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ONTOLOGY REPORT - ANNOTATIONS


Term:dopamine secretion
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Accession:GO:0014046 term browser browse the term
Definition:The regulated release of dopamine by a cell. Dopamine is a catecholamine and a precursor of adrenaline and noradrenaline. It acts as a neurotransmitter in the central nervous system but it is also produced peripherally and acts as a hormone.


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negative regulation of dopamine secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abat 4-aminobutyrate aminotransferase ISO RGD PMID:590329 RGD:10047092 NCBI chrNW_004936530:7,543,743...7,621,392 JBrowse link
G Cnr1 cannabinoid receptor 1 ISO RGD PMID:19187091 RGD:2314679 NCBI chrNW_004936510:3,779,930...3,806,615 JBrowse link
G Drd2 dopamine receptor D2 ISO RGD PMID:16490190 RGD:1625068 NCBI chrNW_004936612:1,094,686...1,154,149 JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 ISO RGD PMID:12872287 RGD:2315496 NCBI chrNW_004936723:1,108,105...1,137,602 JBrowse link
G LOC101959685 complement C5 ISO RGD PMID:18648551 RGD:5130170 NCBI chrNW_004936487:9,391,774...9,474,168 JBrowse link
G Syt11 synaptotagmin 11 ISO (MGI:MGI:6114813|PMID:29311685) UniProt PMID:29311685 MGI:MGI:6114813, RGD:14929208 NCBI chrNW_004936580:5,123,196...5,142,976 JBrowse link
positive regulation of dopamine secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit ISO (MGI:MGI:1194464|PMID:9428762) MGI PMID:9428762 MGI:MGI:1194464 NCBI chrNW_004936580:4,165,255...4,179,285 JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 ISO RGD PMID:18671738 RGD:2306573 NCBI chrNW_004936617:4,224,131...4,239,080 JBrowse link
G Htr6 5-hydroxytryptamine receptor 6 ISO RGD PMID:16987217 RGD:2317005 NCBI chrNW_004936474:5,848,719...5,858,520 JBrowse link
G Npy2r neuropeptide Y receptor Y2 ISO RGD PMID:17382974 RGD:1642505 NCBI chrNW_004936576:1,932,526...1,939,560 JBrowse link
G Oprk1 opioid receptor kappa 1 ISO RGD PMID:17568430 RGD:9831445 NCBI chrNW_004936496:280,593...305,900 JBrowse link
G Pcp4 Purkinje cell protein 4 ISO RGD PMID:21671256 RGD:9850149 NCBI chrNW_004936500:3,416,840...3,468,893 JBrowse link
G Pink1 PTEN induced kinase 1 ISO (MGI:MGI:3715376|PMID:17563363) MGI PMID:17563363 MGI:MGI:3715376 NCBI chrNW_004936474:6,574,471...6,589,478 JBrowse link
G Rtn4 reticulon 4 ISO RGD PMID:19112410 RGD:2314933 NCBI chrNW_004936491:1,407,414...1,474,031 JBrowse link
G Slc18a1 solute carrier family 18 member A1 ISO RGD PMID:17244889 RGD:5131195 NCBI chrNW_004936555:4,249,821...4,271,379 JBrowse link
G Syt1 synaptotagmin 1 ISO PMID:28370453 CACAO PMID:28370453 RGD:15023476 NCBI chrNW_004936698:65,210...575,538 JBrowse link
regulation of dopamine secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit ISO (MGI:MGI:2673776|PMID:12944511) MGI PMID:12944511 MGI:MGI:2673776 NCBI chrNW_004936514:10,680,893...10,695,859 JBrowse link
G Chrna6 cholinergic receptor nicotinic alpha 6 subunit ISO (MGI:MGI:2673776|PMID:12944511) MGI PMID:12944511 MGI:MGI:2673776 NCBI chrNW_004936785:17,588...28,565 JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit ISO (MGI:MGI:2673776|PMID:12944511) MGI PMID:12944511 MGI:MGI:2673776 NCBI chrNW_004936580:4,165,255...4,179,285 JBrowse link
