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ONTOLOGY REPORT - ANNOTATIONS

Term:striated muscle adaptation
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Accession:GO:0014888 term browser browse the term
Definition:Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities.
Synonyms:related_synonym: striated muscle plasticity

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cardiac muscle hypertrophy in response to stress term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 ISO (MGI:5576864|PMID:24137001) RGD PMID:24137001 MGI:5576864 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326 		JBrowse link
G Camta2 calmodulin binding transcription activator 2 ISO (PMID:16678093) RGD PMID:16678093 NCBI chr10:57,291,192...57,309,638
Ensembl chr10:57,291,192...57,309,298 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit ISO (MGI:5576864|PMID:24137001) RGD PMID:24137001 MGI:5576864 NCBI chr 4:77,284,404...77,347,011
Ensembl chr 4:77,284,404...77,347,011 		JBrowse link
G Gata4 GATA binding protein 4 ISO MGI:3054171|MGI:3778685 (MGI:5002493|PMID:20705924) RGD PMID:20705924 MGI:5002493 NCBI chr15:46,386,703...46,458,679
Ensembl chr15:46,386,712...46,432,965 		JBrowse link
G Gata6 GATA binding protein 6 IEA
ISO		 GO_REF:0000107
MGI:3054171|MGI:3654150 (MGI:5002493|PMID:20705924)		 Ensembl
RGD		 PMID:20705924 GO_REF:0000107 MGI:5002493 NCBI chr18:2,415,821...2,447,087
Ensembl chr18:2,416,552...2,446,338 		JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 ISO (MGI:3624193|PMID:16603706) RGD PMID:16603706 MGI:3624193 NCBI chr 1:29,191,170...29,201,257
Ensembl chr 1:29,191,192...29,201,531 		JBrowse link
G Inpp5f inositol polyphosphate-5-phosphatase F ISO MGI:4128518 (MGI:4943859|PMID:19875726) RGD PMID:19875726 MGI:4943859 NCBI chr 1:200,037,749...200,116,524
Ensembl chr 1:200,037,749...200,116,524 		JBrowse link
G Kdm4a lysine demethylase 4A ISO (MGI:5050547|PMID:21555854) RGD PMID:21555854 MGI:5050547 NCBI chr 5:136,967,650...137,014,402
Ensembl chr 5:136,967,650...137,014,430 		JBrowse link
G Klf15 Kruppel-like factor 15 ISO (MGI:3709247|PMID:17438289) RGD PMID:17438289 MGI:3709247 NCBI chr 4:122,364,688...122,377,690
Ensembl chr 4:122,365,093...122,377,659 		JBrowse link
G Mef2c myocyte enhancer factor 2C ISO (MGI:1346950|PMID:10531040) RGD PMID:10531040 MGI:1346950 NCBI chr 2:11,658,534...11,822,788
Ensembl chr 2:11,658,568...11,822,787 		JBrowse link
G Mir208b microRNA 208b ISO (MGI:5576864|PMID:24137001) RGD PMID:24137001 MGI:5576864 NCBI chr15:33,639,510...33,639,621
Ensembl chr15:33,639,510...33,639,621 		JBrowse link
G Myh6 myosin heavy chain 6 IEA
ISO		 GO_REF:0000107
(MGI:5576864|PMID:24137001)		 Ensembl
RGD		 PMID:24137001 GO_REF:0000107 MGI:5576864 NCBI chr15:33,605,653...33,629,730
Ensembl chr15:33,605,654...33,629,699 		JBrowse link
G Myh7 myosin heavy chain 7 IEA
ISO		 GO_REF:0000107
(MGI:5576864|PMID:24137001)		 Ensembl
RGD		 PMID:24137001 GO_REF:0000107 MGI:5576864 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089 		JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 ISO MGI:107164 (MGI:2388546|PMID:12370307) RGD PMID:12370307 MGI:2388546 NCBI chr19:38,039,542...38,114,003
Ensembl chr19:38,039,564...38,114,003 		JBrowse link
G Nppa natriuretic peptide A ISO MGI:1857231 (MGI:3606834|PMID:14985074), (MGI:3610438|PMID:15452027), (MGI:5576864|PMID:24137001) RGD PMID:14985074 PMID:15452027 PMID:24137001 MGI:3606834 MGI:3610438 MGI:5576864 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705 		JBrowse link
