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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of translational initiation by eIF2 alpha phosphorylation
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Accession:GO:0010998 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the phosphorylation of eIF2 alpha.
Comment:Consider also annotating to 'eukaryotic translation initiation factor 2alpha kinase activity ; GO:0004694'.
Synonyms:exact_synonym: eIF2 alpha phosphorylation in response to stress;   regulation of translational initiation by eIF2 alpha phosphorylation in response to stress


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regulation of translational initiation by eIF2 alpha phosphorylation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 JBrowse link 12 12,749,026 12,782,078 RGD:1600115
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 JBrowse link 6 1,428,845 1,466,193 RGD:1600115
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 JBrowse link 4 98,648,513 98,709,695 RGD:1624291
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 JBrowse link 3 110,159,624 110,245,382 RGD:1624291
RGD:1600115
eiF2alpha phosphorylation in response to endoplasmic reticulum stress term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 JBrowse link 4 98,648,513 98,709,695 RGD:1624291
RGD:1600115
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 JBrowse link 3 110,159,624 110,245,382 RGD:1624291
negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 JBrowse link 15 104,186,918 104,226,236 RGD:1624291
RGD:1600115
G Nck1 NCK adaptor protein 1 JBrowse link 8 108,787,797 108,847,779 RGD:1624291
G Nck2 NCK adaptor protein 2 JBrowse link 9 50,246,767 50,373,307 RGD:1624291
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A JBrowse link 1 101,511,899 101,515,043 RGD:1624291
G Ppp1r15b protein phosphatase 1, regulatory subunit 15B JBrowse link 13 49,933,155 49,940,961 RGD:1624291
G Tmed2 transmembrane p24 trafficking protein 2 JBrowse link 12 37,471,259 37,480,344 RGD:1624291
regulation of eIF2 alpha phosphorylation by amino acid starvation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 JBrowse link 3 110,159,624 110,245,382 RGD:1624291
RGD:1600115
G Impact impact RWD domain protein JBrowse link 18 4,325,872 4,346,734 RGD:1624291
RGD:13792537
RGD:1600115
regulation of eIF2 alpha phosphorylation by dsRNA term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Npm1 nucleophosmin 1 JBrowse link 10 18,080,949 18,091,062 RGD:1624291
RGD:1600115
regulation of eIF2 alpha phosphorylation by heme term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 JBrowse link 12 12,749,026 12,782,078 RGD:1624291
G Fech ferrochelatase JBrowse link 18 59,941,992 59,975,192 RGD:1624291
G Hbb hemoglobin subunit beta JBrowse link 1 168,971,269 168,972,680 RGD:1624291
regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 JBrowse link 4 98,648,513 98,709,695 RGD:1624291
RGD:1600115
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A JBrowse link 1 101,511,899 101,515,043 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19676
    cellular process 18449
      cellular response to stimulus 8831
        cellular response to stress 1982
          regulation of translation in response to stress 22
            regulation of translational initiation in response to stress 16
              regulation of translational initiation by eIF2 alpha phosphorylation 14
                eiF2alpha phosphorylation in response to endoplasmic reticulum stress + 8
                regulation of eIF2 alpha phosphorylation by amino acid starvation 2
                regulation of eIF2 alpha phosphorylation by dsRNA 1
                regulation of eIF2 alpha phosphorylation by heme 3
Path 2
Term Annotations click to browse term
  biological_process 19676
    metabolic process 11952
      nitrogen compound metabolic process 10058
        cellular nitrogen compound metabolic process 6417
          cellular amide metabolic process 1421
            peptide metabolic process 1163
              peptide biosynthetic process 1011
                translation 993
                  translational initiation 130
                    regulation of translational initiation 72
                      regulation of translational initiation in response to stress 16
                        regulation of translational initiation by eIF2 alpha phosphorylation 14
                          eiF2alpha phosphorylation in response to endoplasmic reticulum stress + 8
                          regulation of eIF2 alpha phosphorylation by amino acid starvation 2
                          regulation of eIF2 alpha phosphorylation by dsRNA 1
                          regulation of eIF2 alpha phosphorylation by heme 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.