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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of calcidiol 1-monooxygenase activity
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Accession:GO:0010956 term browser browse the term
Definition:Any process that decreases the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is the catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O.



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negative regulation of calcidiol 1-monooxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP27B1 cytochrome P450 family 27 subfamily B member 1 involved_in ISO (PMID:16549446) BHF-UCL PMID:16549446 NCBI chr10:1,825,224...1,830,845
Ensembl chr10:1,826,046...1,829,911
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G GFI1 growth factor independent 1 transcriptional repressor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:56,473,032...56,484,422
Ensembl chr 6:56,256,305...56,484,422
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G NFKB1 nuclear factor kappa B subunit 1 involved_in ISO (PMID:15243130) BHF-UCL PMID:15243130 NCBI chr32:23,948,598...24,040,704
Ensembl chr32:23,942,954...24,040,703
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 13969
    metabolic process 9103
      negative regulation of metabolic process 2818
        negative regulation of hormone metabolic process 13
          negative regulation of hormone biosynthetic process 11
            negative regulation of calcidiol 1-monooxygenase activity 3
Path 2
Term Annotations click to browse term
  biological_process 13969
    biological regulation 10140
      regulation of biological process 9581
        regulation of metabolic process 5750
          regulation of primary metabolic process 4811
            regulation of lipid metabolic process 358
              regulation of steroid metabolic process 105
                negative regulation of steroid metabolic process 25
                  negative regulation of steroid biosynthetic process 24
                    negative regulation of vitamin D biosynthetic process 5
                      negative regulation of calcidiol 1-monooxygenase activity 3
paths to the root