G Nppb natriuretic peptide B ISO (MGI:5576864|PMID:24137001) RGD PMID:24137001 MGI:5576864 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531 		JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha ISO MGI:103296 (MGI:2388546|PMID:12370307) RGD PMID:12370307 MGI:2388546 NCBI chr 2:241,909,332...242,186,861
Ensembl chr 2:241,909,832...242,184,854 		JBrowse link
G Tcap titin-cap ISO
IEA		 (PMID:12507422)
GO_REF:0000107		 RGD
Ensembl		 PMID:12507422 GO_REF:0000107 NCBI chr10:86,337,705...86,338,414
Ensembl chr10:86,337,728...86,338,411 		JBrowse link
negative regulation of cardiac muscle adaptation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oga O-GlcNAcase IMP RGD PMID:17573462 RGD:2305953 NCBI chr 1:265,506,752...265,542,452
Ensembl chr 1:265,507,451...265,542,276 		JBrowse link
negative regulation of cardiac muscle hypertrophy in response to stress term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 ISO (PMID:19287093)
(MGI:3848765|PMID:19287093)		 RGD PMID:19287093 MGI:3848765 NCBI chr13:50,091,644...50,153,808
Ensembl chr13:50,091,430...50,153,823 		JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 IDA RGD PMID:19204184 RGD:9685562 NCBI chr 5:167,951,564...167,966,011
Ensembl chr 5:167,952,728...167,966,009 		JBrowse link
G Foxo1 forkhead box O1 IMP PMID:26436652 UniProt PMID:26436652 RGD:13210548 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016 		JBrowse link
G Lmna lamin A/C IEA
ISO
ISS		 GO_REF:0000107
(MGI:5700584|PMID:26436652)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:26436652 GO_REF:0000024 GO_REF:0000107 MGI:5700584 NCBI chr 2:187,842,884...187,863,552
Ensembl chr 2:187,842,885...187,863,516 		JBrowse link
G Mlip muscular LMNA-interacting protein ISO (MGI:5700584|PMID:26436652), (MGI:5908525|PMID:26359501) RGD PMID:26359501 PMID:26436652 MGI:5700584 MGI:5908525 NCBI chr 8:84,409,957...84,634,637
Ensembl chr 8:84,434,784...84,632,817 		JBrowse link
G Smad3 SMAD family member 3 IGI PMID:27038547 BHF-UCL PMID:27038547 RGD:11535100 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349 		JBrowse link
negative regulation of skeletal muscle hypertrophy term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Igfbp5 insulin-like growth factor binding protein 5 ISO (MGI:3039207|PMID:15010534) RGD PMID:15010534 MGI:3039207 NCBI chr 9:80,154,230...80,166,813
Ensembl chr 9:80,150,211...80,167,033 		JBrowse link
positive regulation of cardiac muscle hypertrophy in response to stress term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppp3ca protein phosphatase 3 catalytic subunit alpha ISO (MGI:3848765|PMID:19287093) RGD PMID:19287093 MGI:3848765 NCBI chr 2:241,909,332...242,186,861
Ensembl chr 2:241,909,832...242,184,854 		JBrowse link
G Trpc3 transient receptor potential cation channel, subfamily C, member 3 ISO
IEA		 (PMID:19287093)
GO_REF:0000107		 RGD
Ensembl		 PMID:19287093 GO_REF:0000107 NCBI chr 2:123,329,954...123,467,574
Ensembl chr 2:123,329,875...123,407,496 		JBrowse link
positive regulation of skeletal muscle hypertrophy term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mtor mechanistic target of rapamycin kinase IMP RGD PMID:23470307 RGD:10041029 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967 		JBrowse link
G Mymk myomaker, myoblast fusion factor ISO (MGI:6116777|PMID:28186492) RGD PMID:28186492 MGI:6116777 NCBI chr 3:5,608,243...5,617,689
Ensembl chr 3:5,608,243...5,617,225 		JBrowse link
regulation of cardiac muscle hypertrophy in response to stress term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp10 bone morphogenetic protein 10 ISO
IEA		 (PMID:17921333)
GO_REF:0000107		 RGD
