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ONTOLOGY REPORT - ANNOTATIONS

Term:astrocyte development
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Accession:GO:0014002 term browser browse the term
Definition:The process aimed at the progression of an astrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.
Synonyms:exact_synonym: astrocyte cell development


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astrocyte development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor acts_upstream_of_or_within IMP (PMID:22577135) MGI PMID:22577135 NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910 		JBrowse link
G Dll1 delta like canonical Notch ligand 1 involved_in IMP (MGI:5504540|PMID:23688253) UniProt PMID:23688253 MGI:5504540 NCBI chr17:15,587,616...15,597,275
Ensembl chr17:15,587,616...15,597,134 		JBrowse link
G Drd1 dopamine receptor D1 acts_upstream_of_or_within IMP (PMID:17360497) MGI PMID:17360497 NCBI chr13:54,205,202...54,209,677
Ensembl chr13:54,205,202...54,209,724 		JBrowse link
G Eif2b5 eukaryotic translation initiation factor 2B, subunit 5 epsilon involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr16:20,317,544...20,328,073
Ensembl chr16:20,317,567...20,328,073 		JBrowse link
G Gfap glial fibrillary acidic protein acts_upstream_of_or_within IGI (PMID:11487638) MGI PMID:11487638 NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738 		JBrowse link
G Gm5849 predicted gene 5849 involved_in IBA GO_Central GO_REF:0000033 Ensembl chr 3:90,683,126...90,685,187 JBrowse link
G Lamb2 laminin, beta 2 acts_upstream_of_or_within IGI (PMID:19907020) MGI PMID:19907020 NCBI chr 9:108,357,080...108,367,729
Ensembl chr 9:108,356,935...108,367,729 		JBrowse link
G Lamc3 laminin gamma 3 acts_upstream_of_or_within IGI (PMID:19907020) MGI PMID:19907020 NCBI chr 2:31,777,293...31,839,095
Ensembl chr 2:31,777,303...31,836,551 		JBrowse link
G Plp1 proteolipid protein (myelin) 1 acts_upstream_of_or_within IGI (PMID:24038504) MGI PMID:24038504 NCBI chr  X:135,720,897...135,739,331
Ensembl chr  X:135,723,420...135,740,482 		JBrowse link
G Ror1 receptor tyrosine kinase-like orphan receptor 1 involved_in ISO RGD
MGI		 PMID:15095375 GO_REF:0000096 MGI:4417868 RGD:11537371 NCBI chr 4:99,952,988...100,302,003
Ensembl chr 4:99,952,988...100,301,962 		JBrowse link
G Ror2 receptor tyrosine kinase-like orphan receptor 2 involved_in ISO RGD
MGI		 PMID:15095375 GO_REF:0000096 MGI:4417868 RGD:11537371 NCBI chr13:53,263,353...53,440,160
Ensembl chr13:53,263,348...53,440,160 		JBrowse link
G S100a8 S100 calcium binding protein A8 (calgranulin A) acts_upstream_of_or_within IGI (PMID:22577135) MGI PMID:22577135 NCBI chr 3:90,576,378...90,577,341
Ensembl chr 3:90,576,285...90,577,342 		JBrowse link
G S100a9 S100 calcium binding protein A9 (calgranulin B) acts_upstream_of_or_within
involved_in		 IGI
IBA		 (PMID:22577135) MGI
GO_Central		 PMID:22577135 GO_REF:0000033 NCBI chr 3:90,599,937...90,603,028
Ensembl chr 3:90,599,939...90,603,028 		JBrowse link
G Tlr4 toll-like receptor 4 acts_upstream_of_or_within IMP (PMID:22577135) MGI PMID:22577135 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
G Tspan2 tetraspanin 2 acts_upstream_of_or_within IGI
IMP		 (PMID:24038504) MGI PMID:24038504 NCBI chr 3:102,642,086...102,679,626
Ensembl chr 3:102,641,845...102,708,829 		JBrowse link
G Vim vimentin acts_upstream_of_or_within IGI (PMID:11487638) MGI PMID:11487638 NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637 		JBrowse link
astrocyte activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor involved_in ISO RGD
MGI		 PMID:12838511 GO_REF:0000096 MGI:4417868 RGD:1625689 NCBI chr10:75,152,711...75,170,626
Ensembl chr10:75,152,711...75,170,618 		JBrowse link
G Ager advanced glycosylation end product-specific receptor involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910 		JBrowse link
G Agt angiotensinogen acts_upstream_of_or_within IMP (PMID:9734405) MGI PMID:9734405 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G App amyloid beta precursor protein involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654 		JBrowse link
G Bace2 beta-site APP-cleaving enzyme 2 ISO RGD PMID:21073551 RGD:13782176 NCBI chr16:97,157,928...97,244,136
Ensembl chr16:97,157,942...97,244,136 		JBrowse link
G C1qa complement component 1, q subcomponent, alpha polypeptide involved_in IGI (MGI:3607035|PMID:15269255) ARUK-UCL PMID:15269255 MGI:3607035 NCBI chr 4:136,623,227...136,626,155
Ensembl chr 4:136,623,228...136,626,114 		JBrowse link
G C5ar1 complement component 5a receptor 1 involved_in IGI (MGI:4354701|PMID:19561098) ARUK-UCL PMID:19561098 MGI:4354701 NCBI chr 7:15,980,668...15,993,465
Ensembl chr 7:15,980,668...15,993,465 		JBrowse link
G Cntf ciliary neurotrophic factor involved_in ISO
IBA		 spinal cord astrocytes RGD
GO_Central
MGI		 PMID:11771938 GO_REF:0000033 GO_REF:0000096 MGI:4417868 RGD:1626172 NCBI chr19:12,740,892...12,742,996
Ensembl chr19:12,741,024...12,742,996 		JBrowse link
G Egfr epidermal growth factor receptor involved_in ISO RGD
