...62,961,591
Ensembl chr10:62,961,520...62,961,591 		JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 IMP RGD PMID:22082674 RGD:11533929 NCBI chr 1:152,111,172...152,226,390
Ensembl chr 1:152,111,188...152,226,383 		JBrowse link
G Pi16 peptidase inhibitor 16 acts_upstream_of_or_within ISO (MGI:3810223|PMID:17909105) RGD PMID:17909105 MGI:3810223 NCBI chr20:7,376,073...7,385,386
Ensembl chr20:7,376,126...7,385,383 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha IMP RGD PMID:22198280 RGD:5687133 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Rbm10 RNA binding motif protein 10 IMP RGD PMID:30257214 RGD:151667449 NCBI chr  X:1,540,399...1,572,571
Ensembl chr  X:1,540,398...1,572,575 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 IMP RGD PMID:16380388 RGD:13524577 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 IDA RGD PMID:9918533 RGD:7207376 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068 		JBrowse link
G Tomm70 translocase of outer mitochondrial membrane 70 IMP RGD PMID:25022898 RGD:13464131 NCBI chr11:43,378,719...43,417,166
Ensembl chr11:43,377,216...43,417,202 		JBrowse link
G Yy1 YY1 transcription factor IMP RGD PMID:18632988 RGD:9588273 NCBI chr 6:127,706,739...127,731,907
Ensembl chr 6:127,707,596...127,732,747 		JBrowse link
G Zfp418 zinc finger protein 418 acts_upstream_of_or_within ISO (MGI:5920524|PMID:29065170) RGD PMID:29065170 MGI:5920524 NCBI chr 1:66,581,406...66,594,247
Ensembl chr 1:66,581,287...66,594,242 		JBrowse link
negative regulation of skeletal muscle hypertrophy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Igfbp5 insulin-like growth factor binding protein 5 involved_in ISO (MGI:3039207|PMID:15010534) RGD PMID:15010534 MGI:3039207 NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156 		JBrowse link
positive regulation of cardiac muscle hypertrophy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adk adenosine kinase IMP RGD PMID:21335462 RGD:6482642 NCBI chr15:2,863,241...3,246,453
Ensembl chr15:2,863,244...3,246,510 		JBrowse link
G Adra1a adrenoceptor alpha 1A acts_upstream_of_or_within ISO (MGI:5888970|PMID:27994061) RGD PMID:27994061 MGI:5888970 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500 		JBrowse link
G Agt angiotensinogen involved_in IDA PMID:8348686 BHF-UCL PMID:8348686 RGD:8553767 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Becn1 beclin 1 acts_upstream_of_or_within ISO MGI:2683833 (MGI:5888970|PMID:27994061) RGD PMID:27994061 MGI:5888970 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bmp10 bone morphogenetic protein 10 involved_in ISO
IEA
IMP		 (PMID:17921333)
GO_REF:0000107		 RGD
Ensembl		 PMID:17921333 PMID:17921333 GO_REF:0000107, RGD:2302083 NCBI chr 4:119,872,066...119,877,694
Ensembl chr 4:119,872,045...119,878,627 		JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II delta involved_in ISO
ISS		 (PMID:17179159)
GO_REF:0000024		 RGD
UniProt		 PMID:17179159 GO_REF:0000024 NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178 		JBrowse link
G Cdk9 cyclin-dependent kinase 9 IMP RGD PMID:20081228 RGD:9698419 NCBI chr 3:15,996,467...16,001,315
Ensembl chr 3:15,996,468...16,002,410 		JBrowse link
G Ece1 endothelin converting enzyme 1 IMP RGD PMID:20099522 RGD:7243873 NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371 		JBrowse link
G Edn1 endothelin 1 involved_in ISO (PMID:12847114) RGD PMID:12847114 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Hand2 heart and neural crest derivatives expressed 2 involved_in ISO
IEA		 UniProtKB:P63328|UniProtKB:Q02078 (PMID:24161931)
GO_REF:0000107		 RGD
Ensembl		 PMID:24161931 GO_REF:0000107 NCBI chr16:32,917,826...32,919,880
Ensembl chr16:32,917,823...32,919,891 		JBrowse link
G Igf1 insulin-like growth factor 1 involved_in ISO (PMID:19654000), (PMID:19933931) RGD PMID:19654000 PMID:19933931 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Mef2a myocyte enhancer factor 2a involved_in ISO
IEA		 UniProtKB:P61296 (PMID:24161931)
GO_REF:0000107		 RGD
Ensembl		 PMID:24161931 GO_REF:0000107 NCBI chr 1:120,847,874...120,982,488
Ensembl chr 1:120,850,080...120,981,948 		JBrowse link
