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ONTOLOGY REPORT - ANNOTATIONS

Term:vascular associated smooth muscle contraction
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Accession:GO:0014829 term browser browse the term
Definition:A process, occurring in the vascular tissue, whereby actin/myosin complex activity generates force through ATP hydrolysis resulting in a change in smooth muscle geometry. This process is always coupled to chemo-mechanical energy conversion.
Synonyms:exact_synonym: vascular smooth muscle contraction


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vascular associated smooth muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta1 actin, alpha 1, skeletal muscle involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742 		JBrowse link
G Acta2 actin alpha 2, smooth muscle involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3665248 (PMID:11053242)		 Ensembl
RGD		 PMID:11053242 GO_REF:0000107 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Actc1 actin, alpha, cardiac muscle 1 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 3:100,811,987...100,817,523
Ensembl chr 3:100,811,987...100,817,523 		JBrowse link
G Actg2 actin gamma 2, smooth muscle involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 4:116,021,832...116,046,475
Ensembl chr 4:116,021,832...116,046,465 		JBrowse link
G Comp cartilage oligomeric matrix protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2180787 (PMID:27498005)		 Ensembl
RGD		 PMID:27498005 GO_REF:0000107 NCBI chr16:19,047,206...19,055,584
Ensembl chr16:19,047,207...19,055,845 		JBrowse link
G Rap1gds1 Rap1 GTPase-GDP dissociation stimulator 1 IMP RGD PMID:18348285 RGD:2314690 NCBI chr 2:227,500,366...227,645,213
Ensembl chr 2:227,500,367...227,645,169 		JBrowse link
G Slc8a1 solute carrier family 8 member A1 involved_in ISO (MGI:1927695|PMID:10967099) RGD PMID:10967099 MGI:1927695 NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628 		JBrowse link
artery smooth muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen IDA RGD PMID:21076237 RGD:5129195 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Bbs2 Bardet-Biedl syndrome 2 acts_upstream_of_or_within ISO MGI:3521669 (PMID:20852044) RGD PMID:20852044 NCBI chr19:10,909,653...10,944,998
Ensembl chr19:10,909,619...10,944,993 		JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G IMP RGD PMID:18759855 RGD:2308879 NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752 		JBrowse link
G Cd38 CD38 molecule IMP RGD PMID:21431168 RGD:13506923 NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986 		JBrowse link
G Edn1 endothelin 1 involved_in IDA
ISO		 (PMID:8982507) RGD PMID:8982507 PMID:7586220 RGD:8662314 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Edn2 endothelin 2 involved_in ISO
IEA		 (PMID:8982507)
GO_REF:0000107		 RGD
Ensembl		 PMID:8982507 GO_REF:0000107 NCBI chr 5:133,751,316...133,756,814
Ensembl chr 5:133,751,217...133,756,814 		JBrowse link
G Edn3 endothelin 3 NOT|involved_in ISO (PMID:8982507) RGD PMID:8982507 NCBI chr 3:163,562,307...163,586,636
Ensembl chr 3:163,562,520...163,585,093 		JBrowse link
G Ednra endothelin receptor type A involved_in ISO
IEA		 (PMID:8982507)
GO_REF:0000107		 RGD
Ensembl		 PMID:8982507 GO_REF:0000107 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049 		JBrowse link
G Grip2 glutamate receptor interacting protein 2 acts_upstream_of_or_within ISO MGI:3035933 (PMID:23117660) RGD PMID:23117660 NCBI chr 4:124,271,456...124,356,538
Ensembl chr 4:124,271,456...124,321,268 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A IMP RGD PMID:14752059 RGD:7257678 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928 		JBrowse link
G Mkks MKKS centrosomal shuttling protein acts_upstream_of_or_within ISO MGI:3526444 (PMID:20852044) RGD PMID:20852044 NCBI chr 3:124,201,877...124,221,142
Ensembl chr 3:124,201,877...124,220,162 		JBrowse link
G Scnn1b sodium channel epithelial 1 subunit beta involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2179831 (PMID:19553501)		 Ensembl
RGD		 PMID:19553501 GO_REF:0000107 NCBI chr 1:176,430,063...176,484,451
Ensembl chr 1:176,430,103...176,484,451 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 IMP RGD PMID:19088082 RGD:10042965 NCBI chr19:34,162,337...34,245,786
Ensembl chr19:34,162,341...34,245,749 		JBrowse link
negative regulation of vascular associated smooth muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgap42 Rho GTPase activating protein 42 acts_upstream_of_or_within ISO MGI:3871380 (PMID:24335996) RGD PMID:24335996 NCBI chr 8:6,154,759...6,384,497
Ensembl chr 8:6,156,865...6,384,870 		JBrowse link
G Dock4 dedicator of cytokinesis 4 involved_in ISO (PMID:22158624) RGD PMID:22158624 NCBI chr 6:57,512,929...57,902,597
