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ONTOLOGY REPORT - ANNOTATIONS


Term:striated muscle adaptation
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Accession:GO:0014888 term browser browse the term
Definition:Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities.
Synonyms:related_synonym: striated muscle plasticity



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cardiac muscle hypertrophy in response to stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:24137001)
Ensembl
RGD
PMID:24137001 GO_REF:0000107 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
JBrowse link
G Bmp2 bone morphogenetic protein 2 IMP RGD PMID:26873969 RGD:11526363 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Bmp4 bone morphogenetic protein 4 IMP RGD PMID:26873969 RGD:11526363 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
JBrowse link
G Camta2 calmodulin binding transcription activator 2 acts_upstream_of_or_within ISO (PMID:16678093) RGD PMID:16678093 NCBI chr10:55,383,450...55,401,838
Ensembl chr10:55,383,450...55,401,558
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit acts_upstream_of_or_within ISO (PMID:24137001) RGD PMID:24137001 NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362
JBrowse link
G Gata4 GATA binding protein 4 acts_upstream_of_or_within ISO MGI:3054171|MGI:3778685 (PMID:20705924) RGD PMID:20705924 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636
JBrowse link
G Gata6 GATA binding protein 6 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3054171|MGI:3654150 (PMID:20705924)
Ensembl
RGD
PMID:20705924 GO_REF:0000107 NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532
JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 acts_upstream_of_or_within ISO (PMID:16603706) RGD PMID:16603706 NCBI chr 1:26,822,131...26,832,218
Ensembl chr 1:26,822,131...26,832,218
JBrowse link
G Inpp5f inositol polyphosphate-5-phosphatase F acts_upstream_of_or_within ISO MGI:4128518 (PMID:19875726) RGD PMID:19875726 NCBI chr 1:183,190,480...183,270,276
Ensembl chr 1:183,190,480...183,270,276
JBrowse link
G Kdm4a lysine demethylase 4A acts_upstream_of_or_within ISO (PMID:21555854) RGD PMID:21555854 NCBI chr 5:131,672,754...131,719,534
Ensembl chr 5:131,672,754...131,719,501
JBrowse link
G Klf15 KLF transcription factor 15 involved_in ISO (MGI:3709247|PMID:17438289) RGD PMID:17438289 MGI:3709247 NCBI chr 4:122,965,718...122,978,403
Ensembl chr 4:122,965,807...122,978,374
JBrowse link
G Mef2c myocyte enhancer factor 2C acts_upstream_of_or_within ISO (PMID:10531040) RGD PMID:10531040 NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880
JBrowse link
G Mir208b microRNA 208b acts_upstream_of_or_within ISO (PMID:24137001) RGD PMID:24137001 NCBI chr15:28,451,638...28,451,749
Ensembl chr15:28,451,638...28,451,749
JBrowse link
G Myh6 myosin heavy chain 6 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:24137001)
Ensembl
RGD
PMID:24137001 GO_REF:0000107 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720
JBrowse link
G Myh7 myosin heavy chain 7 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:24137001)
Ensembl
RGD
PMID:24137001 GO_REF:0000107 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 acts_upstream_of_or_within ISO MGI:107164 (PMID:12370307) RGD PMID:12370307 NCBI chr19:33,960,643...34,035,150
Ensembl chr19:33,960,852...34,035,150
JBrowse link
G Nppa natriuretic peptide A acts_upstream_of
acts_upstream_of_or_within
ISO MGI:1857231 (PMID:26536903)
MGI:1857231 (PMID:14985074), (PMID:15452027), (PMID:24137001)
RGD PMID:14985074 PMID:15452027 PMID:24137001 PMID:26536903 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Nppb natriuretic peptide B acts_upstream_of_or_within ISO (PMID:24137001) RGD PMID:24137001 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha acts_upstream_of_or_within ISO MGI:103296 (PMID:12370307) RGD PMID:12370307 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
JBrowse link
G Smad1 SMAD family member 1 IMP RGD PMID:26873969 RGD:11526363 NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651
JBrowse link
G Smad4 SMAD family member 4 IMP RGD PMID:26873969 RGD:11526363 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438
JBrowse link
G Tcap titin-cap involved_in ISO (PMID:12507422) RGD PMID:12507422 NCBI chr10:83,381,719...83,382,887
Ensembl chr10:83,381,719...83,382,887
JBrowse link
negative regulation of cardiac muscle adaptation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oga O-GlcNAcase IMP RGD PMID:17573462 RGD:2305953 NCBI chr 1:244,598,285...244,633,835
Ensembl chr 1:244,598,292...244,634,359
JBrowse link
negative regulation of cardiac muscle hypertrophy in response to stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 involved_in ISO (PMID:19287093)
(MGI:3848765|PMID:19287093)
RGD PMID:19287093 MGI:3848765 NCBI chr13:45,156,137...45,255,292
Ensembl chr13:45,156,146...45,255,246
JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 IDA RGD PMID:19204184 RGD:9685562 NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282