G Mef2c myocyte enhancer factor 2C involved_in IMP PMID:19654000 UniProt PMID:19654000 RGD:5131609 NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880 		JBrowse link
G Mtpn myotrophin involved_in ISO
IMP		 (PMID:10329199)
PMID:18693253		 RGD PMID:10329199 PMID:18693253 RGD:8553542 NCBI chr 4:64,159,273...64,186,686
Ensembl chr 4:64,157,641...64,186,724 		JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 involved_in IMP PMID:25625556 UniProt PMID:25625556 RGD:10054073 NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 involved_in IMP PMID:25625556 UniProt PMID:25625556 RGD:10054073 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pde5a phosphodiesterase 5A involved_in ISO (MGI:3836877|PMID:19127022) RGD PMID:19127022 MGI:3836877 NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701 		JBrowse link
G Pde9a phosphodiesterase 9A involved_in ISS
ISO		 GO_REF:0000024
(MGI:5634842|PMID:25799991)		 UniProt
RGD		 PMID:25799991 GO_REF:0000024 MGI:5634842 NCBI chr20:9,469,809...9,562,949
Ensembl chr20:9,469,848...9,562,948 		JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha involved_in ISO RNAcentral:URS0000021B51_10090|UniProtKB:P61296 (MGI:5562625|PMID:24161931), (MGI:5784969|PMID:24657879) RGD PMID:24161931 PMID:24657879 MGI:5562625 MGI:5784969 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974 		JBrowse link
G Prkca protein kinase C, alpha involved_in IDA PMID:11864993 UniProt PMID:11864993 RGD:8554603 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Ptk2 protein tyrosine kinase 2 acts_upstream_of_or_within ISO (MGI:5888970|PMID:27994061) RGD PMID:27994061 MGI:5888970 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:28679962)		 Ensembl
RGD		 PMID:28679962 GO_REF:0000107 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571 		JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 involved_in IMP
ISO		 PMID:28679962
(MGI:6158813|PMID:28679962)		 RGD PMID:28679962 PMID:28679962 MGI:6158813, RGD:13601991 NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031 		JBrowse link
G Slc9a1 solute carrier family 9 member A1 involved_in ISO (PMID:21359875) RGD PMID:21359875 NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624 		JBrowse link
G Twf1 twinfilin actin-binding protein 1 involved_in ISO (MGI:5882879|PMID:20571053) RGD PMID:20571053 MGI:5882879 NCBI chr 7:125,715,938...125,727,834
Ensembl chr 7:125,716,015...125,727,894 		JBrowse link
positive regulation of cardiac muscle hypertrophy in response to stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppp3ca protein phosphatase 3 catalytic subunit alpha involved_in ISO (MGI:3848765|PMID:19287093) RGD PMID:19287093 MGI:3848765 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974 		JBrowse link
G Trpc3 transient receptor potential cation channel, subfamily C, member 3 involved_in ISO (PMID:19287093) RGD PMID:19287093 NCBI chr 2:119,481,313...119,619,333
Ensembl chr 2:119,481,400...119,558,855 		JBrowse link
positive regulation of cell growth involved in cardiac muscle cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 IMP RGD PMID:18194989 RGD:5129139 NCBI chr 1:255,772,217...255,773,617
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Akap6 A-kinase anchoring protein 6 IMP
IDA		 RGD PMID:21550986 PMID:16306226 RGD:6902940, RGD:2312613 NCBI chr 6:70,184,101...70,624,369
Ensembl chr 6:70,184,175...70,619,738 		JBrowse link
G Ccn4 cellular communication network factor 4 IMP RGD PMID:21376054 RGD:5129173 NCBI chr 7:98,645,238...98,677,253
Ensembl chr 7:98,645,182...98,677,248 		JBrowse link
G Ddx39b DExD-box helicase 39B IMP RGD PMID:20116367 RGD:10401141 NCBI chr20:3,547,702...3,585,064
Ensembl chr20:3,572,056...3,584,996 		JBrowse link
G Edn1 endothelin 1 involved_in ISO RNAcentral:URS000006FDD4_9606|RNAcentral:URS000013D17D_9606 (PMID:24117217) RGD PMID:24117217 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Ep300 E1A binding protein p300 IMP RGD PMID:12724418 RGD:2312280 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Fdps farnesyl diphosphate synthase IMP RGD PMID:19716825 RGD:2316294 NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776 		JBrowse link