Ensembl chr 6:57,512,908...57,901,855 		JBrowse link
G Dock5 dedicator of cytokinesis 5 involved_in ISO (PMID:22158624) RGD PMID:22158624 NCBI chr15:41,979,728...42,158,733
Ensembl chr15:41,979,729...42,158,649 		JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 involved_in IMP PMID:19237536 UniProt PMID:19237536 RGD:401901238 NCBI chr10:14,850,765...14,853,046
Ensembl chr10:14,850,765...14,853,046 		JBrowse link
positive regulation of vascular associated smooth muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrm3 cholinergic receptor, muscarinic 3 IMP RGD PMID:8428203 RGD:2303387 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278 		JBrowse link
G Mir21 microRNA 21 involved_in ISO (PMID:22158624) RGD PMID:22158624 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Rhoa ras homolog family member A acts_upstream_of_or_within ISO (PMID:24335996) RGD PMID:24335996 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
regulation of vascular associated smooth muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2b adrenoceptor alpha 2B IMP RGD PMID:18054907 RGD:2313547 NCBI chr 3:114,585,174...114,589,220
Ensembl chr 3:114,585,169...114,589,355 		JBrowse link
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:6282934|PMID:24805951)		 UniProt
Ensembl
RGD		 PMID:24805951 GO_REF:0000024 GO_REF:0000107 MGI:6282934 NCBI chr 7:33,735,595...33,845,226
Ensembl chr 7:33,735,871...33,843,295 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 IMP inhibition decreases both calcium-stimulated and unstimulated myogenic tone in middle cerebral arteries (p<0.001) RGD PMID:10198244 RGD:2293329 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G P2rx1 purinergic receptor P2X 1 acts_upstream_of_or_within ISO MGI:2181608 (PMID:16920810) RGD PMID:16920810 NCBI chr10:57,618,586...57,633,648
Ensembl chr10:57,618,586...57,633,623 		JBrowse link
G Zdhhc21 zinc finger DHHC-type palmitoyltransferase 21 involved_in ISO (MGI:5921050|PMID:26715683) RGD PMID:26715683 MGI:5921050 NCBI chr 5:97,227,621...97,286,866
Ensembl chr 5:97,229,345...97,286,537 		JBrowse link
regulation of vein smooth muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 enables IDA salbutamol, isoproterenol, clenbuterol, norepinephrine RGD PMID:6289140 RGD:2301944 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 IMP RGD PMID:31125290 RGD:14696717 NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626 		JBrowse link
vein smooth muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edn1 endothelin 1 involved_in ISO
IBA		 (PMID:9422810)
GO_REF:0000033		 RGD
GO_Central		 PMID:9422810 GO_REF:0000033 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Edn2 endothelin 2 involved_in ISO
IBA
IEA		 (PMID:8982507), (PMID:9422810)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:8982507 PMID:9422810 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:133,751,316...133,756,814
Ensembl chr 5:133,751,217...133,756,814 		JBrowse link
G Edn3 endothelin 3 involved_in ISO
IBA		 (PMID:8982507)
GO_REF:0000033		 RGD
GO_Central		 PMID:8982507 GO_REF:0000033 NCBI chr 3:163,562,307...163,586,636
Ensembl chr 3:163,562,520...163,585,093 		JBrowse link
G Ednrb endothelin receptor type B involved_in ISO (PMID:8982507) RGD PMID:8982507 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20115
    multicellular organismal process 8865
      system process 3531
        muscle system process 486
          muscle contraction 345
            smooth muscle contraction 128
              vascular associated smooth muscle contraction 35
                artery smooth muscle contraction + 13
                negative regulation of vascular associated smooth muscle contraction + 4
                positive regulation of vascular associated smooth muscle contraction + 3
                regulation of vascular associated smooth muscle contraction + 14
                vein smooth muscle contraction + 6
Path 2
Term Annotations click to browse term
  biological_process 20115
    biological regulation 13553
      regulation of biological quality 3386
        regulation of anatomical structure size 611
          regulation of tube size 207
            regulation of tube diameter 206
              blood vessel diameter maintenance 206
                vasoconstriction 125
                  vascular associated smooth muscle contraction 35
                    artery smooth muscle contraction + 13
                    negative regulation of vascular associated smooth muscle contraction + 4
                    positive regulation of vascular associated smooth muscle contraction + 3
                    regulation of vascular associated smooth muscle contraction + 14
                    vein smooth muscle contraction + 6
paths to the root