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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
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Accession:GO:0010881 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction.


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regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ank2 ankyrin 2 ISO (MGI:MGI:5427070|PMID:21859974), (MGI:MGI:5430893|PMID:17178715)
(PMID:17178715)
BHF-UCL PMID:17178715, PMID:21859974 MGI:MGI:5427070, MGI:MGI:5430893 NCBI chrNW_004936563:3,520,195...4,170,716 JBrowse link
G Asph aspartate beta-hydroxylase ISO (PMID:17400717) BHF-UCL PMID:17400717 NCBI chrNW_004936496:11,604,992...11,815,680 JBrowse link
G Casq2 calsequestrin 2 ISO (MGI:MGI:1202079|PMID:9525981)
PMID:17569730
(MGI:MGI:3689635|PMID:16932808)
(PMID:16601229), (PMID:16908766)
MGI
BHF-UCL
UniProtKB
PMID:9525981, PMID:16601229, PMID:16908766, PMID:16932808, PMID:17569730 MGI:MGI:1202079, MGI:MGI:3689635, RGD:2314601 NCBI chrNW_004936627:1,001,681...1,069,377 JBrowse link
G Dmd dystrophin ISO (MGI:MGI:4420848|PMID:20080623) BHF-UCL PMID:20080623 MGI:MGI:4420848 NCBI chrNW_004936553:7,157,526...7,943,703 JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B ISO (MGI:MGI:3621834|PMID:12837242) BHF-UCL PMID:12837242 MGI:MGI:3621834 NCBI chrNW_004936493:7,916,002...7,922,747 JBrowse link
G Pln phospholamban ISO (MGI:MGI:82999|PMID:8831698) MGI PMID:8831698 MGI:MGI:82999 NCBI chrNW_004936658:1,443,626...1,453,770 JBrowse link
G Ryr2 ryanodine receptor 2 ISO (MGI:MGI:3621834|PMID:12837242) BHF-UCL PMID:12837242 MGI:MGI:3621834 NCBI chrNW_004936484:15,402,488...15,825,410 JBrowse link
G Slc8a1 solute carrier family 8 member A1 ISO PMID:21779914 BHF-UCL PMID:21779914 RGD:8554732 NCBI chrNW_004936508:10,894,918...11,256,084 JBrowse link
G Tmem38a transmembrane protein 38A ISO (MGI:MGI:3715564|PMID:17611541) MGI PMID:17611541 MGI:MGI:3715564 NCBI chrNW_004936596:3,965,220...3,984,120 JBrowse link
G Tmem38b transmembrane protein 38B ISO (MGI:MGI:3715564|PMID:17611541) MGI PMID:17611541 MGI:MGI:3715564 NCBI chrNW_004936559:6,501,890...6,553,446 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11992
    regulation of biological process 8319
      regulation of localization 2583
        regulation of sequestering of calcium ion 109
          regulation of release of sequestered calcium ion into cytosol 80
            regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 24
              regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 10
Path 2
Term Annotations click to browse term
  biological_process 11992
    biological regulation 8776
      regulation of biological quality 3378
        homeostatic process 1724
          chemical homeostasis 1060
            ion homeostasis 690
              cellular ion homeostasis 546
                cellular cation homeostasis 534
                  cellular metal ion homeostasis 486
                    cellular calcium ion homeostasis 397
                      regulation of cytosolic calcium ion concentration 305
                        positive regulation of cytosolic calcium ion concentration 269
                          calcium ion transport into cytosol 156
                            calcium ion transmembrane import into cytosol 133
                              release of sequestered calcium ion into cytosol 108
                                release of sequestered calcium ion into cytosol by endoplasmic reticulum 26
                                  release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 25
                                    regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 24
                                      regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 10
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.