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ONTOLOGY REPORT - ANNOTATIONS

Term:response to isoquinoline alkaloid
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Accession:GO:0014072 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isoquinoline alkaloid stimulus. An isoquinoline alkaloid is any member of a group of compounds with the heterocyclic ring structure of benzo(c)pyridine which is a structure characteristic of the group of opium alkaloids.


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response to isoquinoline alkaloid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A IEP oxycodone RGD PMID:23439660 RGD:11041186 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
cellular response to isoquinoline alkaloid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egr1 early growth response 1 IEP berberine RGD PMID:16448624 RGD:5131909 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Mecp2 methyl CpG binding protein 2 IDA bicuculline RGD PMID:22262897 RGD:12790719 NCBI chr  X:151,781,177...151,844,687
Ensembl chr  X:151,789,930...151,844,689 		JBrowse link
cellular response to morphine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy8 adenylate cyclase 8 involved_in IEA
ISO
ISS
IDA		 GO_REF:0000107
(MGI:3808962|PMID:18222416)
GO_REF:0000024
PMID:16186630		 Ensembl
RGD
UniProt		 PMID:18222416 PMID:16186630 GO_REF:0000024 GO_REF:0000107 MGI:3808962, RGD:13825193 NCBI chr 7:96,417,310...96,665,911
Ensembl chr 7:96,417,324...96,665,911 		JBrowse link
G Aif1 allograft inflammatory factor 1 IEP morphine RGD PMID:19176808 RGD:2313012 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668 		JBrowse link
G Atg7 autophagy related 7 IEP RGD PMID:23800874 RGD:11557986 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 IEP RGD PMID:20578038 RGD:4889899 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 IEP RGD PMID:18178009 RGD:6483056 NCBI chr11:34,061,705...34,309,128
Ensembl chr11:34,061,708...34,308,758 		JBrowse link
G Oprm1 opioid receptor, mu 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Ppp1r9b protein phosphatase 1, regulatory subunit 9B involved_in ISS
ISO		 GO_REF:0000024
(MGI:3834288|PMID:18439408)		 UniProt
RGD		 PMID:18439408 GO_REF:0000024 MGI:3834288 NCBI chr10:79,938,055...79,954,085
Ensembl chr10:79,938,066...79,954,083 		JBrowse link
G RT1-Bb RT1 class II, locus Bb IEP RGD PMID:14742686 RGD:7488923 NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597 		JBrowse link
response to codeine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A IEP RGD PMID:24914722 RGD:11041146 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
response to morphine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A IEP RGD PMID:26554626 RGD:11041102 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 IEP RGD PMID:22845665 RGD:11099987 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Ada adenosine deaminase IMP RGD PMID:19934879 RGD:5128863 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088 		JBrowse link
G Adcy5 adenylate cyclase 5 IEP RGD PMID:18801381 RGD:13464135 NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974 		JBrowse link
G Adra1b adrenoceptor alpha 1B acts_upstream_of_or_within ISO MGI:2148638 (MGI:2178201|PMID:11923452) RGD PMID:11923452 MGI:2178201 NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919 		JBrowse link
G Cnr1 cannabinoid receptor 1 IMP RGD PMID:19804815 PMID:19463710 RGD:2314642, RGD:2314667 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 IEP RGD PMID:18657552 RGD:10059657 NCBI chr18:55,017,049...55,050,184
