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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of low-density lipoprotein particle clearance
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Accession:GO:0010988 term browser browse the term
Definition:Any process that modulates the rate, frequency or extent of low-density lipoprotein particle clearance. Low-density lipoprotein particle clearance is the process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.


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regulation of low-density lipoprotein particle clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CNPY2 canopy FGF signaling regulator 2 acts_upstream_of
involved_in		 ISS
IEA		 (PMID:22378787) BHF-UCL
Ensembl		 PMID:22378787 GO_REF:0000107 NCBI chr12:56,309,844...56,316,346
Ensembl chr12:56,309,842...56,316,119 		JBrowse link
G CRP C-reactive protein ISO RGD PMID:8305421 RGD:9586002 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589 		JBrowse link
G FGF21 fibroblast growth factor 21 acts_upstream_of NAS (PMID:22378787) BHF-UCL PMID:22378787 NCBI chr19:48,755,524...48,758,330
Ensembl chr19:48,755,524...48,758,333 		JBrowse link
G HNRNPK heterogeneous nuclear ribonucleoprotein K acts_upstream_of IMP (PMID:20371611) BHF-UCL PMID:20371611 NCBI chr 9:83,968,083...83,980,615
Ensembl chr 9:83,968,083...83,980,631 		JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 involved_in IDA (PMID:12660231) UniProt PMID:12660231 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414 		JBrowse link
negative regulation of low-density lipoprotein particle clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC8 ATP binding cassette subfamily C member 8 involved_in ISO
IEA		 RGD
Ensembl		 PMID:23828271 GO_REF:0000107 RGD:12792253 NCBI chr11:17,392,498...17,476,845
Ensembl chr11:17,392,498...17,476,894 		JBrowse link
G APOC3 apolipoprotein C3 involved_in IMP
IBA
IEA		 (PMID:15778093) BHF-UCL
GO_Central
TreeGrafter		 PMID:15778093 GO_REF:0000033 GO_REF:0000118 NCBI chr11:116,829,907...116,833,072
Ensembl chr11:116,829,706...116,833,072 		JBrowse link
G CSK C-terminal Src kinase involved_in ISO
IEA		 RGD
Ensembl		 PMID:10884975 GO_REF:0000107 RGD:5134370 NCBI chr15:74,782,080...74,803,197
Ensembl chr15:74,782,080...74,803,197 		JBrowse link
G IL19 interleukin 19 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:206,770,773...206,842,981
Ensembl chr 1:206,770,764...206,842,981 		JBrowse link
G KHSRP KH-type splicing regulatory protein involved_in IGI (PMID:26523989) BHF-UCL PMID:26523989 NCBI chr19:6,413,102...6,424,811
Ensembl chr19:6,413,102...6,424,811 		JBrowse link
G LDLR low density lipoprotein receptor involved_in IDA (PMID:17452316) ComplexPortal PMID:17452316 NCBI chr19:11,089,463...11,133,820
Ensembl chr19:11,089,418...11,133,820 		JBrowse link
G MIR133A1 microRNA 133a-1 involved_in IDA (PMID:28257760) BHF-UCL PMID:28257760 NCBI chr18:21,825,698...21,825,785
Ensembl chr18:21,825,698...21,825,785 		JBrowse link
G MIR133A2 microRNA 133a-2 involved_in IDA (PMID:28257760) BHF-UCL PMID:28257760 NCBI chr20:62,564,912...62,565,013
Ensembl chr20:62,564,912...62,565,013 		JBrowse link
G MIR148A microRNA 148a involved_in IDA (PMID:26437365) BHF-UCL PMID:26437365 NCBI chr 7:25,949,919...25,949,986
Ensembl chr 7:25,949,919...25,949,986 		JBrowse link
G MIR17 microRNA 17 involved_in IDA (PMID:23285084) ARUK-UCL PMID:23285084 NCBI chr13:91,350,605...91,350,688
Ensembl chr13:91,350,605...91,350,688 		JBrowse link
G MIR185 microRNA 185 acts_upstream_of
involved_in		 IGI
IDA		 (PMID:24296663)
(PMID:26523989)		 BHF-UCL PMID:24296663 PMID:26523989 NCBI chr22:20,033,139...20,033,220
Ensembl chr22:20,033,139...20,033,220 		JBrowse link
G MIR199A1 microRNA 199a-1 involved_in IDA (PMID:26163491) BHF-UCL PMID:26163491 NCBI chr19:10,817,426...10,817,496
Ensembl chr19:10,817,426...10,817,496 		JBrowse link
G MIR199A2 microRNA 199a-2 involved_in IDA (PMID:26163491) BHF-UCL PMID:26163491 NCBI chr 1:172,144,535...172,144,644
Ensembl chr 1:172,144,535...172,144,644 		JBrowse link
G MIR27A microRNA 27a involved_in IDA (PMID:26318398) BHF-UCL PMID:26318398 NCBI chr19:13,836,440...13,836,517
Ensembl chr19:13,836,440...13,836,517 		JBrowse link
G MIR27B microRNA 27b involved_in IDA (PMID:26520906) BHF-UCL PMID:26520906 NCBI chr 9:95,085,445...95,085,541
Ensembl chr 9:95,085,445...95,085,541 		JBrowse link
G MYLIP myosin regulatory light chain interacting protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:16,129,086...16,163,887
Ensembl chr 6:16,129,086...16,148,248 		JBrowse link
G PCSK9 proprotein convertase subtilisin/kexin type 9 involved_in IDA (PMID:17328821), (PMID:22848640) BHF-UCL PMID:17328821 PMID:22848640 NCBI chr 1:55,039,548...55,064,852
Ensembl chr 1:55,039,447...55,064,852 		JBrowse link
positive regulation of low-density lipoprotein particle clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA2 annexin A2 involved_in IDA
IEA		 (PMID:22848640) BHF-UCL
Ensembl		 PMID:22848640 GO_REF:0000107 NCBI chr15:60,347,151...60,397,986
Ensembl chr15:60,347,134...60,402,883 		JBrowse link
G LDLRAP1 low density lipoprotein receptor adaptor protein 1 involved_in IMP (PMID:28257760) BHF-UCL PMID:28257760 NCBI chr 1:25,543,606...25,590,400
Ensembl chr 1:25,543,606...25,568,886 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in ISS
IEA		 ARUK-UCL
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:41,158,508...41,163,116
Ensembl chr 6:41,158,506...41,163,186 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19669
    multicellular organismal process 8456
      plasma lipoprotein particle clearance 62
        regulation of lipoprotein particle clearance 40
          regulation of low-density lipoprotein particle clearance 25
            negative regulation of low-density lipoprotein particle clearance 17
            positive regulation of low-density lipoprotein particle clearance 3
Path 2
Term Annotations click to browse term
  biological_process 19669
    biological regulation 13397
      regulation of biological process 13016
        regulation of plasma lipoprotein particle levels 104
          plasma lipoprotein particle clearance 62
            regulation of lipoprotein particle clearance 40
              regulation of low-density lipoprotein particle clearance 25
                negative regulation of low-density lipoprotein particle clearance 17
                positive regulation of low-density lipoprotein particle clearance 3
paths to the root