MGI		 PMID:16837601 GO_REF:0000096 MGI:4417868 RGD:1581900 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158 		JBrowse link
G Ifng interferon gamma involved_in IGI
ISO		 (MGI:4454469|PMID:20368278) ARUK-UCL
MGI		 PMID:20368278 GO_REF:0000119 MGI:4454469 MGI:4834177 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Ifngr1 interferon gamma receptor 1 involved_in IGI (MGI:3697769|PMID:17255335) ARUK-UCL PMID:17255335 MGI:3697769 NCBI chr10:19,467,697...19,485,977
Ensembl chr10:19,467,697...19,485,977 		JBrowse link
G Il1b interleukin 1 beta acts_upstream_of_or_within IDA (PMID:28377412) MGI PMID:28377412 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Mt2 metallothionein 2 ISO RGD PMID:19837066 RGD:6483825 NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196 		JBrowse link
G Naglu alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB) acts_upstream_of_or_within IMP (PMID:26607664) MGI PMID:26607664 NCBI chr11:100,960,918...100,968,483
Ensembl chr11:100,960,838...100,968,498 		JBrowse link
G Psen1 presenilin 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr12:83,734,926...83,781,869
Ensembl chr12:83,734,926...83,781,973 		JBrowse link
G Smo smoothened, frizzled class receptor acts_upstream_of_or_within IMP (PMID:23680462) MGI PMID:23680462 NCBI chr 6:29,735,480...29,761,359
Ensembl chr 6:29,735,502...29,761,364 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in IGI (MGI:6095556|PMID:29073081) ARUK-UCL PMID:29073081 MGI:6095556 NCBI chr17:48,653,429...48,659,304
Ensembl chr17:48,653,429...48,661,175 		JBrowse link
G Zeb2 zinc finger E-box binding homeobox 2 involved_in ISO RGD
MGI		 PMID:34852714 GO_REF:0000096 MGI:4417868 RGD:155882542 NCBI chr 2:44,873,523...45,007,378
Ensembl chr 2:44,873,644...45,007,407 		JBrowse link
astrocyte activation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654 		JBrowse link
G Grn granulin involved_in IMP (MGI:4421471|PMID:20026663) UniProt PMID:20026663 MGI:4421471 NCBI chr11:102,321,333...102,327,635
Ensembl chr11:102,321,141...102,327,874 		JBrowse link
G Lrp1 low density lipoprotein receptor-related protein 1 involved_in IGI (MGI:5465209|PMID:23152628) ARUK-UCL PMID:23152628 MGI:5465209 NCBI chr10:127,374,026...127,457,158
Ensembl chr10:127,374,030...127,457,017 		JBrowse link
G Psen1 presenilin 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr12:83,734,926...83,781,869
Ensembl chr12:83,734,926...83,781,973 		JBrowse link
forebrain astrocyte development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kras Kirsten rat sarcoma viral oncogene homolog acts_upstream_of_or_within IMP (PMID:22577135) MGI PMID:22577135 NCBI chr 6:145,162,425...145,197,631
Ensembl chr 6:145,162,425...145,195,965 		JBrowse link
G Nf1 neurofibromin 1 acts_upstream_of_or_within IMP (PMID:15944386) MGI PMID:15944386 NCBI chr11:79,223,541...79,472,435
Ensembl chr11:79,230,519...79,472,438 		JBrowse link
G Pou3f2 POU domain, class 3, transcription factor 2 acts_upstream_of_or_within IMP (PMID:8543156) MGI PMID:8543156 NCBI chr 4:22,482,095...22,488,366
Ensembl chr 4:22,482,780...22,488,366 		JBrowse link
negative regulation of astrocyte activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ldlr low density lipoprotein receptor involved_in IGI (MGI:4415751|PMID:20005821) ARUK-UCL PMID:20005821 MGI:4415751 NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215 		JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 involved_in IMP (MGI:6283959|PMID:30792350) UniProt PMID:30792350 MGI:6283959 NCBI chr11:98,658,758...98,666,233
Ensembl chr11:98,658,758...98,666,159 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in IDA (MGI:6152919|PMID:29407460) ARUK-UCL PMID:29407460 MGI:6152919 NCBI chr17:48,653,429...48,659,304
Ensembl chr17:48,653,429...48,661,175 		JBrowse link
positive regulation of astrocyte activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csf1r colony stimulating factor 1 receptor involved_in ISO RGD
MGI		 PMID:33841088 GO_REF:0000096 MGI:4417868 RGD:151665762 NCBI chr18:61,238,644...61,264,211
Ensembl chr18:61,233,670...61,265,221 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28573
    developmental process 7369
      anatomical structure development 6841
        cell development 3447
          glial cell development 158
            astrocyte development 41
              astrocyte activation + 23
              forebrain astrocyte development 3
Path 2
Term Annotations click to browse term
  biological_process 28573
    developmental process 7369
      anatomical structure development 6841
        multicellular organism development 5433
          system development 4660
            nervous system development 2850
              neurogenesis 2097
                gliogenesis 446
                  glial cell differentiation 330
                    glial cell development 158
                      astrocyte development 41
                        astrocyte activation + 23
                        forebrain astrocyte development 3
paths to the root