Ensembl chr18:55,017,055...55,049,271 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 IEP RGD PMID:28108674 RGD:13463594 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 IEP RGD PMID:20977699 RGD:4890043 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Drd1 dopamine receptor D1 IEP RGD PMID:23775491 RGD:7248563 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd2 dopamine receptor D2 acts_upstream_of_or_within ISO MGI:1857875|MGI:2387895|MGI:2388386|MGI:2656648 (MGI:2151226|PMID:11567069), (MGI:2178015|PMID:11264672), (MGI:3576272|PMID:12182883), (MGI:3653553|PMID:9252189)
MGI:2387895 (MGI:3655899|PMID:11943831)		 RGD PMID:9252189 PMID:11264672 PMID:11567069 PMID:11943831 PMID:12182883 MGI:2151226 MGI:2178015 MGI:3576272 MGI:3653553 MGI:3655899 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Drd3 dopamine receptor D3 acts_upstream_of_or_within ISO MGI:1857159 (MGI:2450222|PMID:12574430) RGD PMID:12574430 MGI:2450222 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596 		JBrowse link
G Ednra endothelin receptor type A IMP RGD PMID:16293342 PMID:16741068 RGD:1581828, RGD:4892606 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049 		JBrowse link
G Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 IEP RGD PMID:20553911 RGD:9685461 NCBI chr 1:239,425,515...239,552,323
Ensembl chr 1:239,425,430...239,552,317 		JBrowse link
G Fadd Fas associated via death domain IDA RGD PMID:21088039 RGD:11341805 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fga fibrinogen alpha chain IEP in conjunction with memory test RGD PMID:24855564 RGD:9685019 NCBI chr 2:168,365,364...168,381,533
Ensembl chr 2:168,374,120...168,381,528 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit IEP RGD PMID:15772255 RGD:2293776 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465 		JBrowse link
G Ghr growth hormone receptor IEP RGD PMID:11335057 RGD:2307381 NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735 		JBrowse link
G Gnao1 G protein subunit alpha o1 IEP RGD PMID:8458398 RGD:2302014 NCBI chr19:11,034,874...11,192,502
Ensembl chr19:11,035,956...11,192,493 		JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 IEP RGD PMID:24528483 RGD:13506244 NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994 		JBrowse link
G Gpi glucose-6-phosphate isomerase IMP RGD PMID:6447740 RGD:11051960 NCBI chr 1:86,828,211...86,856,077
Ensembl chr 1:86,828,216...86,856,086 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 acts_upstream_of_or_within ISO MGI:1928270 (MGI:3797147|PMID:18423864) RGD PMID:18423864 MGI:3797147 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 IEP RGD PMID:29081032 RGD:13506833 NCBI chr 1:201,581,480...201,601,580
Ensembl chr 1:201,581,480...201,601,582 		JBrowse link
G Grk3 G protein-coupled receptor kinase 3 IEP RGD PMID:29081032 RGD:13506833 NCBI chr12:43,624,778...43,735,375
Ensembl chr12:43,624,897...43,731,262 		JBrowse link
G Grk5 G protein-coupled receptor kinase 5 IEP RGD PMID:12384166 RGD:727454 NCBI chr 1:260,028,269...260,223,699
Ensembl chr 1:260,028,242...260,218,701 		JBrowse link
G Il1b interleukin 1 beta IEP RGD PMID:15317861 RGD:1626676 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha IEP RGD PMID:20190558 RGD:11560529 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670 		JBrowse link
G Mdm2 MDM2 proto-oncogene IEP RGD PMID:14625023 RGD:2317407 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mir338 microRNA 338 IEP RGD PMID:28108674 RGD:13463594 NCBI chr10:105,297,923...105,297,988 JBrowse link
G Mtor mechanistic target of rapamycin kinase IMP RGD PMID:24382350 RGD:10040983 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Npff neuropeptide FF-amide peptide precursor IEP RGD PMID:15207282 RGD:2316569 NCBI chr 7:133,654,530...133,655,319 JBrowse link
G Oprk1 opioid receptor, kappa 1 IEP RGD PMID:16753266 RGD:9831397 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Oprm1 opioid receptor, mu 1 IEP RGD PMID:16194531 PMID:16753266 RGD:2316627, RGD:9831397 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 IEP RGD PMID:18771713 RGD:2308891 NCBI chr 2:4,395,543...4,442,434
Ensembl chr 2:4,395,543...4,442,434 		JBrowse link
