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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
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Accession:GO:0010881 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction.


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regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANK2 ankyrin 2 ISO (MGI:MGI:5427070|PMID:21859974), (MGI:MGI:5430893|PMID:17178715)
(PMID:17178715)
BHF-UCL PMID:17178715, PMID:21859974 MGI:MGI:5427070, MGI:MGI:5430893 NCBI chr 8:109,306,793...109,661,970 JBrowse link
G ASPH aspartate beta-hydroxylase ISO (PMID:17400717) BHF-UCL PMID:17400717 NCBI chr 4:71,902,891...72,107,047
Ensembl chr 4:71,903,359...72,107,046
JBrowse link
G CASQ2 calsequestrin 2 IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr 4:104,918,204...104,984,019
Ensembl chr 4:104,918,501...104,999,787
JBrowse link
G DMD dystrophin IEA Ensembl GO_REF:0000107 NCBI chr  X:27,028,223...29,650,728
Ensembl chr  X:27,028,223...29,181,689
JBrowse link
G FKBP1B FKBP prolyl isomerase 1B ISO (MGI:MGI:3621834|PMID:12837242) BHF-UCL PMID:12837242 MGI:MGI:3621834 NCBI chr 3:114,623,529...114,636,200
Ensembl chr 3:114,623,529...114,634,628
JBrowse link
G PLN phospholamban ISO (MGI:MGI:82999|PMID:8831698) MGI PMID:8831698 MGI:MGI:82999 NCBI chr 1:43,449,354...43,458,925 JBrowse link
G RYR2 ryanodine receptor 2 IEA Ensembl GO_REF:0000107 NCBI chr14:53,652,140...54,406,691
Ensembl chr14:53,652,245...54,406,355
JBrowse link
G SLC8A1 solute carrier family 8 member A1 ISO PMID:21779914 BHF-UCL PMID:21779914 RGD:8554732 NCBI chr 3:99,823,503...100,257,306
Ensembl chr 3:99,897,162...100,245,140
JBrowse link
G TMEM38A transmembrane protein 38A IEA Ensembl GO_REF:0000107 NCBI chr 2:60,929,043...60,960,527
Ensembl chr 2:60,929,049...60,960,467
JBrowse link
G TMEM38B transmembrane protein 38B IEA Ensembl GO_REF:0000107 NCBI chr 1:246,973,447...247,024,019
Ensembl chr 1:246,973,436...247,027,527
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16545
    regulation of biological process 11420
      regulation of localization 2871
        regulation of sequestering of calcium ion 123
          regulation of release of sequestered calcium ion into cytosol 83
            regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 23
              regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 10
Path 2
Term Annotations click to browse term
  biological_process 16545
    biological regulation 12011
      regulation of biological quality 3985
        homeostatic process 1962
          chemical homeostasis 1249
            ion homeostasis 828
              cellular ion homeostasis 672
                cellular cation homeostasis 659
                  cellular metal ion homeostasis 592
                    cellular calcium ion homeostasis 481
                      regulation of cytosolic calcium ion concentration 380
                        positive regulation of cytosolic calcium ion concentration 335
                          calcium ion transport into cytosol 172
                            calcium ion transmembrane import into cytosol 149
                              release of sequestered calcium ion into cytosol 121
                                release of sequestered calcium ion into cytosol by endoplasmic reticulum 28
                                  release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 27
                                    regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 23
                                      regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 10
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.