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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of calcidiol 1-monooxygenase activity
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Accession:GO:0010956 term browser browse the term
Definition:Any process that decreases the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is the catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O.



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negative regulation of calcidiol 1-monooxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP27B1 cytochrome P450 family 27 subfamily B member 1 involved_in ISO (PMID:16549446) BHF-UCL PMID:16549446 NCBI chr12:31,158,814...31,164,462
Ensembl chr12:31,419,773...31,424,822
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G GFI1 growth factor independent 1 transcriptional repressor involved_in ISO (PMID:15947108) BHF-UCL PMID:15947108 NCBI chr 1:95,139,171...95,151,054
Ensembl chr 1:93,876,245...93,883,528
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 involved_in ISO (PMID:15243130) BHF-UCL PMID:15243130 NCBI chr 4:94,925,048...95,040,849
Ensembl chr 4:105,589,062...105,704,098
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Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19444
    cellular process 18997
      metabolic process 12930
        biosynthetic process 9813
          negative regulation of biosynthetic process 2636
            negative regulation of hormone biosynthetic process 12
              negative regulation of calcidiol 1-monooxygenase activity 3
Path 2
Term Annotations click to browse term
  biological_process 19444
    biological regulation 11901
      regulation of biological process 11518
        regulation of cellular process 11168
          regulation of metabolic process 6637
            regulation of primary metabolic process 5234
              regulation of lipid metabolic process 360
                regulation of steroid metabolic process 115
                  negative regulation of steroid metabolic process 28
                    negative regulation of steroid biosynthetic process 26
                      negative regulation of vitamin D biosynthetic process 5
                        negative regulation of calcidiol 1-monooxygenase activity 3
paths to the root