G Pea15 proliferation and apoptosis adaptor protein 15 IEP RGD PMID:19758790 RGD:2326031 NCBI chr13:84,657,815...84,667,437
Ensembl chr13:84,654,870...84,667,499 		JBrowse link
G Penk proenkephalin IEP RGD PMID:23300784 RGD:10003095 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129 		JBrowse link
G Pitx3 paired-like homeodomain 3 IEP RGD PMID:23215787 RGD:11535121 NCBI chr 1:245,001,106...245,013,881
Ensembl chr 1:245,001,164...245,013,892 		JBrowse link
G Plcg1 phospholipase C, gamma 1 IEP RGD PMID:17524370 RGD:2299883 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330 		JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B acts_upstream_of_or_within ISO MGI:3799291 (MGI:3797712|PMID:18496528) RGD PMID:18496528 MGI:3797712 NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775 		JBrowse link
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha acts_upstream_of_or_within ISO (MGI:3588907|PMID:16102737) RGD PMID:16102737 MGI:3588907 NCBI chr15:41,204,659...41,263,924
Ensembl chr15:41,204,200...41,263,924 		JBrowse link
G Ppp5c protein phosphatase 5, catalytic subunit acts_upstream_of_or_within ISO (MGI:3588907|PMID:16102737) RGD PMID:16102737 MGI:3588907 NCBI chr 1:77,690,203...77,714,507
Ensembl chr 1:77,690,208...77,714,456 		JBrowse link
G Prkce protein kinase C, epsilon acts_upstream_of_or_within ISO MGI:2152043 (MGI:3798724|PMID:16899053) RGD PMID:16899053 MGI:3798724 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719 		JBrowse link
G Prkcg protein kinase C, gamma involved_in ISS
ISO		 GO_REF:0000024
(MGI:3760696|PMID:11246146)		 UniProt
RGD		 PMID:11246146 GO_REF:0000024 MGI:3760696 NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit IEP RGD PMID:18400403 RGD:2298784 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 IEP RGD PMID:22056472 PMID:12653973 RGD:13524518, RGD:13524581 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068 		JBrowse link
G Slc1a1 solute carrier family 1 member 1 involved_in ISO MGI:2655190 (MGI:5907783|PMID:28049029) RGD PMID:28049029 MGI:5907783 NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402 		JBrowse link
G Srr serine racemase IEP RGD PMID:18603832 RGD:2302212 NCBI chr10:59,769,563...59,786,688
Ensembl chr10:59,769,571...59,787,011 		JBrowse link
G Tac1 tachykinin, precursor 1 IEP RGD PMID:17950674 RGD:2304334 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tac3 tachykinin precursor 3 IEP RGD PMID:7536308 RGD:2305965 NCBI chr 7:63,562,552...63,569,170
Ensembl chr 7:63,562,552...63,569,170 		JBrowse link
G Tacr1 tachykinin receptor 1 IEP RGD PMID:17950674 RGD:2304334 NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733 		JBrowse link
G Tacr3 tachykinin receptor 3 IEP RGD PMID:7536308 RGD:2305965 NCBI chr 2:223,266,536...223,363,791
Ensembl chr 2:223,266,536...223,363,791 		JBrowse link
G Tlr4 toll-like receptor 4 IEP RGD PMID:18599265 RGD:7777128 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19497
    response to stimulus 10416
      response to chemical 6209
        response to organic substance 3921
          response to organic cyclic compound 1467
            response to isoquinoline alkaloid 61
              cellular response to isoquinoline alkaloid + 10
              response to codeine + 1
              response to dextromethorphan + 0
              response to morphine + 59
Path 2
Term Annotations click to browse term
  biological_process 19497
    response to stimulus 10416
      response to chemical 6209
        response to organic substance 3921
          response to organonitrogen compound 1482
            response to alkaloid 189
              response to isoquinoline alkaloid 61
                cellular response to isoquinoline alkaloid + 10
                response to codeine + 1
                response to dextromethorphan + 0
                response to morphine + 59
paths to the root