Ensembl		 PMID:17921333 GO_REF:0000107 NCBI chr 4:119,224,906...119,230,534
Ensembl chr 4:119,225,040...119,230,728 		JBrowse link
regulation of skeletal muscle adaptation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cmya5 cardiomyopathy associated 5 ISO MGI:107164 (MGI:5056263|PMID:21427212) RGD PMID:21427212 MGI:5056263 NCBI chr 2:22,646,694...22,744,536
Ensembl chr 2:22,646,712...22,744,407 		JBrowse link
skeletal muscle adaptation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1s calcium voltage-gated channel subunit alpha1 S ISO MGI:1856326 (MGI:3616422|PMID:2419767) RGD PMID:2419767 MGI:3616422 NCBI chr13:52,889,570...52,964,558
Ensembl chr13:52,889,737...52,964,155 		JBrowse link
skeletal muscle atrophy term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn3 actinin alpha 3 ISO (MGI:5554485|PMID:24234654) RGD PMID:24234654 MGI:5554485 NCBI chr 1:220,120,532...220,136,460
Ensembl chr 1:220,120,533...220,136,470 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator ISO (MGI:5707584|PMID:21364645) RGD PMID:21364645 MGI:5707584 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251 		JBrowse link
G Il15 interleukin 15 IEP RGD PMID:17135303 RGD:1626613 NCBI chr19:23,542,606...23,624,366
Ensembl chr19:23,542,889...23,554,594 		JBrowse link
G Ireb2 iron responsive element binding protein 2 IEP RGD PMID:23994517 RGD:12904021 NCBI chr 8:59,450,974...59,503,634
Ensembl chr 8:59,420,123...59,501,118 		JBrowse link
G Mstn myostatin IEP RGD PMID:15758361 RGD:2303594 NCBI chr 9:53,310,977...53,315,804
Ensembl chr 9:53,309,598...53,315,915 		JBrowse link
G Myod1 myogenic differentiation 1 IEP RGD PMID:12839833 RGD:1302305 NCBI chr 1:102,396,538...102,399,248
Ensembl chr 1:102,396,538...102,399,248 		JBrowse link
G Myog myogenin IEP RGD PMID:12839833 RGD:1302305 NCBI chr13:51,126,459...51,129,048
Ensembl chr13:51,126,459...51,129,048 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha IEP RGD PMID:16870628 RGD:10053649 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 IEP RGD PMID:17885021 RGD:1642984 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364 		JBrowse link
G Trim63 tripartite motif containing 63 IEP RGD PMID:11679633 RGD:633893 NCBI chr 5:152,533,362...152,547,138
Ensembl chr 5:152,533,349...152,547,179 		JBrowse link
skeletal muscle fiber adaptation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta1 actin, alpha 1, skeletal muscle IEP RGD PMID:16428321 RGD:1598721 NCBI chr19:56,674,072...56,677,084
Ensembl chr19:56,674,074...56,677,084 		JBrowse link
G Myod1 myogenic differentiation 1 IEA
ISO		 GO_REF:0000107
(MGI:3840749|PMID:19319192)		 Ensembl
RGD		 PMID:19319192 GO_REF:0000107 MGI:3840749 NCBI chr 1:102,396,538...102,399,248
Ensembl chr 1:102,396,538...102,399,248 		JBrowse link
G Myoz1 myozenin 1 ISO (MGI:3831256|PMID:18846255) RGD PMID:18846255 MGI:3831256 NCBI chr15:4,077,066...4,084,306
Ensembl chr15:4,077,091...4,084,314 		JBrowse link
G Myoz2 myozenin 2 ISO (MGI:3513659|PMID:15543153) RGD PMID:15543153 MGI:3513659 NCBI chr 2:227,180,887...227,207,629
Ensembl chr 2:227,180,886...227,207,635 		JBrowse link
skeletal muscle hypertrophy term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor IMP RGD PMID:7957162 RGD:10043318 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Myoc myocilin IEA
ISO
ISS		 GO_REF:0000107
(MGI:5320812|PMID:22371502)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:22371502 GO_REF:0000024 GO_REF:0000107 MGI:5320812 NCBI chr13:80,517,531...80,527,928
Ensembl chr13:80,517,536...80,527,928 		JBrowse link