JBrowse link
G Foxo1 forkhead box O1 involved_in IMP PMID:26436652 UniProt PMID:26436652 RGD:13210548 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Lmna lamin A/C involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:5700584|PMID:26436652)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:26436652 GO_REF:0000024 GO_REF:0000107 MGI:5700584 NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423
JBrowse link
G Mlip muscular LMNA-interacting protein involved_in ISO (MGI:5700584|PMID:26436652), (MGI:5908525|PMID:26359501) RGD PMID:26359501 PMID:26436652 MGI:5700584 MGI:5908525 NCBI chr 8:77,935,087...78,204,725
Ensembl chr 8:77,935,079...78,204,254
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma acts_upstream_of_or_within IDA PMID:29695452 BHF-UCL PMID:29695452 RGD:150521636 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Smad3 SMAD family member 3 involved_in IGI PMID:27038547 BHF-UCL PMID:27038547 RGD:11535100 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
negative regulation of skeletal muscle hypertrophy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Igfbp5 insulin-like growth factor binding protein 5 involved_in ISO (MGI:3039207|PMID:15010534) RGD PMID:15010534 MGI:3039207 NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156
JBrowse link
positive regulation of cardiac muscle hypertrophy in response to stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppp3ca protein phosphatase 3 catalytic subunit alpha involved_in ISO (MGI:3848765|PMID:19287093) RGD PMID:19287093 MGI:3848765 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
JBrowse link
G Trpc3 transient receptor potential cation channel, subfamily C, member 3 involved_in ISO (PMID:19287093) RGD PMID:19287093 NCBI chr 2:119,481,313...119,619,333
Ensembl chr 2:119,481,400...119,558,855
JBrowse link
positive regulation of skeletal muscle hypertrophy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mtor mechanistic target of rapamycin kinase IMP RGD PMID:23470307 RGD:10041029 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Mymk myomaker, myoblast fusion factor involved_in ISO (MGI:6116777|PMID:28186492) RGD PMID:28186492 MGI:6116777 NCBI chr 3:10,388,363...10,397,294
Ensembl chr 3:10,388,361...10,397,343
JBrowse link
regulation of cardiac muscle hypertrophy in response to stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acacb acetyl-CoA carboxylase beta IMP RGD PMID:31709908 RGD:329901803 NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655
JBrowse link
G Bmp10 bone morphogenetic protein 10 involved_in ISO
IEA
(PMID:17921333)
GO_REF:0000107
RGD
Ensembl
PMID:17921333 GO_REF:0000107 NCBI chr 4:119,872,066...119,877,694
Ensembl chr 4:119,872,045...119,878,627
JBrowse link
regulation of skeletal muscle adaptation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cmya5 cardiomyopathy associated 5 acts_upstream_of_or_within ISO MGI:107164 (PMID:21427212) RGD PMID:21427212 NCBI chr 2:24,279,520...24,378,253
Ensembl chr 2:24,279,528...24,378,364
JBrowse link
skeletal muscle adaptation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1s calcium voltage-gated channel subunit alpha1 S involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1856326 (PMID:2419767)
Ensembl
RGD
PMID:2419767 GO_REF:0000107 NCBI chr13:47,493,949...47,564,194
Ensembl chr13:47,493,949...47,564,318
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 IEP RGD PMID:24284598 RGD:329337337 NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028
JBrowse link
skeletal muscle atrophy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn3 actinin alpha 3 involved_in ISO (MGI:5554485|PMID:24234654) RGD PMID:24234654 MGI:5554485 NCBI chr 1:202,159,081...202,175,012
Ensembl chr 1:202,159,082...202,175,012
JBrowse link
G Asb2 ankyrin repeat and SOCS box-containing 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:6716965|PMID:27182554)
UniProt
RGD
PMID:27182554 GO_REF:0000024 MGI:6716965 NCBI chr 6:122,474,754...122,511,014
Ensembl chr 6:122,474,756...122,510,854
JBrowse link
G Cast calpastatin IEP RGD PMID:28800153 RGD:405100967 NCBI chr 2:3,973,112...4,082,658
Ensembl chr 2:3,973,112...4,082,659
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator involved_in ISO (MGI:5707584|PMID:21364645) RGD PMID:21364645 MGI:5707584 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
JBrowse link
G Il15 interleukin 15 IEP RGD PMID:17135303 RGD:1626613 NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820
JBrowse link
G Ireb2 iron responsive element binding protein 2 IEP RGD PMID:23994517 RGD:12904021 NCBI chr 8:55,228,080...55,311,613
Ensembl chr 8:55,228,085...55,311,611
JBrowse link
G Mstn myostatin IEP RGD PMID:15758361 RGD:2303594 NCBI chr 9:48,452,533...48,458,933
Ensembl chr 9:48,452,533...48,458,933
JBrowse link
G Myod1 myogenic differentiation 1 IEP RGD PMID:12839833 RGD:1302305 NCBI chr 1:96,884,864...96,887,574
Ensembl chr 1:96,884,948...96,887,554
JBrowse link
G Myog myogenin IEP RGD PMID:12839833 RGD:1302305 NCBI chr13:45,745,455...45,748,044