G Drd2 dopamine receptor D2 ISO (MGI:MGI:3655899|PMID:11943831) MGI PMID:11943831 MGI:MGI:3655899 NCBI chrNW_004936612:1,094,686...1,154,149 JBrowse link
G Drd3 dopamine receptor D3 ISO (MGI:MGI:3698022|PMID:12044470)
(MGI:MGI:1202050|PMID:9482807)
MGI
RGD
PMID:9482807, PMID:12044470, PMID:16490190 MGI:MGI:1202050, MGI:MGI:3698022, RGD:1625068 NCBI chrNW_004936536:1,580,732...1,616,726 JBrowse link
G Dtnbp1 dystrobrevin binding protein 1 ISO (MGI:MGI:4398782|PMID:19887632) UniProtKB PMID:19887632 MGI:MGI:4398782 NCBI chrNW_004936552:1,787,687...1,926,516 JBrowse link
G Grm2 glutamate metabotropic receptor 2 ISO RGD PMID:30283001 RGD:38501063 NCBI chrNW_004936529:3,042,220...3,053,670 JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B ISO RGD PMID:16885935 RGD:1626459 NCBI chrNW_004936890:154,252...157,044 JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A ISO RGD PMID:15999145 RGD:1624397 NCBI chrNW_004936565:335,238...394,683 JBrowse link
G Kcna2 potassium voltage-gated channel subfamily A member 2 ISO (MGI:MGI:4947004|PMID:21233214) UniProtKB PMID:21233214 MGI:MGI:4947004 NCBI chrNW_004936704:2,007,577...2,019,520 JBrowse link
G Prkcb protein kinase C beta ISO RGD PMID:15647254 RGD:1625522 NCBI chrNW_004936501:8,410,273...8,729,238 JBrowse link
G Rab3a RAB3A, member RAS oncogene family ISO PMID:28370453 CACAO PMID:28370453 RGD:15023476 NCBI chrNW_004936596:2,990,367...2,995,935 JBrowse link
G Snca synuclein alpha ISO (MGI:MGI:3777215|PMID:18333965) MGI PMID:18333965 MGI:MGI:3777215 NCBI chrNW_004936685:2,077,017...2,175,298 JBrowse link
G Sncg synuclein gamma ISO (MGI:MGI:3777215|PMID:18333965) MGI PMID:18333965 MGI:MGI:3777215 NCBI chrNW_004936804:16,869...21,684 JBrowse link
G Syt1 synaptotagmin 1 ISO (MGI:MGI:5795818|PMID:21576241) ParkinsonsUK-UCL PMID:21576241 MGI:MGI:5795818 NCBI chrNW_004936698:65,210...575,538 JBrowse link
G Syt4 synaptotagmin 4 ISO (MGI:MGI:5795818|PMID:21576241) ParkinsonsUK-UCL PMID:21576241 MGI:MGI:5795818 NCBI chrNW_004936517:3,035,840...3,044,065 JBrowse link
G Syt7 synaptotagmin 7 ISO (MGI:MGI:5795818|PMID:21576241) ParkinsonsUK-UCL PMID:21576241 MGI:MGI:5795818 NCBI chrNW_004936581:1,516,199...1,557,992 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12001
    signaling 4174
      cell-cell signaling 1355
        signal release 557
          dopamine secretion 30
            axonal dopamine secretion + 0
            negative regulation of dopamine secretion 6
            positive regulation of dopamine secretion 10
            regulation of dopamine secretion + 30
            somato-dendritic dopamine secretion 0
Path 2
Term Annotations click to browse term
  biological_process 12001
    localization 4781
      establishment of localization 3430
        transport 3278
          organic substance transport 1722
            monoamine transport 89
              catecholamine transport 74
                dopamine transport 45
                  dopamine secretion 30
                    axonal dopamine secretion + 0
                    negative regulation of dopamine secretion 6
                    positive regulation of dopamine secretion 10
                    regulation of dopamine secretion + 30
                    somato-dendritic dopamine secretion 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.