G Hamp hepcidin antimicrobial peptide IMP RGD PMID:24424338 RGD:11041632 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891 		JBrowse link
G Igf1 insulin-like growth factor 1 involved_in ISO
IEA		 RNAcentral:URS000006FDD4_9606|RNAcentral:URS000013D17D_9606 (PMID:24117217)
GO_REF:0000107		 RGD
Ensembl		 PMID:24117217 GO_REF:0000107 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Mir19a microRNA 19a involved_in ISO UniProtKB:P05019 (PMID:24117217) RGD PMID:24117217 NCBI chr15:92,180,912...92,180,993
Ensembl chr15:92,180,912...92,180,993 		JBrowse link
G Mir19b1 microRNA 19b-1 involved_in ISO UniProtKB:P05019 (PMID:24117217) RGD PMID:24117217 NCBI chr15:92,181,214...92,181,300
Ensembl chr15:92,181,214...92,181,300 		JBrowse link
G Mir19b2 microRNA 19b-2 involved_in ISO UniProtKB:P05019 (PMID:24117217) RGD PMID:24117217 NCBI chr  X:132,422,072...132,422,167
Ensembl chr  X:132,422,072...132,422,167 		JBrowse link
G Mtor mechanistic target of rapamycin kinase IMP RGD PMID:21318349 PMID:21933187 RGD:10040977, RGD:10040978 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 IMP RGD PMID:22989630 RGD:7174736 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Parp2 poly (ADP-ribose) polymerase 2 IMP RGD PMID:23261455 RGD:13514044 NCBI chr15:24,034,069...24,044,340
Ensembl chr15:24,034,106...24,044,338 		JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 IMP RGD PMID:23487407 RGD:8693424 NCBI chr 8:19,189,408...19,200,785
Ensembl chr 8:19,189,373...19,200,785 		JBrowse link
G Sirt1 sirtuin 1 IMP RGD PMID:25281201 RGD:13514043 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc25a4 solute carrier family 25 member 4 IDA RGD PMID:21325829 RGD:9681466 NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733 		JBrowse link
G Trip10 thyroid hormone receptor interactor 10 IMP RGD PMID:23915320 RGD:11535145 NCBI chr 9:2,133,085...2,147,795
Ensembl chr 9:2,133,671...2,147,799 		JBrowse link
positive regulation of skeletal muscle hypertrophy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mtor mechanistic target of rapamycin kinase IMP RGD PMID:23470307 RGD:10041029 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Mymk myomaker, myoblast fusion factor involved_in ISO (MGI:6116777|PMID:28186492) RGD PMID:28186492 MGI:6116777 NCBI chr 3:10,388,361...10,397,364
Ensembl chr 3:10,388,361...10,397,343 		JBrowse link
regulation of cardiac muscle hypertrophy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lmcd1 LIM and cysteine-rich domains 1 involved_in ISO (PMID:20026769)
(MGI:4442539|PMID:20026769)		 RGD PMID:20026769 MGI:4442539 NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046 		JBrowse link
regulation of cardiac muscle hypertrophy in response to stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp10 bone morphogenetic protein 10 involved_in ISO
IEA		 (PMID:17921333)
GO_REF:0000107		 RGD
Ensembl		 PMID:17921333 GO_REF:0000107 NCBI chr 4:119,872,066...119,877,694
Ensembl chr 4:119,872,045...119,878,627 		JBrowse link
regulation of cell growth involved in cardiac muscle cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col14a1 collagen type XIV alpha 1 chain acts_upstream_of_or_within ISO MGI:3846440 (MGI:5444801|PMID:22906538) RGD PMID:22906538 MGI:5444801 NCBI chr 7:86,722,093...86,937,215
Ensembl chr 7:86,722,094...86,937,214 		JBrowse link
skeletal muscle hypertrophy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor IMP RGD PMID:7957162 RGD:10043318 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Myoc myocilin involved_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:5320812|PMID:22371502)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:22371502 GO_REF:0000024 GO_REF:0000107 MGI:5320812 NCBI chr13:74,976,730...74,987,128
Ensembl chr13:74,976,730...74,987,127 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20091
    multicellular organismal process 8961
      system process 3560
        muscle system process 477
          muscle hypertrophy 123
            striated muscle hypertrophy 121
              cardiac muscle hypertrophy + 117
              skeletal muscle hypertrophy + 5
paths to the root