Ensembl chr13:45,745,436...45,748,039
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha IEP RGD PMID:16870628 RGD:10053649 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 IEP RGD PMID:17885021 RGD:1642984 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Trim63 tripartite motif containing 63 IEP RGD PMID:11679633 RGD:633893 NCBI chr 5:146,533,492...146,547,332
Ensembl chr 5:146,533,507...146,547,322
JBrowse link
skeletal muscle fiber adaptation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta1 actin, alpha 1, skeletal muscle IEP RGD PMID:16428321 RGD:1598721 NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742
JBrowse link
G Myod1 myogenic differentiation 1 acts_upstream_of_or_within ISO (PMID:19319192) RGD PMID:19319192 NCBI chr 1:96,884,864...96,887,574
Ensembl chr 1:96,884,948...96,887,554
JBrowse link
G Myoz1 myozenin 1 acts_upstream_of_or_within_positive_effect ISO (MGI:3831256|PMID:18846255) RGD PMID:18846255 MGI:3831256 NCBI chr15:3,644,333...3,651,584
Ensembl chr15:3,644,368...3,652,884
JBrowse link
G Myoz2 myozenin 2 involved_in ISO (MGI:3513659|PMID:15543153) RGD PMID:15543153 MGI:3513659 NCBI chr 2:211,141,463...211,168,187
Ensembl chr 2:211,141,463...211,168,221
JBrowse link
skeletal muscle hypertrophy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor IMP RGD PMID:7957162 RGD:10043318 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Myoc myocilin involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:5320812|PMID:22371502)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:22371502 GO_REF:0000024 GO_REF:0000107 MGI:5320812 NCBI chr13:74,976,730...74,987,128
Ensembl chr13:74,976,730...74,987,127
JBrowse link
striated muscle atrophy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsn gelsolin involved_in ISO
IEA
(PMID:19549824)
GO_REF:0000107
RGD
Ensembl
PMID:19549824 GO_REF:0000107 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
JBrowse link
G Myog myogenin involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(MGI:5508727|PMID:21465538)
UniProt
Ensembl
RGD
PMID:21465538 GO_REF:0000024 GO_REF:0000107 MGI:5508727 NCBI chr13:45,745,455...45,748,044
Ensembl chr13:45,745,436...45,748,039
JBrowse link
transition between fast and slow fiber term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn3 actinin alpha 3 involved_in ISO (MGI:3759354|PMID:17828264) RGD PMID:17828264 MGI:3759354 NCBI chr 1:202,159,081...202,175,012
Ensembl chr 1:202,159,082...202,175,012
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:18978355)
Ensembl
RGD
PMID:18978355 GO_REF:0000107 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
JBrowse link
G Gtf2ird2 GTF2I repeat domain containing 2 acts_upstream_of_or_within ISO (PMID:22899722) RGD PMID:22899722 NCBI chr12:22,497,767...22,536,455
Ensembl chr12:22,498,091...22,536,263
JBrowse link
G Myh7 myosin heavy chain 7 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:18978355)
Ensembl
RGD
PMID:18978355 GO_REF:0000107 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 acts_upstream_of_or_within ISO (PMID:18408153) RGD PMID:18408153 NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha acts_upstream_of_or_within ISO (PMID:21427212) RGD PMID:21427212 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
JBrowse link
G Tead1 TEA domain transcription factor 1 acts_upstream_of_or_within ISO (PMID:18978355) RGD PMID:18978355 NCBI chr 1:166,791,900...167,010,591
Ensembl chr 1:166,792,628...167,003,369
JBrowse link
G Tnnc1 troponin C1, slow skeletal and cardiac type acts_upstream_of_or_within ISO (PMID:18978355) RGD PMID:18978355 NCBI chr16:6,400,801...6,405,634
Ensembl chr16:6,402,171...6,405,634
JBrowse link
G Tnni1 troponin I1, slow skeletal type involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:18978355)
Ensembl
RGD
PMID:18978355 GO_REF:0000107 NCBI chr13:47,229,217...47,241,640
Ensembl chr13:47,229,216...47,241,644
JBrowse link
G Tnnt1 troponin T1, slow skeletal type acts_upstream_of_or_within ISO (PMID:18978355) RGD PMID:18978355 NCBI chr 1:69,306,362...69,316,721
Ensembl chr 1:69,306,362...69,316,721
JBrowse link
transition between slow and fast fiber term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gtf2ird1 GTF2I repeat domain containing 1 acts_upstream_of_or_within ISO (PMID:22899722) RGD PMID:22899722 NCBI chr12:22,254,113...22,361,052
Ensembl chr12:22,254,221...22,361,040
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20413
    response to stimulus 10920
      muscle adaptation 156
        striated muscle adaptation 63
          cardiac muscle adaptation + 33
          skeletal muscle adaptation + 32
          striated muscle atrophy + 13
Path 2
Term Annotations click to browse term
  biological_process 20413
    multicellular organismal process 8921
      system process 3548
        muscle system process 493
          muscle adaptation 156
            striated muscle adaptation 63
              cardiac muscle adaptation + 33
              skeletal muscle adaptation + 32
              striated muscle atrophy + 13
paths to the root