striated muscle atrophy term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsn gelsolin ISO (PMID:19549824) RGD PMID:19549824 NCBI chr 3:14,456,106...14,508,922
Ensembl chr 3:14,467,330...14,508,911 		JBrowse link
G Myog myogenin ISS
ISO		 GO_REF:0000024
(MGI:5508727|PMID:21465538)		 UniProt
RGD		 PMID:21465538 GO_REF:0000024 MGI:5508727 NCBI chr13:51,126,459...51,129,048
Ensembl chr13:51,126,459...51,129,048 		JBrowse link
transition between fast and slow fiber term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn3 actinin alpha 3 ISO (MGI:3759354|PMID:17828264) RGD PMID:17828264 MGI:3759354 NCBI chr 1:220,120,532...220,136,460
Ensembl chr 1:220,120,533...220,136,470 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 ISO (MGI:3829334|PMID:18978355) RGD PMID:18978355 MGI:3829334 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326 		JBrowse link
G Gtf2ird2 GTF2I repeat domain containing 2 ISO (MGI:5504578|PMID:22899722) RGD PMID:22899722 MGI:5504578 NCBI chr12:25,509,059...25,555,554
Ensembl chr12:25,509,653...25,546,200 		JBrowse link
G Myh7 myosin heavy chain 7 IEA
ISO		 GO_REF:0000107
(MGI:3829334|PMID:18978355)		 Ensembl
RGD		 PMID:18978355 GO_REF:0000107 MGI:3829334 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089 		JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 ISO (MGI:3829530|PMID:18408153) RGD PMID:18408153 MGI:3829530 NCBI chr18:77,203,517...77,322,690
Ensembl chr18:77,203,525...77,322,690 		JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha ISO (MGI:5056263|PMID:21427212) RGD PMID:21427212 MGI:5056263 NCBI chr 2:241,909,332...242,186,861
Ensembl chr 2:241,909,832...242,184,854 		JBrowse link
G Tead1 TEA domain transcription factor 1 ISO (MGI:3829334|PMID:18978355) RGD PMID:18978355 MGI:3829334 NCBI chr 1:177,495,500...177,714,795
Ensembl chr 1:177,495,782...177,707,061 		JBrowse link
G Tnnc1 troponin C1, slow skeletal and cardiac type ISO (MGI:3829334|PMID:18978355) RGD PMID:18978355 MGI:3829334 NCBI chr16:7,292,207...7,295,238
Ensembl chr16:7,292,096...7,295,465 		JBrowse link
G Tnni1 troponin I1, slow skeletal type IEA
ISO		 GO_REF:0000107
(MGI:3829334|PMID:18978355)		 Ensembl
RGD		 PMID:18978355 GO_REF:0000107 MGI:3829334 NCBI chr13:52,624,856...52,637,297
Ensembl chr13:52,624,878...52,637,297 		JBrowse link
G Tnnt1 troponin T1, slow skeletal type ISO (MGI:3829334|PMID:18978355) RGD PMID:18978355 MGI:3829334 NCBI chr 1:72,889,270...72,899,629
Ensembl chr 1:72,889,270...72,899,659 		JBrowse link
transition between slow and fast fiber term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gtf2i general transcription factor II I ISO (MGI:5504578|PMID:22899722) RGD PMID:22899722 MGI:5504578 NCBI chr12:25,410,804...25,487,970
Ensembl chr12:25,411,207...25,488,156 		JBrowse link
G Gtf2ird1 GTF2I repeat domain containing 1 ISO (MGI:5504578|PMID:22899722) RGD PMID:22899722 MGI:5504578 NCBI chr12:25,264,052...25,370,947
Ensembl chr12:25,264,192...25,371,001 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20045
    response to stimulus 10557
      muscle adaptation 140
        striated muscle adaptation 56
          cardiac muscle adaptation + 27
          skeletal muscle adaptation + 31
          striated muscle atrophy + 11
Path 2
Term Annotations click to browse term
  biological_process 20045
    multicellular organismal process 9042
      system process 3454
        muscle system process 460
          muscle adaptation 140
            striated muscle adaptation 56
              cardiac muscle adaptation + 27
              skeletal muscle adaptation + 31
              striated muscle atrophy + 11
paths to the root